Portrait of Guillaume Dumas

Guillaume Dumas

Associate Academic Member
Associate Professor, Université de Montréal, Department of Psychiatry and Addiction
Adjunct Professor, McGill University, Department of Psychiatry
Research Topics
Computational Biology
Computational Neuroscience
Deep Learning
Dynamical Systems
Machine Learning Theory
Medical Machine Learning
Reinforcement Learning
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Biography

Guillaume Dumas is an associate professor of computational psychiatry in the Faculty of Medicine, Université de Montréal, and principal investigator in the Precision Psychiatry and Social Physiology laboratory at the Centre hospitalier universitaire (CHU) Sainte-Justine Research Centre. He holds the IVADO professorship for AI in Mental Health, and the Fonds de recherche du Québec - Santé (FRQS) J1 in AI and Digital Health. In 2023, Dumas was recognized as a CIFAR Azrieli Global Scholar – Brain, Mind, and Consciousness program, and nominated as a Future Leader in Canadian Brain Research by the Brain Canada Foundation.

Dumas was previously a permanent researcher in neuroscience and computational biology at the Institut Pasteur (Paris). Before that, he was a postdoctoral fellow at the Center for Complex Systems and Brain Sciences (Florida Atlanta University). He holds an engineering degree in advanced engineering and computer science (École Centrale Paris), two MSc degrees (theoretical physics, Paris-Saclay University; cognitive science, ENS/EHESS/Paris 5), and a PhD in cognitive neuroscience (Sorbonne University).

The goal of his research is to cross-fertilize AI/ML, cognitive neuroscience and digital medicine through an interdisciplinary program with two main axes:

- AI/ML for Mental Health, which aims to create new algorithms to investigate the development of human cognitive architecture and deliver personalized medicine in neuropsychiatry using data from genomes to smartphones.

- Social Neuroscience for AI/ML, which translates basic brain research and dynamical systems formalism into neurocomputational and machine learning hybrid models (NeuroML) and machines with social learning abilities (Social NeuroAI & HMI).

Current Students

Juan David Vargas
Master's Research - Université de Montréal
Kastel Natalie
PhD - Université de Montréal
Mahta Ramezanian
Master's Research - Université de Montréal
Principal supervisor :
Irina Rish
Pascal Tikeng Notsawo
PhD - Université de Montréal
Principal supervisor :
Guillaume Rabusseau
Website
Github
Google Scholar
Tommaso Tosato
Postdoctorate - Université de Montréal
Website
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Google Scholar

Publications

Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes
Guillaume Huguet
Thomas Renne
Cécile Poulain
Alma Dubuc
Kuldeep Kumar
Sayeh Kazem
Worrawat Engchuan
Omar Shanta
Elise Douard
Catherine Proulx
Martineau Jean-Louis
Zohra Saci
Josephine Mollon
Laura Schultz
Emma E M Knowles
Simon R. Cox
David Porteous
Gail Davies
Paul Redmond
Sarah E. Harris … (see 10 more)
Gunter Schumann
Guillaume Dumas
Aurélie Labbe
Zdenka Pausova
Tomas Paus
Stephen W Scherer
Jonathan Sebat
Laura Almasy
David C. Glahn
Sébastien Jacquemont
Genomic Copy Number Variants (CNVs) that increase risk for neurodevelopmental disorders are also associated with lower cognitive ability in … (see more)general population cohorts. Studies have focussed on a small set of recurrent CNVs, but burden analyses suggested that the vast majority of CNVs affecting cognitive ability are too rare to reach variant-level association. As a result, the full range of gene-dosage-sensitive biological processes linked to cognitive ability remains unknown. To investigate this issue, we identified all CNVs >50 kilobases in 258k individuals from 6 general population cohorts with assessments of general cognitive abilities. We performed a CNV-GWAS and functional burden analyses, which tested 6502 gene-sets defined by tissue and cell-type transcriptomics as well as gene ontology disrupted by all rare coding CNVs. CNV-GWAS identified a novel duplication at 2q12.3 associated with higher performance in cognitive ability. Among the 864 gene-sets associated with cognitive ability, only 11% showed significant effects for both deletions and duplication. Accordingly, we systematically observed negative correlations between deletion and duplication effect sizes across all levels of biological observations. We quantified the preferential effects of deletions versus duplication using tagDS, a new normalized metric. Cognitive ability was preferentially affected by cortical, presynaptic, and negative-regulation gene-sets when duplicated. In contrast, preferential effects of deletions were observed for subcortical, post-synaptic, and positive-regulation gene-sets. A large proportion of gene-sets assigned to non-brain organs were associated with cognitive ability due to low tissue specificity genes, which were associated with higher sensitive to haploinsufficiency. Overall, most biological functions associated with cognitive ability are divided into those sensitive to either deletion or duplications.
2024-04-17
bioRxiv (preprint)
doi.org
Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes
Guillaume Huguet
Thomas Renne
Cécile Poulain
Alma Dubuc
Kuldeep Kumar
Sayeh Kazem
Worrawat Engchuan
Omar Shanta
Elise Douard
Catherine Proulx
Martineau Jean-Louis
Zohra Saci
Josephine Mollon
Laura Schultz
Emma E M Knowles
Simon R. Cox
David Porteous
Gail Davies
Paul Redmond
Sarah E. Harris … (see 10 more)
Gunter Schumann
Guillaume Dumas
Aurélie Labbe
Zdenka Pausova
Tomas Paus
Stephen W Scherer
Jonathan Sebat
Laura Almasy
David C. Glahn
Sébastien Jacquemont
Genomic Copy Number Variants (CNVs) that increase risk for neurodevelopmental disorders are also associated with lower cognitive ability in … (see more)general population cohorts. Studies have focussed on a small set of recurrent CNVs, but burden analyses suggested that the vast majority of CNVs affecting cognitive ability are too rare to reach variant-level association. As a result, the full range of gene-dosage-sensitive biological processes linked to cognitive ability remains unknown. To investigate this issue, we identified all CNVs >50 kilobases in 258k individuals from 6 general population cohorts with assessments of general cognitive abilities. We performed a CNV-GWAS and functional burden analyses, which tested 6502 gene-sets defined by tissue and cell-type transcriptomics as well as gene ontology disrupted by all rare coding CNVs. CNV-GWAS identified a novel duplication at 2q12.3 associated with higher performance in cognitive ability. Among the 864 gene-sets associated with cognitive ability, only 11% showed significant effects for both deletions and duplication. Accordingly, we systematically observed negative correlations between deletion and duplication effect sizes across all levels of biological observations. We quantified the preferential effects of deletions versus duplication using tagDS, a new normalized metric. Cognitive ability was preferentially affected by cortical, presynaptic, and negative-regulation gene-sets when duplicated. In contrast, preferential effects of deletions were observed for subcortical, post-synaptic, and positive-regulation gene-sets. A large proportion of gene-sets assigned to non-brain organs were associated with cognitive ability due to low tissue specificity genes, which were associated with higher sensitive to haploinsufficiency. Overall, most biological functions associated with cognitive ability are divided into those sensitive to either deletion or duplications.
2024-04-17
bioRxiv (preprint)
doi.org
Association between arterial oxygen and mortality across critically ill patients with hematologic malignancies: results from an international collaborative network
Guillaume Dumas
Idunn S. Morris
Tamishta Hensman
Sean M. Bagshaw
Alexandre Demoule
Bruno Ferreyro
Achille Kouatchet
Virginie Lemiale
Djamel Mokart
Frédéric Pène
Sangeeta Mehta
Elie Azoulay
Laveena Munshi
Laurent Argaud
François Barbier
Dominique Benoit
Naike Bigé
Fabrice Bruneel
Emmanuel Canet
Yves Cohen … (see 30 more)
Michaël Darmon
Didier Gruson
Kada Klouche
Loay Kontar
Alexandre Lautrette
Christine Lebert
Guillaume Louis
Julien Mayaux
Anne-Pascale Meert
Anne-Sophie Moreau
Martine Nyunga
Vincent Peigne
Pierre Perez
Jean Herlé Raphalen
Carole Schwebel
Jean-Marie Tonnelier
Florent Wallet
Lara Zafrani
Bram Rochwerg
Farah Shoukat
Dean Fergusson
Paul Heffernan
Margaret Herridge
Sheldon Magder
Mark Minden
Rakesh Patel
Salman Qureshi
Aaron Schimmer
Santhosh Thyagu
Han Ting Wang
2024-04-10
Intensive Care Medicine (published)
doi.org
Long-term survival and functional outcomes of critically ill patients with hematologic malignancies: a Canadian multicenter prospective study
Laveena Munshi
Guillaume Dumas
Bram Rochwerg
Farah Shoukat
Michael Detsky
Dean A. Fergusson
Bruno Ferreyro
Paul Heffernan
Margaret Herridge
Sheldon Magder
Mark Minden
Rakesh Patel
Salman Qureshi
Aaron Schimmer
Santhosh Thyagu
Han Ting Wang
Sangeeta Mehta
2024-03-11
Intensive Care Medicine (published)
doi.org
Predicting Grokking Long Before it Happens: A look into the loss landscape of models which grok
Tikeng Notsawo Pascal Junior
Pascal Notsawo
Hattie Zhou
Mohammad Pezeshki
Irina Rish
Guillaume Dumas
2024-03-04
ICLR.cc/2024/Workshop/ME-FoMo (poster)
doi.org
openreview.net
Sources of richness and ineffability for phenomenally conscious states
Xu Ji
Eric Elmoznino
George Deane
Axel Constant
Guillaume Dumas
Guillaume Lajoie
Jonathan Simon
Yoshua Bengio
2024-03-01
Neuroscience of Consciousness (published)
doi.org
arxiv.org
The « jingle-jangle fallacy » of empathy: Delineating affective, cognitive and motor components of empathy from behavioral synchrony using a virtual agent
Julia Ayache
Guillaume Dumas
Alexander Sumich
D. Kuss
Darren Rhodes
Nadja Heym
2024-03-01
Personality and Individual Differences (published)
doi.org
Effective Latent Differential Equation Models via Attention and Multiple Shooting
Germán Abrevaya
Mahta Ramezanian-Panahi
Jean-Christophe Gagnon-Audet
Irina Rish
Pablo Polosecki
Silvina Ponce Dawson
Guillermo Cecchi
Guillaume Dumas
2024-02-26
TMLR (accepted)
openreview.net
openreview.net
Prospective evaluation of bleeding risk among thrombocytopenic patients admitted in intensive care unit.
Geoffroy HARIRI
Vincent Belossi
Louis Pérol
Louai Missri
Paul GABARRE
Vincent BONNY
Tomas URBINA
Jean-Luc Baudel
Bertrand GUIDET
Jérémie JOFFRE
Eric Maury
Guillaume Dumas
Hafid AIT-OUFELLA
2024-02-01
Journal of Critical Care (published)
doi.org
Protocol for fever control using external cooling in mechanically ventilated patients with septic shock: SEPSISCOOL II randomised controlled trial
Armelle Guénégou-Arnoux
Juliette Murris
Stéphane Bechet
Camille Jung
Johann Auchabie
Julien Dupeyrat
Nadia Anguel
Pierre Asfar
Julio Badie
Dorothée Carpentier
Benjamin Chousterman
Jeremy Bourenne
Agathe Delbove
Jérôme Devaquet
Nicolas Deye
Guillaume Dumas
Anne-Florence Dureau
Jean-Baptiste Lascarrou
Stephane Legriel
Christophe Guitton … (see 14 more)
Caroline Jannière-Nartey
Jean-Pierre Quenot
Jean-Claude Lacherade
Julien Maizel
Armand Mekontso Dessap
Bruno Mourvillier
Philippe Petua
Gaetan Plantefeve
Jean-Christophe Richard
Alexandre Robert
Clément Saccheri
Ly Van Phach Vong
Sandrine Katsahian
Frédérique Schortgen
2024-01-29
BMJ Open (published)
doi.org
Corticosteroids induce an early but limited decrease in IL-6 dependent pro-inflammatory responses in critically ill COVID-19 patients
Tomas URBINA
Paul GABARRE
Vincent BONNY
Jean-Rémi Lavillegrand
Marc GARNIER
Jérémie JOFFRE
Nathalie MARIO
Guillaume Dumas
Geoffroy HARIRI
Matthieu TURPIN
Emmanuel PARDO
Muriel FARTOUKH
Bertrand GUIDET
Eric Maury
Yannick CHANTRAN
Pierre-Yves BOELLE
Guillaume VOIRIOT
Hafid AIT-OUFELLA
2024-01-01
Minerva Anestesiologica (published)
doi.org
Resilience and Mental-Health Symptoms in ICU Healthcare Professionals Facing Repeated COVID-19 Waves
Elie Azoulay
Frédéric Pochard
Laurent Argaud
Alain Cariou
Raphael Clere-Jehl
Olivier Guisset
Vincent Labbé
Fabienne Tamion
Fabrice Bruneel
Mercé Jourdain
Danielle Reuter
Kada Klouche
Achille Kouatchet
Virginie Souppart
Alexandre Lautrette
Julien Bohé
Antoine Vieillard Baron
Jean Dellamonica
Laurent Papazian
Jean Reignier … (see 3 more)
François Barbier
Guillaume Dumas
Nancy Kentish-Barnes
2024-01-01
American Journal of Respiratory and Critical Care Medicine (published)
doi.org