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Karin Saltoun

PhD - McGill University
Supervisor
Danilo Bzdok
Research Topics
Computational Biology
Medical Machine Learning

Publications

Using rare genetic mutations to revisit structural brain asymmetry
Jakub Kopal
Kuldeep Kumar
Kimia Shafighi
Karin Saltoun
Claudia Modenato
Clara A. Moreau
Guillaume Huguet
Martineau Jean-Louis
Charles-Olivier Martin
C.O. Martin
Zohra Saci
Nadine Younis
Elise Douard
Khadije Jizi
Alexis Beauchamp-Chatel
Leila Kushan
Ana I. Silva
Marianne B.M. van den Bree
David E.J. Linden
M. J. Owen … (see 11 more)
Jeremy Hall
Sarah Lippé
Bogdan Draganski
Ida E. Sønderby
Ole A. Andreassen
David C. Glahn
Paul M. Thompson
Carrie E. Bearden
Robert Zatorre
Sébastien Jacquemont
Danilo Bzdok
2023-04-18
bioRxiv (preprint)
doi.org
Rare CNVs and phenome-wide profiling highlight brain structural divergence and phenotypical convergence
Jakub Kopal
Kuldeep Kumar
Karin Saltoun
Claudia Modenato
Clara A. Moreau
Sandra Martin-Brevet
Guillaume Huguet
Martineau Jean-Louis
Charles-Olivier Martin
C.O. Martin
Zohra Saci
Nadine Younis
Petra Tamer
Elise Douard
Anne M. Maillard
Borja Rodriguez-Herreros
Aurélie Pain
Sonia Richetin
Leila Kushan
Ana I. Silva … (see 13 more)
Marianne B.M. van den Bree
David E.J. Linden
M. J. Owen
Jeremy Hall
Sarah Lippé
Bogdan Draganski
Ida E. Sønderby
Ole A. Andreassen
David C. Glahn
Paul M. Thompson
Carrie E. Bearden
Sébastien Jacquemont
Danilo Bzdok
2023-03-02
Nature human behaviour (published)
doi.org
APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer’s disease and related dementia
Chloé Savignac
Sylvia Villeneuve
AmanPreet Badhwar
Karin Saltoun
Kimia Shafighi
Chris Zajner
Vaibhav Sharma
Sarah A. Gagliano Taliun
Sali Farhan
Judes Poirier
Danilo Bzdok
2022-12-01
PLoS Biology (published)
doi.org
Dissociable brain structural asymmetry patterns reveal unique phenome-wide profiles
Karin Saltoun
Ralph Adolphs
Lynn Paul
Vaibhav Sharma
Joern Diedrichsen
B.T. Thomas Yeo
Danilo Bzdok
2022-11-07
Nature Human Behaviour (published)
doi.org
Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence
J. Kopal
Kuldeep Kumar
Karin Saltoun
Claudia Modenato
Clara A. Moreau
Sandra Martin-Brevet
Guillaume Huguet
Martineau Jean-Louis
C.O. Martin
Zohra Saci
Nadine Younis
Petra Tamer
Elise Douard
Anne M. Maillard
Borja Rodriguez-Herreros
Aurélie Pain
Sonia Richetin
Leila Kushan
Ana I. Silva
Marianne B.M. van den Bree … (see 12 more)
David E.J. Linden
M. J. Owen
Jeremy Hall
Sarah Lippé
Bogdan Draganski
Ida E. Sønderby
Ole A. Andreassen
David C. Glahn
Paul M. Thompson
Carrie E. Bearden
Sébastien Jacquemont
Danilo Bzdok
Copy number variations (CNVs) are rare genomic deletions and duplications that can exert profound effects on brain and behavior. Previous re… (see more)ports of pleiotropy in CNVs imply that they converge on shared mechanisms at some level of pathway cascades, from genes to large-scale neural circuits to the phenome. However, studies to date have primarily examined single CNV loci in small clinical cohorts. It remains unknown how distinct CNVs escalate the risk for the same developmental and psychiatric disorders. Here, we quantitatively dissect the impact on brain organization and behavioral differentiation across eight key CNVs. In 534 clinical CNV carriers from multiple sites, we explored CNV-specific brain morphology patterns. We extensively annotated these CNV-associated patterns with deep phenotyping assays through the UK Biobank resource. Although the eight CNVs cause disparate brain changes, they are tied to similar phenotypic profiles across ∼1000 lifestyle indicators. Our population-level investigation established brain structural divergences and phenotypical convergences of CNVs, with direct relevance to major brain disorders.
2022-04-25
bioRxiv (preprint)
doi.org
APOE ɛ2 vs APOE ɛ4 dosage shows sex-specific links to hippocampus-default network subregion co-variation
Chloé Savignac
Sylvia Villeneuve
AmanPreet Badhwar
Karin Saltoun
Kimia Shafighi
Chris Zajner
Vaibhav Sharma
Sarah A Gagliano Taliun
Sali Farhan
Judes Poirier
Danilo Bzdok
Alzheimer’s disease and related dementias (ADRD) are marked by intracellular tau aggregates in the medial-temporal lobe (MTL) and extracel… (see more)lular amyloid aggregates in the default network (DN). Here, we sought to clarify ADRD-related co-dependencies between the MTL’s most vulnerable structure, the hippocampus (HC), and the highly associative DN at a subregion resolution. We confronted the effects of APOE ɛ2 and ɛ4, rarely investigated together, with their impact on HC-DN co-variation regimes at the population level. In a two-pronged decomposition of structural brain scans from ∼40,000 UK Biobank participants, we located co-deviating structural patterns in HC and DN subregions as a function of ADRD family risk. Across the disclosed HC-DN signatures, recurrent deviations in the CA1, CA2/3, molecular layer, fornix’s fimbria, and their cortical partners related to ADRD risk. Phenome-wide profiling of HC-DN co- variation expressions from these population signatures revealed male-specific associations with air-pollution, and female-specific associations with cardiovascular traits. We highlighted three main factors associated with brain-APOE associations across the different gene variants: happiness, and satisfaction with friendships, and with family. We further showed that APOE ɛ2/2 interacts preferentially with HC-DN co-variation patterns in estimating social lifestyle in males and physical activity in females. Our findings reinvigorate the often-neglected interplay between APOE ɛ2 dosage and sex, which we have linked to fine-grained structural divergences indicative of ADRD susceptibility.
2022-03-15
bioRxiv (preprint)
doi.org