Portrait of Guillaume Dumas

Guillaume Dumas

Associate Academic Member
Associate Professor, Université de Montréal, Department of Psychiatry and Addiction
Adjunct Professor, McGill University, Department of Psychiatry
Research Topics
Computational Biology
Computational Neuroscience
Deep Learning
Dynamical Systems
Machine Learning Theory
Medical Machine Learning
Reinforcement Learning
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Biography

Guillaume Dumas is an associate professor of computational psychiatry in the Faculty of Medicine, Université de Montréal, and principal investigator in the Precision Psychiatry and Social Physiology laboratory at the Centre hospitalier universitaire (CHU) Sainte-Justine Research Centre. He holds the IVADO professorship for AI in Mental Health, and the Fonds de recherche du Québec - Santé (FRQS) J1 in AI and Digital Health. In 2023, Dumas was recognized as a CIFAR Azrieli Global Scholar – Brain, Mind, and Consciousness program, and nominated as a Future Leader in Canadian Brain Research by the Brain Canada Foundation.

Dumas was previously a permanent researcher in neuroscience and computational biology at the Institut Pasteur (Paris). Before that, he was a postdoctoral fellow at the Center for Complex Systems and Brain Sciences (Florida Atlanta University). He holds an engineering degree in advanced engineering and computer science (École Centrale Paris), two MSc degrees (theoretical physics, Paris-Saclay University; cognitive science, ENS/EHESS/Paris 5), and a PhD in cognitive neuroscience (Sorbonne University).

The goal of his research is to cross-fertilize AI/ML, cognitive neuroscience and digital medicine through an interdisciplinary program with two main axes:

- AI/ML for Mental Health, which aims to create new algorithms to investigate the development of human cognitive architecture and deliver personalized medicine in neuropsychiatry using data from genomes to smartphones.

- Social Neuroscience for AI/ML, which translates basic brain research and dynamical systems formalism into neurocomputational and machine learning hybrid models (NeuroML) and machines with social learning abilities (Social NeuroAI & HMI).

Current Students

Saskia Helbling
Postdoctorate - Université de Montréal
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Nadine Mohamed
Master's Research - Université de Montréal
Rémy Ramadour
Independent visiting researcher - CHU Sainte Justine / Université de Montréal
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Mahta Ramezanian
Master's Research - Université de Montréal
Principal supervisor :
Irina Rish
Pascal Tikeng Notsawo
PhD - Université de Montréal
Principal supervisor :
Guillaume Rabusseau
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Publications

Collective Decision Making by Embodied Neural Agents
Nicolas Coucke
Mary Katherine Heinrich
Axel Cleeremans
Marco Dorigo
Guillaume Dumas
Collective decision making using simple social interactions has been studied in many types of multi-agent systems, including robot swarms an… (see more)d human social networks. However, existing multi-agent studies have rarely modeled the neural dynamics that underlie sensorimotor coordination in embodied biological agents. In this study, we investigated collective decisions that resulted from sensorimotor coordination among agents with simple neural dynamics. We equipped our agents with a model of minimal neural dynamics based on the coordination dynamics framework, and embedded them in an environment with a stimulus gradient. In our single-agent setup, the decision between two stimulus sources depends solely on the coordination of the agent's neural dynamics with its environment. In our multi-agent setup, that same decision also depends on the sensorimotor coordination between agents, via their simple social interactions. Our results show that the success of collective decisions depended on a balance of intra-agent, inter-agent, and agent-environment coupling, and we use these results to identify the influences of environmental factors on decision difficulty. More generally, our results demonstrate the impact of intra- and inter-brain coordination dynamics on collective behavior, can contribute to existing knowledge on the functional role of inter-agent synchrony, and are relevant to ongoing developments in neuro-AI and self-organized multi-agent systems.
2025-03-24
PNAS Nexus (published)
doi.org
arxiv.org
Determinants of pleiotropy and monotonic gene dosage responses across human traits
Sayeh Kazem
Kuldeep Kumar
Guillaume Huguet
Josephine Mollon
Thomas Renne
Laura M. Schultz
Emma E.M. Knowles
Worrawat Engchuan
Omar Shanta
Bhooma Thiruvahindrapuram
Jeffrey R. MacDonald
Celia M.T. Greenwood
Stephen W. Scherer
Laura Almasy
Jonathan Sebat
David C. Glahn
Guillaume Dumas
Sébastien Jacquemont
Pleiotropic effects of gene dosage are central to understanding comorbidities in developmental pediatric and psychiatric disorders, yet the … (see more)underlying biological processes are unknown. We developed Functional Burden analysis (FunBurd) to investigate the association of all protein-coding copy-number-variants (CNVs), genome-wide, with 43 complex traits in ∼500,000 UK-Biobank participants. We tested CNV associations disrupting 172 tissue or cell-type gene-sets, observing associations across all traits. Pleiotropy was correlated with genetic constraint and was higher in the brain compared to non-brain functions, even after normalizing for genetic constraint. Cognition and mental health traits showed specific gene-dosage effects across cortical/sub-cortical and neuronal/glial functional categories. The levels of pleiotropy, measured by burden correlation, were similar in deletions and loss-of-function SNVs, and higher compared to common variants and duplications. Gene sets under high genetic constraint showed less monotonic gene dosage responses across traits. Across most traits, we observed a negative deletion-duplication effect size correlation, indicating that functional gene sets are preferentially sensitive to either deletion or duplication, but rarely both. Our results highlight the key role of genetic constraint and brain-specific mechanisms in shaping CNV-driven pleiotropy, providing a mechanistic basis for the whole-body multimorbidity observed in neurodevelopmental and psychiatric conditions.
2025-02-25
medRxiv (preprint)
doi.org
La communication financière à l’épreuve de la crise COVID : une gestion des impressions ?
Corinne Bessieux-Ollier
Grégoire Davrinche
Guillaume Dumas
Nous étudions l’impact de la crise du COVID-19 sur la gestion des impressions pratiquée par les entreprises françaises cotées. Cette c… (see more)rise ayant eu un impact fort sur l’activité des entreprises, nous observons si les dirigeants modifient la manière de présenter l’information liée aux résultats non-GAAP, à travers l’utilisation de stratégies d’obscurcissement. Les données sur la gestion des impressions ont été collectées manuellement dans les communiqués de résultats annuels des entreprises du SBF 120 sur la période 2018-2020. Nous constatons une diminution générale du niveau de gestion des impressions en période de crise, notamment pour les entreprises des secteurs ayant été les plus impactés par la crise COVID. Cette diminution est toutefois moins prononcée pour les entreprises ayant sous-performé par rapport à leur secteur d’activité et pour les entreprises dont la performance a le plus diminué (indépendamment du secteur auquel elles appartiennent). Nos résultats suggèrent que les entreprises dont la baisse de performance pourrait être attribuée à des causes internes (résultats très défavorables, résultats en deçà du secteur d’activité) demeurent soucieuses de l’image qu’elles renvoient et maintiennent leur niveau de gestion des impressions malgré la crise.
2025-01-28
Comptabilité Contrôle Audit (published)
doi.org
A multivariable prediction model for invasive pulmonary aspergillosis in immunocompromised patients with acute respiratory failure (IPA-GRRR-OH score).
Alice Friol
Guillaume Dumas
Frédéric Pène
Alexandre Demoule
Achille Kouatchet
Laurent Argaud
Naike Bigé
Anne-Sophie Moreau
François Barbier
Djamel Mokart
Virginie Lemiale
Elie Azoulay
2025-01-23
Intensive Care Medicine (published)
doi.org
A video-based approach to decipher intubation decisions for the critically ill
Guillaume Dumas
Jean-Rémi Lavillegrand
Elie Azoulay
2025-01-06
Intensive Care Medicine (published)
doi.org
Changer le regard des étudiants sur les métiers de la comptabilité : Les effets de la simulation de gestion
Guillaume Dumas
Yann QUÉMÉNER
La comptabilité véhicule souvent injustement, une image terne et ennuyeuse, auprès du grand public et des jeunes étudiants choisissant l… (see more)eur orientation. Dans cet article, nous questionnons l’effet de pratiques pédagogiques sur la perception par les étudiants, des soft skills attendues par les employeurs. Pour cela nous réalisons une quasi-expérimentation dans laquelle nous comparons les perceptions des étudiants selon que le cours ait été animé sous un format classique (application des connaissances par le biais d’exercices avec corrigé par l’enseignant) ou sous la forme d’une simulation de gestion (application des connaissances en vue de prendre des décisions et piloter une entreprise fictive). Les résultats de la recherche montrent qu’une simulation de gestion, plus que les travaux dirigés classiques, permettent aux primo-apprenants en comptabilité, d’avoir une meilleure perception des soft skills attendues par les praticiens et les recruteurs. Nos résultats rappellent l’importance de donner une représentation réaliste (éloignée des clichés) de la profession, afin de rendre les filières d’enseignement de la comptabilité plus attractives.
2024-12-31
Finance Contrôle Stratégie (published)
doi.org
A "fine-cuts" approach disentangling psychopathic, autistic and alexithymic traits in their associations with affective, cognitive and motor empathy
Julia Ayache
Nikki Stevenson
Elisha Patel
Alexander Sumich
Guillaume Dumas
Nadja Heym
2024-12-31
Personality and Individual Differences (published)
doi.org
https://www.neuromodec.org/journal/4/2/NzBlvmDpUYspQQbvI4B Online Transcranial Random Noise Stimulation of the Right Temporoparietal Junction Acutely Modulates Human-Machine Social Interactions
Vincent Chamberland
Quentin Moreau
Lisane Moses
Gabriela Milanova
Guillaume Dumas
2024-12-31
Neuromodec Journal (published)
doi.org
Performance modulations phase-locked to action depend on internal state
Tommaso Tosato
Guillaume Dumas
Gustavo Rohenkohl
Pascal Fries
Several studies have probed perceptual performance at different times after a self-paced motor action and found frequency-specific modulatio… (see more)ns of perceptual performance phase-locked to the action. Such action-related modulation has been reported for various frequencies and modulation strengths. In an attempt to establish a basic effect at the population level, we had a relatively large number of participants (n=50) perform a self-paced button press followed by a detection task at threshold, and we applied both fixed- and random-effects tests. The combined data of all trials and participants surprisingly did not show any significant action-related modulation. However, based on previous studies, we explored the possibility that such modulation depends on the participant’s internal state. Indeed, when we split trials based on performance in neighboring trials, then trials in periods of low performance showed an action-related modulation at ≈17 Hz. When we split trials based on the performance in the preceding trial, we found that trials following a “miss” showed an action-related modulation at ≈17 Hz. Finally, when we split participants based on their false-alarm rate, we found that participants with no false alarms showed an action-related modulation at ≈17 Hz. All these effects were significant in random-effects tests, supporting an inference on the population. Together, these findings indicate that action-related modulations are not always detectable. However, the results suggest that specific internal states such as lower attentional engagement and/or higher decision criterion are characterized by a modulation in the beta-frequency range.
2024-12-31
iScience (published)
doi.org
Is sharing always caring? Entropy, boundaries and the plurality of psychotherapeutic process.
Lena Adel
Ana Gómez-Carrillo
Jonas Mago
Michael Lifshitz
Guillaume Dumas
2024-12-31
Physics of Life Reviews (published)
doi.org
Decomposing the Brain in Autism: Linking Behavioral Domains to Neuroanatomical Variation and Genomic Underpinnings.
Hanna Seelemeyer
Caroline Gurr
Johanna Leyhausen
Lisa M. Berg
Charlotte M. Pretzsch
Tim Schäfer
Bassem Hermila
Christine M. Freitag
Eva Loth
Beth Oakley
Luke Mason
Jan K. Buitelaar
Christian Beckmann
Dorothea L. Floris
Tony Charman
Tobias Banaschewski
Emily Jones
Thomas Bourgeron
Jumana Ahmad
Sara Ambrosino … (see 58 more)
Bonnie Auyeung
Simon Baron-Cohen
Sarah Baumeister
Sven Bölte
Carsten Bours
Michael Brammer
Daniel Brandeis
Claudia Brogna
Yvette de Bruijn
Bhismadev Chakrabarti
Ineke Cornelissen
Daisy Crawley
Flavio Dell’Acqua
Guillaume Dumas
Sarah Durston
Christine Ecker
Jessica Faulkner
Vincent Frouin
Pilar Garcés
David Goyard
Lindsay Ham
Hannah Hayward
Joerg F. Hipp
Rosemary Holt
Mark Johnson
Emily J. H. Jones
Prantik Kundu
Meng-Chuan Lai
Xavier Liogier D’ardhuy
Michael V. Lombardo
David J. Lythgoe
René Mandl
Andre Marquand
Maarten Mennes
Andreas Meyer-Lindenberg
Carolin Moessnang
Nico Bast
Larry O’Dwyer
Marianne Oldehinkel
Bob Oranje
Gahan Pandina
Antonio Persico
Barbara Ruggeri
Declan G.M. Murphy
Amber N. V. Ruigrok
Jessica Sabet
Roberto Sacco
Antonia San José Cáceres
Emily Simonoff
Will Spooren
Julian Tillmann
Roberto Toro
Heike Tost
Jack Waldman
Steve C. R. Williams
Caroline Wooldridge
Marcel P. Zwiers
Declan Murphy
2024-11-30
Biological Psychiatry: Cognitive Neuroscience and Neuroimaging (published)
doi.org
Effects of gene dosage on cognitive ability: A function-based association study across brain and non-brain processes
Guillaume Huguet
Thomas Renne
Cécile Poulain
Alma Dubuc
Kuldeep Kumar
Sayeh Kazem
Worrawat Engchuan
Omar Shanta
Élise Douard
Catherine Proulx
Martineau Jean-Louis
Zohra Saci
Josephine Mollon
Laura M. Schultz
Emma E.M. Knowles
Simon R. Cox
David Porteous
Gail Davies
Paul Redmond
Sarah E. Harris … (see 10 more)
Gunter Schumann
Guillaume Dumas
Aurélie Labbe
Zdenka Pausova
Tomáš Paus
Stephen W. Scherer
Jonathan Sebat
Laura Almasy
David C. Glahn
Sébastien Jacquemont
Copy-number variants (CNVs) that increase the risk for neurodevelopmental disorders also affect cognitive ability. However, such CNVs remain… (see more) challenging to study due to their scarcity, limiting our understanding of gene-dosage-sensitive biological processes linked to cognitive ability. We performed a genome-wide association study (GWAS) in 258,292 individuals, which identified—for the first time—a duplication at 2q12.3 associated with higher cognitive performance. We developed a functional-burden analysis, which tested the association between cognition and CNVs disrupting 6,502 gene sets biologically defined across tissues, cell types, and ontologies. Among those, 864 gene sets were associated with cognition, and effect sizes of deletion and duplication were negatively correlated. The latter suggested that functions across all biological processes were sensitive to either deletions (e.g., subcortical regions, postsynaptic) or duplications (e.g., cerebral cortex, presynaptic). Associations between non-brain tissues and cognition were driven partly by constrained genes, which may shed light on medical comorbidities in neurodevelopmental disorders.
2024-11-30
Cell Genomics (published)
doi.org