Publications

Ex Post Conditions for the Exactness of Optimal Power Flow Conic Relaxations
Jean-Luc Lupien
Antoine Lesage-Landry
Convex relaxations of the optimal power flow (OPF) problem provide an efficient alternative to solving the intractable alternating current (… (see more)AC) optimal power flow. The conic subset of OPF convex relaxations, in particular, greatly accelerate resolution while leading to high-quality approximations that are exact in several scenarios. However, the sufficient conditions guaranteeing exactness are stringent, e.g., requiring radial topologies. In this short communication, we present two equivalent ex post conditions for the exactness of any conic relaxation of the OPF. These rely on obtaining either a rank-1 voltage matrix or self-coherent cycles. Instead of relying on sufficient conditions a priori, satisfying one of the presented ex post conditions acts as an exactness certificate for the computed solution. The operator can therefore obtain an optimality guarantee when solving a conic relaxation even when a priori exactness requirements are not met. Finally, we present numerical examples from the MATPOWER library where the ex post conditions hold even though the exactness sufficient conditions do not, thereby illustrating the use of the conditions.
2025-01-01
Electric Power Systems Research (published)
doi.org
arxiv.org
A stochastic integer programming approach to reserve staff scheduling with preferences
Carl Perreault‐Lafleur
Margarida Carvalho
Guy Desaulniers
2025-01-01
Int. Trans. Oper. Res. (published)
doi.org
arxiv.org
Combining supervised learning and local search for the multicommodity capacitated fixed-charge network design problem
Charly Robinson La Rocca
Jean-François Cordeau
Emma Frejinger
The multicommodity capacitated fixed-charge network design problem has been extensively studied in the literature due to its wide range of a… (see more)pplications. Despite the fact that many sophisticated solution methods exist today, finding high-quality solutions to large-scale instances remains challenging. In this paper, we explore how a data-driven approach can help improve upon the state of the art. By leveraging machine learning models, we attempt to reveal patterns hidden in the data that might be difficult to capture with traditional optimization methods. For scalability, we propose a prediction method where the machine learning model is called at the level of each arc of the graph. We take advantage of off-the-shelf models trained via supervised learning to predict near-optimal solutions. Our experimental results include an algorithm design analysis that compares various integration strategies of predictions within local search algorithms. We benchmark the ML-based approach with respect to the state-of-the-art heuristic for this problem. The findings indicate that our method can outperform the leading heuristic on sets of instances sampled from a uniform distribution.
2024-12-01
Transportation Research Part E: Logistics and Transportation Review (published)
doi.org
arxiv.org
UTG: Towards a Unified View of Snapshot and Event Based Models for Temporal Graphs
Shenyang Huang
Farimah Poursafaei
Reihaneh Rabbany
Guillaume Rabusseau
Emanuele Rossi
2024-11-16
logconference.io/LOG/2024/Conference (poster)
doi.org
openreview.net
EDAI Framework for Integrating Equity, Diversity, and Inclusion Throughout the Lifecycle of AI to Improve Health and Oral Health Care: Qualitative Study
Samira Abbasgholizadeh-Rahimi
Richa Shrivastava
Anita Brown-Johnson
Pascale Caidor
Claire Davies
Amal Idrissi Janati
Pascaline Kengne Talla
Sreenath Madathil
Bettina M Willie
Elham Emami
2024-11-15
Journal of Medical Internet Research (published)
doi.org
Outcomes of guidelines from health technology assessment organizations in community-based primary care: a systematic mixed studies review
Ashkan Baradaran
Raymond Tolentino
Roland Grad
Isabelle Ganache
Genevieve Gore
Samira Abbasgholizadeh-Rahimi
Pierre Pluye
2024-11-14
International Journal of Technology Assessment in Health Care (published)
doi.org
Deciphering lineage-relevant gene regulatory networks during endoderm formation by InPheRNo-ChIP.
Chen Su
William A Pastor
Amin Emad
Deciphering the underlying gene regulatory networks (GRNs) that govern early human embryogenesis is critical for understanding developmental… (see more) mechanisms yet remains challenging due to limited sample availability and the inherent complexity of the biological processes involved. To address this, we developed InPheRNo-ChIP, a computational framework that integrates multimodal data, including RNA-seq, transcription factor (TF)-specific ChIP-seq, and phenotypic labels, to reconstruct phenotype-relevant GRNs associated with endoderm development. The core of this method is a probabilistic graphical model that models the simultaneous effect of TFs on their putative target genes to influence a particular phenotypic outcome. Unlike the majority of existing GRN inference methods that are agnostic to the phenotypic outcomes, InPheRNo-ChIP directly incorporates phenotypic information during GRN inference, enabling the distinction between lineage-specific and general regulatory interactions. We integrated data from three experimental studies and applied InPheRNo-ChIP to infer the GRN governing the differentiation of human embryonic stem cells into definitive endoderm. Benchmarking against a scRNA-seq CRISPRi study demonstrated InPheRNo-ChIP's ability to identify regulatory interactions involving endoderm markers FOXA2, SMAD2, and SOX17, outperforming other methods. This highlights the importance of incorporating the phenotypic context during network inference. Furthermore, an ablation study confirms the synergistic contribution of ChIP-seq, RNA-seq, and phenotypic data, highlighting the value of multimodal integration for accurate phenotype-relevant GRN reconstruction.
2024-11-13
Briefings in Bioinformatics (published)
doi.org
Abstract 4142894: Multimorbidity Trajectories Across the Lifespan in Patients with Congenital Heart Disease
Chao Li
Aihua Liu
Solomon Bendayan
Liming Guo
Judith Therrien
Archer Yang
Robyn Tamblyn
Jay Brophy
Yue Li
Ariane Marelli
Background: Befitted from advances in medical care, patients with congenital heart disease (CHD) now survive to adulthood but face elevated… (see more) risks of both cardiac and non-cardiac complications. Understanding the trajectories of comorbidity development over a patient's lifespan is cornerstone to optimize care expected to improve long-term health outcomes. Research Aim: This study aims to investigate the temporal sequences and evolution of comorbidities in CHD patients across their lifespan. We hypothesize that multimorbidity trajectories in CHD patients are linked to CHD lesion severity and age at onset of specific comorbidities. Methods: Using the Quebec CHD database which comprised data in outpatient visits, hospitalization records and vital status from 1983 to 2017, we designed a longitudinal cohort study evaluating the development of 39 comorbidities coded using ICD-9/10. Temporal sequences were mapped using median age of onset. Associations between disease pairs were quantified by hazard ratios from Cox proportional hazard models adjusting for age, sex, genetic syndrome, competing risks of death, and taking into account the time-varying nature of the predictor diseases. Results: The cohort included 9,764 individuals with severe and 127,729 with non-severe CHD lesions. In severe CHD patients, most comorbidities developed between ages 25 and 40. Comorbidity progression began with childhood cardiovascular diseases, followed by systemic diseases such as diabetes, liver and kidney diseases, and advanced to heart failure and dementia in middle adulthood. In addition, mental disorders emerged in early adulthood and were associated with subsequent development of kidney diseases and dementia. Different trajectories were observed in non-severe CHD patients with 2-3 decades later disease onsets and non-differential onsets between cardiovascular and systemic complications (Figure). Conclusions: Distinct multimorbidity trajectories were observed in CHD patients by CHD lesion severity. In patients with severe CHD lesions, early systemic diseases significantly influenced subsequent complications. These findings highlight the need for well-timed surveillance guidelines and interventions to improve health outcomes.
2024-11-12
Circulation (published)
doi.org
Beyond the Safety Bundle: Auditing the Helpful and Harmless Dataset
Khaoula Chehbouni
Jonathan Colacco-Carr
Yash More
Jackie Ck Cheung
Golnoosh Farnadi
In an effort to mitigate the harms of large language models (LLMs), learning from human feedback (LHF) has been used to steer LLMs towards o… (see more)utputs that are intended to be both less harmful and more helpful. Despite the widespread adoption of LHF in practice, the quality of this feedback and its effectiveness as a safety mitigation technique remain unclear. This study addresses these issues by auditing the widely-used Helpful and Harmless (HH) dataset by Anthropic. Our work includes: (1) a thorough investigation of the dataset's content through both manual and automated evaluation; (2) experiments demonstrating the dataset's impact on models' safety; and (3) an analysis of the 100 most influential papers citing this dataset. Through our audit, we showcase how conceptualization failures and quality issues identified in the HH dataset can create additional harms by leading to disparate safety behaviors across demographic groups. Our findings highlight the need for more nuanced, context-sensitive approaches to safety mitigation in LLMs.
2024-11-12
ArXiv (preprint)
arxiv.org
arxiv.org
Fault Localization in Deep Learning-based Software: A System-level Approach
Mohammad Mehdi Morovati
Amin Nikanjam
Foutse Khomh
2024-11-12
ArXiv (preprint)
arxiv.org
arxiv.org
Investigating the Effectiveness of Explainability Methods in Parkinson's Detection from Speech
Eleonora Mancini
Francesco Paissan
Paolo Torroni
Mirco Ravanelli
Cem Subakan
Speech impairments in Parkinson's disease (PD) provide significant early indicators for diagnosis. While models for speech-based PD detectio… (see more)n have shown strong performance, their interpretability remains underexplored. This study systematically evaluates several explainability methods to identify PD-specific speech features, aiming to support the development of accurate, interpretable models for clinical decision-making in PD diagnosis and monitoring. Our methodology involves (i) obtaining attributions and saliency maps using mainstream interpretability techniques, (ii) quantitatively evaluating the faithfulness of these maps and their combinations obtained via union and intersection through a range of established metrics, and (iii) assessing the information conveyed by the saliency maps for PD detection from an auxiliary classifier. Our results reveal that, while explanations are aligned with the classifier, they often fail to provide valuable information for domain experts.
2024-11-12
ArXiv (preprint)
arxiv.org
arxiv.org
Refining SARS-CoV-2 Intra-host Variation by Leveraging Large-scale Sequencing Data
Fatima Mostefai
Jean-Christophe Grenier
Raphael Poujol
Julie Hussin
2024-11-12
NAR Genomics and Bioinformatics (published)
doi.org