Publications

Assessing Intrapartum Risk of Hypoxic-Ischemic Encephalopathy using Fetal Heart Rate with Long Short-term Memory Networks
"Derek Kweku DEGBEDZUI
Michael Kuzniewicz
Cornet Marie-Coralie
Yvonne Wu
Heather Forquer
Lawrence Gerstley
Emily Hamilton
Doina Precup
Philip Warrick
Robert Kearney"
This study investigated the prediction of the risk of hypoxic ischemic encephalopathy using intrapartum cardiotocography records with a long… (voir plus) short-term memory re-current neural network. Across the 12 hours of labour, HIE sensitivity rose from 0.25 to 0.56 as delivery approached while specificity remained approximately constant with a mean of 0.71 and standard deviation of 0.04. The results show that classification improves as delivery approaches but that performance needs improvement. Future work will address the limitations of this preliminary study by investigating input signal transformations and the use of other network architectures to improve the model performance.
2022-09-03
2022 Computing in Cardiology (CinC) (publié)
doi.org
Re-expression of CA1 and entorhinal activity patterns preserves temporal context memory at long timescales
Futing Zou
Wanjia Guo
Emily J. Allen
Yihan Wu
Ian Charest
Thomas Naselaris
Kendrick Kay
Brice A. Kuhl
J. Benjamin Hutchinson
Sarah DuBrow
Converging, cross-species evidence indicates that memory for time is supported by hippocampal area CA1 and entorhinal cortex. However, limit… (voir plus)ed evidence characterizes how these regions preserve temporal memories over long timescales (e.g., months). At long timescales, memoranda may be encountered in multiple temporal contexts, potentially creating interference. Here, using 7T fMRI, we measured CA1 and entorhinal activity patterns as human participants viewed thousands of natural scene images distributed, and repeated, across many months. We show that memory for an image’s original temporal context was predicted by the degree to which CA1/entorhinal activity patterns from the first encounter with an image were re-expressed during re-encounters occurring minutes to months later. Critically, temporal memory signals were dissociable from predictors of recognition confidence, which were carried by distinct medial temporal lobe expressions. These findings suggest that CA1 and entorhinal cortex preserve temporal memories across long timescales by coding for and reinstating temporal context information.
2022-09-02
bioRxiv (prépublication)
doi.org
Digitalization and the Anthropocene
Felix Creutzig
Daron Acemoglu
Xuemei Bai
Paul N. Edwards
Marie Josefine Hintz
Lynn H. Kaack
Siir Kilkis
Stefanie Kunkel
Amy Luers
Nikola Milojevic-Dupont
Dave Rejeski
Jürgen Renn
David Rolnick
Christoph Rosol
Daniela Russ
Thomas Turnbull
Elena Verdolini
Felix Wagner
Charlie Wilson
Aicha Zekar … (voir 1 de plus)
Marius Zumwald
Great claims have been made about the benefits of dematerialization in a digital service economy. However, digitalization has historically i… (voir plus)ncreased environmental impacts at local and planetary scales, affecting labor markets, resource use, governance, and power relationships. Here we study the past, present, and future of digitalization through the lens of three interdependent elements of the Anthropocene: ( a) planetary boundaries and stability, ( b) equity within and between countries, and ( c) human agency and governance, mediated via ( i) increasing resource efficiency, ( ii) accelerating consumption and scale effects, ( iii) expanding political and economic control, and ( iv) deteriorating social cohesion. While direct environmental impacts matter, the indirect and systemic effects of digitalization are more profoundly reshaping the relationship between humans, technosphere and planet. We develop three scenarios: planetary instability, green but inhumane, and deliberate for the good. We conclude with identifying leverage points that shift human–digital–Earth interactions toward sustainability.
2022-09-01
Annual Review Environment and Resources (publié)
doi.org
Researcher perspectives on ethics considerations in epigenetics: an international survey
Charles Dupras
Terese Knoppers
Nicole Palmour
Elisabeth Beauchamp
Stamatina Liosi
Reiner Siebert
Alison May Berner
Stephan Beck
Ian Charest
Yann Joly
Over the past decade, bioethicists, legal scholars and social scientists have started to investigate the potential implications of epigeneti… (voir plus)c research and technologies on medicine and society. There is growing literature discussing the most promising opportunities, as well as arising ethical, legal and social issues (ELSI). This paper explores the views of epigenetic researchers about some of these discussions. From January to March 2020, we conducted an online survey of 189 epigenetic researchers working in 31 countries. We questioned them about the scope of their field, opportunities in different areas of specialization, and ELSI in the conduct of research and knowledge translation. We also assessed their level of concern regarding four emerging non-medical applications of epigenetic testing—i.e., in life insurance, forensics, immigration and direct-to-consumer testing. Although there was strong agreement on DNA methylation, histone modifications, 3D structure of chromatin and nucleosomes being integral elements of the field, there was considerable disagreement on transcription factors, RNA interference, RNA splicing and prions. The most prevalent ELSI experienced or witnessed by respondents were in obtaining timely access to epigenetic data in existing databases, and in the communication of epigenetic findings by the media. They expressed high levels of concern regarding non-medical applications of epigenetics, echoing cautionary appraisals in the social sciences and humanities literature.
2022-09-01
Clinical Epigenetics (publié)
doi.org
Small, correlated changes in synaptic connectivity may facilitate rapid motor learning
Barbara Feulner
Matthew G Perich
Raeed H. Chowdhury
Lee Miller
Juan A. Gallego
Claudia Clopath
2022-09-01
Nature Communications (publié)
doi.org
Interpretable domain adaptation using unsupervised feature selection on pre-trained source models
Luxin Zhang
Pascal Germain
Yacine Kessaci
C. Biernacki
2022-08-31
Neurocomputing (publié)
doi.org
A novel domain adaptation theory with Jensen-Shannon divergence
Changjian Shui
Qi CHEN
Jun Wen
Fan Zhou
Christian Gagné
Boyu Wang
2022-08-31
Knowledge-Based Systems (publié)
doi.org
The load planning and sequencing problem for double-stack trains
Moritz Ruf
Jean-François Cordeau
Emma Frejinger
2022-08-31
Journal of Rail Transport Planning & Management (publié)
doi.org
Two types of human TCR differentially regulate reactivity to self and non-self antigens
Assya Trofimov
Philippe Brouillard
Jean-David Larouche
Jonathan Séguin
Jean-Philippe Laverdure
Ann Brasey
Gregory Ehx
Denis-Claude Roy
Lambert Busque
Silvy Lachance
Sébastien Lemieux
Claude Perreault
Based on analyses of TCR sequences from over 1,000 individuals, we report that the TCR repertoire is composed of two ontogenically and funct… (voir plus)ionally distinct types of TCRs. Their production is regulated by variations in thymic output and terminal deoxynucleotidyl transferase (TDT) activity. Neonatal TCRs derived from TDT-negative progenitors persist throughout life, are highly shared among subjects, and are reported as disease-associated. Thus, 10%–30% of most frequent cord blood TCRs are associated with common pathogens and autoantigens. TDT-dependent TCRs present distinct structural features and are less shared among subjects. TDT-dependent TCRs are produced in maximal numbers during infancy when thymic output and TDT activity reach a summit, are more abundant in subjects with AIRE mutations, and seem to play a dominant role in graft-versus-host disease. Factors decreasing thymic output (age, male sex) negatively impact TCR diversity. Males compensate for their lower repertoire diversity via hyperexpansion of selected TCR clonotypes.
2022-08-31
iScience (publié)
doi.org
QU-BraTS: MICCAI BraTS 2020 Challenge on Quantifying Uncertainty in Brain Tumor Segmentation - Analysis of Ranking Scores and Benchmarking Results
Raghav Mehta
Angelos Filos
Ujjwal Baid
Chiharu Sako
Richard McKinley
Michael Rebsamen
Katrin Datwyler
Raphaël Meier
Piotr Radojewski
Gowtham Krishnan Murugesan
Sahil Nalawade
Chandan Ganesh
Ben Wagner
Fang Yu
Baowei Fei
Ananth J. Madhuranthakam
Joseph A. Maldjian
Laura Daza
Catalina Gómez
Pablo Arbeláez … (voir 72 de plus)
Chengliang Dai
Shuo Wang
Hadrien Reynaud
Yuan-han Mo
Elsa D. Angelini
Yike Guo
Wenjia Bai
Subhashis Banerjee
Lin-min Pei
Murat AK
Sarahi Rosas-González
Ilyess Zemmoura
Clovis Tauber
Minh H. Vu
Tufve Nyholm
Tommy Löfstedt
Laura Mora Ballestar
Verónica Vilaplana
Hugh McHugh
Gonzalo D. Maso Talou
Alan Wang
Jay Patel
Ken Chang
Katharina Hoebel
Mishka Gidwani
Nishanth Arun
Sharut Gupta
Mehak Aggarwal
Praveer Singh
Elizabeth R. Gerstner
Jayashree Kalpathy-Cramer
Nicolas Boutry
Alexis Huard
Lasitha Vidyaratne
Md Monibor Rahman
Khan M. Iftekharuddin
Joseph Chazalon
Élodie Puybareau
Guillaume Tochon
Jun Ma
Mariano Cabezas
Xavier Lladó
Arnau Oliver
Liliana Patricia Marlés Valencia
Sergi Valverde
Mehdi Amian
Mohammadreza Soltaninejad
Andriy Myronenko
Ali Hatamizadeh
Xue Feng
Fang Yu
Nicholas Tustison
Craig H. Meyer
Nisarg A. Shah
Sanjay N. Talbar
Marc‐André Weber
Abhishek Mahajan
Andras Jakab
Roland Wiest
Hassan M. Fathallah‐Shaykh
Arash Nazeri
Mikhail Milchenko
Daniel C. Marcus
Aikaterini Kotrotsou
Rivka R. Colen
John Freymann
Justin Kirby
Christos Davatzikos
Bjoern Menze
Spyridon Bakas
Yarin Gal
Tal Arbel
Deep learning (DL) models have provided state-of-the-art performance in various medical imaging benchmarking challenges, including the Brain… (voir plus) Tumor Segmentation (BraTS) challenges. However, the task of focal pathology multi-compartment segmentation (e.g., tumor and lesion sub-regions) is particularly challenging, and potential errors hinder translating DL models into clinical workflows. Quantifying the reliability of DL model predictions in the form of uncertainties could enable clinical review of the most uncertain regions, thereby building trust and paving the way toward clinical translation. Several uncertainty estimation methods have recently been introduced for DL medical image segmentation tasks. Developing scores to evaluate and compare the performance of uncertainty measures will assist the end-user in making more informed decisions. In this study, we explore and evaluate a score developed during the BraTS 2019 and BraTS 2020 task on uncertainty quantification (QU-BraTS) and designed to assess and rank uncertainty estimates for brain tumor multi-compartment segmentation. This score (1) rewards uncertainty estimates that produce high confidence in correct assertions and those that assign low confidence levels at incorrect assertions, and (2) penalizes uncertainty measures that lead to a higher percentage of under-confident correct assertions. We further benchmark the segmentation uncertainties generated by 14 independent participating teams of QU-BraTS 2020, all of which also participated in the main BraTS segmentation task. Overall, our findings confirm the importance and complementary value that uncertainty estimates provide to segmentation algorithms, highlighting the need for uncertainty quantification in medical image analyses. Finally, in favor of transparency and reproducibility, our evaluation code is made publicly available at https://github.com/RagMeh11/QU-BraTS.
2022-08-25
Machine Learning for Biomedical Imaging (publié)
doi.org
arxiv.org
Fractal impedance for passive controllers: a framework for interaction robotics
Keyhan Kouhkiloui Babarahmati
Carlo Tiseo
Joshua Smith
Hsiu-Chin Lin
M. S. Erden
Michael Nalin Mistry
2022-08-24
Nonlinear Dynamics (publié)
doi.org
arxiv.org
Learning Shared Neural Manifolds from Multi-Subject fMRI Data
Jessie Huang
Jessie Huang
Erica L. Busch
Tom Wallenstein
Michal Gerasimiuk
Andrew Benz
Guillaume Lajoie
Guy Wolf
Nicholas B. Turk-Browne
Smita Krishnaswamy
Functional magnetic resonance imaging (fMRI) is a notoriously noisy measurement of brain activity because of the large variations between in… (voir plus)dividuals, signals marred by environmental differences during collection, and spatiotemporal averaging required by the measurement resolution. In addition, the data is extremely high dimensional, with the space of the activity typically having much lower intrinsic dimension. In order to understand the connection between stimuli of interest and brain activity, and analyze differences and commonalities between subjects, it becomes important to learn a meaningful embedding of the data that denoises, and reveals its intrinsic structure. Specifically, we assume that while noise varies significantly between individuals, true responses to stimuli will share common, low-dimensional features between subjects which are jointly discoverable. Similar approaches have been exploited previously but they have mainly used linear methods such as PCA and shared response modeling (SRM). In contrast, we propose a neural network called MRMD-AE (manifold-regularized multiple decoder, autoencoder), that learns a common embedding from multiple subjects in an experiment while retaining the ability to decode to individual raw fMRI signals. We show that our learned common space represents an extensible manifold (where new points not seen during training can be mapped), improves the classification accuracy of stimulus features of unseen timepoints, as well as improves cross-subject translation of fMRI signals. We believe this framework can be used for many downstream applications such as guided brain-computer interface (BCI) training in the future.
2022-08-21
2022 IEEE 32nd International Workshop on Machine Learning for Signal Processing (MLSP) (publié)
doi.org
openreview.net