Marco Bonizzato

Biographie

Marco Bonizzato est ingénieur en contrôle, en électricité et en sciences de la vie, et cumule plus de 10 ans d'expérience dans le domaine des interfaces cerveau-ordinateur implantables et de la technologie de neuromodulation. Il possède une double expertise unique en prothèses neurales et en intelligence et optimisation des machines.

Il est professeur adjoint de génie électrique à Polytechnique Montréal et professeur auxiliaire de neurosciences à l'Université de Montréal.

Il dirige également le laboratoire sciNeurotech. L'objectif de la recherche qui y est menée est de développer l'arc translationnel complet de nouvelles thérapies de neurostimulation afin de restaurer la fonction sensorimotrice après un neurotraumatisme, depuis la découverte chez le rongeur jusqu'à l'application dans la technologie médicale humaine, adaptée et personnalisée à chaque utilisateur par l'intelligence artificielle.

Étudiants actuels

Alireza Aminian

Doctorat - Polytechnique

Ivan Brillo

Stagiaire de recherche - Polytechnique

Davide Burchielli

Doctorat - Polytechnique

Radu Darie

Postdoctorat - Polytechnique

Postdoctorat - Polytechnique

Jean-Sébastien Giroux

Maîtrise recherche - Polytechnique

Juan Guerra

Maîtrise recherche - Polytechnique

Co-superviseur⋅e :

Doctorat - UdeM

Maîtrise recherche - UdeM

Co-superviseur⋅e :

Salamanca-Giron Salamanca-Giron

Postdoctorat - Polytechnique

Github

Benjamin Wilhelm

Stagiaire de recherche - Polytechnique

Publications

Characterization of limb representation in the pig’s motor cortex

David Bergeron

Hugo Delivet-Mongrain

Marina Martinez

Due to its large gyrencephalic brain, the pig is increasingly used for neuroscience research, especially for the preclinical testing of nove… (voir plus)l neuroprostheses. However, our understanding of the pig’s motor system remains limited compared to the common species used for neuroscience research. Here, we aimed to characterize the forelimb and hindlimb representation of the pig motor cortex using intracortical microstimulation (ICMS). Three domestic pigs ( Sus scrofa) were placed in a modified stereotactic frame and maintained under intravenous propofol sedation. We mapped the motor cortex using ICMS, applied at varying cortical coordinates and depths. For each site, we recorded the electrode depth eliciting the maximal limb response and determined the motor threshold. Responses were assessed visually and via electromyographic recordings. ICMS uncovered a large forelimb representation, with stereotypical contralateral responses. Conversely, the hindlimb representation was smaller and located within the interhemispheric fissure. The mean threshold of the five most responsive forelimb sites was 75 ± 25 μA, compared to 280 ± 45 μA for hindlimb sites (p<0.01). A summation of stimulations in the hindlimb representation of the motor cortex unilaterally triggered bilateral alternating hindlimb movements. These results suggest that while the porcine cortex can directly command forelimb movements via the corticospinal pathway, cortical control of hindlimb likely relies on polysynaptic pathways through the brainstem, such as the cortico-reticulospinal pathway.

2026-05-18

Journal of Neurophysiology (publié)

Neuromodulation for gait disorders

Arjun Balachandar

Gianluca Sorrento

Eduardo M. Moraud

Alfonso Fasano

2026-04-19

Nature Reviews Bioengineering (publié)

Motor Recovery After a Hemispherectomy: Review of Mechanisms and the Potential of Neuromodulation to Enhance Motor Outcomes

David Bergeron

Dorothy Barthélemy

Aristides Hadjinicolaou

Marina Martinez

Numa Dancause

Alexander G. Weil

In children with severe, refractory hemispheric epilepsy syndromes, the removal or disconnection of the diseased cortex on one hemisphere fr… (voir plus)om the rest of the brain (hemispherectomy) is a last-resort treatment to cure epilepsy. The removal or disconnection of the motor cortex expectedly leads to contralateral hemiparesis. Partial recovery of the leg or proximal arm may occur over time from the plasticity of alternate motor pathways, but finer hand movements generally do not recover. The advent of neuroprostheses delivering invasive or non-invasive stimulation at different levels of the motor pathways holds promise to enhance motor recovery after a neurologic injury. In this manuscript, we review the mechanisms of motor recovery after a hemispherectomy and discuss how emerging neuromodulation options could be used to improve function. We conclude that the most suitable neuromodulation options for short-term clinical trials are vagal nerve stimulation paired with rehabilitation, and tonic spinal cord stimulation (transcutaneous or with implanted electrodes). We also identify promising neuromodulation options that would require further preclinical investigation in animal models: subcortical deep brain stimulation (motor thalamus, contralateral dentate nucleus), brain-spine interfacing, and motor cortex stimulation. Altogether, this manuscript lays the theoretical foundations for the investigation of neuromodulation therapies to improve the motor outcomes of patients who underwent a hemispherectomy for refractory epilepsy.

2026-02-12

Journal of Child Neurology (publié)

Gait training combined with transcutaneous spinal stimulation to enhance lower limbs motor recovery in people with spinal cord injury: Pilot Study

Nicolas Hoang Quang

Marianne Cossette-Levasseur

Sammy-Jo Beauregard-Veillette

Nancy Dubé

El-Mehdi Meftah

Héloïse Bourgeois

Nok-Yeung Law

Amedeo Ceglia

Marina Martinez

Diana Zidarov

Dorothy Barthélemy

2025-12-31

Neuromodulation: Technology at the Neural Interface (publié)

Modulation of leg trajectory by transcranial magnetic stimulation during walking

Héloïse Bourgeois

Rose Guay-Hottin

El-Mehdi Meftah

Marina Martinez

Dorothy Barthélemy

The primary motor cortex is involved in initiation and adaptive control of locomotion. However, the role of the motor cortex in controlling … (voir plus)gait trajectories remains unclear. In animals, cortical neuromodulation allows for precise control of step height. We hypothesized that a similar control framework applies to humans, whereby cortical stimulation would primarily increase foot elevation. Transcranial magnetic stimulation (TMS) was applied over the motor cortex to assess the involvement of the corticospinal tract over the limb trajectory during human walking. Ten healthy adults (aged 20–32 years) participated in treadmill walking at 1.5 km/h. TMS was applied over the left motor cortex at an intensity of 120% of the threshold to elicit a dorsiflexion of the right ankle during the swing phase of gait. Electromyographic (EMG) measurements and three-dimensional (3D) lower limb kinematics were collected. When delivered during the early swing phase, TMS led to a significant increase in the maximum height of the right toe by a mean of 34.9% ± 9.6% (21.4 mm ± 7.9 mm, p = 0.032) and knee height by 52.8% ± 14.1% (28.8 mm ± 7.7 mm, p = 0.0021) across participants. These findings indicate that TMS can influence limb trajectory during walking, highlighting its potential as a tool for studying cortical control of locomotion.

2025-06-30

Scientific Reports (publié)

Combining cortical and spinal stimulation maximizes improvement of gait after spinal cord injury

Roxanne Drainville

Davide Burchielli

Rose Guay-Hottin

Alexandre Sheasby

Marina Martinez

Most spinal cord injuries (SCI) spare descending motor pathways and sublesional networks, which can be activated through motor cortex and sp… (voir plus)inal cord stimulation to mitigate locomotor deficits. However, the potential synergy between cortical and spinal stimulation as a neuroprosthetic intervention remains unknown. Here, we first investigated phase-locked electrical stimulation of the motor cortex and lumbar spinal cord at 40 Hz in a rat model of unilateral SCI. Combining cortical and lumbar stimulation around the anticipated lift synergistically enhanced leg movements. When integrated into rehabilitation training, cortical stimulation proved essential for recovery of skilled locomotion. As a further refinement, we next investigated the effects of high-frequency (330 Hz) lumbar and sacral stimulation combined with cortical stimulation. Timely integration during the swing phase showed that cortical and rostral lumbar stimulations enhance the initial and mid-swing phases, while sacral stimulation improves extension velocity in the late swing. These findings indicate that supraspinal and sublesional neuromodulation offer complementary neuroprosthetic effects in targeted SCI gait rehabilitation. Cortical and spinal stimulations summate motor outputs via distinct pathways. Each improves gait post-SCI, but combined stimulation maximizes gait improvement. Integrating cortico-spinal stimulation into rehabilitation promotes lasting recovery. EES capabilities extended using high-frequency lumbosacral protocols.

2025-05-26

BioRxiv (prépublication)

Bidirectional Information Flow (BIF) -- A Sample Efficient Hierarchical Gaussian Process for Bayesian Optimization

Juan D. Guerra

Thomas Garbay

Hierarchical Gaussian Process (H-GP) models divide problems into different subtasks, allowing for different models to address each part, mak… (voir plus)ing them well-suited for problems with inherent hierarchical structure. However, typical H-GP models do not fully take advantage of this structure, only sending information up or down the hierarchy. This one-way coupling limits sample efficiency and slows convergence. We propose Bidirectional Information Flow (BIF), an efficient H-GP framework that establishes bidirectional information exchange between parent and child models in H-GPs for online training. BIF retains the modular structure of hierarchical models - the parent combines subtask knowledge from children GPs - while introducing top-down feedback to continually refine children models during online learning. This mutual exchange improves sample efficiency, enables robust training, and allows modular reuse of learned subtask models. BIF outperforms conventional H-GP Bayesian Optimization methods, achieving up to 4x and 3x higher

2024-12-31

arXiv (prépublication)

arxiv.org

Hallucination Detox: Sensitivity Dropout (SenD) for Large Language Model Training

Shahrad Mohammadzadeh

Juan David Guerra

Reihaneh Rabbany

Golnoosh Farnadi

As large language models (LLMs) become increasingly prevalent, concerns about their reliability, particularly due to hallucinations - factua… (voir plus)lly inaccurate or irrelevant outputs - have grown. Our research investigates the relationship between the uncertainty in training dynamics and the emergence of hallucinations. Using models from the Pythia suite and several hallucination detection metrics, we analyze hallucination trends and identify significant variance during training. To address this, we propose Sensitivity Dropout (SenD), a novel training protocol designed to reduce hallucination variance during training by deterministically dropping embedding indices with significant variability. In addition, we develop an unsupervised hallucination detection metric, Efficient EigenScore (EES), which approximates the traditional EigenScore in 2x speed. This metric is integrated into our training protocol, allowing SenD to be both computationally scalable and effective at reducing hallucination variance. SenD improves test-time reliability of Pythia and Meta's Llama models by up to 17% and enhances factual accuracy in Wikipedia, Medical, Legal, and Coding domains without affecting downstream task performance.

2024-12-31

Association for Computational Linguistics (publié)

openreview.net

Robust prior-biased acquisition function for human-in-the-loop Bayesian optimization.

Rose Guay-Hottin

Lison Kardassevitch

Hugo Pham

2024-12-31

Knowl. Based Syst. (publié)

Gaussian-process-based Bayesian optimization for neurostimulation interventions in rats

Leo Choiniere

Rose Guay-Hottin

Rémi Picard

Numa Dancause

2024-02-29

STAR Protocols (publié)

Cortical neuroprosthesis-mediated functional ipsilateral control of locomotion in rats with spinal cord hemisection

Elena Massai

Isley De Jesus

Roxanne Drainville

Marina Martinez

Abstract Control of voluntary limb movement is predominantly attributed to the contralateral motor cortex. However, increasi… (voir plus)ng evidence suggests the involvement of ipsilateral cortical networks in this process, especially in motor tasks requiring bilateral coordination, such as locomotion. In this study, we combined a unilateral thoracic spinal cord injury (SCI) with a cortical neuroprosthetic approach to investigate the functional role of the ipsilateral motor cortex in rat movement through spared contralesional pathways. Our findings reveal that in all SCI rats, stimulation of the ipsilesional motor cortex promoted a bilateral synergy. This synergy involved the elevation of the contralateral foot along with ipsilateral hindlimb extension. Additionally, in two out of seven animals, stimulation of a sub-region of the hindlimb motor cortex modulated ipsilateral hindlimb flexion. Importantly, ipsilateral cortical stimulation delivered after SCI immediately alleviated multiple locomotor and postural deficits, and this effect persisted after ablation of the homologous motor cortex. These results provide strong evidence of a causal link between cortical activation and precise ipsilateral control of hindlimb movement. This study has significant implications for the development of future neuroprosthetic technology and our understanding of motor control in the context of spinal cord injury.

2023-12-26

eLife (publié)

Invasive Brain Computer Interface for Motor Restoration in Spinal Cord Injury: A Systematic Review.

Jordan J. Levett

Lior M. Elkaim

Farbod Niazi

Michael H. Weber

Christian Iorio-Morin

Alexander G. Weil

2023-10-31

Neuromodulation: Technology at the Neural Interface (publié)