Portrait de Guillaume Dumas

Guillaume Dumas

Membre académique associé
Professeur agrégé, Université de Montréal, Département de psychiatrie et d’addictologie
Professeur adjoint, McGill University, Département de psychiatrie
Sujets de recherche
Apprentissage automatique médical
Apprentissage par renforcement
Apprentissage profond
Biologie computationnelle
Neurosciences computationnelles
Systèmes dynamiques
Théorie de l'apprentissage automatique

Biographie

Guillaume Dumas est professeur agrégé de psychiatrie computationnelle à la Faculté de médecine de l'Université de Montréal et chercheur principal du laboratoire de psychiatrie de précision et de physiologie sociale du Centre de recherche du CHU Sainte-Justine. Il est titulaire de la chaire IVADO IA en santé mentale et chercheur-boursier junior 1 du Fonds de recherche du Québec - Santé (FRQS) dans le domaine de l’ IA en santé et de la santé numérique. En 2023, il a été retenu dans le cadre du Programme des chercheurs mondiaux CIFAR-Azrieli pour le programme de recherche Cerveau, esprit et conscience. Il a également été nommé parmi les Futurs leaders canadiens de la recherche sur le cerveau par la Fondation Brain Canada.

Il a auparavant été chercheur permanent en neurosciences et en biologie computationnelle à l'Institut Pasteur (Paris, France), ainsi que chercheur postdoctoral au Center for Complex Systems and Brain Sciences à l’Université Florida Atlantic (FAU), aux États-Unis. Il est titulaire d'un diplôme d'ingénieur en ingénierie avancée et informatique (École centrale Paris), de deux masters (physique théorique, Université Paris-Saclay; sciences cognitives, ENS/EHESS/Paris 5) et d'un doctorat en neurosciences cognitives (Sorbonne Université).

Ses recherches visent à combiner l’intelligence artificielle, les neurosciences cognitives et la médecine numérique à travers un programme interdisciplinaire suivant deux axes principaux :

- L’intelligence artificielle en santé mentale, par la création de nouveaux algorithmes pour étudier le développement de l'architecture cognitive humaine et pour fournir une médecine personnalisée en neuropsychiatrie grâce à des données allant du génome à celles des téléphones intelligents;

- Les neurosciences sociales en intelligence artificielle, par la traduction de la recherche fondamentale sur le cerveau et le formalisme des systèmes dynamiques en des modèles hybrides neurocomputationnels et d’apprentissage automatique (NeuroML) et de nouvelles architectures présentant des capacités d'apprentissage social (NeuroIA Sociale et IHM).

Étudiants actuels

Maîtrise recherche - UdeM
Doctorat - UdeM
Maîtrise recherche - UdeM
Superviseur⋅e principal⋅e :
Doctorat - UdeM
Superviseur⋅e principal⋅e :

Publications

Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes
Guillaume Huguet
Thomas Renne
Cécile Poulain
Alma Dubuc
Kuldeep Kumar
Sayeh Kazem
Worrawat Engchuan
Omar Shanta
Elise Douard
Catherine Proulx
Martineau Jean-Louis
Zohra Saci
Josephine Mollon
Laura Schultz
Emma E M Knowles
Simon R. Cox
David Porteous
Gail Davies
Paul Redmond
Sarah E. Harris … (voir 10 de plus)
Gunter Schumann
Aurélie Labbe
Zdenka Pausova
Tomas Paus
Stephen W Scherer
Jonathan Sebat
Laura Almasy
David C. Glahn
Sébastien Jacquemont
Genomic Copy Number Variants (CNVs) that increase risk for neurodevelopmental disorders are also associated with lower cognitive ability in … (voir plus)general population cohorts. Studies have focussed on a small set of recurrent CNVs, but burden analyses suggested that the vast majority of CNVs affecting cognitive ability are too rare to reach variant-level association. As a result, the full range of gene-dosage-sensitive biological processes linked to cognitive ability remains unknown. To investigate this issue, we identified all CNVs >50 kilobases in 258k individuals from 6 general population cohorts with assessments of general cognitive abilities. We performed a CNV-GWAS and functional burden analyses, which tested 6502 gene-sets defined by tissue and cell-type transcriptomics as well as gene ontology disrupted by all rare coding CNVs. CNV-GWAS identified a novel duplication at 2q12.3 associated with higher performance in cognitive ability. Among the 864 gene-sets associated with cognitive ability, only 11% showed significant effects for both deletions and duplication. Accordingly, we systematically observed negative correlations between deletion and duplication effect sizes across all levels of biological observations. We quantified the preferential effects of deletions versus duplication using tagDS, a new normalized metric. Cognitive ability was preferentially affected by cortical, presynaptic, and negative-regulation gene-sets when duplicated. In contrast, preferential effects of deletions were observed for subcortical, post-synaptic, and positive-regulation gene-sets. A large proportion of gene-sets assigned to non-brain organs were associated with cognitive ability due to low tissue specificity genes, which were associated with higher sensitive to haploinsufficiency. Overall, most biological functions associated with cognitive ability are divided into those sensitive to either deletion or duplications.
Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes
Guillaume Huguet
Thomas Renne
Cécile Poulain
Alma Dubuc
Kuldeep Kumar
Sayeh Kazem
Worrawat Engchuan
Omar Shanta
Elise Douard
Catherine Proulx
Martineau Jean-Louis
Zohra Saci
Josephine Mollon
Laura Schultz
Emma E M Knowles
Simon R. Cox
David Porteous
Gail Davies
Paul Redmond
Sarah E. Harris … (voir 10 de plus)
Gunter Schumann
Aurélie Labbe
Zdenka Pausova
Tomas Paus
Stephen W Scherer
Jonathan Sebat
Laura Almasy
David C. Glahn
Sébastien Jacquemont
Genomic Copy Number Variants (CNVs) that increase risk for neurodevelopmental disorders are also associated with lower cognitive ability in … (voir plus)general population cohorts. Studies have focussed on a small set of recurrent CNVs, but burden analyses suggested that the vast majority of CNVs affecting cognitive ability are too rare to reach variant-level association. As a result, the full range of gene-dosage-sensitive biological processes linked to cognitive ability remains unknown. To investigate this issue, we identified all CNVs >50 kilobases in 258k individuals from 6 general population cohorts with assessments of general cognitive abilities. We performed a CNV-GWAS and functional burden analyses, which tested 6502 gene-sets defined by tissue and cell-type transcriptomics as well as gene ontology disrupted by all rare coding CNVs. CNV-GWAS identified a novel duplication at 2q12.3 associated with higher performance in cognitive ability. Among the 864 gene-sets associated with cognitive ability, only 11% showed significant effects for both deletions and duplication. Accordingly, we systematically observed negative correlations between deletion and duplication effect sizes across all levels of biological observations. We quantified the preferential effects of deletions versus duplication using tagDS, a new normalized metric. Cognitive ability was preferentially affected by cortical, presynaptic, and negative-regulation gene-sets when duplicated. In contrast, preferential effects of deletions were observed for subcortical, post-synaptic, and positive-regulation gene-sets. A large proportion of gene-sets assigned to non-brain organs were associated with cognitive ability due to low tissue specificity genes, which were associated with higher sensitive to haploinsufficiency. Overall, most biological functions associated with cognitive ability are divided into those sensitive to either deletion or duplications.
Association between arterial oxygen and mortality across critically ill patients with hematologic malignancies: results from an international collaborative network
Idunn S. Morris
Tamishta Hensman
Sean M. Bagshaw
Alexandre Demoule
Bruno Ferreyro
Achille Kouatchet
Virginie Lemiale
Djamel Mokart
Frédéric Pène
Sangeeta Mehta
Elie Azoulay
Laveena Munshi
Laurent Argaud
François Barbier
Dominique Benoit
Naike Bigé
Fabrice Bruneel
Emmanuel Canet
Yves Cohen … (voir 30 de plus)
Michaël Darmon
Didier Gruson
Kada Klouche
Loay Kontar
Alexandre Lautrette
Christine Lebert
Guillaume Louis
Julien Mayaux
Anne-Pascale Meert
Anne-Sophie Moreau
Martine Nyunga
Vincent Peigne
Pierre Perez
Jean Herlé Raphalen
Carole Schwebel
Jean-Marie Tonnelier
Florent Wallet
Lara Zafrani
Bram Rochwerg
Farah Shoukat
Dean Fergusson
Paul Heffernan
Margaret Herridge
Sheldon Magder
Mark Minden
Rakesh Patel
Salman Qureshi
Aaron Schimmer
Santhosh Thyagu
Han Ting Wang
Long-term survival and functional outcomes of critically ill patients with hematologic malignancies: a Canadian multicenter prospective study
Laveena Munshi
Bram Rochwerg
Farah Shoukat
Michael Detsky
Dean A. Fergusson
Bruno Ferreyro
Paul Heffernan
Margaret Herridge
Sheldon Magder
Mark Minden
Rakesh Patel
Salman Qureshi
Aaron Schimmer
Santhosh Thyagu
Han Ting Wang
Sangeeta Mehta
Predicting Grokking Long Before it Happens: A look into the loss landscape of models which grok
Tikeng Notsawo Pascal Junior
Pascal Notsawo
Hattie Zhou
Mohammad Pezeshki
Sources of richness and ineffability for phenomenally conscious states
Xu Ji
Eric Elmoznino
George Deane
Axel Constant
Jonathan Simon
The « jingle-jangle fallacy » of empathy: Delineating affective, cognitive and motor components of empathy from behavioral synchrony using a virtual agent
Julia Ayache
Alexander Sumich
D. Kuss
Darren Rhodes
Nadja Heym
Effective Latent Differential Equation Models via Attention and Multiple Shooting
Germán Abrevaya
Mahta Ramezanian-Panahi
Jean-Christophe Gagnon-Audet
Pablo Polosecki
Silvina Ponce Dawson
Guillermo Cecchi
Prospective evaluation of bleeding risk among thrombocytopenic patients admitted in intensive care unit.
Geoffroy HARIRI
Vincent Belossi
Louis Pérol
Louai Missri
Paul GABARRE
Vincent BONNY
Tomas URBINA
Jean-Luc Baudel
Bertrand GUIDET
Jérémie JOFFRE
Eric Maury
Hafid AIT-OUFELLA
Protocol for fever control using external cooling in mechanically ventilated patients with septic shock: SEPSISCOOL II randomised controlled trial
Armelle Guénégou-Arnoux
Juliette Murris
Stéphane Bechet
Camille Jung
Johann Auchabie
Julien Dupeyrat
Nadia Anguel
Pierre Asfar
Julio Badie
Dorothée Carpentier
Benjamin Chousterman
Jeremy Bourenne
Agathe Delbove
Jérôme Devaquet
Nicolas Deye
Anne-Florence Dureau
Jean-Baptiste Lascarrou
Stephane Legriel
Christophe Guitton … (voir 14 de plus)
Caroline Jannière-Nartey
Jean-Pierre Quenot
Jean-Claude Lacherade
Julien Maizel
Armand Mekontso Dessap
Bruno Mourvillier
Philippe Petua
Gaetan Plantefeve
Jean-Christophe Richard
Alexandre Robert
Clément Saccheri
Ly Van Phach Vong
Sandrine Katsahian
Frédérique Schortgen
Corticosteroids induce an early but limited decrease in IL-6 dependent pro-inflammatory responses in critically ill COVID-19 patients
Tomas URBINA
Paul GABARRE
Vincent BONNY
Jean-Rémi Lavillegrand
Marc GARNIER
Jérémie JOFFRE
Nathalie MARIO
Geoffroy HARIRI
Matthieu TURPIN
Emmanuel PARDO
Muriel FARTOUKH
Bertrand GUIDET
Eric Maury
Yannick CHANTRAN
Pierre-Yves BOELLE
Guillaume VOIRIOT
Hafid AIT-OUFELLA
Resilience and Mental-Health Symptoms in ICU Healthcare Professionals Facing Repeated COVID-19 Waves
Elie Azoulay
Frédéric Pochard
Laurent Argaud
Alain Cariou
Raphael Clere-Jehl
Olivier Guisset
Vincent Labbé
Fabienne Tamion
Fabrice Bruneel
Mercé Jourdain
Danielle Reuter
Kada Klouche
Achille Kouatchet
Virginie Souppart
Alexandre Lautrette
Julien Bohé
Antoine Vieillard Baron
Jean Dellamonica
Laurent Papazian
Jean Reignier … (voir 3 de plus)
François Barbier
Nancy Kentish-Barnes