Portrait de Guillaume Dumas

Guillaume Dumas

Membre académique associé
Professeur agrégé, Université de Montréal, Département de psychiatrie et d’addictologie
Professeur adjoint, McGill University, Département de psychiatrie
Sujets de recherche
Apprentissage automatique médical
Apprentissage par renforcement
Apprentissage profond
Biologie computationnelle
Neurosciences computationnelles
Systèmes dynamiques
Théorie de l'apprentissage automatique
Site web
Google Scholar
LinkedIn
X

Biographie

Guillaume Dumas est professeur agrégé de psychiatrie computationnelle à la Faculté de médecine de l'Université de Montréal et chercheur principal du laboratoire de psychiatrie de précision et de physiologie sociale du Centre de recherche du CHU Sainte-Justine. Il est titulaire de la chaire IVADO IA en santé mentale et chercheur-boursier junior 1 du Fonds de recherche du Québec - Santé (FRQS) dans le domaine de l’ IA en santé et de la santé numérique. En 2023, il a été retenu dans le cadre du Programme des chercheurs mondiaux CIFAR-Azrieli pour le programme de recherche Cerveau, esprit et conscience. Il a également été nommé parmi les Futurs leaders canadiens de la recherche sur le cerveau par la Fondation Brain Canada.

Il a auparavant été chercheur permanent en neurosciences et en biologie computationnelle à l'Institut Pasteur (Paris, France), ainsi que chercheur postdoctoral au Center for Complex Systems and Brain Sciences à l’Université Florida Atlantic (FAU), aux États-Unis. Il est titulaire d'un diplôme d'ingénieur en ingénierie avancée et informatique (École centrale Paris), de deux masters (physique théorique, Université Paris-Saclay; sciences cognitives, ENS/EHESS/Paris 5) et d'un doctorat en neurosciences cognitives (Sorbonne Université).

Ses recherches visent à combiner l’intelligence artificielle, les neurosciences cognitives et la médecine numérique à travers un programme interdisciplinaire suivant deux axes principaux :

- L’intelligence artificielle en santé mentale, par la création de nouveaux algorithmes pour étudier le développement de l'architecture cognitive humaine et pour fournir une médecine personnalisée en neuropsychiatrie grâce à des données allant du génome à celles des téléphones intelligents;

- Les neurosciences sociales en intelligence artificielle, par la traduction de la recherche fondamentale sur le cerveau et le formalisme des systèmes dynamiques en des modèles hybrides neurocomputationnels et d’apprentissage automatique (NeuroML) et de nouvelles architectures présentant des capacités d'apprentissage social (NeuroIA Sociale et IHM).

Étudiants actuels

Germán Abrevaya
Visiteur de recherche indépendant - UdeM
Superviseur⋅e principal⋅e :
Irina Rish
Google Scholar
Juan David Vargas
Maîtrise recherche - UdeM
Kastel Natalie
Doctorat - UdeM
Mahta Ramezanian
Maîtrise recherche - UdeM
Superviseur⋅e principal⋅e :
Irina Rish
Zahra Sheikhbahaee
Postdoctorat - UdeM
Co-superviseur⋅e :
Irina Rish
Github
Pascal Tikeng Notsawo
Doctorat - UdeM
Superviseur⋅e principal⋅e :
Guillaume Rabusseau
Site web
Github
Google Scholar
Tommie Tosato
Postdoctorat - UdeM
Github

Publications

Hypo- and hyper- sensory processing heterogeneity in Autism Spectrum Disorder
Aline Lefebvre
Julian Tillmann
Freddy Cliquet
Frederique Amsellem
Anna Maruani
Claire Leblond
Anita Beggiato
David Germanaud
Anouck Amestoy
Myriam Ly‐Le Moal
Daniel Umbricht
Christopher Chattam
Lorraine Murtagh
Manuel Bouvard
Marion Leboyer
Tony Charman
Thomas Bourgeron
Richard Delorme
Guillaume Dumas
Background. Sensory processing atypicalities are part of the core symptoms of autism spectrum disorder (ASD) and could result from an excita… (voir plus)tion/inhibition imbalance. Yet, the convergence level of phenotypic sensory processing atypicalities with genetic alterations in GABA-ergic and glutamatergic pathways remains poorly understood. This study aimed to characterize the distribution of hypo/hyper-sensory profile among individuals with ASD and investigate the role of deleterious mutations in GABAergic and glutamatergic pathways related genes in sensory processing atypicalities. Method. From the Short Sensory Profile (SSP) questionnaire, we defined and explored a score – the differential Short Sensory Profile (dSSP) - as a normalized and centralized hypo/hypersensitivity ratio for 1136 participants (533 with ASD, 210 first-degree relatives, and 267 controls) from two independent study samples (PARIS and LEAP). We also performed an unsupervised item-based clustering analysis on SSP items scores to validate this new categorization in terms of hypo and hyper sensitivity. We then explored the link between the dSSP score and the burden of deleterious mutations in a subset of individuals for which whole-genome sequencing data were available. Results. We observed a mean dSSP score difference between ASD and controls, driven mostly by a high dSSP score variability among groups (PARIS: p0.0001, η2 = 0.0001, LEAP: p0.0001, Cohen’s d=3.67). First-degree relatives were with an intermediate distribution variability prof
2021-11-30
(publié)
doi.org
The meaning of significant mean group differences for biomarker discovery
Eva Loth
Jumana Ahmad
Christopher H. Chatham
Beatriz López
Ben Carter
Daisy Crawley
Beth Oakley
Hannah Hayward
Jennifer Cooke
Antonia San José Cáceres
Danilo Bzdok
Emily J. H. Jones
Tony Charman
Christian Beckmann
Thomas Bourgeron
Roberto Toro
Jan K. Buitelaar
Declan Murphy
Guillaume Dumas
2021-11-18
PLoS Computational Biology (publié)
doi.org
Inter-Brain Synchronization: From Neurobehavioral Correlation to Causal Explanation
Guillaume Dumas
2021-10-01
International Journal of Psychophysiology (publié)
doi.org
THE EFFECT SIZE OF GENES ON COGNITIVE ABILITIES IS LINKED TO THEIR EXPRESSION ALONG THE MAJOR HIERARCHICAL GRADIENT IN THE HUMAN BRAIN
Sébastien Jacquemont
Guillaume Huguet
Elise Douard
Zohra Saci
Guillaume Dumas
Laura Almasy
David C. Glahn
2021-10-01
European Neuropsychopharmacology (publié)
doi.org
Hybrid Harmony: A Multi-Person Neurofeedback Application for Interpersonal Synchrony
Phoebe Chen
Sophie Hendrikse
Kaia Sargent
Michele Romani
Matthias Oostrik
Tom F. Wilderjans
Sander Koole
Guillaume Dumas
David Medine
Suzanne Dikker
Recent years have seen a dramatic increase in studies measuring brain activity, physiological responses, and/or movement data from multiple … (voir plus)individuals during social interaction. For example, so-called “hyperscanning” research has demonstrated that brain activity may become synchronized across people as a function of a range of factors. Such findings not only underscore the potential of hyperscanning techniques to capture meaningful aspects of naturalistic interactions, but also raise the possibility that hyperscanning can be leveraged as a tool to help improve such naturalistic interactions. Building on our previous work showing that exposing dyads to real-time inter-brain synchrony neurofeedback may help boost their interpersonal connectedness, we describe the biofeedback application Hybrid Harmony, a Brain-Computer Interface (BCI) that supports the simultaneous recording of multiple neurophysiological datastreams and the real-time visualization and sonification of inter-subject synchrony. We report results from 236 dyads experiencing synchrony neurofeedback during naturalistic face-to-face interactions, and show that pairs' social closeness and affective personality traits can be reliably captured with the inter-brain synchrony neurofeedback protocol, which incorporates several different online inter-subject connectivity analyses that can be applied interchangeably. Hybrid Harmony can be used by researchers who wish to study the effects of synchrony biofeedback, and by biofeedback artists and serious game developers who wish to incorporate multiplayer situations into their practice.
2021-08-12
Frontiers in Neuroergonomics (publié)
doi.org
A systematic analysis of ICSD-3 diagnostic criteria and proposal for further structured iteration.
Christophe Gauld
Régis Lopez
Pierre A. GEOFFROY
Charles Morin
Kelly Guichard
Elodie Giroux
Yves Dauvilliers
Guillaume Dumas
Pierre Philip
Jean‐Arthur Micoulaud‐Franchi
2021-08-01
Sleep Medicine Reviews (publié)
doi.org
Temporal Profiles of Social Attention Are Different Across Development in Autistic and Neurotypical People.
Teresa Del Bianco
Luke Mason
Tony Charman
Julianne Tillman
Eva Loth
Hannah Hayward
F. Shic
Jan K. Buitelaar
Mark Johnson
Emily J. H. Jones
Jumana Ahmad
Sara Ambrosino
Tobias Banaschewski
Simon Baron-Cohen
Sarah Baumeister
Christian Beckmann
Sven Bölte
Thomas Bourgeron
Carsten Bours
M. Brammer … (voir 46 de plus)
Daniel Brandeis
Claudia Brogna
Yvette de Bruijn
Ineke Cornelissen
Daisy Crawley
Flavio Dell’Acqua
Guillaume Dumas
Sarah Durston
Christine Ecker
Jessica Faulkner
Vincent Frouin
Pilar Garcés
David Goyard
Lindsay Ham
Joerg F. Hipp
Rosemary Holt
Meng-Chuan Lai
Xavier Liogier D’ardhuy
Michael V. Lombardo
David J. Lythgoe
René Mandl
Andre Marquand
Maarten Mennes
Andreas Meyer-Lindenberg
Carolin Moessnang
Nico Mueller
Declan Murphy
Beth Oakley
Laurence O’Dwyer
Marianne Oldehinkel
Bob Oranje
Gahan Pandina
Antonio Persico
Barbara Ruggeri
Amber N. V. Ruigrok
Jessica Sabet
Roberto Sacco
Antonia San José Cáceres
Emily Simonoff
Will Spooren
Roberto Toro
Heike Tost
Jack Waldman
Steve C. R. Williams
Caroline Wooldridge
Marcel P. Zwiers
2021-08-01
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (publié)
doi.org
Why do sleep disorders belong to mental disorder classifications? A network analysis of the "Sleep-Wake Disorders" section of the DSM-5.
Christophe Gauld
Régis Lopez
Charles Morin
Julien Maquet
Aileen McGonigal
Pierre A. GEOFFROY
Eric Fakra
Pierre Philip
Guillaume Dumas
Jean‐Arthur Micoulaud‐Franchi
2021-08-01
Journal of Psychiatric Research (publié)
doi.org
Symptom network analysis of the sleep disorders diagnostic criteria based on the clinical text of the ICSD‐3
Christophe Gauld
Régis Lopez
Charles Morin
Pierre A. GEOFFROY
Julien Maquet
Pierre Desvergnes
Aileen McGonigal
Yves Dauvilliers
Pierre Philip
Guillaume Dumas
Jean‐Arthur Micoulaud‐Franchi
2021-07-16
Journal of Sleep Research (publié)
doi.org
Symptom network analysis of the sleep disorders diagnostic criteria based on the clinical text of the ICSD‐3
Christophe Gauld
Régis Lopez
C. Morin
Pierre A. GEOFFROY
Julien Maquet
Pierre Desvergnes
Aileen McGonigal
Yves A. Dauvilliers
Pierre Philip
Guillaume Dumas
J-a Micoulaud-franchi
The third edition of the International Classification of Sleep Disorders (ICSD‐3) is the authoritative clinical text for the diagnosis of … (voir plus)sleep disorders. An important issue of sleep nosology is to better understand the relationship between symptoms found in conventional diagnostic manuals and to compare classifications. Nevertheless, to our knowledge, there is no specific exhaustive work on the general structure of the networks of symptoms of sleep disorders as described in diagnostic manuals. The general aim of the present study was to use symptom network analysis to explore the diagnostic criteria in the ICSD‐3 manual. The ICSD‐3 diagnostic criteria related to clinical manifestations were systematically identified, and the units of analysis (symptoms) were labelled from these clinical manifestation diagnostic criteria using three rules (“Conservation”, “Splitting”, “Lumping”). A total of 37 of the 43 main sleep disorders with 160 units of analysis from 114 clinical manifestations in the ICSD‐3 were analysed. A symptom network representing all individual ICSD‐3 criteria and connections between them was constructed graphically (network estimation), quantified with classical metrics (network inference with global and local measures) and tested for robustness. The global measure of the sleep symptoms network shows that it can be considered as a small world, suggesting a strong interconnection between symptoms in the ICSD‐3. Local measures show the central role of three kinds of bridge sleep symptoms: daytime sleepiness, insomnia, and behaviour during sleep symptoms. Such a symptom network analysis of the ICSD‐3 structure could provide a framework for better systematising and organising symptomatology in sleep medicine.
2021-07-16
Journal of Sleep Research (published)
doi.org
Brainhack: Developing a culture of open, inclusive, community-driven neuroscience
Rémi Gau
Stephanie Noble
Katja Heuer
Katherine L. Bottenhorn
Isil P. Bilgin
Yu-Fang Yang
Julia M. Huntenburg
Johanna M.M. Bayer
Richard A.I. Bethlehem
Shawn A. Rhoads
Christoph Vogelbacher
V. Borghesani
Elizabeth Levitis
Hao-Ting Wang
Sofie Van Den Bossche
Xenia Kobeleva
Jon Haitz Legarreta
Samuel Guay
Selim Melvin Atay
Gael Varoquaux … (voir 199 de plus)
Dorien C. Huijser
Malin S. Sandström
Peer Herholz
Samuel A. Nastase
AmanPreet Badhwar
Guillaume Dumas
Simon Schwab
Stefano Moia
Michael Dayan
Yasmine Bassil
Paula P. Brooks
Matteo Mancini
James M. Shine
David O’Connor
Xihe Xie
Davide Poggiali
Patrick Friedrich
Anibal S. Heinsfeld
Lydia Riedl
Roberto Toro
César Caballero-Gaudes
Anders Eklund
Kelly G. Garner
Christopher R. Nolan
Damion V. Demeter
Fernando A. Barrios
Junaid S. Merchant
Elizabeth A. McDevitt
Robert Oostenveld
R. Cameron Craddock
Ariel Rokem
Andrew Doyle
Satrajit S. Ghosh
Aki Nikolaidis
Olivia W. Stanley
Eneko Uruñuela
Nasim Anousheh
Aurina Arnatkeviciute
Guillaume Auzias
Dipankar Bachar
Elise Bannier
Ruggero Basanisi
Arshitha Basavaraj
Marco Bedini
Lune Bellec
R. Austin Benn
Kathryn Berluti
Steffen Bollmann
Saskia Bollmann
Claire Bradley
Jesse Brown
Augusto Buchweitz
Patrick Callahan
Micaela Y. Chan
Bramsh Q. Chandio
Theresa Cheng
Sidhant Chopra
Ai Wern Chung
Thomas G. Close
Etienne Combrisson
Giorgia Cona
R. Todd Constable
Claire Cury
Kamalaker Dadi
Pablo F. Damasceno
Samir Das
Fabrizio De Vico Fallani
Krista DeStasio
Erin W. Dickie
Lena Dorfschmidt
Eugene P. Duff
Elizabeth DuPre
Sarah Dziura
Nathalia B. Esper
Oscar Esteban
Shreyas Fadnavis
Guillaume Flandin
Jessica E. Flannery
John Flournoy
Stephanie J. Forkel
Alexandre R. Franco
Saampras Ganesan
Siyuan Gao
José C. García Alanis
Eleftherios Garyfallidis
Tristan Glatard
Enrico Glerean
Javier Gonzalez-Castillo
Cassandra D. Gould van Praag
Abigail S. Greene
Geetika Gupta
Catherine Alice Hahn
Yaroslav O. Halchenko
Daniel Handwerker
Thomas S. Hartmann
Valérie Hayot-Sasson
Stephan Heunis
Felix Hoffstaedter
Daniela M. Hohmann
Corey Horien
Horea-Ioan Ioanas
Alexandru Iordan
Chao Jiang
Michael Joseph
Jason Kai
Agah Karakuzu
David N. Kennedy
Anisha Keshavan
Ali R. Khan
Gregory Kiar
P. Christiaan Klink
Vincent Koppelmans
Serge Koudoro
Angela R. Laird
Georg Langs
Marissa Laws
Roxane Licandro
Sook-Lei Liew
Tomislav Lipic
Krisanne Litinas
Daniel J. Lurie
Désirée Lussier
Christopher R. Madan
Lea-Theresa Mais
Sina Mansour L
J.P. Manzano-Patron
Dimitra Maoutsa
Matheus Marcon
Daniel S. Margulies
Giorgio Marinato
Daniele Marinazzo
Christopher J. Markiewicz
Camille Maumet
Felipe Meneguzzi
David Meunier
Michael P. Milham
Kathryn L. Mills
Davide Momi
Clara A. Moreau
Aysha Motala
Iska Moxon-Emre
Thomas E. Nichols
Dylan M. Nielson
Gustav Nilsonne
Lisa Novello
Caroline O’Brien
Emily Olafson
Lindsay D. Oliver
John A. Onofrey
Edwina R. Orchard
Kendra Oudyk
Patrick J. Park
Mahboobeh Parsapoor
Lorenzo Pasquini
Scott Peltier
Cyril R. Pernet
Rudolph Pienaar
Pedro Pinheiro-Chagas
Jean-Baptiste Poline
Anqi Qiu
Tiago Quendera
Laura C. Rice
Joscelin Rocha-Hidalgo
Saige Rutherford
Mathias Scharinger
Dustin Scheinost
Deena Shariq
Thomas B. Shaw
Viviana Siless
Molly Simmonite
Nikoloz Sirmpilatze
Hayli Spence
Julia Sprenger
Andrija Stajduhar
Martin Szinte
Sylvain Takerkart
Angela Tam
Link Tejavibulya
Michel Thiebaut de Schotten
Ina Thome
Laura Tomaz da Silva
Nicolas Traut
Lucina Q. Uddin
Antonino Vallesi
John W. VanMeter
Nandita Vijayakumar
Matteo Visconti di Oleggio Castello
Jakub Vohryzek
Jakša Vukojević
Kirstie Jane Whitaker
Lucy Whitmore
Steve Wideman
Suzanne T. Witt
Hua Xie
Ting Xu
Chao-Gan Yan
Fang-Cheng Yeh
B.T. Thomas Yeo
Xi-Nian Zuo
2021-06-01
Neuron (publié)
doi.org
Learning Brain Dynamics With Coupled Low-Dimensional Nonlinear Oscillators and Deep Recurrent Networks
Germán Abrevaya
Guillaume Dumas
Aleksandr Y. Aravkin
Peng Zheng
Jean-Christophe Gagnon-Audet
James Kozloski
Pablo Polosecki
Guillaume Lajoie
David Cox
Silvina Ponce Dawson
Guillermo Cecchi
Irina Rish
Many natural systems, especially biological ones, exhibit complex multivariate nonlinear dynamical behaviors that can be hard to capture by … (voir plus)linear autoregressive models. On the other hand, generic nonlinear models such as deep recurrent neural networks often require large amounts of training data, not always available in domains such as brain imaging; also, they often lack interpretability. Domain knowledge about the types of dynamics typically observed in such systems, such as a certain type of dynamical systems models, could complement purely data-driven techniques by providing a good prior. In this work, we consider a class of ordinary differential equation (ODE) models known as van der Pol (VDP) oscil lators and evaluate their ability to capture a low-dimensional representation of neural activity measured by different brain imaging modalities, such as calcium imaging (CaI) and fMRI, in different living organisms: larval zebrafish, rat, and human. We develop a novel and efficient approach to the nontrivial problem of parameters estimation for a network of coupled dynamical systems from multivariate data and demonstrate that the resulting VDP models are both accurate and interpretable, as VDP's coupling matrix reveals anatomically meaningful excitatory and inhibitory interactions across different brain subsystems. VDP outperforms linear autoregressive models (VAR) in terms of both the data fit accuracy and the quality of insight provided by the coupling matrices and often tends to generalize better to unseen data when predicting future brain activity, being comparable to and sometimes better than the recurrent neural networks (LSTMs). Finally, we demonstrate that our (generative) VDP model can also serve as a data-augmentation tool leading to marked improvements in predictive accuracy of recurrent neural networks. Thus, our work contributes to both basic and applied dimensions of neuroimaging: gaining scientific insights and improving brain-based predictive models, an area of potentially high practical importance in clinical diagnosis and neurotechnology.
2021-05-26
Neural Computation (publié)
doi.org