Yoshua Bengio

Biographie

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Reconnu comme une sommité mondiale en intelligence artificielle, Yoshua Bengio s’est surtout distingué par son rôle de pionnier en apprentissage profond, ce qui lui a valu le prix A. M. Turing 2018, le « prix Nobel de l’informatique », avec Geoffrey Hinton et Yann LeCun. Il est professeur titulaire à l’Université de Montréal, fondateur et conseiller scientifique de Mila – Institut québécois d’intelligence artificielle, et codirige en tant que senior fellow le programme Apprentissage automatique, apprentissage biologique de l'Institut canadien de recherches avancées (CIFAR). Il occupe également la fonction de conseiller spécial et directeur scientifique fondateur d’IVADO.

En 2018, il a été l’informaticien qui a recueilli le plus grand nombre de nouvelles citations au monde. En 2019, il s’est vu décerner le prestigieux prix Killam. Depuis 2022, il détient le plus grand facteur d’impact (h-index) en informatique à l’échelle mondiale. Il est fellow de la Royal Society de Londres et de la Société royale du Canada, et officier de l’Ordre du Canada.

Soucieux des répercussions sociales de l’IA et de l’objectif que l’IA bénéficie à tous, il a contribué activement à la Déclaration de Montréal pour un développement responsable de l’intelligence artificielle.

Étudiants actuels

Jamal Abou Haibeh

Collaborateur·rice alumni - McGill

Mohammed Abukalam

Collaborateur·rice alumni - UdeM

Berkes Anaïs

Collaborateur·rice de recherche - Cambridge University

Superviseur⋅e principal⋅e :

Rim Assouel

Doctorat - UdeM

Stefan Bauer

Visiteur de recherche indépendant

Co-superviseur⋅e :

Guillaume Lajoie

Paul Bertin

Doctorat - UdeM

Joyce Chai

Visiteur de recherche indépendant

Superviseur⋅e principal⋅e :

Siva Reddy

Shahana Chatterjee

Collaborateur·rice de recherche - N/A

Superviseur⋅e principal⋅e :

Doctorat - UdeM

Collaborateur·rice de recherche - KAIST

Collaborateur·rice alumni - UdeM

Doctorat - UdeM

Collaborateur·rice alumni - UdeM

Co-superviseur⋅e :

Loubna Benabbou

Desmond Elliott

Visiteur de recherche indépendant

Superviseur⋅e principal⋅e :

Doctorat - UdeM

Co-superviseur⋅e :

Doctorat - UdeM

Doctorat - UdeM

Leo Feng

Doctorat - UdeM

Doctorat

Doctorat - UdeM

Edward Hu

Doctorat - UdeM

Moksh Jain

Doctorat - UdeM

Doctorat - UdeM

Superviseur⋅e principal⋅e :

Collaborateur·rice alumni - UdeM

Hyeonah Kim

Postdoctorat - UdeM

Superviseur⋅e principal⋅e :

Alex Hernandez-Garcia

Salem Lahlou

Collaborateur·rice alumni - UdeM

Tabitha Edith Lee

Postdoctorat - UdeM

Superviseur⋅e principal⋅e :

Collaborateur·rice alumni

Zhen Liu

Collaborateur·rice alumni - UdeM

Superviseur⋅e principal⋅e :

Liam Paull

Kanika Madan

Doctorat - UdeM

Nikolay Malkin

Collaborateur·rice alumni - UdeM

Cristian Dragos Manta

Doctorat - UdeM

Co-superviseur⋅e :

Dhanya Sridhar

Sarthak Mittal

Doctorat - UdeM

Superviseur⋅e principal⋅e :

Doctorat - UdeM

Superviseur⋅e principal⋅e :

Postdoctorat - UdeM

Superviseur⋅e principal⋅e :

Visiteur de recherche indépendant - UdeM

Padideh Nouri

Doctorat - UdeM

Superviseur⋅e principal⋅e :

Ali Parviz

Collaborateur·rice de recherche - Ying Wu Coll of Computing

Lena Podina

Collaborateur·rice de recherche - University of Waterloo

Superviseur⋅e principal⋅e :

David Rolnick

Nassim Rahaman

Collaborateur·rice alumni - Max-Planck-Institute for Intelligent Systems

Amine RAZIG

Collaborateur·rice de recherche - UdeM

Co-superviseur⋅e :

Doctorat - UdeM

Postdoctorat - UdeM

Visiteur de recherche indépendant - UdeM

Oli RICHARDSON

Postdoctorat - UdeM

Camille Rochefort-Boulanger

Doctorat - UdeM

Superviseur⋅e principal⋅e :

Julie Hussin

Abhik Roychoudhury Roychoudhury

Visiteur de recherche indépendant

Superviseur⋅e principal⋅e :

Postdoctorat - UdeM

Collaborateur·rice alumni - UdeM

Marcin Sendera

Collaborateur·rice alumni - UdeM

Divya Sharma

Postdoctorat

Co-superviseur⋅e :

Alex Hernandez-Garcia

Marco Stock

Visiteur de recherche indépendant - Technical University of Munich

Mélisande Astrid Crystal Teng

Doctorat - UdeM

Co-superviseur⋅e :

Hugo Larochelle

Ivan Titov

Visiteur de recherche indépendant

Superviseur⋅e principal⋅e :

Siva Reddy

Alex Tong

Collaborateur·rice alumni - UdeM

Postdoctorat - UdeM

Co-superviseur⋅e :

Doctorat - UdeM

Superviseur⋅e principal⋅e :

Collaborateur·rice de recherche

Collaborateur·rice de recherche - UdeM

Skipper : combiner l’abstraction spatiale et temporelle afin d’améliorer la généralisation

Nicole Zhang

Doctorat - McGill

Superviseur⋅e principal⋅e :

Doctorat - UdeM

Superviseur⋅e principal⋅e :

Doctorat - UdeM

Harry Zhao

Collaborateur·rice alumni - McGill

Superviseur⋅e principal⋅e :

Billets de blogue

Generic thumbnail for Mila Blog articles.

22 février 2024

par

Mingde Harry Zhao

Safa Alver

Harm van Seijen

Romain Laroche

Doina Precup

Yoshua Bengio

Mise à l’échelle au service du raisonnement et de l’apprentissage automatique basé sur un modèle

Scaling in the service of reasoning & model-based ML

4 avril 2023

par

Yoshua Bengio

Edward J. Hu

Une collaboration entre Mila et Relation Therapeutics pour découvrir in vitro de nouvelles associations médicamenteuses synergiques

A collaboration between Mila and Relation Therapeutics to discover novel synergistic combinations of drugs in vitro

23 mars 2022

par

Paul Bertin

Jake P. Taylor-King

Yoshua Bengio

Les réseaux de flot génératifs

15 mars 2022

par

Yoshua Bengio

Publications

A high-throughput phenotypic screen combined with an ultra-large-scale deep learning-based virtual screening reveals novel scaffolds of antibacterial compounds

Gabriele Scalia

Steven T. Rutherford

Ziqing Lu

Kerry R. Buchholz

Nicholas Skelton

Kangway Chuang

Nathaniel Diamant

Jan-Christian Hütter

Jerome-Maxim Luescher

Anh Miu

Jeff Blaney

Leo Gendelev

Elizabeth Skippington

Greg Zynda

Nia Dickson

Michał Koziarski

Aviv Regev

Man-Wah Tan

Tommasso Biancalani

The proliferation of multi-drug-resistant bacteria underscores an urgent need for novel antibiotics. Traditional discovery methods face chal… (voir plus)lenges due to limited chemical diversity, high costs, and difficulties in identifying structurally novel compounds. Here, we explore the integration of small molecule high-throughput screening with a deep learning-based virtual screening approach to uncover new antibacterial compounds. Leveraging a diverse library of nearly 2 million small molecules, we conducted comprehensive phenotypic screening against a sensitized Escherichia coli strain that, at a low hit rate, yielded thousands of hits. We trained a deep learning model, GNEprop, to predict antibacterial activity, ensuring robustness through out-of-distribution generalization techniques. Virtual screening of over 1.4 billion compounds identified potential candidates, of which 82 exhibited antibacterial activity, illustrating a 90X improved hit rate over the high-throughput screening experiment GNEprop was trained on. Importantly, a significant portion of these newly identified compounds exhibited high dissimilarity to known antibiotics, indicating promising avenues for further exploration in antibiotic discovery.

2024-09-14

bioRxiv (prépublication)

A high-throughput phenotypic screen combined with an ultra-large-scale deep learning-based virtual screening reveals novel scaffolds of antibacterial compounds

Gabriele Scalia

Steven T. Rutherford

Ziqing Lu

Kerry R. Buchholz

Nicholas Skelton

Kangway Chuang

Nathaniel Diamant

Jan-Christian Hütter

Jerome-Maxim Luescher

Anh Miu

Jeff Blaney

Leo Gendelev

Elizabeth Skippington

Greg Zynda

Nia Dickson

Michał Koziarski

Aviv Regev

Man-Wah Tan

Tommaso Biancalani

2024-09-14

bioRxiv (prépublication)

Meta Flow Matching: Integrating Vector Fields on the Wasserstein Manifold

Lazar Atanackovic

Xi Zhang

Brandon Amos

Leo J Lee

Numerous biological and physical processes can be modeled as systems of interacting entities evolving continuously over time, e.g. the dynam… (voir plus)ics of communicating cells or physical particles. Learning the dynamics of such systems is essential for predicting the temporal evolution of populations across novel samples and unseen environments. Flow-based models allow for learning these dynamics at the population level - they model the evolution of the entire distribution of samples. However, current flow-based models are limited to a single initial population and a set of predefined conditions which describe different dynamics. We argue that multiple processes in natural sciences have to be represented as vector fields on the Wasserstein manifold of probability densities. That is, the change of the population at any moment in time depends on the population itself due to the interactions between samples. In particular, this is crucial for personalized medicine where the development of diseases and their respective treatment response depend on the microenvironment of cells specific to each patient. We propose Meta Flow Matching (MFM), a practical approach to integrate along these vector fields on the Wasserstein manifold by amortizing the flow model over the initial populations. Namely, we embed the population of samples using a Graph Neural Network (GNN) and use these embeddings to train a Flow Matching model. This gives MFM the ability to generalize over the initial distributions, unlike previously proposed methods. We demonstrate the ability of MFM to improve the prediction of individual treatment responses on a large-scale multi-patient single-cell drug screen dataset.

2024-08-26

ArXiv (prépublication)

Zero-Shot Object-Centric Representation Learning

Aniket Rajiv Didolkar

Andrii Zadaianchuk

Michael Curtis Mozer

Georg Martius

Maximilian Seitzer

The goal of object-centric representation learning is to decompose visual scenes into a structured representation that isolates the entities… (voir plus). Recent successes have shown that object-centric representation learning can be scaled to real-world scenes by utilizing pre-trained self-supervised features. However, so far, object-centric methods have mostly been applied in-distribution, with models trained and evaluated on the same dataset. This is in contrast to the wider trend in machine learning towards general-purpose models directly applicable to unseen data and tasks. Thus, in this work, we study current object-centric methods through the lens of zero-shot generalization by introducing a benchmark comprising eight different synthetic and real-world datasets. We analyze the factors influencing zero-shot performance and find that training on diverse real-world images improves transferability to unseen scenarios. Furthermore, inspired by the success of task-specific fine-tuning in foundation models, we introduce a novel fine-tuning strategy to adapt pre-trained vision encoders for the task of object discovery. We find that the proposed approach results in state-of-the-art performance for unsupervised object discovery, exhibiting strong zero-shot transfer to unseen datasets.

2024-08-17

ArXiv (prépublication)

Zero-Shot Object-Centric Representation Learning

Aniket Rajiv Didolkar

Andrii Zadaianchuk

Michael Curtis Mozer

Georg Martius

Maximilian Seitzer

2024-08-17

ArXiv (prépublication)

Zero-Shot Object-Centric Representation Learning

Aniket Rajiv Didolkar

Andrii Zadaianchuk

Michael Curtis Mozer

Georg Martius

Maximilian Seitzer

2024-08-17

ArXiv (prépublication)

Zero-Shot Object-Centric Representation Learning

Aniket Rajiv Didolkar

Andrii Zadaianchuk

Michael Curtis Mozer

Georg Martius

Maximilian Seitzer

2024-08-17

ArXiv (prépublication)

Zero-Shot Object-Centric Representation Learning

Aniket Rajiv Didolkar

Andrii Zadaianchuk

Michael Curtis Mozer

Georg Martius

Maximilian Seitzer

2024-08-17

ArXiv (prépublication)

Cell Morphology-Guided Small Molecule Generation with GFlowNets

Stephen Zhewen Lu

Ziqing Lu

Ehsan Hajiramezanali

Tommaso Biancalani

Gabriele Scalia

Michał Koziarski

High-content phenotypic screening, including high-content imaging (HCI), has gained popularity in the last few years for its ability to char… (voir plus)acterize novel therapeutics without prior knowledge of the protein target. When combined with deep learning techniques to predict and represent molecular-phenotype interactions, these advancements hold the potential to significantly accelerate and enhance drug discovery applications. This work focuses on the novel task of HCI-guided molecular design. Generative models for molecule design could be guided by HCI data, for example with a supervised model that links molecules to phenotypes of interest as a reward function. However, limited labeled data, combined with the high-dimensional readouts, can make training these methods challenging and impractical. We consider an alternative approach in which we leverage an unsupervised multimodal joint embedding to define a latent similarity as a reward for GFlowNets. The proposed model learns to generate new molecules that could produce phenotypic effects similar to those of the given image target, without relying on pre-annotated phenotypic labels. We demonstrate that the proposed method generates molecules with high morphological and structural similarity to the target, increasing the likelihood of similar biological activity, as confirmed by an independent oracle model.

2024-08-09

ArXiv (prépublication)

AI-Assisted Generation of Difficult Math Questions

Vedant Shah

Dingli Yu

Kaifeng Lyu

Simon Park

Nan Rosemary Ke

Michael Curtis Mozer

Sanjeev Arora

Current LLM training positions mathematical reasoning as a core capability. With publicly available sources fully tapped, there is unmet dem… (voir plus)and for diverse and challenging math questions. Relying solely on human experts is both time-consuming and costly, while LLM-generated questions often lack the requisite diversity and difficulty. We present a design framework that combines the strengths of LLMs with a human-in-the-loop approach to generate a diverse array of challenging math questions. We leverage LLM metacognition skills [Didolkar et al., 2024] of a strong LLM to extract core"skills"from existing math datasets. These skills serve as the basis for generating novel and difficult questions by prompting the LLM with random pairs of core skills. The use of two different skills within each question makes finding such questions an"out of distribution"task for both LLMs and humans. Our pipeline employs LLMs to iteratively generate and refine questions and solutions through multiturn prompting. Human annotators then verify and further refine the questions, with their efficiency enhanced via further LLM interactions. Applying this pipeline on skills extracted from the MATH dataset [Hendrycks et al., 2021] resulted in MATH

2024-07-30

ArXiv (prépublication)

AI-Assisted Generation of Difficult Math Questions

Vedant Shah

Dingli Yu

Kaifeng Lyu

Simon Park

Nan Rosemary Ke

Michael Curtis Mozer