Portrait of Guillaume Dumas

Guillaume Dumas

Associate Academic Member
Associate Professor, Université de Montréal, Department of Psychiatry and Addiction
Adjunct Professor, McGill University, Department of Psychiatry
Research Topics
Computational Biology
Computational Neuroscience
Deep Learning
Dynamical Systems
Machine Learning Theory
Medical Machine Learning
Reinforcement Learning
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Biography

Guillaume Dumas is an associate professor of computational psychiatry in the Faculty of Medicine, Université de Montréal, and principal investigator in the Precision Psychiatry and Social Physiology laboratory at the Centre hospitalier universitaire (CHU) Sainte-Justine Research Centre. He holds the IVADO professorship for AI in Mental Health, and the Fonds de recherche du Québec - Santé (FRQS) J1 in AI and Digital Health. In 2023, Dumas was recognized as a CIFAR Azrieli Global Scholar – Brain, Mind, and Consciousness program, and nominated as a Future Leader in Canadian Brain Research by the Brain Canada Foundation.

Dumas was previously a permanent researcher in neuroscience and computational biology at the Institut Pasteur (Paris). Before that, he was a postdoctoral fellow at the Center for Complex Systems and Brain Sciences (Florida Atlanta University). He holds an engineering degree in advanced engineering and computer science (École Centrale Paris), two MSc degrees (theoretical physics, Paris-Saclay University; cognitive science, ENS/EHESS/Paris 5), and a PhD in cognitive neuroscience (Sorbonne University).

The goal of his research is to cross-fertilize AI/ML, cognitive neuroscience and digital medicine through an interdisciplinary program with two main axes:

- AI/ML for Mental Health, which aims to create new algorithms to investigate the development of human cognitive architecture and deliver personalized medicine in neuropsychiatry using data from genomes to smartphones.

- Social Neuroscience for AI/ML, which translates basic brain research and dynamical systems formalism into neurocomputational and machine learning hybrid models (NeuroML) and machines with social learning abilities (Social NeuroAI & HMI).

Current Students

Saskia Helbling
Postdoctorate - Université de Montréal
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Nadine Mohamed
Master's Research - Université de Montréal
Rémy Ramadour
Independent visiting researcher - CHU Sainte Justine / Université de Montréal
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Mahta Ramezanian
Master's Research - Université de Montréal
Principal supervisor :
Irina Rish
Pascal Tikeng Notsawo
PhD - Université de Montréal
Principal supervisor :
Guillaume Rabusseau
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Publications

Grokking Beyond the Euclidean Norm of Model Parameters
Pascal Jr Tikeng Notsawo
Pascal Jr Tikeng Notsawo
Guillaume Dumas
Guillaume Rabusseau
Grokking refers to a delayed generalization following overfitting when optimizing artificial neural networks with gradient-based methods. In… (see more) this work, we demonstrate that grokking can be induced by regularization, either explicit or implicit. More precisely, we show that when there exists a model with a property
2025-10-05
Proceedings of the 42nd International Conference on Machine Learning (published)
doi.org
proceedings.mlr.press
Asymmetric developmental bifurcations in polarized environments: a new class of human variants, which may include autism.
Laurent Mottron
Alix Lavigne-Champagne
Boris Bernhardt
Guillaume Dumas
Sébastien Jacquemont
David Gagnon
2025-09-28
Molecular Psychiatry (published)
doi.org
Acute respiratory distress syndrome in patients with cancer: the YELENNA prospective multinational observational cohort study.
Peter Schellongowski
Michael Darmon
Philipp Eller
Laveena Munshi
Tobias Liebregts
Victoria Metaxa
Luca Montini
Tobias Lahmer
Andry Van de Louw
Martin Balik
Peter Pickkers
Pleun Hemelaar
Hemang Yadav
Andreas Barratt-Due
Thomas Karvunidis
Jordi Riera
Gennaro Martucci
Ignacio Martin-Loeches
Pedro Castro
Nina Buchtele … (see 24 more)
Virginie Lemiale
Stefan Hatzl
Guillaume Dumas
Thomas Staudinger
Elie Azoulay
Gottfried Gürkan Christian Elisabeth Alexis Gennaro Giovanna Heinz Sengölge Zauner Lobmeyr Maillard De Pascale
Gottfried Heinz
G. Sengölge
Christian Zauner
Elisabeth Lobmeyr
Alexis Maillard
G. De Pascale
G. Panarello
Philippe R. Bauer
M. Flaksa
Brozek
Fabio S. Taccone
I. Crippa
Andreas Barrat-Due
Sandra García-Roche
Cándido Díaz-Lagares
Andrés Pacheco
A. Téllez
I. Loeches
2025-09-24
Intensive Care Medicine (published)
doi.org
Aperiodic and Periodic EEG Component Lifespan Trajectories: Monotonic Decrease versus Growth-then-Decline
Min Li
Ying Wang
Yaqi Chen
Adrien E. E. Dubois
Gangyong Jia
Ying Wang
Maria L. Bringas-Vega
Guillaume Dumas
Pedro A. Valdes-Sosab
1.1 Unraveling the lifespan trajectories of human brain development is critical for understanding brain health and … (see more)disease. Recent research demonstrates that electroencephalography signals are composed of periodic and aperiodic components reflecting distinct physiological substrates. This dissociation raises the possibility that they follow different developmental tendencies. Here, we delineate the lifespan trajectories of aperiodic and periodic neural oscillations using a large international cohort (N=1,563, ages 5–95, resting state, eyes closed). We reveal two fundamental developmental patterns: a Monotonic decrease in aperiodic activity and a Growth-and-Decline pattern for periodic activity. Both components have inflections around age 20 and transition to a stable senescent phase around age 40. Spatially, anterior regions mainly exhibit aperiodic activity, while periodic activity concentrate on posterior regions and these patterns remain stable throughout life. Crucially, multimodal analysis shows these trajectories map onto distinct biological substrates. The periodic component’s Growth and Decline trajectory aligns with GABAergic function and myelination. In contrast, the monotonically decreasing trajectory of aperiodic activity mirrors fundamental biomarkers of biological aging, such as DNA methylation and telomere length. Transforming age to a logarithmic scale simplifies these nonlinear trajectories into a linear decreasing and a piecewise concave linear model for aperiodic and periodic components. This form provides a robust and parsimonious framework for quantifying maturation and identifying neurological deviations. We delineate distinct lifespan trajectories of aperiodic and periodic neural activity in a large-scale international cohort (N=1,563, ages 5–95). Aperiodic activity undergoes a Monotonic Decrease with age. In contrast, periodic activity follows a Growth-then-Decline trajectory, peaking in early adulthood. Both trajectories feature a critical transition around age 20 and stabilize into a protracted senescent phase from approximately 40 onward. These neural trajectories map onto distinct biological substrates: periodic activity tracks integrative functions (myelination, GABAergic, and aperiodic decline mirrors fundamental aging processes (DNA methylation). A stable pattern observed throughout the lifespan is the spatial segregation of neural activity, where aperiodic signals are dominant in anterior regions and periodic signals are concentrated in posterior ones. Logarithmically transforming age linearized the developmental trajectories, yielding a monotonic decline for the aperiodic component and a concave piecewise for the periodic one. This process establishes robust linear norms for the personalized assessment of brain dysfunction.
2025-08-26
bioRxiv (preprint)
doi.org
Pathfinding: a neurodynamical account of intuition
Steven Kotler
Michael Mannino
Karl Friston
Gyorgy Buzsáki
J. A. Scott Kelso
Guillaume Dumas
2025-08-12
Communications Biology (published)
doi.org
Persistent Instability in LLM's Personality Measurements: Effects of Scale, Reasoning, and Conversation History
Tommaso Tosato
Saskia Helbling
Yorguin-Jose Mantilla-Ramos
Mahmood Hegazy
Alberto Tosato
D. Lemay
Irina Rish
Guillaume Dumas
2025-08-05
ArXiv (preprint)
doi.org
arxiv.org
Posttraumatic Growth in Intensive Care Unit Health Care Professionals After COVID-19
Elie Azoulay
Laurent Argaud
Vincent Labbé
Guillaume Dumas
Fabrice Bruneel
Mercé Jourdain
Christophe Guitton
Amelie Seguin
Samir Jaber
David Schnell
Isabelle Vinatier
Fanny Ardisson
Michel Ramakers
Antoine Herault
Olivier Lesieur
Alain Cariou
Antoine Vieillard-Baron
Olivier Guisset
Frédéric Pochard
Michael Darmon … (see 1 more)
Nancy Kentish-Barnes
2025-07-31
JAMA Network Open (published)
doi.org
Parsing Autism Heterogeneity: Transcriptomic Subgrouping of Imaging-Derived Phenotypes in Autism.
Johanna Leyhausen
Caroline Gurr
Lisa M. Berg
Hanna Seelemeyer
Bassem Hermila
Tim Schäfer
Andreas Chiocchetti
Charlotte M. Pretzsch
Eva Loth
Beth Oakley
Jan K. Buitelaar
Christian Beckmann
Tony Charman
Thomas Bourgeron
Eli Barthome
Tobias Banaschewski
Jumana Ahmad
Sara Ambrosino
Bonnie Auyeung
Simon Baron-Cohen … (see 56 more)
Sarah Baumeister
Sven Bölte
Carsten Bours
Michael Brammer
Daniel Brandeis
Claudia Brogna
Yvette de Bruijn
Bhismadev Chakrabarti
Ineke Cornelissen
Daisy Crawley
Flavio Dell’Acqua
Guillaume Dumas
Sarah Durston
Christine Ecker
Jessica Faulkner
Vincent Frouin
Pilar Garcés
David Goyard
Lindsay Ham
Hannah Hayward
Joerg F. Hipp
Rosemary Holt
Mark Johnson
Emily J. H. Jones
Prantik Kundu
Meng-Chuan Lai
Xavier Liogier D’ardhuy
Michael V. Lombardo
David J. Lythgoe
René Mandl
Andre Marquand
Luke Mason
Maarten Mennes
Andreas Meyer-Lindenberg
Carolin Moessnang
Nico Bast
Larry O’Dwyer
Marianne Oldehinkel
Bob Oranje
Gahan Pandina
Antonio Persico
Barbara Ruggeri
Amber N. V. Ruigrok
Jessica Sabet
Roberto Sacco
Antonia San José Cáceres
Emily Simonoff
Will Spooren
Julian Tillmann
Roberto Toro
Heike Tost
Jack Waldman
Steve C. R. Williams
Caroline Wooldridge
Marcel P. Zwiers
Declan Murphy
2025-06-30
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (published)
doi.org
Inter-brain Synchronization in the Alpha Band during Minimal Tactile Interaction
Chen Lam Loh
Leonardo Zapata-Fonseca
Mark M. James
Guillaume Dumas
Tom Froese
Recently the minimal requirements for inter-brain coupling have attracted attention. Moreover, researchers have found that brains can couple… (see more) not only when individuals are in the same space, but also during technologically mediated interactions. Here we investigate whether inter-brain synchronization occurs when both conditions of spatial isolation and minimal interaction are satisfied. In particular, we use a real-time interaction paradigm, the Perceptual Crossing Experiment where individuals must locate their partners in a minimal virtual space using tactile stimuli alone. We report novel findings that contribute to our understanding of inter-brain synchronization and the minimal conditions of social interaction in virtual spaces : 1)inter-brain synchronization is present in the Alpha band during online minimal interaction, 2)five behavioral patterns and three inter-brain patterns can be found in the PCE and 3)different behavioral patterns in the interaction environment recruited different inter-brain networks such that frontal-fronto-central synchrony occurs when people are further apart in space, interacting with a multitude of objects. These findings have important implications for the understanding of social interaction processes, such that inter-brain coupling can occur even without extensive communication channels.
2025-06-23
bioRxiv (preprint)
doi.org
Impact de l'antibiothérapie par Daptomycine dans le traitement des bactériémies à Enterococcus faecium en réanimation : l'étude rétrospective multicentrique ENTERODAPTO.
S. Herbel
Guillaume Dumas
L. Chantelot
J. Massol
Q. Moyon
J. Ricard
E. Azoulay
C. Hauw-Berlemont
E. Maury
T. Urbina
2025-05-31
Médecine et Maladies Infectieuses Formation (published)
doi.org
A systematic review of hyperscanning in clinical encounters
Lena Adel
Lisane Moses
Elisabeth Irvine
Kyle T Greenway
Guillaume Dumas
Michael Lifshitz
2025-05-31
Neuroscience and Biobehavioral Reviews (published)
doi.org
Response letter to “Confounding by indication and exposure misclassification may undermine corticosteroid effect estimates in ICU patients with alcohol-related hepatitis”
Guillaume Dumas
Maxime Gasperment
Hafid AIT-OUFELLA
2025-05-23
Annals of Intensive Care (published)
doi.org