Portrait de Guillaume Dumas

Guillaume Dumas

Membre académique associé
Professeur agrégé, Université de Montréal, Département de psychiatrie et d’addictologie
Professeur adjoint, McGill University, Département de psychiatrie
Sujets de recherche
Apprentissage automatique médical
Apprentissage par renforcement
Apprentissage profond
Biologie computationnelle
Neurosciences computationnelles
Systèmes dynamiques
Théorie de l'apprentissage automatique
Site web
Google Scholar
LinkedIn
X

Biographie

Guillaume Dumas est professeur agrégé de psychiatrie computationnelle à la Faculté de médecine de l'Université de Montréal et chercheur principal du laboratoire de psychiatrie de précision et de physiologie sociale du Centre de recherche du CHU Sainte-Justine. Il est titulaire de la chaire IVADO IA en santé mentale et chercheur-boursier junior 1 du Fonds de recherche du Québec - Santé (FRQS) dans le domaine de l’ IA en santé et de la santé numérique. En 2023, il a été retenu dans le cadre du Programme des chercheurs mondiaux CIFAR-Azrieli pour le programme de recherche Cerveau, esprit et conscience. Il a également été nommé parmi les Futurs leaders canadiens de la recherche sur le cerveau par la Fondation Brain Canada.

Il a auparavant été chercheur permanent en neurosciences et en biologie computationnelle à l'Institut Pasteur (Paris, France), ainsi que chercheur postdoctoral au Center for Complex Systems and Brain Sciences à l’Université Florida Atlantic (FAU), aux États-Unis. Il est titulaire d'un diplôme d'ingénieur en ingénierie avancée et informatique (École centrale Paris), de deux masters (physique théorique, Université Paris-Saclay; sciences cognitives, ENS/EHESS/Paris 5) et d'un doctorat en neurosciences cognitives (Sorbonne Université).

Ses recherches visent à combiner l’intelligence artificielle, les neurosciences cognitives et la médecine numérique à travers un programme interdisciplinaire suivant deux axes principaux :

- L’intelligence artificielle en santé mentale, par la création de nouveaux algorithmes pour étudier le développement de l'architecture cognitive humaine et pour fournir une médecine personnalisée en neuropsychiatrie grâce à des données allant du génome à celles des téléphones intelligents;

- Les neurosciences sociales en intelligence artificielle, par la traduction de la recherche fondamentale sur le cerveau et le formalisme des systèmes dynamiques en des modèles hybrides neurocomputationnels et d’apprentissage automatique (NeuroML) et de nouvelles architectures présentant des capacités d'apprentissage social (NeuroIA Sociale et IHM).

Étudiants actuels

Juan David Vargas
Maîtrise recherche - UdeM
Kastel Natalie
Doctorat - UdeM
Mahta Ramezanian
Maîtrise recherche - UdeM
Superviseur⋅e principal⋅e :
Irina Rish
Pascal Tikeng Notsawo
Doctorat - UdeM
Superviseur⋅e principal⋅e :
Guillaume Rabusseau
Site web
Github
Google Scholar
Tommaso Tosato
Postdoctorat - UdeM
Site web
Github
Google Scholar

Publications

Mass‐spectrometry analysis of the human pineal proteome during night and day and in autism
Guillaume Dumas
Hany Goubran‐Botros
Mariette Matondo
Cécile Pagan
Cyril Boulègue
Thibault Chaze
Julia Chamot‐Rooke
Erik Maronde
Thomas Bourgeron
The human pineal gland regulates day‐night dynamics of multiple physiological processes, especially through the secretion of melatonin. Us… (voir plus)ing mass‐spectrometry‐based proteomics and dedicated analysis tools, we identify proteins in the human pineal gland and analyze systematically their variation throughout the day and compare these changes in the pineal proteome between control specimens and donors diagnosed with autism. Results reveal diverse regulated clusters of proteins with, among others, catabolic carbohydrate process and cytoplasmic membrane‐bounded vesicle‐related proteins differing between day and night and/or control versus autism pineal glands. These data show novel and unexpected processes happening in the human pineal gland during the day/night rhythm as well as specific differences between autism donor pineal glands and those from controls.
2020-12-23
Journal of Pineal Research (publié)
doi.org
#EEGManyLabs: Investigating the replicability of influential EEG experiments
Yuri G Pavlov
N. Adamian
Stefan Appelhoff
Mahnaz Arvaneh
C. Benwell
Christian Beste
A. Bland
Daniel E. Bradford
Florian Bublatzky
Niko A. Busch
Peter E. Clayson
Damian Cruse
Artur Czeszumski
Anna Dreber
Guillaume Dumas
Benedikt V. Ehinger
Giorgio Ganis
Xun He
J. Hinojosa
Christoph Huber-Huber … (voir 39 de plus)
Michael Inzlicht
B. Jack
Magnus Johannesson
Rhiannon Jones
Evgenii Kalenkovich
Laura Kaltwasser
Hamid Karimi-rouzbahani
And Andreas Keil
P. König
Layla Kouara
Louisa V. Kulke
C. Ladouceur
Nicolas Langer
Heinrich R. Liesefeld
David Luque
Annmarie MacNamara
Liad Mudrik
Muthuraman Muthuraman
Lauren Browning Neal
Gustav Nilsonne
Guiomar Niso
Sebastian Ocklenburg
Robert Oostenveld
Cyril R. Pernet
G. Pourtois
Manuela Ruzzoli
S. Sass
Alexandre Schaefer
Magdalena Senderecka
Joel S. Snyder
Christian Krog Tamnes
E Tognoli
M. V. Vugt
Edelyn Verona
Robin Vloeberghs
Dominik Welke
J. Wessel
Ilya V Zakharov
Faisal Mushtaq
2020-11-27
Cortex (publié)
doi.org
Human attachments shape interbrain synchrony toward efficient performance of social goals
Amir Djalovski
Guillaume Dumas
Sivan Kinreich
Ruth Pinkenson Feldman
2020-11-26
NeuroImage (publié)
doi.org
Interactive Psychometrics for Autism With the Human Dynamic Clamp: Interpersonal Synchrony From Sensorimotor to Sociocognitive Domains
Florence Baillin
Aline Lefebvre
Amandine Pedoux
Yann Beauxis
Denis-Alexander Engemann
Anna Maruani
Frederique Amsellem
J. A. Scott Kelso
Thomas Bourgeron
Richard Delorme
Guillaume Dumas
The human dynamic clamp (HDC) is a human–machine interface designed on the basis of coordination dynamics for studying realistic social in… (voir plus)teraction under controlled and reproducible conditions. Here, we propose to probe the validity of the HDC as a psychometric instrument for quantifying social abilities in children with autism spectrum disorder (ASD) and neurotypical development. To study interpersonal synchrony with the HDC, we derived five standardized scores following a gradient from sensorimotor and motor to higher sociocognitive skills in a sample of 155 individuals (113 participants with ASD, 42 typically developing participants; aged 5 to 25 years; IQ > 70). Regression analyses were performed using normative modeling on global scores according to four subconditions (HDC behavior “cooperative/competitive,” human task “in-phase/anti-phase,” diagnosis, and age at inclusion). Children with ASD had lower scores than controls for motor skills. HDC motor coordination scores were the best candidates for stratification and diagnostic biomarkers according to exploratory analyses of hierarchical clustering and multivariate classification. Independently of phenotype, sociocognitive skills increased with developmental age while being affected by the ongoing task and HDC behavior. Weaker performance in ASD for motor skills suggests the convergent validity of the HDC for evaluating social interaction. Results provided additional evidence of a relationship between sensorimotor and sociocognitive skills. HDC may also be used as a marker of maturation of sociocognitive skills during real-time social interaction. Through its standardized and objective evaluation, the HDC not only represents a valid paradigm for the study of interpersonal synchrony but also offers a promising, clinically relevant psychometric instrument for the evaluation and stratification of sociomotor dysfunctions.
2020-11-26
Frontiers in Psychiatry (publié)
doi.org
Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia
Clara A. Moreau
Sebastian G. W. Urchs
Kumar Kuldeep
Pierre Orban
Catherine Schramm
Guillaume Dumas
Aurélie Labbe
Guillaume Huguet
Elise Douard
Pierre-Olivier Quirion
Amy Lin
Leila Kushan
Stephanie Grot
David Luck
Adrianna Mendrek
Stephane Potvin
Emmanuel Stip
Thomas Bourgeron
Alan C. Evans
Carrie E. Bearden … (voir 2 de plus)
Lune Bellec
Sébastien Jacquemont
2020-10-19
Nature Communications (publié)
doi.org
HyPyP: a Hyperscanning Python Pipeline for inter-brain connectivity analysis
Anaël Ayrolles
Florence Brun
Phoebe Chen
Amir Djalovski
Yann Beauxis
Richard Delorme
Thomas Bourgeron
Suzanne Dikker
Guillaume Dumas
Abstract The bulk of social neuroscience takes a ‘stimulus-brain’ approach, typically comparing brain responses to different types of so… (voir plus)cial stimuli, but most of the time in the absence of direct social interaction. Over the last two decades, a growing number of researchers have adopted a ‘brain-to-brain’ approach, exploring similarities between brain patterns across participants as a novel way to gain insight into the social brain. This methodological shift has facilitated the introduction of naturalistic social stimuli into the study design (e.g. movies) and, crucially, has spurred the development of new tools to directly study social interaction, both in controlled experimental settings and in more ecologically valid environments. Specifically, ‘hyperscanning’ setups, which allow the simultaneous recording of brain activity from two or more individuals during social tasks, has gained popularity in recent years. However, currently, there is no agreed-upon approach to carry out such ‘inter-brain connectivity analysis’, resulting in a scattered landscape of analysis techniques. To accommodate a growing demand to standardize analysis approaches in this fast-growing research field, we have developed Hyperscanning Python Pipeline, a comprehensive and easy open-source software package that allows (social) neuroscientists to carry-out and to interpret inter-brain connectivity analyses.
2020-10-08
Social Cognitive and Affective Neuroscience (publié)
doi.org
A normative modelling approach reveals age-atypical cortical thickness in a subgroup of males with autism spectrum disorder
Richard A.I. Bethlehem
Jakob Seidlitz
Rafael Romero-Garcia
Stavros Trakoshis
Guillaume Dumas
Michael V. Lombardo
2020-09-04
Communications Biology (publié)
doi.org
''COGITO in Space'': a thought experiment in exo-neurobiology
Daniela de Paulis
Stephen Whitmarsh
Robert Oostenveld
Guillaume Dumas
Michael Sanders
2020-08-04
(publié)
doi.org
Attenuated Anticipation of Social and Monetary Rewards in Autism Spectrum Disorders
Sarah Baumeister
Carolin Moessnang
Nico Bast
Sarah Hohmann
Julian Tillmann
David Goyard
Tony Charman
Sara Ambrosino
Simon Baron-Cohen
Christian Beckmann
Sven Bölte
Thomas Bourgeron
Annika Rausch
Daisy Crawley
Flavio Dell’Acqua
Guillaume Dumas
Sarah Durston
Christine Ecker
Dorothea L. Floris
Vincent Frouin … (voir 19 de plus)
Hannah Hayward
Rosemary Holt
Mark Johnson
Emily J. H. Jones
Meng-Chuan Lai
Michael V. Lombardo
Luke Mason
Marianne Oldehinkel
Tony Persico
Antonia San José Cáceres
Thomas Wolfers
Will Spooren
Eva Loth
Declan Murphy
Jan K. Buitelaar
Heike Tost
Andreas Meyer-Lindenberg
Tobias Banaschewski
Daniel Brandeis
Background Reward processing has been proposed to underpin atypical social behavior, a core feature of autism spectrum disorder (ASD). Howev… (voir plus)er, previous neuroimaging studies have yielded inconsistent results regarding the specificity of atypicalities for social rewards in ASD. Utilizing a large sample, we aimed to assess altered reward processing in response to reward type (social, monetary) and reward phase (anticipation, delivery) in ASD. Methods Functional magnetic resonance imaging during social and monetary reward anticipation and delivery was performed in 212 individuals with ASD (7.6-30.5 years) and 181 typically developing (TD) participants (7.6-30.8 years). Results Across social and monetary reward anticipation, whole-brain analyses (p0.05, family-wise error-corrected) showed hypoactivation of the right ventral striatum (VS) in ASD. Further, region of interest (ROI) analy
2020-07-06
bioRxiv (prépublication)
doi.org
Individual differences in interpersonal coordination
Julia Ayache
Guillaume Dumas
A. Sumich
D. Kuss
Darren Rhodes
Nadja Heym
2020-06-18
(publié)
doi.org
Dark control: The default mode network as a reinforcement learning agent
Elvis Dohmatob
Guillaume Dumas
Danilo Bzdok
2020-06-05
Human Brain Mapping (publié)
doi.org
Differential neural circuitry behind autism subtypes with imbalanced social-communicative and restricted repetitive behavior symptoms
Natasha Bertelsen
Isotta Landi
Richard A.I. Bethlehem
Jakob Seidlitz
Elena Maria Busuoli
Veronica Mandelli
Eleonora Satta
Stavros Trakoshis
Bonnie Auyeung
Prantik Kundu
Eva Loth
Guillaume Dumas
Sarah Baumeister
Christian Beckmann
Sven Bölte
Thomas Bourgeron
Tony Charman
Sarah Durston
Christine Ecker
Rosemary Holt … (voir 15 de plus)
Mark Johnson
Emily J. H. Jones
Luke Mason
Andreas Meyer-Lindenberg
Carolin Moessnang
Marianne Oldehinkel
Antonio Persico
Julian Tillmann
Steven C. R. Williams
Will Spooren
Declan Murphy
Jan K. Buitelaar
Simon Baron-Cohen
Meng-Chuan Lai
Michael V. Lombardo
Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly … (voir plus)differ within and between individuals and may be underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here we developed a phenotypic stratification model that makes highly accurate (97-99%) out-of-sample SC=RRB, SC>RRB, and RRB>SC subtype predictions. Applying this model to resting state fMRI data from the EU-AIMS LEAP dataset (n=509), we find that while the phenotypic subtypes share many commonalities in terms of intrinsic functional connectivity, they also show subtype-specific qualitative differences compared to a typically-developing group (TD). Specifically, the somatomotor network is hypoconnected with perisylvian circuitry in SC>RRB and visual association circuitry in SC=RRB. The SC=RRB subtype also showed hyperconnectivity between medial motor and anterior salience circuitry. Genes that are highly expressed within these subtype-specific networks show a differential enrichment pattern with known ASD associated genes, indicating that such circuits are affected by differing autism-associated genomic mechanisms. These results suggest that SC-RRB imbalance subtypes share some commonalities but also express subtle differences in functional neural circuitry and the genomic underpinnings behind such circuitry.
2020-05-10
bioRxiv (prépublication)
doi.org