Portrait de Guillaume Dumas

Guillaume Dumas

Membre académique associé
Professeur agrégé, Université de Montréal, Département de psychiatrie et d’addictologie
Professeur adjoint, McGill University, Département de psychiatrie
Sujets de recherche
Apprentissage automatique médical
Apprentissage par renforcement
Apprentissage profond
Biologie computationnelle
Neurosciences computationnelles
Systèmes dynamiques
Théorie de l'apprentissage automatique
Site web
Google Scholar
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Biographie

Guillaume Dumas est professeur agrégé de psychiatrie computationnelle à la Faculté de médecine de l'Université de Montréal et chercheur principal du laboratoire de psychiatrie de précision et de physiologie sociale du Centre de recherche du CHU Sainte-Justine. Il est titulaire de la chaire IVADO IA en santé mentale et chercheur-boursier junior 1 du Fonds de recherche du Québec - Santé (FRQS) dans le domaine de l’ IA en santé et de la santé numérique. En 2023, il a été retenu dans le cadre du Programme des chercheurs mondiaux CIFAR-Azrieli pour le programme de recherche Cerveau, esprit et conscience. Il a également été nommé parmi les Futurs leaders canadiens de la recherche sur le cerveau par la Fondation Brain Canada.

Il a auparavant été chercheur permanent en neurosciences et en biologie computationnelle à l'Institut Pasteur (Paris, France), ainsi que chercheur postdoctoral au Center for Complex Systems and Brain Sciences à l’Université Florida Atlantic (FAU), aux États-Unis. Il est titulaire d'un diplôme d'ingénieur en ingénierie avancée et informatique (École centrale Paris), de deux masters (physique théorique, Université Paris-Saclay; sciences cognitives, ENS/EHESS/Paris 5) et d'un doctorat en neurosciences cognitives (Sorbonne Université).

Ses recherches visent à combiner l’intelligence artificielle, les neurosciences cognitives et la médecine numérique à travers un programme interdisciplinaire suivant deux axes principaux :

- L’intelligence artificielle en santé mentale, par la création de nouveaux algorithmes pour étudier le développement de l'architecture cognitive humaine et pour fournir une médecine personnalisée en neuropsychiatrie grâce à des données allant du génome à celles des téléphones intelligents;

- Les neurosciences sociales en intelligence artificielle, par la traduction de la recherche fondamentale sur le cerveau et le formalisme des systèmes dynamiques en des modèles hybrides neurocomputationnels et d’apprentissage automatique (NeuroML) et de nouvelles architectures présentant des capacités d'apprentissage social (NeuroIA Sociale et IHM).

Étudiants actuels

Saskia Helbling
Postdoctorat - UdeM
Site web
Github
Google Scholar
Nadine Mohamed
Maîtrise recherche - UdeM
Rémy Ramadour
Visiteur de recherche indépendant - CHU Sainte Justine / Université de Montréal
Site web
Github
Mahta Ramezanian
Maîtrise recherche - UdeM
Superviseur⋅e principal⋅e :
Irina Rish
Pascal Tikeng Notsawo
Doctorat - UdeM
Superviseur⋅e principal⋅e :
Guillaume Rabusseau
Site web
Github
Google Scholar

Publications

Towards Multi-Brain Decoding in Autism: A Self-Supervised Learning Approach
Ghazaleh Ranjabaran
Quentin Moreau
Adrien Dubois
Guillaume Dumas
Abstract This study introduces a self-supervised learning (SSL) approach to hyperscanning electroencephalog… (voir plus)raphy (EEG) data, targeting the identification of autism spectrum condition (ASC) during social interactions. Hyperscanning enables simultaneous recording of neural activity across interacting individuals, offering a novel path for studying brain-to-brain synchrony in ASC. Leveraging a large-scale, single-brain EEG dataset for SSL pretraining, we developed a multi-brain classification model fine-tuned with hyperscanning data from dyadic interactions involving ASC and neurotypical participants. The SSL model demonstrated superior performance (78.13% accuracy) compared to supervised baselines and logistic regression using spectral EEG biomarkers. These results underscore the efficacy of SSL in addressing the challenges of limited labeled data, enhancing EEG-based diagnostic tools for ASC, and advancing research in social neuroscience.
2025-12-31
Neuroinformatics (publié)
doi.org
Now is the time: operationalizing generative neurophenomenology through interpersonal methods
Anne Monnier
Lena Adel
Guillaume Dumas

Lived experience is shaped by intersubjective, social, cultural, and historical dimensions. For the past 30 years, neurophenomenology has… (voir plus) adopted an embodied perspective of the mind by integrating first-person experiential and third-person neurobehavioral perspectives. Indeed, the neurophenomenology pragmatic approach has embraced an embodied perspective of the mind by integrating experiential first-person and neurobehavioural third-person perspectives. Neurophenomenology reveals mutual constraints between both, as they co-constitute a person’s lived experience. This article emphasizes the intersubjective and social facets of lived experience as well as the readiness of the scientific community to use a "generative neurophenomenology" approach, envisioned in the 1990s by Francisco Varela. For this endeavour, we clarify three meanings of “generative” as it applies distinctly to generative phenomenology, generative passages, and generative models. Then, we propose to combine existing methods to update neurophenomenology program: First, by transitioning from individual to multiple people phenomenology methods that include intersubjectivity experience; second, by expanding traditional neuroscience to include measures of multimodal interpersonal synchrony; and third, by leveraging multiple computational tools to integrate different viewpoints, thereby enriching our understanding of lived experience; We also underscore the potential of diverse mathematical formalisms to capture aspects of human experience, all while underscoring that using computational approaches to model neurophenomenology does not entail endorsing computationalism as a grounding hypothesis of human experience. Finally, we illustrate the clinical relevance of this paradigm through two case studies in psychiatry—(1) with interactive dyads in autism and (2) with multiple members in family therapy sessions—demonstrating its translational potential.

2025-12-26
Neuroscience of Consciousness (publié)
doi.org
Mirror effect of genomic deletions and duplications on cognitive ability across the human cerebral cortex
Kuldeep Kumar
Sayeh Kazem
Guillaume Huguet
Worrawat Engchuan
Jakub Kopal
Thomas Renne
Martineau Jean-Louis
Omar Shanta
Zohra Saci
Bhooma Thiruvahindrapuram
Jeffrey MacDonald
Josephine Mollon
Laura M Schultz
Emma E M Knowles
David Porteous
Gail Davies
Paul Redmond
Sarah Harris
Simon Cox
Gunter Schumann … (voir 9 de plus)
Zdenka Pausova
Celia Greenwood
Tomas Paus
Stephen Scherer
Laura Almasy
Jonathan Sebat
David Glahn
Guillaume Dumas
Sébastien Jacquemont
Cognitive deficits are common across many neurodevelopmental and psychiatric conditions, including those studied in the current set of PGC-C… (voir plus)NV papers. How changes in regional gene expression across the cerebral cortex influence cognitive ability remains unknown. Population variation in gene dosage—which significantly impacts gene expression—represents a unique paradigm to address this question. We developed a cerebral-cortex gene-set burden analysis (CC-GSBA) to associate a trait with genomic deletions and duplications that disrupt genes with similar expression profiles across 180 cortical regions. We performed CC-GSBA across 180 cortical regions to test associations with cognitive ability in 260,000 individuals from general population cohorts. Most cortical gene sets were associated with a decrease in cognitive ability when deleted or duplicated, and this novel approach revealed opposing cortical patterns for the effect sizes of deletions and duplications. These cortical patterns of effect sizes followed the cortical gradient previously characterized at the molecular, cellular, and functional levels. We show that genes with preferential expression in sensorimotor regions demonstrated the largest effect on cognition when deleted. At the opposing end of the cortical gradient, genes with preferential expression in multimodal association regions affected cognition the most when duplicated. These two gene dosage cortical patterns could not be explained by particular cell types, developmental epochs, or genetic constraints, highlighting the fact that the macroscopic network organization of the cerebral cortex is key to understanding the effects of gene dosage on cognitive traits.
2025-11-27
Research Square (prépublication)
doi.org
Determinants of pleiotropy and monotonic gene dosage responses across human traits
Sayeh Kazem
Kuldeep Kumar
Guillaume Huguet
Josephine Mollon
Thomas Renne
Laura M. Schultz
Emma E.M. Knowles
Worrawat Engchuan
Omar Shanta
Bhooma Thiruvahindrapuram
Jeffrey R. MacDonald
Celia M. T. Greenwood
Stephen W. Scherer
Laura Almasy
Jonathan Sebat
David C. Glahn
Guillaume Dumas
Sébastien Jacquemont
While pleiotropic effects of gene dosage are of particular relevance for comorbidities observed in the developmental pediatric and psychiatr… (voir plus)ic clinic, the biological processes underlying such pleiotropy remain unknown. We developed a new functional burden analysis (FunBurd) to investigate all CNVs, genome-wide, beyond well-studied recurrent CNVs. In ~500,000 UK-Biobank participants, we tested the association between 43 traits and CNVs disrupting 172 tissue or cell-type gene-sets. CNVs affected all traits. Pleiotropy was correlated with genetic constraint and was higher in the brain compared to non-brain functions, even after normalizing for genetic constraint. The levels of pleiotropy, measured by burden correlation, were similar in deletions and loss-of-function SNVs and higher compared to common variants and duplications. Gene sets under high genetic constraint showed less monotonic gene dosage responses across traits. Even in the absence of a monotonic response, we observed a negative correlation between deletion and duplication effect sizes across most traits. Overall, functional gene sets are preferentially associated with a given trait when either deleted or duplicated, but rarely both.
2025-11-18
Research Square (prépublication)
doi.org
Longitudinal intergenerational hyperscanning reveals indices of relationship formation and loneliness
Ryssa Moffat
Guillaume Dumas
Emily S. Cross
2025-10-15
bioRxiv (prépublication)
doi.org
Online HD-tRNS Over the Right Temporoparietal Junction Modulates Social Inference But Not Motor Coordination
Quentin Moreau
Vincent Chamberland
Lisane Moses
Gabriela Milanova
Guillaume Dumas
2025-10-08
eNeuro (publié)
doi.org
Online HD-tRNS over the right temporoparietal junction modulates social inference but not motor coordination
Quentin Moreau
Vincent Chamberland
Lisane Moses
Gabriela Milanova
Guillaume Dumas
2025-10-08
eNeuro (publié)
doi.org
Grokking Beyond the Euclidean Norm of Model Parameters
Tikeng Notsawo Pascal Junior
Pascal Notsawo
Guillaume Dumas
Guillaume Rabusseau
Grokking refers to a delayed generalization following overfitting when optimizing artificial neural networks with gradient-based methods. I… (voir plus)n this work, we demonstrate that grokking can be induced by regularization, either explicit or implicit. More precisely, we show that when there exists a model with a property
2025-10-06
Proceedings of the 42nd International Conference on Machine Learning (publié)
doi.org
openreview.net
Grokking Beyond the Euclidean Norm of Model Parameters
Tikeng Notsawo Pascal Junior
Guillaume Dumas
Guillaume Rabusseau
Grokking refers to a delayed generalization following overfitting when optimizing artificial neural networks with gradient-based methods. In… (voir plus) this work, we demonstrate that grokking can be induced by regularization, either explicit or implicit. More precisely, we show that when there exists a model with a property
2025-10-06
Proceedings of the 42nd International Conference on Machine Learning (publié)
proceedings.mlr.press
Asymmetric developmental bifurcations in polarized environments: a new class of human variants, which may include autism.
Laurent Mottron
Alix Lavigne-Champagne
Boris C. Bernhardt
Guillaume Dumas
Sébastien Jacquemont
D. Gagnon
2025-09-29
Molecular Psychiatry (publié)
doi.org
Asymmetric developmental bifurcations in polarized environments: a new class of human variants, which may include autism.
Laurent Mottron
Alix Lavigne-Champagne
Boris C. Bernhardt
Guillaume Dumas
Sébastien Jacquemont
D. Gagnon
2025-09-29
Molecular Psychiatry (publié)
doi.org
Asymmetric developmental bifurcations in polarized environments: a new class of human variants, which may include autism.
Laurent Mottron
Alix Lavigne-Champagne
Boris C. Bernhardt
Guillaume Dumas
Sébastien Jacquemont
D. Gagnon
2025-09-29
Molecular Psychiatry (publié)
doi.org