Karin Saltoun

Claudia Modenato

Clara A. Moreau

Guillaume Huguet

Martineau Jean-Louis

Charles-Olivier Martin

C.O. Martin

Zohra Saci

Nadine Younis

Elise Douard

Khadije Jizi

Alexis Beauchamp-Chatel

Leila Kushan

Ana I. Silva

Marianne B.M. van den Bree

David E.J. Linden

M. J. Owen … (voir 11 de plus)

Jeremy Hall

Sarah Lippé

Bogdan Draganski

Ida E. Sønderby

Ole A. Andreassen

David C. Glahn

Paul M. Thompson

Carrie E. Bearden

Robert Zatorre

Sébastien Jacquemont

2023-04-18

bioRxiv (prépublication)

Rare CNVs and phenome-wide profiling highlight brain structural divergence and phenotypical convergence

Jakub Kopal

Kuldeep Kumar

Claudia Modenato

Clara A. Moreau

Sandra Martin-Brevet

Guillaume Huguet

Martineau Jean-Louis

Charles-Olivier Martin

C.O. Martin

Zohra Saci

Nadine Younis

Petra Tamer

Elise Douard

Anne M. Maillard

Borja Rodriguez-Herreros

Aurélie Pain

Sonia Richetin

Leila Kushan

Ana I. Silva … (voir 13 de plus)

Marianne B.M. van den Bree

David E.J. Linden

M. J. Owen

Jeremy Hall

Sarah Lippé

Bogdan Draganski

Ida E. Sønderby

Ole A. Andreassen

David C. Glahn

Paul M. Thompson

Carrie E. Bearden

Sébastien Jacquemont

2023-03-02

Nature human behaviour (publié)

APOE alleles are associated with sex-specific structural differences in brain regions affected in Alzheimer’s disease and related dementia

Chloé Savignac

Sylvia Villeneuve

AmanPreet Badhwar

Kimia Shafighi

Chris Zajner

Vaibhav Sharma

Sarah A. Gagliano Taliun

Sali Farhan

Judes Poirier

2022-12-01

PLoS Biology (publié)

Dissociable brain structural asymmetry patterns reveal unique phenome-wide profiles

Ralph Adolphs

Lynn Paul

Vaibhav Sharma

Joern Diedrichsen

B.T. Thomas Yeo

2022-11-07

Nature Human Behaviour (publié)

Rare CNVs and phenome-wide profiling: a tale of brain-structural divergence and phenotypical convergence

J. Kopal

Kuldeep Kumar

Claudia Modenato

Clara A. Moreau

Sandra Martin-Brevet

Guillaume Huguet

Martineau Jean-Louis

C.O. Martin

Zohra Saci

Nadine Younis

Petra Tamer

Elise Douard

Anne M. Maillard

Borja Rodriguez-Herreros

Aurélie Pain

Sonia Richetin

Leila Kushan

Ana I. Silva

Marianne B.M. van den Bree … (voir 12 de plus)

David E.J. Linden

M. J. Owen

Jeremy Hall

Sarah Lippé

Bogdan Draganski

Ida E. Sønderby

Ole A. Andreassen

David C. Glahn

Paul M. Thompson

Carrie E. Bearden

Sébastien Jacquemont

Copy number variations (CNVs) are rare genomic deletions and duplications that can exert profound effects on brain and behavior. Previous re… (voir plus)ports of pleiotropy in CNVs imply that they converge on shared mechanisms at some level of pathway cascades, from genes to large-scale neural circuits to the phenome. However, studies to date have primarily examined single CNV loci in small clinical cohorts. It remains unknown how distinct CNVs escalate the risk for the same developmental and psychiatric disorders. Here, we quantitatively dissect the impact on brain organization and behavioral differentiation across eight key CNVs. In 534 clinical CNV carriers from multiple sites, we explored CNV-specific brain morphology patterns. We extensively annotated these CNV-associated patterns with deep phenotyping assays through the UK Biobank resource. Although the eight CNVs cause disparate brain changes, they are tied to similar phenotypic profiles across ∼1000 lifestyle indicators. Our population-level investigation established brain structural divergences and phenotypical convergences of CNVs, with direct relevance to major brain disorders.

2022-04-25

bioRxiv (prépublication)

APOE ɛ2 vs APOE ɛ4 dosage shows sex-specific links to hippocampus-default network subregion co-variation

Chloé Savignac

Sylvia Villeneuve

AmanPreet Badhwar

Kimia Shafighi

Chris Zajner

Vaibhav Sharma

Sarah A Gagliano Taliun

Sali Farhan

Judes Poirier

Alzheimer’s disease and related dementias (ADRD) are marked by intracellular tau aggregates in the medial-temporal lobe (MTL) and extracel… (voir plus)lular amyloid aggregates in the default network (DN). Here, we sought to clarify ADRD-related co-dependencies between the MTL’s most vulnerable structure, the hippocampus (HC), and the highly associative DN at a subregion resolution. We confronted the effects of APOE ɛ2 and ɛ4, rarely investigated together, with their impact on HC-DN co-variation regimes at the population level. In a two-pronged decomposition of structural brain scans from ∼40,000 UK Biobank participants, we located co-deviating structural patterns in HC and DN subregions as a function of ADRD family risk. Across the disclosed HC-DN signatures, recurrent deviations in the CA1, CA2/3, molecular layer, fornix’s fimbria, and their cortical partners related to ADRD risk. Phenome-wide profiling of HC-DN co- variation expressions from these population signatures revealed male-specific associations with air-pollution, and female-specific associations with cardiovascular traits. We highlighted three main factors associated with brain-APOE associations across the different gene variants: happiness, and satisfaction with friendships, and with family. We further showed that APOE ɛ2/2 interacts preferentially with HC-DN co-variation patterns in estimating social lifestyle in males and physical activity in females. Our findings reinvigorate the often-neglected interplay between APOE ɛ2 dosage and sex, which we have linked to fine-grained structural divergences indicative of ADRD susceptibility.

2022-03-15

bioRxiv (prépublication)