Portrait de Danilo Bzdok

Danilo Bzdok

Membre académique principal
bzdokdan@mila.quebec
Chaire en IA Canada-CIFAR
Professeur agrégé, McGill University, Département de génie biomédicale
Sujets de recherche
Apprentissage profond
Biologie computationnelle
Grands modèles de langage (LLM)
Traitement du langage naturel

Biographie

Danilo Bzdok est informaticien et médecin de formation. Il possède une double formation unique en neurosciences systémiques et en algorithmes d'apprentissage automatique. Après une formation à l'Université d'Aix-la-Chapelle (RWTH) (Allemagne), à l'Université de Lausanne (Suisse) et à la Harvard Medical School (États-Unis), il a obtenu un doctorat en neurosciences du Centre de recherche de Jülich (Allemagne) et un doctorat en informatique dans le domaine des statistiques d'apprentissage automatique à l'INRIA Saclay et à NeuroSpin (Paris, France). Il est actuellement professeur agrégé à la Faculté de médecine de l'Université McGill et titulaire d’une chaire en IA Canada-CIFAR à Mila – Institut québécois d'intelligence artificielle. Son activité de recherche interdisciplinaire est centrée sur la réduction des lacunes dans la connaissance des bases cérébrales des types de pensée qui définissent l'être humain, afin de découvrir les principes clés de conception computationnelle qui sous-tendent l'intelligence humaine.

Étudiants actuels

Shambhavi Aggarwal
Maîtrise recherche - McGill
Github
Google Scholar
Badr Ait Hammou
Postdoctorat - McGill
Karan Bali Bali
Doctorat - McGill
Gregory Bell
Doctorat - McGill
Anwesha Bhattacharya
Doctorat - McGill
Pedro Carneiro Carneiro
Doctorat - McGill
Github
Liam Hodgson
Doctorat - McGill
Ryan McPhedrain McPhedrain
Postdoctorat - McGill
ryan.mcphedrain@mail.mcgill.ca
David Payette
Maîtrise recherche - McGill
Github
Sepehr Radmannia
Visiteur de recherche indépendant - McGill
sradmannia@gmail.com
Github
Karin Saltoun
Doctorat - McGill
Chloé Savignac
Doctorat - McGill
Github
Google Scholar
Jack Stanley
Doctorat - McGill
Site web
Github
Praneet Suresh
Doctorat - McGill
Le Zhou
Doctorat - McGill

Publications

Sex-specific lesion pattern of functional outcomes after stroke
Anna K. Bonkhoff
Martin Bretzner
Sungmin Hong
Markus D. Schirmer
Alexander Cohen
Robert W. Regenhardt
Kathleen Donahue
Marco Nardin
Adrian Dalca
Anne-Katrin Giese
Mark R. Etherton
Brandon L. Hancock
Steven J.T. Mocking
Elissa McIntosh
John Attia
Oscar Benavente
Stephen Bevan
John W. Cole
Amanda Donatti
Christoph Griessenauer … (voir 39 de plus)
Laura Heitsch
Lukas Holmegaard
Katarina Jood
Jordi Jimenez-Conde
Steven Kittner
Robin Lemmens
Christopher Levi
Caitrin W. McDonough
James Meschia
Chia-Ling Phuah
Arndt Rolfs
Stefan Ropele
Jonathan Rosand
Jaume Roquer
Tatjana Rundek
Ralph L. Sacco
Reinhold Schmidt
Pankaj Sharma
Agnieszka Slowik
Martin Soederholm
Alessandro Sousa
Tara M. Stanne
Daniel Strbian
Turgut Tatlisumak
Vincent Thijs
Achala Vagal
Johan Wasselius
Daniel Woo
Ramin Zand
Patrick McArdle
Bradford B. Worrall
Christina Jern
Arne G. Lindgren
Jane Maguire
Michael D. Fox
Danilo Bzdok
Ona Wu
Natalia S. Rost
Anna K. Martin Sungmin Markus D. Alexander Robert W. Kathleen L. Marco J. Adrian V. Anne-Katrin Mark R. Brandon L. Steven J. T. Elissa C. John Oscar R. Stephen John W. Amanda Christoph J. Laura Lukas Katarina Jordi Steven J. Robin Christopher R. Caitrin W. James F. Chia-Ling Arndt Stefan Jonathan Jaume Tatjana Ralph L. Reinhold Pankaj Agnieszka Martin Alessandro Tara M. Daniel Turgut Vincent Achala Johan Daniel Ramin Patrick F. Bradford B. Christina Arne G. Jane Michael D. Danilo Ona Natalia S. Bonkhoff
2022-02-02
Brain Communications (publié)
doi.org
Lacking social support is associated with structural divergences in hippocampus–default network co-variation patterns
Chris Zajner
Nathan Spreng
Danilo Bzdok
2022-01-27
Social Cognitive and Affective Neuroscience (publié)
doi.org
Bayesian stroke modeling details sex biases in the white matter substrates of aphasia
Julius M. Kernbach
Gesa Hartwigsen
Jae‐Sung Lim
Hee-Joon Bae
Kyung‐Ho Yu
Gottfried Schlaug
Anna K. Bonkhoff
Natalia S. Rost
Danilo Bzdok
2022-01-18
bioRxiv (preprint)
doi.org
Representational ethical model calibration
Robert Carruthers
Isabel Straw
James K. Ruffle
Daniel Herron
Amy Nelson
Danilo Bzdok
Delmiro Fernandez-Reyes
Geraint Rees
Parashkev Nachev
2022-01-01
npj Digit. Medicine (publié)
doi.org
arxiv.org
The meaning of significant mean group differences for biomarker discovery
Eva Loth
Jumana Ahmad
Christopher H. Chatham
Beatriz López
Ben Carter
Daisy Crawley
Beth Oakley
Hannah Hayward
Jennifer Cooke
Antonia San José Cáceres
Danilo Bzdok
Emily J. H. Jones
Tony Charman
Christian Beckmann
Thomas Bourgeron
Roberto Toro
Jan K. Buitelaar
Declan Murphy
Guillaume Dumas
2021-11-18
PLoS Computational Biology (publié)
doi.org
Social isolation is linked to classical risk factors of Alzheimer’s disease-related dementias
Kimia Shafighi
Sylvia Villeneuve
P. Rosa-Neto
AmanPreet Badhwar
Judes Poirier
Vaibhav Sharma
Yasser Iturria-Medina
Patricia P. Silveira
Laurette Dubé
David C. Glahn
Danilo Bzdok
Alzheimer’s disease and related dementias is a major public health burden – compounding over upcoming years due to longevity. Recently, … (voir plus)clinical evidence hinted at the experience of social isolation in expediting dementia onset. In 502,506 UK Biobank participants and 30,097 participants from the Canadian Longitudinal Study of Aging, we revisited traditional risk factors for developing dementia in the context of loneliness and lacking social support. Across these measures of subjective and objective social deprivation, we have identified strong links between individuals’ social capital and various indicators of Alzheimer’s disease and related dementias risk, which replicated across both population cohorts. The quality and quantity of daily social encounters had deep connections with key aetiopathological factors, which represent 1) personal habits and lifestyle factors, 2) physical health, 3) mental health, and 4) societal and external factors. Our population-scale assessment suggest that social lifestyle determinants are linked to most neurodegeneration risk factors, highlighting them promising targets for preventive clinical action.
2021-09-15
bioRxiv (preprint)
doi.org
Lacking social support is associated with structural divergences in hippocampus–default network co-variation patterns
Chris Zajner
Nathan Spreng
Danilo Bzdok
Elaborate social interaction is a pivotal asset of the human species. The complexity of people’s social lives may constitute the dominatin… (voir plus)g factor in the vibrancy of many individuals’ environment. The neural substrates linked to social cognition thus appear especially susceptible when people endure periods of social isolation: here, we zoom in on the systematic inter-relationships between two such neural substrates, the allocortical hippocampus (HC) and the neocortical default network (DN). Previous human social neuroscience studies have focused on the DN, while HC subfields have been studied in most detail in rodents and monkeys. To bring into contact these two separate research streams, we directly quantified how DN subregions are coherently co-expressed with specific HC subfields in the context of social isolation. A two-pronged decomposition of structural brain scans from ∼40,000 UK Biobank participants linked lack of social support to mostly lateral subregions in the DN patterns. This lateral DN association co-occurred with HC patterns that implicated especially subiculum, presubiculum, CA2, CA3, and dentate gyrus. Overall, the subregion divergences within spatially overlapping signatures of HC-DN co-variation followed a clear segregation divide into the left and right brain hemispheres. Separable regimes of structural HC-DN co-variation also showed distinct associations with the genetic predisposition for lacking social support at the population level.
2021-08-19
bioRxiv (preprint)
doi.org
Human brain anatomy reflects separable genetic and environmental components of socioeconomic status
H. Kweon
Gökhan Aydogan
Alain Dagher
Danilo Bzdok
C. Ruff
Gideon Nave
Martha J Farah
Philipp Koellinger
Recent studies report that socioeconomic status (SES) correlates with brain structure. Yet, such findings are variable and little is known a… (voir plus)bout underlying causes. We present a well-powered voxel-based analysis of grey matter volume (GMV) across levels of SES, finding many small SES effects widely distributed across the brain, including cortical, subcortical and cerebellar regions. We also construct a polygenic index of SES to control for the additive effects of common genetic variation related to SES, which attenuates observed SES-GMV relations, to different degrees in different areas. Remaining variance, which may be attributable to environmental factors, is substantially accounted for by body mass index, a marker for lifestyle related to SES. In sum, SES affects multiple brain regions through measurable genetic and environmental effects. One-sentence Summary Socioeconomic status is linked with brain anatomy through a varying balance of genetic and environmental influences.
2021-07-29
bioRxiv (preprint)
doi.org
A parsimonious description of global functional brain organization in three spatiotemporal patterns
Taylor Bolt
Jason S. Nomi
Danilo Bzdok
Jorge A. Salas
Catie Chang
B. T. Thomas Yeo
Lucina Q. Uddin
S. Keilholz
2021-06-20
Nature Neuroscience (published)
doi.org
How does hemispheric specialization contribute to human-defining cognition?
Gesa Hartwigsen
Yoshua Bengio
Danilo Bzdok
2021-05-11
Neuron (publié)
doi.org
Multi-tract multi-symptom relationships in pediatric concussion
Guido Ivan Guberman
Sonja Stojanovski
Eman Nishat
Alain Ptito
Danilo Bzdok
A. Wheeler
Maxime Descoteaux
The heterogeneity of white matter damage and symptoms in concussions has been identified as a major obstacle to therapeutic innovation. In c… (voir plus)ontrast, the vast majority of diffusion MRI studies on concussion have traditionally employed group-comparison approaches. Such studies do not consider heterogeneity of damage and symptoms in concussion. To parse concussion heterogeneity, the present study combines diffusion MRI (dMRI) and multivariate statistics to investigate multi-tract multi-symptom relationships. Using dMRI data from a sample of 306 children ages 9 and 10 with a history of concussion from the Adolescent Brain Cognitive Development Study (ABCD study), we built connectomes weighted by classical and emerging diffusion measures. These measures were combined into two informative indices, the first capturing a mixture of patterns suggestive of microstructural complexity, the second representing almost exclusively axonal density. We deployed pattern-learning algorithms to jointly decompose these connectivity features and 19 behavioural measures that capture well-known symptoms of concussions. We found idiosyncratic symptom-specific multi-tract connectivity features, which would not be captured in traditional univariate analyses. Multivariable connectome-symptom correspondences were stronger than all single-tract/single-symptom associations. Multi-tract connectivity features were also expressed equally across different sociodemographic strata and their expression was not accounted for by injury-related variables. In a replication dataset, the expression of multi-tract connectivity features predicted adverse psychiatric outcomes after accounting for other psychopathology-related variables. By defining cross-demographic multi-tract multi-symptom relationships to parse concussion heterogeneity, the present study can pave the way for the development of improved stratification strategies that may contribute to the success of future clinical trials and the improvement of concussion management.
2021-04-07
medRxiv (preprint)
doi.org
Interacting brains revisited: A cross‐brain network neuroscience perspective
Christian Gerloff
Kerstin Konrad
Danilo Bzdok
Christina Büsing
Vanessa Reindl
Elucidating the neural basis of social behavior is a long-standing challenge in neuroscience. Such endeavors are driven by attempts to exten… (voir plus)d the isolated perspective on the human brain by considering interacting persons’ brain activities, but a theoretical and computational framework for this purpose is still in its infancy. Here, we posit a comprehensive framework based on bipartite graphs for interbrain networks and address whether they provide meaningful insights into the neural underpinnings of social interactions. First, we show that the nodal density of such graphs exhibits nonrandom properties. While the current analyses mostly rely on global metrics, we encode the regions’ roles via matrix decomposition to obtain an interpretable network representation yielding both global and local insights. With Bayesian modeling, we reveal how synchrony patterns seeded in specific brain regions contribute to global effects. Beyond inferential inquiries, we demonstrate that graph representations can be used to predict individual social characteristics, outperforming functional connectivity estimators for this purpose. In the future, this may provide a means of characterizing individual variations in social behavior or identifying biomarkers for social interaction and disorders.
2021-02-20
bioRxiv (preprint)
doi.org