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Le Zhou

Doctorat - McGill
Superviseur⋅e principal⋅e
Danilo Bzdok
Sujets de recherche
Apprentissage automatique médical
Apprentissage profond
Exploration des données
Traitement du langage naturel

Publications

Latent brain subtypes of chronotype reveal unique behavioral and health profiles across population cohorts
Le Zhou
Karin Saltoun
Justin Marotta
Shambhavi Aggarwal
Jakub Kopal
Julie Carrier
Kai-Florian Storch
Robin I. M. Dunbar
Danilo Bzdok
Chronotype is shaped by the complex interplay of endogenous and exogenous factors. This time-enduring trait ties into societal behaviors an… (voir plus)d is linked to psychiatric and metabolic conditions. Despite its multifaceted nature, prior research has treated chronotype as a monolithic trait across the population, risking overlooking substantial heterogeneity in neural and behavioral fingerprints. To uncover hidden subgroups, we develop a supervised pattern-learning framework integrating three complementary brain-imaging modalities with deep behavioral and health profiling from 27,030 UK Biobank participants. We identify five distinct, biologically valid chronotype subtypes. Each demonstrates unique patterns across brain, behavioral and health profiles. External validation in 10,550 US children from the ABCD Study cohort reveals reversed age distributions and replicates sex-associated brain-behavioral patterns, suggesting that potential divergences between chronotype traits observed throughout adulthood may begin to emerge early in life. These findings highlight underappreciated sources of population variation that echo the rhythm of people’s inner clock.
2025-12-21
Nature Communications (publié)
doi.org
Latent brain subtypes of chronotype reveal unique behavioral and health profiles across population cohorts
Le Zhou
Karin Saltoun
Justin Marotta
Shambhavi Aggarwal
Jakub Kopal
Julie Carrier
Kai-Florian Storch
Robin I. M. Dunbar
Danilo Bzdok
Chronotype is shaped by the complex interplay of endogenous and exogenous factors. This time-enduring trait ties into societal behaviors an… (voir plus)d is linked to psychiatric and metabolic conditions. Despite its multifaceted nature, prior research has treated chronotype as a monolithic trait across the population, risking overlooking substantial heterogeneity in neural and behavioral fingerprints. To uncover hidden subgroups, we develop a supervised pattern-learning framework integrating three complementary brain-imaging modalities with deep behavioral and health profiling from 27,030 UK Biobank participants. We identify five distinct, biologically valid chronotype subtypes. Each demonstrates unique patterns across brain, behavioral and health profiles. External validation in 10,550 US children from the ABCD Study cohort reveals reversed age distributions and replicates sex-associated brain-behavioral patterns, suggesting that potential divergences between chronotype traits observed throughout adulthood may begin to emerge early in life. These findings highlight underappreciated sources of population variation that echo the rhythm of people’s inner clock.
2025-12-21
Nature Communications (publié)
doi.org
Latent brain subtypes of chronotype reveal unique behavioral and health profiles: an across-cohort validation
Le Zhou
Karin Saltoun
Justin Marotta
Shambhavi Aggarwal
Jakub Kopal
Julie Carrier
Kai-Florian Storch
Robin Dunbar
Danilo Bzdok
Chronotype is shaped by the complex interplay of endogenous and exogenous factors. This trait ties into various behaviors in the wider socie… (voir plus)ty and is linked to the prevalence of psychiatric and metabolic conditions. Despite its multifaceted nature, prior research has treated chronotype as a monolithic trait across the population, risking overlooking substantial heterogeneity in neural and behavioral fingerprints of both early risers and night owls. To test for such hidden subgroups, we developed a supervised pattern-learning framework for trait subtyping, integrating three complementary brain-imaging modalities with deep behavior, diagnosis, and drug prescription profiling from 27,030 UK Biobank participants. We identified and characterized five distinct biologically valid chronotype subtypes: (1) typical eveningness, (2) depression-associated eveningness, (3) typical morningness, (4) morningness with greater expression in females, and (5) eveningness with greater expression in males. Each uncovered subtype showed unique patterns across brain, behavioral and health profiles. We finally externally validated these subtypes in 10,550 US children from the ABCD Study® cohort, which revealed reversed age distributions and replicated sex-associated brain-behavioral patterns, underscoring the fact that potential divergences between chronotype traits observed throughout adulthood may begin to emerge early in life. These findings highlight underappreciated sources of population variation that echo the rhythm of people’s inner clock.
2025-07-28
Research Square (prépublication)
doi.org
Multimodal population study reveals the neurobiological underpinnings of chronotype
Le Zhou
Karin Saltoun
Julie Carrier
Kai-Florian Storch
Robin I. M. Dunbar
Danilo Bzdok
2025-04-16
Nature Human Behaviour (inconnu)
doi.org
On the Neurobiological Basis of Chronotype: Insights from a Multimodal Population Neuroscience Study
Le Zhou
Karin Saltoun
Julie Carrier
Kai-Florian Storch
Robin Dunbar
Danilo Bzdok
Abstract

The rapid shifts of society have brought about changes in human behavioral patterns, with increased eveni… (voir plus)ng activities, increased screen time, and postponed sleep schedules. As an explicit manifestation of circadian rhythms, chronotype is closely intertwined with both physical and mental health. Night owls often exhibit more unhealthy lifestyle habits, are more susceptible to mood disorders, and have poorer physical fitness. Although individual differences in chronotype yield varying consequences, their neurobiological underpinnings remain elusive. Here we carry out a pattern-learning analysis, and capitalize on a vast array of ~ 1,000 phenome-wide phenotypes with three brain-imaging modalities (region volume of gray matter, whiter-matter fiber tracts, and functional connectivity) in 27,030 UK Biobank participants. The resulting multi-level depicts of brain images converge on the basal ganglia, limbic system, hippocampus, as well as cerebellum vermis, thus implicating key nodes in habit formation, emotional regulation and reward processing. Complementary by comprehensive investigations of in-deep phenotypic collections, our population study offers evidence of behavioral pattern disparities linked to distinct chronotype-related behavioral tendencies in our societies.

2024-04-09
Research Square (prépublication)
doi.org