Portrait of Danilo Bzdok

Danilo Bzdok

Core Academic Member
bzdokdan@mila.quebec
Canada CIFAR AI Chair
Associate Professor, McGill University, Department of Biomedical Engineering
Research Topics
Computational Biology
Deep Learning
Large Language Models (LLM)
Natural Language Processing

Biography

Danilo Bzdok is a computer scientist and medical doctor by training with a unique dual background in systems neuroscience and machine learning algorithms. After training at RWTH Aachen University (Germany), Université de Lausanne (Switzerland) and Harvard Medical School, Bzdok completed two doctoral degrees, one in neuroscience at Forschungszentrum Jülich in Germany, and another in computer science (machine learning statistics) at INRIA–Saclay and the Neurospin brain imaging centre in Paris.

Danilo is currently an associate professor at McGill University’s Faculty of Medicine and a Canada CIFAR AI Chair at Mila – Quebec Artificial Intelligence Institute. His interdisciplinary research centres around narrowing knowledge gaps in the brain basis of human-defining types of thinking in order to uncover key computational design principles underlying human intelligence.

Current Students

Shambhavi Aggarwal
Master's Research - McGill University
Github
Google Scholar
Badr Ait Hammou
Postdoctorate - McGill University
Karan Bali Bali
PhD - McGill University
Gregory Bell
PhD - McGill University
Anwesha Bhattacharya
PhD - McGill University
Pedro Carneiro Carneiro
PhD - McGill University
Github
Liam Hodgson
PhD - McGill University
Github
Ryan McPhedrain McPhedrain
Postdoctorate - McGill University
ryan.mcphedrain@mail.mcgill.ca
David Payette
Master's Research - McGill University
Github
Sepehr Radmannia
Independent visiting researcher - McGill University
sradmannia@gmail.com
Github
Karin Saltoun
PhD - McGill University
Chloé Savignac
PhD - McGill University
Github
Google Scholar
Jack Stanley
PhD - McGill University
Website
Github
Google Scholar
Praneet Suresh
PhD - McGill University
Celeste van Dokkum
Independent visiting researcher - Yale University
Github
Le Zhou
PhD - McGill University

Publications

From YouTube to the brain: Transfer learning can improve brain-imaging predictions with deep learning
Nahiyan Malik
Danilo Bzdok
2022-09-01
Neural Networks (published)
doi.org
Endorsing Complexity Through Diversity: Computational Psychiatry Meets Big Data Analytics
Jakub Kopal
Danilo Bzdok
2022-08-01
Biological Psychiatry (published)
doi.org
A parsimonious description of global functional brain organization in three spatiotemporal patterns
Taylor Bolt
Jason S. Nomi
Danilo Bzdok
Jorge A. Salas
Catie Chang
B.T. Thomas Yeo
Lucina Q. Uddin
Shella Keilholz
2022-07-28
Nature Neuroscience (published)
doi.org
Explanatory latent representation of heterogeneous spatial maps of task-fMRI in large-scale datasets
Mariam Zabihi
Seyed Mostafa Kia
Thomas Wolfers
Stijn de Boer
C. Fraza
Sourena Soheili‐nezhad
Richard Dinga
Alberto Llera
Danilo Bzdok
Christian Beckmann
Andre Marquand
2022-07-27
bioRxiv (preprint)
doi.org
Global fMRI signal topography differs systematically across the lifespan
Jason S. Nomi
Danilo Bzdok
Jingwei Li
Taylor Bolt
Catie Chang
Salome Kornfeld
Zachary T. Goodman
B.T. Thomas Yeo
R. Nathan Spreng
Lucina Q. Uddin
2022-07-27
bioRxiv (preprint)
doi.org
From Precision Medicine to Precision Convergence for Multilevel Resilience—The Aging Brain and Its Social Isolation
Laurette Dubé
Patricia P. Silveira
Daiva E. Nielsen
Spencer Moore
Catherine Paquet
J. Miguel Cisneros-Franco
Gina Kemp
Bärbel Knauper
Yu Ma
Mehmood Khan
Gillian Bartlett-Esquilant
Alan C. Evans
Lesley K. Fellows
Jorge L. Armony
R. Nathan Spreng
Jian-Yun Nie
Shawn T. Brown
Georg Northoff
Danilo Bzdok
Citation: Dubé L, Silveira PP, Nielsen DE, Moore S, Paquet C, Cisneros-Franco JM, Kemp G, Knauper B, Ma Y, Khan M, Bartlett-Esquilant G, Ev… (see more)ans AC, Fellows LK, Armony JL, Spreng RN, Nie J-Y, Brown ST, Northoff G and Bzdok D (2022) From Precision Medicine to Precision Convergence for Multilevel Resilience—The Aging Brain and Its Social Isolation. Front. Public Health 10:720117. doi: 10.3389/fpubh.2022.720117 From Precision Medicine to Precision Convergence for Multilevel Resilience—The Aging Brain and Its Social Isolation
2022-07-05
Frontiers in Public Health (published)
doi.org
A guided multiverse study of neuroimaging analyses
Jessica Dafflon
Pedro F. Da Costa
František Váša
Ricardo Pio Monti
Danilo Bzdok
Peter J. Hellyer
Federico Turkheimer
Jonathan Smallwood
Emily J. H. Jones
Robert Leech
2022-06-29
Nature Communications (published)
doi.org
Interacting brains revisited: A cross‐brain network neuroscience perspective
Christian Gerloff
Kerstin Konrad
Danilo Bzdok
Christina Büsing
Vanessa Reindl
2022-06-06
Human Brain Mapping (published)
doi.org
Pattern learning reveals brain asymmetry to be linked to socioeconomic status
Timm B Poeppl
Emile Dimas
Katrin Sakreida
Julius M Kernbach
Ross D Markello
Oliver Schöffski
Alain Dagher
Philipp Koellinger
Gideon Nave
Martha J Farah
Bratislav Mišić
Danilo Bzdok
Abstract Socioeconomic status (SES) anchors individuals in their social network layers. Our embedding in the societal fabric resonates with … (see more)habitus, world view, opportunity, and health disparity. It remains obscure how distinct facets of SES are reflected in the architecture of the central nervous system. Here, we capitalized on multivariate multi-output learning algorithms to explore possible imprints of SES in gray and white matter structure in the wider population (n ≈ 10,000 UK Biobank participants). Individuals with higher SES, compared with those with lower SES, showed a pattern of increased region volumes in the left brain and decreased region volumes in the right brain. The analogous lateralization pattern emerged for the fiber structure of anatomical white matter tracts. Our multimodal findings suggest hemispheric asymmetry as an SES-related brain signature, which was consistent across six different indicators of SES: degree, education, income, job, neighborhood and vehicle count. Hence, hemispheric specialization may have evolved in human primates in a way that reveals crucial links to SES.
2022-05-20
Cerebral Cortex Communications (published)
doi.org
Human brain anatomy reflects separable genetic and environmental components of socioeconomic status
Hyeokmoon Kweon
Gökhan Aydogan
Alain Dagher
Danilo Bzdok
Christian C. Ruff
Gideon Nave
Martha J Farah
Philipp Koellinger
Recent studies report that socioeconomic status (SES) correlates with brain structure. Yet, such findings are variable and little is known a… (see more)bout underlying causes. We present a well-powered voxel-based analysis of grey matter volume (GMV) across levels of SES, finding many small SES effects widely distributed across the brain, including cortical, subcortical and cerebellar regions. We also construct a polygenic index of SES to control for the additive effects of common genetic variation related to SES, which attenuates observed SES-GMV relations, to different degrees in different areas. Remaining variance, which may be attributable to environmental factors, is substantially accounted for by body mass index, a marker for lifestyle related to SES. In sum, SES affects multiple brain regions through measurable genetic and environmental effects. One-sentence Summary Socioeconomic status is linked with brain anatomy through a varying balance of genetic and environmental influences.
2022-05-18
Science Advances (published)
doi.org
Multi-tract multi-symptom relationships in pediatric concussion
Guido I Guberman
Sonja Stojanovski
Eman Nishat
Alain Ptito
Danilo Bzdok
Anne L Wheeler
Maxime Descoteaux
The heterogeneity of white matter damage and symptoms in concussions has been identified as a major obstacle to therapeutic innovation. In c… (see more)ontrast, the vast majority of diffusion MRI studies on concussion have traditionally employed group-comparison approaches. Such studies do not consider heterogeneity of damage and symptoms in concussion. To parse concussion heterogeneity, the present study combines diffusion MRI (dMRI) and multivariate statistics to investigate multi-tract multi-symptom relationships. Using dMRI data from a sample of 306 children ages 9 and 10 with a history of concussion from the Adolescent Brain Cognitive Development Study (ABCD study), we built connectomes weighted by classical and emerging diffusion measures. These measures were combined into two informative indices, the first capturing a mixture of patterns suggestive of microstructural complexity, the second representing almost exclusively axonal density. We deployed pattern-learning algorithms to jointly decompose these connectivity features and 19 behavioural measures that capture well-known symptoms of concussions. We found idiosyncratic symptom-specific multi-tract connectivity features, which would not be captured in traditional univariate analyses. Multivariable connectome-symptom correspondences were stronger than all single-tract/single-symptom associations. Multi-tract connectivity features were also expressed equally across different sociodemographic strata and their expression was not accounted for by injury-related variables. In a replication dataset, the expression of multi-tract connectivity features predicted adverse psychiatric outcomes after accounting for other psychopathology-related variables. By defining cross-demographic multi-tract multi-symptom relationships to parse concussion heterogeneity, the present study can pave the way for the development of improved stratification strategies that may contribute to the success of future clinical trials and the improvement of concussion management.
2022-05-17
eLife (published)
doi.org
Meta-matching as a simple framework to translate phenotypic predictive models from big to small data
Tong He
Lijun An
Pansheng Chen
Jianzhong Chen
Jiashi Feng
Danilo Bzdok
Avram J. Holmes
Simon B. Eickhoff
B.T. Thomas Yeo
2022-05-16
Nature neuroscience (published)
doi.org