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Publications
Bringing proportional recovery into proportion: Bayesian modelling of post-stroke motor impairment.
Accurate predictions of motor impairment after stroke are of cardinal importance for the patient, clinician, and healthcare system. More tha… (voir plus)n 10 years ago, the proportional recovery rule was introduced by promising that high-fidelity predictions of recovery following stroke were based only on the initially lost motor function, at least for a specific fraction of patients. However, emerging evidence suggests that this recovery rule is subject to various confounds and may apply less universally than previously assumed. Here, we systematically revisited stroke outcome predictions by applying strategies to avoid confounds and fitting hierarchical Bayesian models. We jointly analysed 385 post-stroke trajectories from six separate studies-one of the largest overall datasets of upper limb motor recovery. We addressed confounding ceiling effects by introducing a subset approach and ensured correct model estimation through synthetic data simulations. Subsequently, we used model comparisons to assess the underlying nature of recovery within our empirical recovery data. The first model comparison, relying on the conventional fraction of patients called 'fitters', pointed to a combination of proportional to lost function and constant recovery. 'Proportional to lost' here describes the original notion of proportionality, indicating greater recovery in case of a more severe initial impairment. This combination explained only 32% of the variance in recovery, which is in stark contrast to previous reports of >80%. When instead analysing the complete spectrum of subjects, 'fitters' and 'non-fitters', a combination of proportional to spared function and constant recovery was favoured, implying a more significant improvement in case of more preserved function. Explained variance was at 53%. Therefore, our quantitative findings suggest that motor recovery post-stroke may exhibit some characteristics of proportionality. However, the variance explained was substantially reduced compared to what has previously been reported. This finding motivates future research moving beyond solely behaviour scores to explain stroke recovery and establish robust and discriminating single-subject predictions.
This compendium gathers all the accepted extended abstracts from the Third International Conference on Medical Imaging with Deep Learning (M… (voir plus)IDL 2020), held in Montreal, Canada, 6-9 July 2020. Note that only accepted extended abstracts are listed here, the Proceedings of the MIDL 2020 Full Paper Track are published in the Proceedings of Machine Learning Research (PMLR).
The manner through which individual differences in brain network organization track population-level behavioral variability is a fundamental… (voir plus) question in systems neuroscience. Recent work suggests that resting-state and task-state functional connectivity can predict specific traits at the individual level. However, the focus of most studies on single behavioral traits has come at the expense of capturing broader relationships across behaviors. Here, we utilized a large-scale dataset of 1858 typically developing children to estimate whole-brain functional network organization that is predictive of individual differences in cognition, impulsivity-related personality, and mental health during rest and task states. Predictive network features were distinct across the broad behavioral domains: cognition, personality and mental health. On the other hand, traits within each behavioral domain were predicted by highly similar network features. This is surprising given decades of research emphasizing that distinct brain networks support different mental processes. Although tasks are known to modulate the functional connectome, we found that predictive network features were similar between resting and task states. Overall, our findings reveal shared brain network features that account for individual variation within broad domains of behavior in childhood, yet are unique to different behavioral domains.
Domain adaptation (DA) is a technique that transfers predictive models trained on a labeled source domain to an unlabeled target domain, wit… (voir plus)h the core difficulty of resolving distributional shift between domains. Currently, most popular DA algorithms are based on distributional matching (DM). However in practice, realistic domain shifts (RDS) may violate their basic assumptions and as a result these methods will fail. In this paper, in order to devise robust DA algorithms, we first systematically analyze the limitations of DM based methods, and then build new benchmarks with more realistic domain shifts to evaluate the well-accepted DM methods. We further propose InstaPBM, a novel Instance-based Predictive Behavior Matching method for robust DA. Extensive experiments on both conventional and RDS benchmarks demonstrate both the limitations of DM methods and the efficacy of InstaPBM: Compared with the best baselines, InstaPBM improves the classification accuracy respectively by
A major challenge in applying machine learning to automated theorem proving is the scarcity of training data, which is a key ingredient in t… (voir plus)raining successful deep learning models. To tackle this problem, we propose an approach that relies on training with synthetic theorems, generated from a set of axioms. We show that such theorems can be used to train an automated prover and that the learned prover transfers successfully to human-generated theorems. We demonstrate that a prover trained exclusively on synthetic theorems can solve a substantial fraction of problems in TPTP, a benchmark dataset that is used to compare state-of-the-art heuristic provers. Our approach outperforms a model trained on human-generated problems in most axiom sets, thereby showing the promise of using synthetic data for this task.
Deep Neural Networks (DNNs) in general and Convolutional Neural Networks (CNNs) in particular are state-of-the-art in numerous computer visi… (voir plus)on tasks such as object classification and detection. However, the large amount of parameters they contain leads to a high computational complexity and strongly limits their usability in budget-constrained devices such as embedded devices. In this paper, we propose a combination of a pruning technique and a quantization scheme that effectively reduce the complexity and memory usage of convolutional layers of CNNs, by replacing the complex convolutional operation by a low-cost multiplexer. We perform experiments on CIFAR10, CIFAR100 and SVHN datasets and show that the proposed method achieves almost state-of-the-art accuracy, while drastically reducing the computational and memory footprints compared to the baselines. We also propose an efficient hardware architecture, implemented on Field Programmable Gate Arrays (FPGAs), to accelerate inference, which works as a pipeline and accommodates multiple layers working at the same time to speed up the inference process. In contrast with most proposed approaches which have used external memory or software defined memory controllers, our work is based on algorithmic optimization and full-hardware design, enabling a direct, on-chip memory implementation of a DNN while keeping close to state of the art accuracy.
2020-06-16
2020 18th IEEE International New Circuits and Systems Conference (NEWCAS) (publié)
