Portrait of Guillaume Dumas

Guillaume Dumas

Associate Academic Member
Associate Professor, Université de Montréal, Department of Psychiatry and Addiction
Adjunct Professor, McGill University, Department of Psychiatry
Research Topics
Computational Biology
Computational Neuroscience
Deep Learning
Dynamical Systems
Machine Learning Theory
Medical Machine Learning
Reinforcement Learning
Website
Google Scholar
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Biography

Guillaume Dumas is an associate professor of computational psychiatry in the Faculty of Medicine, Université de Montréal, and principal investigator in the Precision Psychiatry and Social Physiology laboratory at the Centre hospitalier universitaire (CHU) Sainte-Justine Research Centre. He holds the IVADO professorship for AI in Mental Health, and the Fonds de recherche du Québec - Santé (FRQS) J1 in AI and Digital Health. In 2023, Dumas was recognized as a CIFAR Azrieli Global Scholar – Brain, Mind, and Consciousness program, and nominated as a Future Leader in Canadian Brain Research by the Brain Canada Foundation.

Dumas was previously a permanent researcher in neuroscience and computational biology at the Institut Pasteur (Paris). Before that, he was a postdoctoral fellow at the Center for Complex Systems and Brain Sciences (Florida Atlanta University). He holds an engineering degree in advanced engineering and computer science (École Centrale Paris), two MSc degrees (theoretical physics, Paris-Saclay University; cognitive science, ENS/EHESS/Paris 5), and a PhD in cognitive neuroscience (Sorbonne University).

The goal of his research is to cross-fertilize AI/ML, cognitive neuroscience and digital medicine through an interdisciplinary program with two main axes:

- AI/ML for Mental Health, which aims to create new algorithms to investigate the development of human cognitive architecture and deliver personalized medicine in neuropsychiatry using data from genomes to smartphones.

- Social Neuroscience for AI/ML, which translates basic brain research and dynamical systems formalism into neurocomputational and machine learning hybrid models (NeuroML) and machines with social learning abilities (Social NeuroAI & HMI).

Current Students

Germán Abrevaya
Independent visiting researcher - Université de Montréal
Principal supervisor :
Irina Rish
Google Scholar
Juan David Vargas
Master's Research - Université de Montréal
Kastel Natalie
PhD - Université de Montréal
Mahta Ramezanian
Master's Research - Université de Montréal
Principal supervisor :
Irina Rish
Zahra Sheikhbahaee
Postdoctorate - Université de Montréal
Co-supervisor :
Irina Rish
Github
Pascal Tikeng Notsawo
PhD - Université de Montréal
Principal supervisor :
Guillaume Rabusseau
Website
Github
Google Scholar
Tommie Tosato
Postdoctorate - Université de Montréal
Github

Publications

Naming Autism in the Right Context.
Andres Roman-Urrestarazu
Guillaume Dumas
Varun Warrier
2022-04-04
JAMA pediatrics (published)
doi.org
Neurobiological Correlates of Change in Adaptive Behavior in Autism.
Charlotte M. Pretzsch
Tim Schäfer
Michael V. Lombardo
Varun Warrier
Caroline Mann
Anke Bletsch
Chris H. Chatham
Dorothea L. Floris
Julian Tillmann
Afsheen Yousaf
Emily J. H. Jones
Tony Charman
Sara Ambrosino
Thomas Bourgeron
Guillaume Dumas
Eva Loth
Beth Oakley
Jan K. Buitelaar
Freddy Cliquet
Claire Leblond … (see 7 more)
Simon Baron-Cohen
Christian Beckmann
Tobias Banaschewski
Sarah Durston
Christine M. Freitag
Declan Murphy
Christine Ecker
2022-03-25
American Journal of Psychiatry (published)
doi.org
WOODS: Benchmarks for Out-of-Distribution Generalization in Time Series Tasks
Jean-Christophe Gagnon-Audet
Kartik Ahuja
Mohammad Javad Darvishi Bayazi
Guillaume Dumas
Irina Rish
2022-03-18
ArXiv (preprint)
doi.org
arxiv.org
Interindividual Differences in Cortical Thickness and Their Genomic Underpinnings in Autism Spectrum Disorder.
Christine Ecker
Charlotte M. Pretzsch
Anke Bletsch
Caroline Mann
Tim Schaefer
Sara Ambrosino
Julian Tillmann
Afsheen Yousaf
Andreas Chiocchetti
Michael V. Lombardo
Varun Warrier
Nico Bast
Carolin Moessnang
Sarah Baumeister
Flavio Dell’Acqua
Dorothea L. Floris
Mariam Zabihi
Andre Marquand
Freddy Cliquet
Claire Leblond … (see 19 more)
Clara A. Moreau
Nick Puts
Tobias Banaschewski
Emily J. H. Jones
Luke Mason
Sven Bölte
Andreas Meyer-Lindenberg
Antonio Persico
Sarah Durston
Simon Baron-Cohen
Will Spooren
Eva Loth
Christine M. Freitag
Tony Charman
Guillaume Dumas
Thomas Bourgeron
Christian Beckmann
Jan K. Buitelaar
Declan Murphy
2022-03-01
American Journal of Psychiatry (published)
doi.org
Patterns of connectome variability in autism across five functional activation tasks: findings from the LEAP project
Tristan Looden
Dorothea L. Floris
Alberto Llera
R. Chauvin
Jumana Sara Bonnie Tobias Simon Sarah Christian F. Sven T Ahmad Ambrosino Auyeung Banaschewski Baron-Cohen B
Jumana Ahmad
Sara Ambrosino
Bonnie Auyeung
Tobias Banaschewski
Simon Baron-Cohen
Sarah Baumeister
Christian Beckmann
Sven Bölte
Thomas Bourgeron
Carsten Bours
Michael Brammer
Daniel Brandeis
Claudia Brogna
Yvette de Bruijn
Jan K. Buitelaar … (see 55 more)
Bhismadev Chakrabarti
Tony Charman
Ineke Cornelissen
Daisy Crawley
F. D. Acqua
Guillaume Dumas
Sarah Durston
Christine Ecker
Jessica Faulkner
Vincent Frouin
Pilar Garcés
David Goyard
Lindsay Ham
Hannah Hayward
Joerg F. Hipp
Rosemary Holt
Mark Johnson
Emily J. H. Jones
Prantik Kundu
Meng-Chuan Lai
Xavier Liogier D’ardhuy
Michael V. Lombardo
Eva Loth
David J. Lythgoe
René Mandl
Andre Marquand
Luke Mason
Maarten Mennes
Andreas Meyer-Lindenberg
Carolin Moessnang
Nico Mueller
Declan Murphy
Beth Oakley
Laurence O’Dwyer
Marianne Oldehinkel
Bob Oranje
Gahan Pandina
Antonio Persico
Annika Rausch
Barbara Ruggeri
Amber N. V. Ruigrok
Jessica Sabet
Roberto Sacco
Antonia San José Cáceres
Emily Simonoff
Will Spooren
Julian Tillmann
Roberto Toro
Heike Tost
Jack Waldman
Steven C. R. Williams
Caroline Wooldridge
Iva Ilioska
Ting Mei
Marcel P. Zwiers
2022-02-23
bioRxiv (preprint)
doi.org
Multilevel development of cognitive abilities in an artificial neural network
Konstantin Volzhenin
Jean-Pierre Changeux
Guillaume Dumas
Several neuronal mechanisms have been proposed to account for the formation of cognitive abilities through postnatal interactions with the p… (see more)hysical and socio-cultural environment. Here, we introduce a three-level computational model of information processing and acquisition of cognitive abilities. We propose minimal architectural requirements to build these levels and how the parameters affect their performance and relationships. The first sensorimotor level handles local nonconscious processing, here during a visual classification task. The second level or cognitive level globally integrates the information from multiple local processors via long-ranged connections and synthesizes it in a global, but still nonconscious manner. The third and cognitively highest level handles the information globally and consciously. It is based on the Global Neuronal Workspace (GNW) theory and is referred to as conscious level. We use trace and delay conditioning tasks to, respectively, challenge the second and third levels. Results first highlight the necessity of epigenesis through selection and stabilization of synapses at both local and global scales to allow the network to solve the first two tasks. At the global scale, dopamine appears necessary to properly provide credit assignment despite the temporal delay between perception and reward. At the third level, the presence of interneurons becomes necessary to maintain a self-sustained representation within the GNW in the absence of sensory input. Finally, while balanced spontaneous intrinsic activity facilitates epigenesis at both local and global scales, the balanced excitatory-inhibitory ratio increases performance. Finally, we discuss the plausibility of the model in both neurodevelopmental and artificial intelligence terms.
2022-01-25
bioRxiv (preprint)
doi.org
Multilevel development of cognitive abilities in an artificial neural network
Konstantin Volzhenin
J. Changeux
Guillaume Dumas
Several neuronal mechanisms have been proposed to account for the formation of cognitive abilities through postnatal interactions with the p… (see more)hysical and socio-cultural environment. Here, we introduce a three-level computational model of information processing and acquisition of cognitive abilities. We propose minimal architectural requirements to build these levels and how the parameters affect their performance and relationships. The first sensorimotor level handles local nonconscious processing, here during a visual classification task. The second level or cognitive level globally integrates the information from multiple local processors via long-ranged connections and synthesizes it in a global, but still nonconscious manner. The third and cognitively highest level handles the information globally and consciously. It is based on the Global Neuronal Workspace (GNW) theory and is referred to as conscious level. We use trace and delay conditioning tasks to, respectively, challenge the second and third levels. Results first highlight the necessity of epigenesis through selection and stabilization of synapses at both local and global scales to allow the network to solve the first two tasks. At the global scale, dopamine appears necessary to properly provide credit assignment despite the temporal delay between perception and reward. At the third level, the presence of interneurons becomes necessary to maintain a self-sustained representation within the GNW in the absence of sensory input. Finally, while balanced spontaneous intrinsic activity facilitates epigenesis at both local and global scales, the balanced excitatory-inhibitory ratio increases performance. Finally, we discuss the plausibility of the model in both neurodevelopmental and artificial intelligence terms.
2022-01-25
bioRxiv (preprint)
doi.org
Analysis of the Human Pineal Proteome by Mass Spectrometry
Mariette Matondo
Guillaume Dumas
Erik Maronde
2022-01-01
Methods in molecular biology (published)
doi.org
Generative Models of Brain Dynamics -- A review
Mahta Ramezanian Panahi
Germán Abrevaya
Jean-Christophe Gagnon-Audet
Vikram Voleti
Irina Rish
Guillaume Dumas
The principled design and discovery of biologically- and physically-informed models of neuronal dynamics has been advancing since the mid-tw… (see more)entieth century. Recent developments in artificial intelligence (AI) have accelerated this progress. This review article gives a high-level overview of the approaches across different scales of organization and levels of abstraction. The studies covered in this paper include fundamental models in computational neuroscience, nonlinear dynamics, data-driven methods, as well as emergent practices. While not all of these models span the intersection of neuroscience, AI, and system dynamics, all of them do or can work in tandem as generative models, which, as we argue, provide superior properties for the analysis of neuroscientific data. We discuss the limitations and unique dynamical traits of brain data and the complementary need for hypothesis- and data-driven modeling. By way of conclusion, we present several hybrid generative models from recent literature in scientific machine learning, which can be efficiently deployed to yield interpretable models of neural dynamics.
2021-12-22
ArXiv (preprint)
arxiv.org
arxiv.org
Preference for biological motion is reduced in ASD: implications for clinical trials and the search for biomarkers
Luke Mason
F. Shic
T. Falck-Ytter
Bhismadev Chakrabarti
Tony Charman
Eva Loth
Julian Tillmann
Tobias Banaschewski
Simon Baron-Cohen
Sven Bölte
J. Buitelaar
Sarah Durston
Bob Oranje
Antonio Persico
C. Beckmann
Thomas Bougeron
Flavio Dell’Acqua
Christine Ecker
Carolin Moessnang
D. Murphy … (see 49 more)
M. H. Johnson
Emily J. H. Jones
Jumana Sara Sarah Carsten Michael Daniel Claudia Yvette Chris Ineke Daisy Guillaume Jessica Vincent Pilar David Lindsay Joerg Rosemary Meng-Chuan Xavier Liogier Michael V. David J. René Andre Maarten Andreas Nico Bethany Laurence Marianne Gahan Barbara Amber Jessica Roberto Antonia San José Emily Will Roberto Heike Jack Steve C. R. Caroline Marcel P. Ahmad
Jumana Sara Sarah Carsten Michael Daniel Claudia Yvette C Ahmad Ambrosino Baumeister Bours Brammer Brandeis
Jumana Ahmad
Sara Ambrosino
Sarah Baumeister
Carsten Bours
Michael Brammer
Daniel Brandeis
Claudia Brogna
Yvette de Bruijn
Christopher H. Chatham
Ineke Cornelissen
Daisy Crawley
Guillaume Dumas
Jessica Faulkner
Vincent Frouin
Pilar Garcés
David Goyard
Lindsay Ham
Joerg F. Hipp
Rosemary Holt
Meng-Chuan Lai
Xavier Liogier D’ardhuy
Michael V. Lombardo
David J. Lythgoe
René Mandl
Andre Marquand
Maarten Mennes
Andreas Meyer-Lindenberg
Nico Bast
Beth Oakley
Laurence O’Dwyer
Marianne Oldehinkel
Gahan Pandina
Barbara Ruggeri
Amber N. V. Ruigrok
Jessica Sabet
Roberto Sacco
Antonia San José Cáceres
Emily Simonoff
Will Spooren
Roberto Toro
Heike Tost
Jack Waldman
Steve C. R. Williams
Caroline Wooldridge
Marcel P. Zwiers
2021-12-15
Molecular Autism (published)
doi.org
Early Transcriptional Changes in Rabies Virus-Infected Neurons and Their Impact on Neuronal Functions
Seonhee Kim
Florence Larrous
Hugo Varet
Rachel Legendre
Lena Feige
Guillaume Dumas
Rebecca Matsas
Georgia Kouroupi
Regis Grailhe
Hervé Bourhy
2021-12-13
Frontiers in Microbiology (published)
doi.org
Maternal chemosignals enhance infant-adult brain-to-brain synchrony
Yaara Endevelt-Shapira
Amir Djalovski
Guillaume Dumas
Ruth Feldman
2021-12-10
Science Advances (published)
doi.org