Portrait of Guillaume Dumas

Guillaume Dumas

Associate Academic Member
Associate Professor, Université de Montréal, Department of Psychiatry and Addiction
Adjunct Professor, McGill University, Department of Psychiatry
Research Topics
Computational Biology
Computational Neuroscience
Deep Learning
Dynamical Systems
Machine Learning Theory
Medical Machine Learning
Reinforcement Learning
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Biography

Guillaume Dumas is an associate professor of computational psychiatry in the Faculty of Medicine, Université de Montréal, and principal investigator in the Precision Psychiatry and Social Physiology laboratory at the Centre hospitalier universitaire (CHU) Sainte-Justine Research Centre. He holds the IVADO professorship for AI in Mental Health, and the Fonds de recherche du Québec - Santé (FRQS) J1 in AI and Digital Health. In 2023, Dumas was recognized as a CIFAR Azrieli Global Scholar – Brain, Mind, and Consciousness program, and nominated as a Future Leader in Canadian Brain Research by the Brain Canada Foundation.

Dumas was previously a permanent researcher in neuroscience and computational biology at the Institut Pasteur (Paris). Before that, he was a postdoctoral fellow at the Center for Complex Systems and Brain Sciences (Florida Atlanta University). He holds an engineering degree in advanced engineering and computer science (École Centrale Paris), two MSc degrees (theoretical physics, Paris-Saclay University; cognitive science, ENS/EHESS/Paris 5), and a PhD in cognitive neuroscience (Sorbonne University).

The goal of his research is to cross-fertilize AI/ML, cognitive neuroscience and digital medicine through an interdisciplinary program with two main axes:

- AI/ML for Mental Health, which aims to create new algorithms to investigate the development of human cognitive architecture and deliver personalized medicine in neuropsychiatry using data from genomes to smartphones.

- Social Neuroscience for AI/ML, which translates basic brain research and dynamical systems formalism into neurocomputational and machine learning hybrid models (NeuroML) and machines with social learning abilities (Social NeuroAI & HMI).

Current Students

Saskia Helbling
Postdoctorate - Université de Montréal
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Nadine Mohamed
Master's Research - Université de Montréal
Rémy Ramadour
Independent visiting researcher - CHU Sainte Justine / Université de Montréal
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Mahta Ramezanian
Master's Research - Université de Montréal
Principal supervisor :
Irina Rish
Pascal Tikeng Notsawo
PhD - Université de Montréal
Principal supervisor :
Guillaume Rabusseau
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Publications

Genetic modulation of brain dynamics in neurodevelopmental disorders: the impact of copy number variations on resting-state EEG
Adrien E. E. Dubois
Elisabeth Audet-Duchesne
Inga Sophia Knoth
Charles-Olivier Martin
Khadije Jizi
Petra Tamer
Nadine Younis
Sébastien Jacquemont
Guillaume Dumas
Sarah Lippé
Research has shown that many copy number variations (CNVs) increase the risk of neurodevelopmental disorders (e.g., autism, ADHD, schizophre… (see more)nia). However, little is known about the effects of CNVs on brain development and function. Resting-state electroencephalography (EEG) is a suitable method to study the disturbances of neuronal functioning in CNVs. We aimed to determine whether there are resting-state EEG signatures that are characteristic of children with pathogenic CNVs. EEG resting-state brain activity of 109 CNV carriers (66 deletion carriers, 43 duplication carriers) aged 3 to 17 years was recorded for 4 minutes. To better account for developmental variations, EEG indices (power spectral density and functional connectivity) were corrected with a normative model estimated from 256 Healthy Brain Network controls. Results showed a decreased exponent of the aperiodic activity and a reduced alpha peak frequency in CNV carriers. Additionally, the study showed altered periodic components and connectivity in several frequency bands. Deletion and duplication carriers exhibited a similar overall pattern of deviations in spectral and connectivity measures, although the significance and effect sizes relative to the control group varied across frequency bands. Deletion and duplication carriers can be differentiated by their periodic power in the gamma band and connectivity in the low alpha band, with duplication carriers showing more disrupted alterations than deletion carriers. The distinctive alterations in spectral patterns were found to be most prominent during adolescence. The results suggest that CNV carriers show electrophysiological alterations compared to neurotypical controls, regardless of the gene dosage effect and their affected genomic region. At the same time, while duplications and deletions share common electrophysiological alterations, each exhibits distinct brain alteration signatures that reflect gene dosage-specific effects.
2025-04-09
Translational Psychiatry (published)
doi.org
Contemporary review of critical illness following allogeneic hematopoietic stem cell transplant in adults.
Laveena Munshi
Guillaume Dumas
Bruno Ferreryro
Cristina Gutierrez
Boris Böll
Pedro Castro
Sanjay Chawla
Matteo Di Nardo
Antoine Lafarge
Colleen McEvoy
Djamel Mokart
Antonio Paulo Nassar
Judith Nelson
Frédéric Pène
Peter Schellongowski
Elie Azoulay
2025-03-31
Intensive Care Medicine (published)
doi.org
Collective Decision Making by Embodied Neural Agents
Nicolas Coucke
Mary Katherine Heinrich
Axel Cleeremans
Marco Dorigo
Guillaume Dumas
Collective decision making using simple social interactions has been studied in many types of multi-agent systems, including robot swarms an… (see more)d human social networks. However, existing multi-agent studies have rarely modeled the neural dynamics that underlie sensorimotor coordination in embodied biological agents. In this study, we investigated collective decisions that resulted from sensorimotor coordination among agents with simple neural dynamics. We equipped our agents with a model of minimal neural dynamics based on the coordination dynamics framework, and embedded them in an environment with a stimulus gradient. In our single-agent setup, the decision between two stimulus sources depends solely on the coordination of the agent's neural dynamics with its environment. In our multi-agent setup, that same decision also depends on the sensorimotor coordination between agents, via their simple social interactions. Our results show that the success of collective decisions depended on a balance of intra-agent, inter-agent, and agent-environment coupling, and we use these results to identify the influences of environmental factors on decision difficulty. More generally, our results demonstrate the impact of intra- and inter-brain coordination dynamics on collective behavior, can contribute to existing knowledge on the functional role of inter-agent synchrony, and are relevant to ongoing developments in neuro-AI and self-organized multi-agent systems.
2025-03-24
PNAS Nexus (published)
doi.org
arxiv.org
Determinants of pleiotropy and monotonic gene dosage responses across human traits
Sayeh Kazem
Kuldeep Kumar
Martineau Jean‐Louis
Guillaume Huguet
Thomas Renne
Zohra Saci
Worrawat Engchuan
Omar Shanta
Bhooma Thiruvahindrapuram
Jeffrey R. MacDonald
Celia M. T. Greenwood
Stephen W. Scherer
Laura Almasy
Jonathan Sebat
David C. Glahn
Guillaume Dumas
Sébastien Jacquemont
Sébastien Jacquemont
Pleiotropic effects of gene dosage are central to understanding comorbidities in developmental pediatric and psychiatric disorders, yet the … (see more)underlying biological processes are unknown. We developed Functional Burden analysis (FunBurd) to investigate the association of all protein-coding copy-number-variants (CNVs), genome-wide, with 43 complex traits in ∼500,000 UK-Biobank participants. We tested CNV associations disrupting 172 tissue or cell-type gene-sets, observing associations across all traits. Pleiotropy was correlated with genetic constraint and was higher in the brain compared to non-brain functions, even after normalizing for genetic constraint. Cognition and mental health traits showed specific gene-dosage effects across cortical/sub-cortical and neuronal/glial functional categories. The levels of pleiotropy, measured by burden correlation, were similar in deletions and loss-of-function SNVs, and higher compared to common variants and duplications. Gene sets under high genetic constraint showed less monotonic gene dosage responses across traits. Across most traits, we observed a negative deletion-duplication effect size correlation, indicating that functional gene sets are preferentially sensitive to either deletion or duplication, but rarely both. Our results highlight the key role of genetic constraint and brain-specific mechanisms in shaping CNV-driven pleiotropy, providing a mechanistic basis for the whole-body multimorbidity observed in neurodevelopmental and psychiatric conditions.
2025-02-25
medRxiv (published)
doi.org
La communication financière à l’épreuve de la crise COVID : une gestion des impressions ?
Corinne Bessieux-Ollier
Grégoire Davrinche
Guillaume Dumas
Nous étudions l’impact de la crise du COVID-19 sur la gestion des impressions pratiquée par les entreprises françaises cotées. Cette c… (see more)rise ayant eu un impact fort sur l’activité des entreprises, nous observons si les dirigeants modifient la manière de présenter l’information liée aux résultats non-GAAP, à travers l’utilisation de stratégies d’obscurcissement. Les données sur la gestion des impressions ont été collectées manuellement dans les communiqués de résultats annuels des entreprises du SBF 120 sur la période 2018-2020. Nous constatons une diminution générale du niveau de gestion des impressions en période de crise, notamment pour les entreprises des secteurs ayant été les plus impactés par la crise COVID. Cette diminution est toutefois moins prononcée pour les entreprises ayant sous-performé par rapport à leur secteur d’activité et pour les entreprises dont la performance a le plus diminué (indépendamment du secteur auquel elles appartiennent). Nos résultats suggèrent que les entreprises dont la baisse de performance pourrait être attribuée à des causes internes (résultats très défavorables, résultats en deçà du secteur d’activité) demeurent soucieuses de l’image qu’elles renvoient et maintiennent leur niveau de gestion des impressions malgré la crise.
2025-01-28
Comptabilité Contrôle Audit (published)
doi.org
A multivariable prediction model for invasive pulmonary aspergillosis in immunocompromised patients with acute respiratory failure (IPA-GRRR-OH score).
Alice Friol
Guillaume Dumas
Frédéric Pène
Alexandre Demoule
Achille Kouatchet
Laurent Argaud
Naike Bigé
Anne-Sophie Moreau
François Barbier
Djamel Mokart
Virginie Lemiale
Elie Azoulay
2025-01-23
Intensive Care Medicine (published)
doi.org
A video-based approach to decipher intubation decisions for the critically ill
Guillaume Dumas
Jean-Rémi Lavillegrand
Elie Azoulay
2025-01-06
Intensive Care Medicine (published)
doi.org
Changer le regard des étudiants sur les métiers de la comptabilité : Les effets de la simulation de gestion
Guillaume Dumas
Yann QUÉMÉNER
La comptabilité véhicule souvent injustement, une image terne et ennuyeuse, auprès du grand public et des jeunes étudiants choisissant l… (see more)eur orientation. Dans cet article, nous questionnons l’effet de pratiques pédagogiques sur la perception par les étudiants, des soft skills attendues par les employeurs. Pour cela nous réalisons une quasi-expérimentation dans laquelle nous comparons les perceptions des étudiants selon que le cours ait été animé sous un format classique (application des connaissances par le biais d’exercices avec corrigé par l’enseignant) ou sous la forme d’une simulation de gestion (application des connaissances en vue de prendre des décisions et piloter une entreprise fictive). Les résultats de la recherche montrent qu’une simulation de gestion, plus que les travaux dirigés classiques, permettent aux primo-apprenants en comptabilité, d’avoir une meilleure perception des soft skills attendues par les praticiens et les recruteurs. Nos résultats rappellent l’importance de donner une représentation réaliste (éloignée des clichés) de la profession, afin de rendre les filières d’enseignement de la comptabilité plus attractives.
2024-12-31
Finance Contrôle Stratégie (published)
doi.org
A "fine-cuts" approach disentangling psychopathic, autistic and alexithymic traits in their associations with affective, cognitive and motor empathy
Julia Ayache
Nikki Stevenson
Elisha Patel
Alexander Sumich
Guillaume Dumas
Nadja Heym
2024-12-31
Personality and Individual Differences (published)
doi.org
https://www.neuromodec.org/journal/4/2/NzBlvmDpUYspQQbvI4B Online Transcranial Random Noise Stimulation of the Right Temporoparietal Junction Acutely Modulates Human-Machine Social Interactions
Vincent Chamberland
Quentin Moreau
Lisane Moses
Gabriela Milanova
Guillaume Dumas
2024-12-31
Neuromodec Journal (published)
doi.org
Performance modulations phase-locked to action depend on internal state
Tommaso Tosato
Guillaume Dumas
Gustavo Rohenkohl
Pascal Fries
Several studies have probed perceptual performance at different times after a self-paced motor action and found frequency-specific modulatio… (see more)ns of perceptual performance phase-locked to the action. Such action-related modulation has been reported for various frequencies and modulation strengths. In an attempt to establish a basic effect at the population level, we had a relatively large number of participants (n=50) perform a self-paced button press followed by a detection task at threshold, and we applied both fixed- and random-effects tests. The combined data of all trials and participants surprisingly did not show any significant action-related modulation. However, based on previous studies, we explored the possibility that such modulation depends on the participant’s internal state. Indeed, when we split trials based on performance in neighboring trials, then trials in periods of low performance showed an action-related modulation at ≈17 Hz. When we split trials based on the performance in the preceding trial, we found that trials following a “miss” showed an action-related modulation at ≈17 Hz. Finally, when we split participants based on their false-alarm rate, we found that participants with no false alarms showed an action-related modulation at ≈17 Hz. All these effects were significant in random-effects tests, supporting an inference on the population. Together, these findings indicate that action-related modulations are not always detectable. However, the results suggest that specific internal states such as lower attentional engagement and/or higher decision criterion are characterized by a modulation in the beta-frequency range.
2024-12-31
iScience (published)
doi.org
Sensory multi-brain stimulation enhances dyadic cooperative behavior
Ivo Leiva-Cisterna
Paulo Barraza
Eugenio Rodríguez
Guillaume Dumas
Hyperscanning research suggests that interbrain synchronization supports the regulation of social behavior. However, the evidence is predomi… (see more)nantly correlational, leaving a gap for epiphenomenal accounts, where synchrony merely represents concurrent stimulus processing rather than a mechanism relevant to interpersonal interactions. Here, we demonstrate that interbrain synchrony causally drives cooperative success, as evidenced by non-invasive stimulation enhancing coupling and subsequently improving performance in a concurrent interdependent cooperation task. We applied dual-sensory entrainment at 16 Hz and 40 Hz to dyads and compared their performance with non-entrained control dyads performing the same cooperation task. We found that dual stimulation improved interbrain synchrony at the targeted frequencies relative to controls, with 16 Hz entrainment producing the most prominent effect. Strikingly, sensory entrainment facilitated sustained behavioral coupling, allowing partners to maintain coordination over extended periods. Notably, these effects are contingent on improved response coordination, indicating the importance of interbrain coupling for facilitating coordination and demonstrating causally that partner neural attunement is necessary to produce effective joint behavior. Thus, our study supports the concept that interbrain synchrony represents a neural mechanism with functional specificity in social interactions.
2024-12-31
Social Cognitive and Affective Neuroscience (published)
doi.org