Portrait de Guillaume Dumas

Guillaume Dumas

Membre académique associé
Professeur agrégé, Université de Montréal, Département de psychiatrie et d’addictologie
Professeur adjoint, McGill University, Département de psychiatrie
Sujets de recherche
Apprentissage automatique médical
Apprentissage par renforcement
Apprentissage profond
Biologie computationnelle
Neurosciences computationnelles
Systèmes dynamiques
Théorie de l'apprentissage automatique
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Biographie

Guillaume Dumas est professeur agrégé de psychiatrie computationnelle à la Faculté de médecine de l'Université de Montréal et chercheur principal du laboratoire de psychiatrie de précision et de physiologie sociale du Centre de recherche du CHU Sainte-Justine. Il est titulaire de la chaire IVADO IA en santé mentale et chercheur-boursier junior 1 du Fonds de recherche du Québec - Santé (FRQS) dans le domaine de l’ IA en santé et de la santé numérique. En 2023, il a été retenu dans le cadre du Programme des chercheurs mondiaux CIFAR-Azrieli pour le programme de recherche Cerveau, esprit et conscience. Il a également été nommé parmi les Futurs leaders canadiens de la recherche sur le cerveau par la Fondation Brain Canada.

Il a auparavant été chercheur permanent en neurosciences et en biologie computationnelle à l'Institut Pasteur (Paris, France), ainsi que chercheur postdoctoral au Center for Complex Systems and Brain Sciences à l’Université Florida Atlantic (FAU), aux États-Unis. Il est titulaire d'un diplôme d'ingénieur en ingénierie avancée et informatique (École centrale Paris), de deux masters (physique théorique, Université Paris-Saclay; sciences cognitives, ENS/EHESS/Paris 5) et d'un doctorat en neurosciences cognitives (Sorbonne Université).

Ses recherches visent à combiner l’intelligence artificielle, les neurosciences cognitives et la médecine numérique à travers un programme interdisciplinaire suivant deux axes principaux :

- L’intelligence artificielle en santé mentale, par la création de nouveaux algorithmes pour étudier le développement de l'architecture cognitive humaine et pour fournir une médecine personnalisée en neuropsychiatrie grâce à des données allant du génome à celles des téléphones intelligents;

- Les neurosciences sociales en intelligence artificielle, par la traduction de la recherche fondamentale sur le cerveau et le formalisme des systèmes dynamiques en des modèles hybrides neurocomputationnels et d’apprentissage automatique (NeuroML) et de nouvelles architectures présentant des capacités d'apprentissage social (NeuroIA Sociale et IHM).

Étudiants actuels

Saskia Helbling
Postdoctorat - UdeM
Site web
Github
Google Scholar
Nadine Mohamed
Maîtrise recherche - UdeM
Rémy Ramadour
Visiteur de recherche indépendant - CHU Sainte Justine / Université de Montréal
Site web
Github
Mahta Ramezanian
Maîtrise recherche - UdeM
Superviseur⋅e principal⋅e :
Irina Rish
Pascal Tikeng Notsawo
Doctorat - UdeM
Superviseur⋅e principal⋅e :
Guillaume Rabusseau
Site web
Github
Google Scholar

Publications

GOKU-UI: Ubiquitous Inference through Attention and Multiple Shooting for Continuous-time Generative Models
Germán Abrevaya
Mahta Ramezanian-Panahi
Jean-christophe Gagnon-audet
Irina Rish
Pablo Polosecki
Silvina Ponce Dawson
Guillermo Cecchi
Guillaume Dumas
Scientific Machine Learning (SciML) is a burgeoning field that synergistically combines domain-aware and interpretable models with agnosti… (voir plus)c machine learning techniques. In this work, we introduce GOKU-UI, an evolution of the SciML generative model GOKU-nets. The GOKU-UI broadens the original model’s spectrum to incorporate other classes of differential equations, such as Stochastic Differential Equations (SDEs), and integrates a distributed, i.e. ubiquitous, inference through attention mechanisms and a novel multiple shooting training strategy in the latent space. These enhancements have led to a significant increase in its performance in both reconstruction and forecast tasks, as demonstrated by our evaluation of simulated and empirical data. Specifically, GOKU-UI outperformed all baseline models on synthetic datasets even with a training set 32-fold smaller, underscoring its remarkable data efficiency. Furthermore, when applied to empirical human brain data, while incorporating stochastic Stuart-Landau
2022-12-31
arXiv.org (prépublication)
doi.org
PyNM: a Lightweight Python implementation of Normative Modeling
Annabelle Harvey
Guillaume Dumas
The majority of studies in neuroimaging and psychiatry are focussed on case-control analysis (Marquand et al., 2019). However, case-control … (voir plus)relies on well-defined groups which is more the exception than the rule in biology. Psychiatric conditions are diagnosed based on symptoms alone, which makes for heterogeneity at the biological level (Marquand et al., 2016). Relying on mean differences obscures this heterogeneity and the resulting loss of information can produce unreliable results or misleading conclusions (Loth et al., 2021).
2022-12-07
Journal of Open Source Software (publié)
doi.org
Tackling hypo and hyper sensory processing heterogeneity in autism: From clinical stratification to genetic pathways
Aline Lefebvre
Julian Tillmann
Freddy Cliquet
Frederique Amsellem
Anna Maruani
Claire Leblond
Anita Beggiato
David Germanaud
Anouck Amestoy
Myriam Ly‐Le Moal
Daniel Umbricht
Christopher H. Chatham
Lorraine Murtagh
Manuel Bouvard
Marion Leboyer
Tony Charman
Thomas Bourgeron
Richard Delorme
Guillaume Dumas
2022-12-03
Autism Research (publié)
doi.org
Autism incidence and spatial analysis in more than 7 million pupils in English schools: a retrospective, longitudinal, school registry study.
Andres Roman-Urrestarazu
Justin Christopher Yang
R. van Kessel
Varun Warrier
Guillaume Dumas
H. Jongsma
Gabriel Gatica-bahamonde
Carrie Allison
F. Matthews
Simon Baron-Cohen
Carol Brayne
2022-11-30
The Lancet Child & Adolescent Health (publié)
doi.org
Towards Clinical Phenotyping at Scale with Serious Games in Mixed Reality
Mariem Hafsia
Romain Trachel
Guillaume Dumas
Context: Mental healthcare systems are facing an ever-growing demand for appropriate assessment and intervention. Unfortunately, services ar… (voir plus)e often centralized, overloaded, and inaccessible, resulting in greater institutional and social inequities. Therefore, there is an urgent need to establish easy-to-implement methods for early diagnosis and personalized follow-up. In recent years, serious games have started to offer such a clinical tool at scale. Problem: There are critical challenges to the development of secure and inclusive serious games for clinical research. First, the quality of the data and features analyzed must be well defined early in the research process in order to draw meaningful conclusions. Second, algorithms must be aligned with the purpose of the research while not perpetuating bias. Finally, the technologies used must be widely accessible and sufficiently engaging for users. Focus of the paper: To tackle these challenges, we designed a participatory project that combines three innovative technologies: Mixed Reality, Serious Gaming, and Machine Learning. We analyze preliminary data with a focus on the identification of the players and the measurement of classical biases such as sex and environment of data collection. Method: We co-developed with patients and their families, as well as clinicians, a serious game in mixed reality specifically designed for evaluation and therapeutic intervention in autism. Preliminary data were collected from neurotypical individuals with a mixed reality headset. Relevant behavioral features were extracted and used to train several classification algorithms for player identification. Results: We were able to classify players above chance with slightly higher accuracy of neural networks. Interestingly, the accuracy was significantly higher when players were separated by sex. Furthermore, the uncontrolled condition showed better levels of accuracy than the controlled condition. This could mean that the data are richer when the player interacts freely with the game. Our proof of concept cannot exclude the possibility that this last result is linked to the experimental setup. Future development will clarify this point with a larger sample size and the use of deep learning algorithms. Implications: We show that serious games in mixed reality can be a valuable tool to collect clinical data. Our preliminary results highlight important biases to consider for future studies, especially for the sex and context of data collection. Next, we will evaluate the usability, accessibility, and tolerability of the device and the game in autistic children. In addition, we will evaluate the psychometric properties of the serious game, especially for patient stratification. This project aims to develop a platform for the diagnosis and therapy of autism, which can eventually be easily extended to other conditions and settings such as the evaluation of depression or stroke rehabilitation. Such a tool can offer novel possibilities for the study, evaluation, and treatment of mental conditions at scale, and thus ease the burden on healthcare systems.
2022-10-20
NeurIPS.cc/2022/Workshop/PAI4MH (poster)
openreview.net
openreview.net
From analytic to synthetic-organizational pluralisms: A pluralistic enactive psychiatry
Christophe Gauld
Kristopher Nielsen
Manon Job
Hugo Bottemanne
Guillaume Dumas
Reliance on sole reductionism, whether explanatory, methodological or ontological, is difficult to support in clinical psychiatry. Rather, p… (voir plus)sychiatry is challenged by a plurality of approaches. There exist multiple legitimate ways of understanding human functionality and disorder, i.e., different systems of representation, different tools, different methodologies and objectives. Pluralistic frameworks have been presented through which the multiplicity of approaches in psychiatry can be understood. In parallel of these frameworks, an enactive approach for psychiatry has been proposed. In this paper, we consider the relationships between the different kinds of pluralistic frameworks and this enactive approach for psychiatry. We compare the enactive approach in psychiatry with wider analytical forms of pluralism. On one side, the enactive framework anchored both in cognitive sciences, theory of dynamic systems, systems biology, and phenomenology, has recently been proposed as an answer to the challenge of an integrative psychiatry. On the other side, two forms of explanatory pluralisms can be described: a non-integrative pluralism and an integrative pluralism. The first is tolerant, it examines the coexistence of different potentially incompatible or untranslatable systems in the scientific or clinical landscape. The second is integrative and proposes to bring together the different levels of understanding and systems of representations. We propose that enactivism is inherently a form of integrative pluralism, but it is at the same time a component of the general framework of explanatory pluralism, composed of a set of so-called analytical approaches. A significant number of mental health professionals are already accepting the variety of clinical and scientific approaches. In this way, a rigorous understanding of the theoretical positioning of psychiatric actors seems necessary to promote quality clinical practice. The study of entanglements between an analytical pluralism and a synthetic-organizational enactivist pluralism could prove fruitful.
2022-09-26
Frontiers in Psychiatry (publié)
doi.org
Stratifying the autistic phenotype using electrophysiological indices of social perception
Luke Mason
Carolin Moessnang
Christopher H. Chatham
Lindsay Ham
Julian Tillmann
Guillaume Dumas
Claire Ellis
Claire Leblond
Freddy Cliquet
Thomas Bourgeron
Christian Beckmann
Tony Charman
Beth Oakley
Tobias Banaschewski
Andreas Meyer-Lindenberg
Simon Baron-Cohen
Sven Bölte
Jan K. Buitelaar
Sarah Durston
Eva Loth … (voir 7 de plus)
Bob Oranje
Antonio Persico
Flavio Dell’Acqua
Christine Ecker
Mark Johnson
Declan Murphy
Emily J. H. Jones
Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by difficulties in social communication, but also great heter… (voir plus)ogeneity. To offer individualized medicine approaches, we need to better target interventions by stratifying autistic people into subgroups with different biological profiles and/or prognoses. We sought to validate neural responses to faces as a potential stratification factor in ASD by measuring neural (electroencephalography) responses to faces (critical in social interaction) in N = 436 children and adults with and without ASD. The speed of early-stage face processing (N170 latency) was on average slower in ASD than in age-matched controls. In addition, N170 latency was associated with responses to faces in the fusiform gyrus, measured with functional magnetic resonance imaging, and polygenic scores for ASD. Within the ASD group, N170 latency predicted change in adaptive socialization skills over an 18-month follow-up period; data-driven clustering identified a subgroup with slower brain responses and poor social prognosis. Use of a distributional data-driven cutoff was associated with predicted improvements of power in simulated clinical trials targeting social functioning. Together, the data provide converging evidence for the utility of the N170 as a stratification factor to identify biologically and prognostically defined subgroups in ASD. Description N170 latency to faces relates to fusiform activity and ASD genetics, predicts social prognosis, and could improve power in clinical trials. Exploiting face processing in patients with ASD The heterogeneity observed in patients with autism spectrum disorder (ASD) highlights the need for better patient stratification methods. Here, Mason et al. evaluated the use of the speed of early-stage face processing (N170 latency) for patient stratification and prognosis in subjects with ASD and age-matched healthy individuals. N170 latency was slower in individuals with ASD and correlated with response to faces measured with fMRI and with polygenic risk score. Among subjects with ASD, the N170 values stratified patients according to socialization prognosis and improved power in a simulated clinical trial. The results suggest that including N170 evaluation in patient stratification might help the design and development of patient-specific therapies for ASD.
2022-08-16
Science Translational Medicine (publié)
doi.org
Generative Models of Brain Dynamics
Mahta Ramezanian-Panahi
Germán Abrevaya
Jean-christophe Gagnon-audet
Vikram Voleti
Irina Rish
Guillaume Dumas
2022-07-14
Frontiers in Artificial Intelligence (publié)
doi.org
Naming Autism in the Right Context
Andres Roman-Urrestarazu
Guillaume Dumas
Varun Warrier
2022-06-30
JAMA Pediatrics (publié)
doi.org
Popular and Scientific Discourse on Autism: Representational Cross-Cultural Analysis of Epistemic Communities to Inform Policy and Practice
Christophe Gauld
Julien Maquet
Jean‐Arthur Micoulaud‐Franchi
Guillaume Dumas
Background Social media provide a window onto the circulation of ideas in everyday folk psychiatry, revealing the themes and issues discusse… (voir plus)d both by the public and by various scientific communities. Objective This study explores the trends in health information about autism spectrum disorder within popular and scientific communities through the systematic semantic exploration of big data gathered from Twitter and PubMed. Methods First, we performed a natural language processing by text-mining analysis and with unsupervised (machine learning) topic modeling on a sample of the last 10,000 tweets in English posted with the term #autism (January 2021). We built a network of words to visualize the main dimensions representing these data. Second, we performed precisely the same analysis with all the articles using the term “autism” in PubMed without time restriction. Lastly, we compared the results of the 2 databases. Results We retrieved 121,556 terms related to autism in 10,000 tweets and 5.7x109 terms in 57,121 biomedical scientific articles. The 4 main dimensions extracted from Twitter were as follows: integration and social support, understanding and mental health, child welfare, and daily challenges and difficulties. The 4 main dimensions extracted from PubMed were as follows: diagnostic and skills, research challenges, clinical and therapeutical challenges, and neuropsychology and behavior. Conclusions This study provides the first systematic and rigorous comparison between 2 corpora of interests, in terms of lay representations and scientific research, regarding the significant increase in information available on autism spectrum disorder and of the difficulty to connect fragments of knowledge from the general population. The results suggest a clear distinction between the focus of topics used in the social media and that of scientific communities. This distinction highlights the importance of knowledge mobilization and exchange to better align research priorities with personal concerns and to address dimensions of well-being, adaptation, and resilience. Health care professionals and researchers can use these dimensions as a framework in their consultations to engage in discussions on issues that matter to beneficiaries and develop clinical approaches and research policies in line with these interests. Finally, our study can inform policy makers on the health and social needs and concerns of individuals with autism and their caregivers, especially to define health indicators based on important issues for beneficiaries.
2022-06-14
Journal of Medical Internet Research (publié)
doi.org
Technologically-assisted communication attenuates inter-brain synchrony
Linoy Schwartz
Jonathan Levy
Yaara Endevelt-Shapira
Amir Djalovski
Olga Hayut
Guillaume Dumas
Ruth Pinkenson Feldman
2022-06-05
NeuroImage (publié)
doi.org
How Can Digital Mental Health Enhance Psychiatry?
Emilie Stern
Jean-Arthur MICOULAUD FRANCHI
Guillaume Dumas
Jeverson Moreira
Stephane Mouchabac
Julia Maruani
Pierre Philip
Michel Lejoyeux
Pierre A. GEOFFROY
The use of digital technologies is constantly growing around the world. The wider-spread adoption of digital technologies and solutions in t… (voir plus)he daily clinical practice in psychiatry seems to be a question of when, not if. We propose a synthesis of the scientific literature on digital technologies in psychiatry and discuss the main aspects of its possible uses and interests in psychiatry according to three domains of influence that appeared to us: 1) assist and improve current care: digital psychiatry allows for more people to have access to care by simply being more accessible but also by being less stigmatized and more convenient; 2) develop new treatments: digital psychiatry allows for new treatments to be distributed via apps, and practical guidelines can reduce ethical challenges and increase the efficacy of digital tools; and 3) produce scientific and medical knowledge: digital technologies offer larger and more objective data collection, allowing for more detection and prevention of symptoms. Finally, ethical and efficacy issues remain, and some guidelines have been put forth on how to safely use these solutions and prepare for the future.
2022-06-03
The Neuroscientist (publié)
doi.org