Portrait de Guillaume Dumas

Guillaume Dumas

Membre académique associé
Professeur agrégé, Université de Montréal, Département de psychiatrie et d’addictologie
Professeur adjoint, McGill University, Département de psychiatrie
Sujets de recherche
Apprentissage automatique médical
Apprentissage par renforcement
Apprentissage profond
Biologie computationnelle
Neurosciences computationnelles
Systèmes dynamiques
Théorie de l'apprentissage automatique
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Biographie

Guillaume Dumas est professeur agrégé de psychiatrie computationnelle à la Faculté de médecine de l'Université de Montréal et chercheur principal du laboratoire de psychiatrie de précision et de physiologie sociale du Centre de recherche du CHU Sainte-Justine. Il est titulaire de la chaire IVADO IA en santé mentale et chercheur-boursier junior 1 du Fonds de recherche du Québec - Santé (FRQS) dans le domaine de l’ IA en santé et de la santé numérique. En 2023, il a été retenu dans le cadre du Programme des chercheurs mondiaux CIFAR-Azrieli pour le programme de recherche Cerveau, esprit et conscience. Il a également été nommé parmi les Futurs leaders canadiens de la recherche sur le cerveau par la Fondation Brain Canada.

Il a auparavant été chercheur permanent en neurosciences et en biologie computationnelle à l'Institut Pasteur (Paris, France), ainsi que chercheur postdoctoral au Center for Complex Systems and Brain Sciences à l’Université Florida Atlantic (FAU), aux États-Unis. Il est titulaire d'un diplôme d'ingénieur en ingénierie avancée et informatique (École centrale Paris), de deux masters (physique théorique, Université Paris-Saclay; sciences cognitives, ENS/EHESS/Paris 5) et d'un doctorat en neurosciences cognitives (Sorbonne Université).

Ses recherches visent à combiner l’intelligence artificielle, les neurosciences cognitives et la médecine numérique à travers un programme interdisciplinaire suivant deux axes principaux :

- L’intelligence artificielle en santé mentale, par la création de nouveaux algorithmes pour étudier le développement de l'architecture cognitive humaine et pour fournir une médecine personnalisée en neuropsychiatrie grâce à des données allant du génome à celles des téléphones intelligents;

- Les neurosciences sociales en intelligence artificielle, par la traduction de la recherche fondamentale sur le cerveau et le formalisme des systèmes dynamiques en des modèles hybrides neurocomputationnels et d’apprentissage automatique (NeuroML) et de nouvelles architectures présentant des capacités d'apprentissage social (NeuroIA Sociale et IHM).

Étudiants actuels

Saskia Helbling
Postdoctorat - UdeM
Site web
Github
Google Scholar
Nadine Mohamed
Maîtrise recherche - UdeM
Rémy Ramadour
Visiteur de recherche indépendant - CHU Sainte Justine / Université de Montréal
Site web
Github
Mahta Ramezanian
Maîtrise recherche - UdeM
Superviseur⋅e principal⋅e :
Irina Rish
Pascal Tikeng Notsawo
Doctorat - UdeM
Superviseur⋅e principal⋅e :
Guillaume Rabusseau
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Github
Google Scholar

Publications

Disorganized Communication and Social Dysfunction in Schizophrenia: Emerging Concepts and Methods
Emmanuel Olarewaju
Guillaume Dumas
L. Palaniyappan
2023-09-22
Current Psychiatry Reports (publié)
doi.org
WOODS: Benchmarks for Out-of-Distribution Generalization in Time Series
Jean-christophe Gagnon-audet
Kartik Ahuja
Mohammad Javad Darvishi Bayazi
Pooneh Mousavi
Guillaume Dumas
Irina Rish
2023-08-31
TMLR (accepté)
openreview.net
openreview.net
Subcortical Brain Alterations in Carriers of Genomic Copy Number Variants.
Kuldeep Kumar
Claudia Modenato
Clara A. Moreau
C. Ching
Christopher R. K. Ching
Annabelle Harvey
Sandra Martin-Brevet
Guillaume Huguet
Martineau Jean-Louis
Elise Douard
Charles-Olivier Martin
C.O. Martin
Nadine Younis
Petra Tamer
Anne M. Maillard
Borja Rodriguez-Herreros
Aurélie Pain
Sonia Richetin
Leila Kushan
Dmitry Isaev … (voir 26 de plus)
Kathryn Alpert
Anjani Ragothaman
Jessica A. Turner
Wei Wang
T. Ho
Tiffany C. Ho
Lianne Schmaal
Ana I. Silva
Marianne B.M. van den Bree
V. Marianne
David E.J. Linden
M. J. Owen
Marie Owen
Jeremy Hall
Sarah Lippé
Guillaume Dumas
Bogdan Draganski
Boris A. Gutman
Ida E. Sønderby
Ole A. Andreassen
Laura Schultz
Laura Almasy
David C. Glahn
Carrie E. Bearden
Paul M. Thompson
Sébastien Jacquemont
OBJECTIVE Copy number variants (CNVs) are well-known genetic pleiotropic risk factors for multiple neurodevelopmental and psychiatric disord… (voir plus)ers (NPDs), including autism (ASD) and schizophrenia. Little is known about how different CNVs conferring risk for the same condition may affect subcortical brain structures and how these alterations relate to the level of disease risk conferred by CNVs. To fill this gap, the authors investigated gross volume, vertex-level thickness, and surface maps of subcortical structures in 11 CNVs and six NPDs. METHODS Subcortical structures were characterized using harmonized ENIGMA protocols in 675 CNV carriers (CNVs at 1q21.1, TAR, 13q12.12, 15q11.2, 16p11.2, 16p13.11, and 22q11.2; age range, 6-80 years; 340 males) and 782 control subjects (age range, 6-80 years; 387 males) as well as ENIGMA summary statistics for ASD, schizophrenia, attention deficit hyperactivity disorder, obsessive-compulsive disorder, bipolar disorder, and major depression. RESULTS All CNVs showed alterations in at least one subcortical measure. Each structure was affected by at least two CNVs, and the hippocampus and amygdala were affected by five. Shape analyses detected subregional alterations that were averaged out in volume analyses. A common latent dimension was identified, characterized by opposing effects on the hippocampus/amygdala and putamen/pallidum, across CNVs and across NPDs. Effect sizes of CNVs on subcortical volume, thickness, and local surface area were correlated with their previously reported effect sizes on cognition and risk for ASD and schizophrenia. CONCLUSIONS The findings demonstrate that subcortical alterations associated with CNVs show varying levels of similarities with those associated with neuropsychiatric conditions, as well distinct effects, with some CNVs clustering with adult-onset conditions and others with ASD. These findings provide insight into the long-standing questions of why CNVs at different genomic loci increase the risk for the same NPD and why a single CNV increases the risk for a diverse set of NPDs.
2023-07-11
American Journal of Psychiatry (publié)
doi.org
Cortico-Cerebellar neurodynamics during social interaction in Autism Spectrum Disorders
Fleur Gaudfernau
Aline Lefebvre
Denis-Alexander Engemann
Amandine Pedoux
Anna Bánki
Florence Baillin
Benjamin Landman
Frederique Amsellem
Anna Maruani
Thomas Bourgeron
Richard Delorme
Guillaume Dumas
2023-06-27
NeuroImage : Clinical (publié)
doi.org
Tri-process model of interpersonal mindfulness: theoretical framework and study protocol
Bassam Khoury
Viktoriya Manova
Lena Adel
Guillaume Dumas
Michael Lifshitz
Rodrigo C. Vergara
Harmehr Sekhon
Soham Rej
According to the Center for Disease Control and Prevention, over 14% of the US population practice mindfulness meditation. The effects of mi… (voir plus)ndfulness training on physical and mental health have been consistently documented, but its effects on interpersonal relationships are not yet fully understood or investigated. Interpersonal relationships play a crucial role in the wellbeing of individuals and society, and therefore, warrants further study. The aim of this paper is to present a tri-process theoretical model of interpersonal mindfulness and a study protocol to validate the proposed model. Specifically, according to the proposed model, mindfulness meditation training increases the self-awareness, self-regulation, and prosociality of those receiving the training, which ameliorates the quality of interpersonal interactions and the socioemotional support provided to other individuals. Finally, better socioemotional support increases the support receiver’s ability to regulate their emotions. Using a multiphasic longitudinal design involving 640 participants randomized into 480 dyads, the proposed protocol aims to validate the tri-process model and to investigate its mechanisms of actions. The proposed study has important theoretical and social implications and will allow devising new and more effective interpersonal mindfulness programs with applications in multiple fields.
2023-04-25
Frontiers in Psychology (publié)
doi.org
Genesis, modelling and methodological remedies to autism heterogeneity
Juliette Rabot
Eya‐mist Rødgaard
Ridha Joober
Guillaume Dumas
Danilo Bzdok
Boris C Bernhardt
Sébastien Jacquemont
Laurent Mottron
2023-03-31
Neuroscience and Biobehavioral Reviews (publié)
doi.org
Cross-sectional and longitudinal neuroanatomical profiles of distinct clinical (adaptive) outcomes in autism
Charlotte M. Pretzsch
Dorothea L. Floris
Tim Schäfer
Anke Bletsch
Caroline Gurr
Michael V. Lombardo
Chris H. Chatham
Julian Tillmann
Tony Charman
Martina Arenella
Emily J. H. Jones
Sara Ambrosino
Thomas Bourgeron
Guillaume Dumas
Freddy Cliquet
Claire Leblond
Eva Loth
Beth Oakley
Jan K. Buitelaar
Simon Baron-Cohen … (voir 7 de plus)
Christian Beckmann
Antonio Persico
Tobias Banaschewski
Sarah Durston
Christine M. Freitag
Declan Murphy
Christine Ecker
2023-03-28
Molecular Psychiatry (publié)
doi.org
A Novel Model for Novelty: Modeling the Emergence of Innovation from Cumulative Culture
Natalie Kastel
Guillaume Dumas
2023-03-21
Active Inference (publié)
doi.org
Processing of social and monetary rewards in autism spectrum disorders
Sarah Baumeister
Carolin Moessnang
Nico Bast
Sarah Hohmann
Pascal Aggensteiner
Anna Kaiser
Julian Tillmann
David Goyard
Tony Charman
Sara Ambrosino
Simon Baron-Cohen
Christian Beckmann
Sven Bölte
Thomas Bourgeron
Annika Rausch
Daisy Crawley
Flavio Dell’Acqua
Guillaume Dumas
Sarah Durston
Christine Ecker … (voir 21 de plus)
Dorothea L. Floris
Vincent Frouin
Hannah Hayward
Rosemary Holt
Mark Johnson
Emily J. H. Jones
Meng-Chuan Lai
Michael V. Lombardo
Luke Mason
Beth Oakley
Marianne Oldehinkel
Antonio Persico
Antonia San José Cáceres
Thomas Wolfers
Eva Loth
Declan Murphy
Jan K. Buitelaar
Heike Tost
Andreas Meyer-Lindenberg
Tobias Banaschewski
Daniel Brandeis
Background Reward processing has been proposed to underpin the atypical social feature of autism spectrum disorder (ASD). However, previous … (voir plus)neuroimaging studies have yielded inconsistent results regarding the specificity of atypicalities for social reward processing in ASD. Aims Utilising a large sample, we aimed to assess reward processing in response to reward type (social, monetary) and reward phase (anticipation, delivery) in ASD. Method Functional magnetic resonance imaging during social and monetary reward anticipation and delivery was performed in 212 individuals with ASD (7.6–30.6 years of age) and 181 typically developing participants (7.6–30.8 years of age). Results Across social and monetary reward anticipation, whole-brain analyses showed hypoactivation of the right ventral striatum in participants with ASD compared with typically developing participants. Further, region of interest analysis across both reward types yielded ASD-related hypoactivation in both the left and right ventral striatum. Across delivery of social and monetary reward, hyperactivation of the ventral striatum in individuals with ASD did not survive correction for multiple comparisons. Dimensional analyses of autism and attention-deficit hyperactivity disorder (ADHD) scores were not significant. In categorical analyses, post hoc comparisons showed that ASD effects were most pronounced in participants with ASD without co-occurring ADHD. Conclusions Our results do not support current theories linking atypical social interaction in ASD to specific alterations in social reward processing. Instead, they point towards a generalised hypoactivity of ventral striatum in ASD during anticipation of both social and monetary rewards. We suggest this indicates attenuated reward seeking in ASD independent of social content and that elevated ADHD symptoms may attenuate altered reward seeking in ASD.
2023-02-28
The British Journal of Psychiatry (publié)
doi.org
Interpersonal attunement in social interactions: from collective psychophysiology to inter-personalized psychiatry and beyond
Dimitris Bolis
Guillaume Dumas
Leonhard Schilbach
In this article, we analyse social interactions, drawing on diverse points of views, ranging from dialectics, second-person neuroscience and… (voir plus) enactivism to dynamical systems, active inference and machine learning. To this end, we define interpersonal attunement as a set of multi-scale processes of building up and materializing social expectations—put simply, anticipating and interacting with others and ourselves. While cultivating and negotiating common ground, via communication and culture-building activities, are indispensable for the survival of the individual, the relevant multi-scale mechanisms have been largely considered in isolation. Here, collective psychophysiology, we argue, can lend itself to the fine-tuned analysis of social interactions, without neglecting the individual. On the other hand, an interpersonal mismatch of expectations can lead to a breakdown of communication and social isolation known to negatively affect mental health. In this regard, we review psychopathology in terms of interpersonal misattunement, conceptualizing psychiatric disorders as disorders of social interaction, to describe how individual mental health is inextricably linked to social interaction. By doing so, we foresee avenues for an inter-personalized psychiatry, which moves from a static spectrum of disorders to a dynamic relational space, focusing on how the multi-faceted processes of social interaction can help to promote mental health. This article is part of the theme issue ‘Concepts in interaction: social engagement and inner experiences’.
2023-02-12
Philosophical Transactions of the Royal Society B: Biological Sciences (publié)
doi.org
Restoring the missing person to personalized medicine and precision psychiatry
Ana Gómez-Carrillo
Vincent Paquin
Guillaume Dumas
Laurence J. Kirmayer
Precision psychiatry has emerged as part of the shift to personalized medicine and builds on frameworks such as the U.S. National Institute … (voir plus)of Mental Health Research Domain Criteria (RDoC), multilevel biological “omics” data and, most recently, computational psychiatry. The shift is prompted by the realization that a one-size-fits all approach is inadequate to guide clinical care because people differ in ways that are not captured by broad diagnostic categories. One of the first steps in developing this personalized approach to treatment was the use of genetic markers to guide pharmacotherapeutics based on predictions of pharmacological response or non-response, and the potential risk of adverse drug reactions. Advances in technology have made a greater degree of specificity or precision potentially more attainable. To date, however, the search for precision has largely focused on biological parameters. Psychiatric disorders involve multi-level dynamics that require measures of phenomenological, psychological, behavioral, social structural, and cultural dimensions. This points to the need to develop more fine-grained analyses of experience, self-construal, illness narratives, interpersonal interactional dynamics, and social contexts and determinants of health. In this paper, we review the limitations of precision psychiatry arguing that it cannot reach its goal if it does not include core elements of the processes that give rise to psychopathological states, which include the agency and experience of the person. Drawing from contemporary systems biology, social epidemiology, developmental psychology, and cognitive science, we propose a cultural-ecosocial approach to integrating precision psychiatry with person-centered care.
2023-02-08
Frontiers in Neuroscience (publié)
doi.org
Enjeux de l’adaptation à la chaleur en ville et action publique : apports de l’interdisciplinarité et de la recherche-action - Cas de la métropole toulousaine
G. Bretagne
Julia Hidalgo
Sinda Haouès-Jouve
Guillaume Dumas
Lise Debrye
Aurélie Hanna
Valéry Masson
Le contexte législatif national, comme les attentes citoyennes exprimées pour plus d’informations et d’actions relatives aux enjeux cl… (voir plus)imatiques, ont progressivement incité à la territorialisation des politiques climatiques et énergétiques locales, ainsi qu’à l’émergence de l’enjeu d’adaptation climatique sur les territoires. Cette dynamique de spatialisation des enjeux climatiques trouve sa déclinaison à l’échelle de la métropole toulousaine depuis plus de 10 ans, du fait d’enjeux multiples sur le territoire : géographiques, climatiques et urbains. Les travaux de recherche menés localement autour des thématiques Ville, Environnement et Climat ont répondu au contexte favorable d’interdisciplinarité et de collaboration avec les acteurs urbains, soutenues par plusieurs appels à projets de recherche nationaux et européens. Deux objectifs majeurs sont affichés : coconstruire une connaissance afin de caractériser les enjeux climatiques et énergétiques propres au territoire toulousain, et proposer un accompagnement spécifique auprès des acteurs urbains pour mieux faire comprendre et objectiver les enjeux locaux, afin d’intégrer ces derniers dans les politiques et les actions publiques locales. Le présent article propose de revenir sur la synergie permise par cette collaboration, en s’attachant d’une part à présenter le processus de travail interdisciplinaire mis en place et, d’autre part, à montrer les productions de données et d’expertises qui en ont résulté.
2022-12-31
Climatologie (publié)
doi.org