Portrait of Danilo Bzdok

Danilo Bzdok

Core Academic Member
bzdokdan@mila.quebec
Canada CIFAR AI Chair
Associate Professor, McGill University, Department of Biomedical Engineering
Research Topics
Computational Biology
Deep Learning
Large Language Models (LLM)
Natural Language Processing

Biography

Danilo Bzdok is a computer scientist and medical doctor by training with a unique dual background in systems neuroscience and machine learning algorithms. After training at RWTH Aachen University (Germany), Université de Lausanne (Switzerland) and Harvard Medical School, Bzdok completed two doctoral degrees, one in neuroscience at Forschungszentrum Jülich in Germany, and another in computer science (machine learning statistics) at INRIA–Saclay and the Neurospin brain imaging centre in Paris.

Danilo is currently an associate professor at McGill University’s Faculty of Medicine and a Canada CIFAR AI Chair at Mila – Quebec Artificial Intelligence Institute. His interdisciplinary research centres around narrowing knowledge gaps in the brain basis of human-defining types of thinking in order to uncover key computational design principles underlying human intelligence.

Current Students

Shambhavi Aggarwal
Master's Research - McGill University
Github
Google Scholar
Badr Ait Hammou
Postdoctorate - McGill University
Karan Bali Bali
PhD - McGill University
Gregory Bell
PhD - McGill University
Anwesha Bhattacharya
PhD - McGill University
Pedro Carneiro Carneiro
PhD - McGill University
Github
Liam Hodgson
PhD - McGill University
Ryan McPhedrain McPhedrain
Postdoctorate - McGill University
ryan.mcphedrain@mail.mcgill.ca
David Payette
Master's Research - McGill University
Github
Sepehr Radmannia
Independent visiting researcher - McGill University
sradmannia@gmail.com
Github
Karin Saltoun
PhD - McGill University
Chloé Savignac
PhD - McGill University
Github
Google Scholar
Jack Stanley
PhD - McGill University
Website
Github
Praneet Suresh
PhD - McGill University
Le Zhou
PhD - McGill University

Publications

Lacking social support is associated with structural divergences in hippocampus–default network co-variation patterns
Chris Zajner
Nathan Spreng
Danilo Bzdok
2022-01-27
Social Cognitive and Affective Neuroscience (published)
doi.org
Bayesian stroke modeling details sex biases in the white matter substrates of aphasia
Julius M. Kernbach
Gesa Hartwigsen
Jae‐Sung Lim
Hee-Joon Bae
Kyung‐Ho Yu
Gottfried Schlaug
Anna K. Bonkhoff
Natalia S. Rost
Danilo Bzdok
2022-01-18
bioRxiv (preprint)
doi.org
Representational ethical model calibration
Robert Carruthers
Isabel Straw
James K. Ruffle
Daniel Herron
Amy Nelson
Danilo Bzdok
Delmiro Fernandez-Reyes
Geraint Rees
Parashkev Nachev
2022-01-01
npj Digit. Medicine (published)
doi.org
arxiv.org
The meaning of significant mean group differences for biomarker discovery
Eva Loth
Jumana Ahmad
Christopher H. Chatham
Beatriz López
Ben Carter
Daisy Crawley
Beth Oakley
Hannah Hayward
Jennifer Cooke
Antonia San José Cáceres
Danilo Bzdok
Emily J. H. Jones
Tony Charman
Christian Beckmann
Thomas Bourgeron
Roberto Toro
Jan K. Buitelaar
Declan Murphy
Guillaume Dumas
2021-11-18
PLoS Computational Biology (published)
doi.org
Social isolation is linked to classical risk factors of Alzheimer’s disease-related dementias
Kimia Shafighi
Sylvia Villeneuve
P. Rosa-Neto
AmanPreet Badhwar
Judes Poirier
Vaibhav Sharma
Yasser Iturria-Medina
Patricia P. Silveira
Laurette Dubé
David C. Glahn
Danilo Bzdok
Alzheimer’s disease and related dementias is a major public health burden – compounding over upcoming years due to longevity. Recently, … (see more)clinical evidence hinted at the experience of social isolation in expediting dementia onset. In 502,506 UK Biobank participants and 30,097 participants from the Canadian Longitudinal Study of Aging, we revisited traditional risk factors for developing dementia in the context of loneliness and lacking social support. Across these measures of subjective and objective social deprivation, we have identified strong links between individuals’ social capital and various indicators of Alzheimer’s disease and related dementias risk, which replicated across both population cohorts. The quality and quantity of daily social encounters had deep connections with key aetiopathological factors, which represent 1) personal habits and lifestyle factors, 2) physical health, 3) mental health, and 4) societal and external factors. Our population-scale assessment suggest that social lifestyle determinants are linked to most neurodegeneration risk factors, highlighting them promising targets for preventive clinical action.
2021-09-15
bioRxiv (preprint)
doi.org
Lacking social support is associated with structural divergences in hippocampus–default network co-variation patterns
Chris Zajner
Nathan Spreng
Danilo Bzdok
Elaborate social interaction is a pivotal asset of the human species. The complexity of people’s social lives may constitute the dominatin… (see more)g factor in the vibrancy of many individuals’ environment. The neural substrates linked to social cognition thus appear especially susceptible when people endure periods of social isolation: here, we zoom in on the systematic inter-relationships between two such neural substrates, the allocortical hippocampus (HC) and the neocortical default network (DN). Previous human social neuroscience studies have focused on the DN, while HC subfields have been studied in most detail in rodents and monkeys. To bring into contact these two separate research streams, we directly quantified how DN subregions are coherently co-expressed with specific HC subfields in the context of social isolation. A two-pronged decomposition of structural brain scans from ∼40,000 UK Biobank participants linked lack of social support to mostly lateral subregions in the DN patterns. This lateral DN association co-occurred with HC patterns that implicated especially subiculum, presubiculum, CA2, CA3, and dentate gyrus. Overall, the subregion divergences within spatially overlapping signatures of HC-DN co-variation followed a clear segregation divide into the left and right brain hemispheres. Separable regimes of structural HC-DN co-variation also showed distinct associations with the genetic predisposition for lacking social support at the population level.
2021-08-19
bioRxiv (preprint)
doi.org
Human brain anatomy reflects separable genetic and environmental components of socioeconomic status
H. Kweon
Gökhan Aydogan
Alain Dagher
Danilo Bzdok
C. Ruff
Gideon Nave
Martha J Farah
Philipp Koellinger
Recent studies report that socioeconomic status (SES) correlates with brain structure. Yet, such findings are variable and little is known a… (see more)bout underlying causes. We present a well-powered voxel-based analysis of grey matter volume (GMV) across levels of SES, finding many small SES effects widely distributed across the brain, including cortical, subcortical and cerebellar regions. We also construct a polygenic index of SES to control for the additive effects of common genetic variation related to SES, which attenuates observed SES-GMV relations, to different degrees in different areas. Remaining variance, which may be attributable to environmental factors, is substantially accounted for by body mass index, a marker for lifestyle related to SES. In sum, SES affects multiple brain regions through measurable genetic and environmental effects. One-sentence Summary Socioeconomic status is linked with brain anatomy through a varying balance of genetic and environmental influences.
2021-07-29
bioRxiv (preprint)
doi.org
A parsimonious description of global functional brain organization in three spatiotemporal patterns
Taylor Bolt
Jason S. Nomi
Danilo Bzdok
Jorge A. Salas
Catie Chang
B. T. Thomas Yeo
Lucina Q. Uddin
S. Keilholz
2021-06-20
Nature Neuroscience (published)
doi.org
How does hemispheric specialization contribute to human-defining cognition?
Gesa Hartwigsen
Yoshua Bengio
Danilo Bzdok
2021-05-11
Neuron (published)
doi.org
Multi-tract multi-symptom relationships in pediatric concussion
Guido Ivan Guberman
Sonja Stojanovski
Eman Nishat
Alain Ptito
Danilo Bzdok
A. Wheeler
Maxime Descoteaux
The heterogeneity of white matter damage and symptoms in concussions has been identified as a major obstacle to therapeutic innovation. In c… (see more)ontrast, the vast majority of diffusion MRI studies on concussion have traditionally employed group-comparison approaches. Such studies do not consider heterogeneity of damage and symptoms in concussion. To parse concussion heterogeneity, the present study combines diffusion MRI (dMRI) and multivariate statistics to investigate multi-tract multi-symptom relationships. Using dMRI data from a sample of 306 children ages 9 and 10 with a history of concussion from the Adolescent Brain Cognitive Development Study (ABCD study), we built connectomes weighted by classical and emerging diffusion measures. These measures were combined into two informative indices, the first capturing a mixture of patterns suggestive of microstructural complexity, the second representing almost exclusively axonal density. We deployed pattern-learning algorithms to jointly decompose these connectivity features and 19 behavioural measures that capture well-known symptoms of concussions. We found idiosyncratic symptom-specific multi-tract connectivity features, which would not be captured in traditional univariate analyses. Multivariable connectome-symptom correspondences were stronger than all single-tract/single-symptom associations. Multi-tract connectivity features were also expressed equally across different sociodemographic strata and their expression was not accounted for by injury-related variables. In a replication dataset, the expression of multi-tract connectivity features predicted adverse psychiatric outcomes after accounting for other psychopathology-related variables. By defining cross-demographic multi-tract multi-symptom relationships to parse concussion heterogeneity, the present study can pave the way for the development of improved stratification strategies that may contribute to the success of future clinical trials and the improvement of concussion management.
2021-04-07
medRxiv (preprint)
doi.org
Interacting brains revisited: A cross‐brain network neuroscience perspective
Christian Gerloff
Kerstin Konrad
Danilo Bzdok
Christina Büsing
Vanessa Reindl
Elucidating the neural basis of social behavior is a long-standing challenge in neuroscience. Such endeavors are driven by attempts to exten… (see more)d the isolated perspective on the human brain by considering interacting persons’ brain activities, but a theoretical and computational framework for this purpose is still in its infancy. Here, we posit a comprehensive framework based on bipartite graphs for interbrain networks and address whether they provide meaningful insights into the neural underpinnings of social interactions. First, we show that the nodal density of such graphs exhibits nonrandom properties. While the current analyses mostly rely on global metrics, we encode the regions’ roles via matrix decomposition to obtain an interpretable network representation yielding both global and local insights. With Bayesian modeling, we reveal how synchrony patterns seeded in specific brain regions contribute to global effects. Beyond inferential inquiries, we demonstrate that graph representations can be used to predict individual social characteristics, outperforming functional connectivity estimators for this purpose. In the future, this may provide a means of characterizing individual variations in social behavior or identifying biomarkers for social interaction and disorders.
2021-02-20
bioRxiv (preprint)
doi.org
Different scaling of linear models and deep learning in UKBiobank brain images versus machine-learning datasets
Marc-Andre Schulz
B.T. Thomas Yeo
Joshua T. Vogelstein
Janaina Mourao-Miranada
Jakob N. Kather
Konrad Paul Kording
Blake Richards
Danilo Bzdok
2020-08-25
Nature Communications (published)
doi.org