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Publications
Learning Brain Dynamics With Coupled Low-Dimensional Nonlinear Oscillators and Deep Recurrent Networks
Many natural systems, especially biological ones, exhibit complex multivariate nonlinear dynamical behaviors that can be hard to capture by … (voir plus)linear autoregressive models. On the other hand, generic nonlinear models such as deep recurrent neural networks often require large amounts of training data, not always available in domains such as brain imaging; also, they often lack interpretability. Domain knowledge about the types of dynamics typically observed in such systems, such as a certain type of dynamical systems models, could complement purely data-driven techniques by providing a good prior. In this work, we consider a class of ordinary differential equation (ODE) models known as van der Pol (VDP) oscil lators and evaluate their ability to capture a low-dimensional representation of neural activity measured by different brain imaging modalities, such as calcium imaging (CaI) and fMRI, in different living organisms: larval zebrafish, rat, and human. We develop a novel and efficient approach to the nontrivial problem of parameters estimation for a network of coupled dynamical systems from multivariate data and demonstrate that the resulting VDP models are both accurate and interpretable, as VDP's coupling matrix reveals anatomically meaningful excitatory and inhibitory interactions across different brain subsystems. VDP outperforms linear autoregressive models (VAR) in terms of both the data fit accuracy and the quality of insight provided by the coupling matrices and often tends to generalize better to unseen data when predicting future brain activity, being comparable to and sometimes better than the recurrent neural networks (LSTMs). Finally, we demonstrate that our (generative) VDP model can also serve as a data-augmentation tool leading to marked improvements in predictive accuracy of recurrent neural networks. Thus, our work contributes to both basic and applied dimensions of neuroimaging: gaining scientific insights and improving brain-based predictive models, an area of potentially high practical importance in clinical diagnosis and neurotechnology.
Cognitive impairment is a frequent and disabling sequela of stroke. There is however incomplete understanding of how lesion topographies in … (voir plus)the left and right cerebral hemisphere brain interact to cause distinct cognitive deficits. We integrated machine learning and Bayesian hierarchical modeling to enable hemisphere-aware analysis of 1080 subacute ischemic stroke patients with deep profiling ∼3 months after stroke. We show relevance of the left hemisphere in the prediction of language and memory assessments, while global cognitive impairments were equally well predicted by lesion topographies from both sides. Damage to the hippocampal and occipital regions on the left were particularly informative about lost naming and memory function. Global cognitive impairment was predominantly linked to lesioned tissue in supramarginal and angular gyrus, the postcentral gyrus as well as the lateral occipital and opercular cortices of the left hemisphere. Hence, our analysis strategy uncovered that lesion patterns with unique hemispheric distributions are characteristic of how cognitive capacity is lost due to ischemic brain tissue damage.
Artificial intelligence in nursing: Priorities and opportunities from an international invitational think‐tank of the Nursing and Artificial Intelligence Leadership Collaborative
We explore creating automated, personalized feedback in an intelligent tutoring system (ITS). Our goal is to pinpoint correct and incorrect … (voir plus)concepts in student answers in order to achieve better student learning gains. Although automatic methods for providing personalized feedback exist, they do not explicitly inform students about which concepts in their answers are correct or incorrect. Our approach involves decomposing students answers using neural discourse segmentation and classification techniques. This decomposition yields a relational graph over all discourse units covered by the reference solutions and student answers. We use this inferred relational graph structure and a neural classifier to match student answers with reference solutions and generate personalized feedback. Although the process is completely automated and data-driven, the personalized feedback generated is highly contextual, domain-aware and effectively targets each student's misconceptions and knowledge gaps. We test our method in a dialogue-based ITS and demonstrate that our approach results in high-quality feedback and significantly improved student learning gains.
2021-05-18
Proceedings of the AAAI Conference on Artificial Intelligence (publié)
AI Safety is a major concern in many deep learning applications such as autonomous driving. Given a trained deep learning model, an importan… (voir plus)t natural problem is how to reliably verify the model's prediction. In this paper, we propose a novel framework --- deep verifier networks (DVN) to detect unreliable inputs or predictions of deep discriminative models, using separately trained deep generative models. Our proposed model is based on conditional variational auto-encoders with disentanglement constraints to separate the label information from the latent representation. We give both intuitive and theoretical justifications for the model. Our verifier network is trained independently with the prediction model, which eliminates the need of retraining the verifier network for a new model. We test the verifier network on both out-of-distribution detection and adversarial example detection problems, as well as anomaly detection problems in structured prediction tasks such as image caption generation. We achieve state-of-the-art results in all of these problems.
2021-05-18
Proceedings of the AAAI Conference on Artificial Intelligence (publié)
Predicting the future interaction of objects when they come into contact with their environment is key for autonomous agents to take intelli… (voir plus)gent and anticipatory actions. This paper presents a perception framework that fuses visual and tactile feedback to make predictions about the expected motion of objects in dynamic scenes. Visual information captures object properties such as 3D shape and location, while tactile information provides critical cues about interaction forces and resulting object motion when it
makes contact with the environment. Utilizing a novel See-Through-your-Skin (STS) sensor that provides high resolution multimodal sensing of contact surfaces, our system captures both the visual appearance and the tactile properties of objects. We interpret the dual stream signals from the sensor using a Multimodal Variational Autoencoder (MVAE), allowing us to capture both modalities of contacting objects and to develop a mapping from visual to tactile interaction and vice-versa. Additionally, the perceptual system can be used to infer the outcome of future physical interactions, which we validate through simulated and real-world experiments in which the resting state of an object is predicted from given initial conditions.
2021-05-18
Proceedings of the AAAI Conference on Artificial Intelligence (publié)
Can meta-learning discover generic ways of processing time series (TS) from a diverse dataset so as to greatly improve generalization on new… (voir plus) TS coming from different datasets? This work provides positive evidence to this using a broad meta-learning framework which we show subsumes many existing meta-learning algorithms. Our theoretical analysis suggests that residual connections act as a meta-learning adaptation mechanism, generating a subset of task-specific parameters based on a given TS input, thus gradually expanding the expressive power of the architecture on-the-fly. The same mechanism is shown via linearization analysis to have the interpretation of a sequential update of the final linear layer. Our empirical results on a wide range of data emphasize the importance of the identified meta-learning mechanisms for successful zero-shot univariate forecasting, suggesting that it is viable to train a neural network on a source TS dataset and deploy it on a different target TS dataset without retraining, resulting in performance that is at least as good as that of state-of-practice univariate forecasting models.
2021-05-18
Proceedings of the AAAI Conference on Artificial Intelligence (publié)
