Portrait of Guillaume Dumas

Guillaume Dumas

Associate Academic Member
Associate Professor, Université de Montréal, Department of Psychiatry and Addiction
Adjunct Professor, McGill University, Department of Psychiatry
Research Topics
Computational Biology
Computational Neuroscience
Deep Learning
Dynamical Systems
Machine Learning Theory
Medical Machine Learning
Reinforcement Learning
Website
Google Scholar
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Biography

Guillaume Dumas is an associate professor of computational psychiatry in the Faculty of Medicine, Université de Montréal, and principal investigator in the Precision Psychiatry and Social Physiology laboratory at the Centre hospitalier universitaire (CHU) Sainte-Justine Research Centre. He holds the IVADO professorship for AI in Mental Health, and the Fonds de recherche du Québec - Santé (FRQS) J1 in AI and Digital Health. In 2023, Dumas was recognized as a CIFAR Azrieli Global Scholar – Brain, Mind, and Consciousness program, and nominated as a Future Leader in Canadian Brain Research by the Brain Canada Foundation.

Dumas was previously a permanent researcher in neuroscience and computational biology at the Institut Pasteur (Paris). Before that, he was a postdoctoral fellow at the Center for Complex Systems and Brain Sciences (Florida Atlanta University). He holds an engineering degree in advanced engineering and computer science (École Centrale Paris), two MSc degrees (theoretical physics, Paris-Saclay University; cognitive science, ENS/EHESS/Paris 5), and a PhD in cognitive neuroscience (Sorbonne University).

The goal of his research is to cross-fertilize AI/ML, cognitive neuroscience and digital medicine through an interdisciplinary program with two main axes:

- AI/ML for Mental Health, which aims to create new algorithms to investigate the development of human cognitive architecture and deliver personalized medicine in neuropsychiatry using data from genomes to smartphones.

- Social Neuroscience for AI/ML, which translates basic brain research and dynamical systems formalism into neurocomputational and machine learning hybrid models (NeuroML) and machines with social learning abilities (Social NeuroAI & HMI).

Current Students

Germán Abrevaya
Independent visiting researcher - Université de Montréal
Principal supervisor :
Irina Rish
Google Scholar
Juan David Vargas
Master's Research - Université de Montréal
Kastel Natalie
PhD - Université de Montréal
Mahta Ramezanian
Master's Research - Université de Montréal
Principal supervisor :
Irina Rish
Zahra Sheikhbahaee
Postdoctorate - Université de Montréal
Co-supervisor :
Irina Rish
Github
Pascal Tikeng Notsawo
PhD - Université de Montréal
Principal supervisor :
Guillaume Rabusseau
Website
Github
Google Scholar
Tommie Tosato
Postdoctorate - Université de Montréal
Github

Publications

HyPyP: a Hyperscanning Python Pipeline for inter-brain connectivity analysis
Anaël Ayrolles
Florence Brun
Phoebe Chen
Amir Djalovski
Yann Beauxis
Richard Delorme
Thomas Bourgeron
Suzanne Dikker
Guillaume Dumas
Abstract The bulk of social neuroscience takes a ‘stimulus-brain’ approach, typically comparing brain responses to different types of so… (see more)cial stimuli, but most of the time in the absence of direct social interaction. Over the last two decades, a growing number of researchers have adopted a ‘brain-to-brain’ approach, exploring similarities between brain patterns across participants as a novel way to gain insight into the social brain. This methodological shift has facilitated the introduction of naturalistic social stimuli into the study design (e.g. movies) and, crucially, has spurred the development of new tools to directly study social interaction, both in controlled experimental settings and in more ecologically valid environments. Specifically, ‘hyperscanning’ setups, which allow the simultaneous recording of brain activity from two or more individuals during social tasks, has gained popularity in recent years. However, currently, there is no agreed-upon approach to carry out such ‘inter-brain connectivity analysis’, resulting in a scattered landscape of analysis techniques. To accommodate a growing demand to standardize analysis approaches in this fast-growing research field, we have developed Hyperscanning Python Pipeline, a comprehensive and easy open-source software package that allows (social) neuroscientists to carry-out and to interpret inter-brain connectivity analyses.
2020-10-08
Social Cognitive and Affective Neuroscience (published)
doi.org
A normative modelling approach reveals age-atypical cortical thickness in a subgroup of males with autism spectrum disorder
Richard A.I. Bethlehem
Jakob Seidlitz
Rafael Romero-Garcia
Stavros Trakoshis
Guillaume Dumas
Michael V. Lombardo
2020-09-04
Communications Biology (published)
doi.org
''COGITO in Space'': a thought experiment in exo-neurobiology
Daniela de Paulis
Stephen Whitmarsh
Robert Oostenveld
Guillaume Dumas
Michael Sanders
2020-08-04
(published)
doi.org
Attenuated Anticipation of Social and Monetary Rewards in Autism Spectrum Disorders
Sarah Baumeister
Carolin Moessnang
Nico Bast
Sarah Hohmann
Julian Tillmann
David Goyard
Tony Charman
Sara Ambrosino
Simon Baron-Cohen
Christian Beckmann
Sven Bölte
Thomas Bourgeron
Annika Rausch
Daisy Crawley
Flavio Dell’Acqua
Guillaume Dumas
Sarah Durston
Christine Ecker
Dorothea L. Floris
Vincent Frouin … (see 19 more)
Hannah Hayward
Rosemary Holt
Mark Johnson
Emily J. H. Jones
Meng-Chuan Lai
Michael V. Lombardo
Luke Mason
Marianne Oldehinkel
Tony Persico
Antonia San José Cáceres
Thomas Wolfers
Will Spooren
Eva Loth
Declan Murphy
Jan K. Buitelaar
Heike Tost
Andreas Meyer-Lindenberg
Tobias Banaschewski
Daniel Brandeis
Background Reward processing has been proposed to underpin atypical social behavior, a core feature of autism spectrum disorder (ASD). Howev… (see more)er, previous neuroimaging studies have yielded inconsistent results regarding the specificity of atypicalities for social rewards in ASD. Utilizing a large sample, we aimed to assess altered reward processing in response to reward type (social, monetary) and reward phase (anticipation, delivery) in ASD. Methods Functional magnetic resonance imaging during social and monetary reward anticipation and delivery was performed in 212 individuals with ASD (7.6-30.5 years) and 181 typically developing (TD) participants (7.6-30.8 years). Results Across social and monetary reward anticipation, whole-brain analyses (p0.05, family-wise error-corrected) showed hypoactivation of the right ventral striatum (VS) in ASD. Further, region of interest (ROI) analy
2020-07-06
bioRxiv (preprint)
doi.org
Individual differences in interpersonal coordination
Julia Ayache
Guillaume Dumas
A. Sumich
D. Kuss
Darren Rhodes
Nadja Heym
2020-06-18
(published)
doi.org
Dark control: The default mode network as a reinforcement learning agent
Elvis Dohmatob
Guillaume Dumas
Danilo Bzdok
2020-06-05
Human Brain Mapping (published)
doi.org
Differential neural circuitry behind autism subtypes with imbalanced social-communicative and restricted repetitive behavior symptoms
Natasha Bertelsen
Isotta Landi
Richard A.I. Bethlehem
Jakob Seidlitz
Elena Maria Busuoli
Veronica Mandelli
Eleonora Satta
Stavros Trakoshis
Bonnie Auyeung
Prantik Kundu
Eva Loth
Guillaume Dumas
Sarah Baumeister
Christian Beckmann
Sven Bölte
Thomas Bourgeron
Tony Charman
Sarah Durston
Christine Ecker
Rosemary Holt … (see 15 more)
Mark Johnson
Emily J. H. Jones
Luke Mason
Andreas Meyer-Lindenberg
Carolin Moessnang
Marianne Oldehinkel
Antonio Persico
Julian Tillmann
Steven C. R. Williams
Will Spooren
Declan Murphy
Jan K. Buitelaar
Simon Baron-Cohen
Meng-Chuan Lai
Michael V. Lombardo
Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly … (see more)differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here we developed a phenotypic stratification model that makes highly accurate (97-99%) out-of-sample SC=RRB, SC>RRB, and RRB>SC subtype predictions. Applying this model to resting state fMRI data from the EU-AIMS LEAP dataset (n=509), we find that while the phenotypic subtypes share many commonalities in terms of intrinsic functional connectivity, they also show subtype-specific qualitative differences compared to a typically-developing group (TD). Specifically, the somatomotor network is hypoconnected with perisylvian circuitry in SC>RRB and visual association circuitry in SC=RRB. The SC=RRB subtype also showed hyperconnectivity between medial motor and anterior salience circuitry. Genes that are highly expressed within these subtype-specific networks show a differential enrichment pattern with known ASD associated genes, indicating that such circuits are affected by differing autism-associated genomic mechanisms. These results suggest that SC-RRB imbalance subtypes share some commonalities but also express subtle differences in functional neural circuitry and the genomic underpinnings behind such circuitry.
2020-05-10
bioRxiv (preprint)
doi.org
Atypical brain asymmetry in autism – a candidate for clinically meaningful stratification
Dorothea L. Floris
Thomas Wolfers
Mariam Zabihi
Nathalie E. Holz
Christine Ecker
Flavio Dell’Acqua
Simon Baron-Cohen
Rosemary Holt
Sarah Durston
Eva Loth
Andre Marquand
Christian Beckmann
Jumana Ahmad
Sara Ambrosino
Bonnie Auyeung
Tobias Banaschewski
Sarah Baumeister
Sven Bölte
Thomas Bourgeron
Carsten Bours … (see 51 more)
Michael Brammer
Daniel Brandeis
Claudia Brogna
Yvette de Bruijn
Jan K. Buitelaar
Bhismadev Chakrabarti
Tony Charman
Ineke Cornelissen
Daisy Crawley
Guillaume Dumas
Jessica Faulkner
Vincent Frouin
Pilar Garcés
David Goyard
Lindsay Ham
Hannah Hayward
Joerg F. Hipp
Mark Johnson
Emily J. H. Jones
Prantik Kundu
Meng-Chuan Lai
Xavier Liogier D’ardhuy
Michael V. Lombardo
David J. Lythgoe
René Mandl
Luke Mason
Maarten Mennes
Andreas Meyer-Lindenberg
Carolin Moessnang
Nico Mueller
Declan Murphy
Beth Oakley
Laurence O’Dwyer
Marianne Oldehinkel
Bob Oranje
Gahan Pandina
Antonio Persico
Barbara Ruggeri
Amber N. V. Ruigrok
Jessica Sabet
Roberto Sacco
Antonia San José Cáceres
Emily Simonoff
Will Spooren
Julian Tillmann
Roberto Toro
Heike Tost
Jack Waldman
Steve C. R. Williams
Caroline Wooldridge
Marcel P. Zwiers
2020-03-25
bioRxiv (preprint)
doi.org
Dissecting the phenotypic heterogeneity in sensory features in autism spectrum disorder: a factor mixture modelling approach
Julian Tillmann
M. Uljarevic
Daisy Crawley
G. Dumas
Eva Loth
D. Murphy
J. Buitelaar
Tony Charman
Jumana Sara Bonnie Sarah Christian Thomas Carsten Michael Daniel Claudia Yvette Bhismadev Ineke Flavio Dell’ Guillaume Christine Jessica Vincent Pilar David Hannah Joerg Mark H. Emily J. H. Prantik Meng-Chuan Xavier Liogier Michael David J. René Luke Andreas Carolin Nico Laurence Marianne Bob Gahan Antonio M. Barbara Amber Jessica Roberto Roberto Heike Jack Steve C. R. Caroline Marcel P. Ahmad
Jumana Sara Bonnie Sarah Christian Thomas Carsten Michael Ahmad Ambrosino Auyeung Baumeister Beckmann Bourge
Jumana Ahmad
Sara Ambrosino
Bonnie Auyeung
Sarah Baumeister
Christian Beckmann
Thomas Bourgeron
Carsten Bours
Michael Brammer
Daniel Brandeis
Claudia Brogna … (see 39 more)
Yvette de Bruijn
Bhismadev Chakrabarti
Ineke Cornelissen
Flavio Dell’ Acqua
Guillaume Dumas
Christine Ecker
Jessica Faulkner
Vincent Frouin
Pilar Garcés
David Goyard
Hannah Hayward
Joerg F. Hipp
Mark Johnson
Emily J. H. Jones
Prantik Kundu
Meng-Chuan Lai
Xavier Liogier D’ardhuy
Michael V. Lombardo
David J. Lythgoe
René Mandl
Luke Mason
Andreas Meyer-Lindenberg
Carolin Moessnang
Nico Mueller
Laurence O’Dwyer
Marianne Oldehinkel
Bob Oranje
Gahan Pandina
Antonio Persico
Barbara Ruggeri
Amber N. V. Ruigrok
Jessica Sabet
Roberto Sacco
Roberto Toro
Heike Tost
Jack Waldman
Steve C. R. Williams
Caroline Wooldridge
Marcel P. Zwiers
2020-03-05
Molecular Autism (published)
doi.org
Autism spectrum disorder
Catherine Lord
Traolach S. Brugha
Tony Charman
James Cusack
Guillaume Dumas
Thomas Frazier
Emily J. H. Jones
Rebecca M. Jones
Andrew Pickles
Matthew W. State
Julie Lounds Taylor
Jeremy Veenstra-VanderWeele
2020-01-16
Nature Reviews Disease Primers (published)
doi.org
Divergent protein-coding genes and brain size in primates
Malesys Bourgeron Dumas
Guillaume Dumas
Simon Malesys
Thomas Bourgeron
17 The human brain differs from that of other primates, but the genetic basis of these differences 18 remains unclear. We investigated the e… (see more)volutionary pressures acting on almost all human 19 protein-coding genes ( N =11,667; 1:1 orthologs in primates) on the basis of their divergence 20 from those of early hominins, such as Neanderthals, and non-human primates. We confirm 21 that genes encoding brain-related proteins are among the most strongly conserved protein- 22 coding genes in the human genome. Combining our evolutionary pressure metrics for the 23 protein-coding genome with recent datasets, we found that this conservation applied to genes 24 functionally associated with the synapse and expressed in brain structures such as the 25 prefrontal cortex and the cerebellum. Conversely, several of the protein-coding genes that 26 diverge most in hominins relative to other primates are associated with brain-associated 27 diseases, such as micro/macrocephaly, dyslexia, and autism. We also showed that cerebellum 28 granule neurons express a set of divergent protein-coding genes that may have contributed to 29 the emergence of fine motor skills and social cognition in humans. This resource is available 30 from http://neanderthal.pasteur.fr and can be used to estimate evolutionary constraints acting 31 on a set of genes and to explore their relative contributions to human traits. 32
2020-01-01
(published)
www.semanticscholar.org
Title : Differential functional neural circuitry behind autism subtypes with marked imbalance between social-communicative and restricted repetitive behavior symptom domains
Natasha Bertelsen
Isotta Landi
Richard A.I. Bethlehem
Jakob Seidlitz
Elena
Maria Busuoli
Veronica Mandelli
Eleonora Satta
Stavros Trakoshis
Bonnie Auyeung
Prantik Kundu
Eva Loth
Guillaume Dumas
Sarah Baumeister
Christian Beckmann
Sven Bölte
Thomas Bourgeron
Tony Charman
Sarah Durston
Christine Ecker … (see 22 more)
Rosemary Holt
Mark Johnson
Emily J. H. Jones
Luke Mason
-. AndreasMeyer
Lindenberg
Carolin
Moessnang
Marianne
Oldehinkel
Antonio
Persico
Julian
Tillmann
Steven C. R. Williams
Will Spooren
Declan Murphy
Katherine Jan
Buitelaar
Simon Baron-Cohen
Meng-Chuan Lai
Michael V. Lombardo
Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly … (see more)differ within and between individuals and is underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here we developed a phenotypic stratification model that makes highly accurate (96-98%) out-of-sample SC=RRB, SC>RRB, and RRB>SC subtype predictions. Applying this model to resting state fMRI data from the EU-AIMS LEAP dataset (n=509), we find replicable somatomotor-perisylvian hypoconnectivity in the SC>RRB subtype versus a typically-developing (TD) comparison group. In contrast, replicable motor-anterior salience hyperconnectivity is apparent in the SC=RRB subtype versus TD. Autism-associated genes affecting astrocytes, excitatory, and inhibitory neurons are highly expressed specifically within SC>RRB hypoconnected networks, but not SC=RRB hyperconnected networks. SC-RRB balance subtypes may indicate different paths individuals take from genome, neural circuitry, to the clinical phenotype. (CIMH). Procedures were undertaken to optimize the MRI sequences for the best scanner-specific options, and phantoms and travelling heads were employed to assure standardization and quality assurance of the multisite image-acquisition 20 . Structural images were obtained using a 5.5 minute MPRAGE sequence (TR=2300ms, TE=2.93ms, T1=900ms, voxels size=1.1x1.1x1.2mm, flip angle=9°, matrix size=256x256, FOV=270mm, 176 slices). An eight-to-ten minute resting-state fMRI (rsfMRI) scan was acquired using a multi-echo planar imaging (ME-EPI) sequence 65,66 ; TR=2300ms, TE~12ms, 31ms, and 48ms (slight variations are present across centers), flip angle=80°, matrix size=64x64, (UMCU), 215 (KCL, CIMH), 265 (RUMC, UCAM). were to relax, with eyes open and fixate on a cross presented on the screen for the duration of the rsfMRI scan.
2020-01-01
(published)
www.semanticscholar.org