Publications

Effect of diversity in Meta-Learning
Few-shot learning aims to learn representations that can tackle novel tasks given a small number of examples. Recent studies show that task … (voir plus)distribution plays a vital role in the performance of the model. Conventional wisdom is that task diversity should improve the performance of meta-learning. In this work, we find evidence to the contrary; we study different task distributions on a myriad of models and datasets to evaluate the effect of task diversity on meta-learning algorithms. For this experiment, we train on two datasets - Omniglot and miniImageNet and with three broad classes of meta-learning models - Metric-based (i.e., Protonet, Matching Networks), Optimization-based (i.e., MAML, Reptile, and MetaOptNet), and Bayesian meta-learning models (i.e., CNAPs). Our experiments demonstrate that the effect of task diversity on all these algorithms follows a similar trend, and task diversity does not seem to offer any benefits to the learning of the model. Furthermore, we also demonstrate that even a handful of tasks, repeated over multiple batches, would be sufficient to achieve a performance similar to uniform sampling and draws into question the need for additional tasks to create better models.
Few Shot Image Generation via Implicit Autoencoding of Support Sets
Andy Huang
Kuan-Chieh Wang
Alireza Makhzani
Recent generative models such as generative adversarial networks have achieved remarkable success in generating realistic images, but they r… (voir plus)equire large training datasets and computational resources. The goal of few-shot image generation is to learn the distribution of a new dataset from only a handful of examples by transferring knowledge learned from structurally similar datasets. Towards achieving this goal, we propose the “Implicit Support Set Autoencoder” (ISSA) that adversarially learns the relationship across datasets using an unsupervised dataset representation, while the distribution of each individual dataset is learned using implicit distributions. Given a few examples from a new dataset, ISSA can generate new samples by inferring the representation of the underlying distribution using a single forward pass. We showcase significant gains from our method on generating high quality and diverse images for unseen classes in the Omniglot and CelebA datasets in few-shot image generation settings.
Maternal chemosignals enhance infant-adult brain-to-brain synchrony
Yaara Endevelt-Shapira
Amir Djalovski
Ruth Feldman
Endocytic proteins with prion-like domains form viscoelastic condensates that enable membrane remodeling
Louis-Philippe Bergeron-Sandoval
Hossein Khadivi Heris
Catherine L. A. Chang
Caitlin E. Cornell
Sarah L. Keller
Adam G. Hendricks
Allen J. Ehrlicher
Rohit V. Pappu
Stephen W. Michnick
The uptake of molecules into cells, known as endocytosis, requires membrane invagination and the formation of vesicles. A version of endocyt… (voir plus)osis that is independent of actin polymerization is aided by the assembly of membraneless biomolecular condensates at the site of membrane invagination. Here, we show that endocytic condensates are viscoelastic bodies that concentrate key proteins with prion-like domains to enable membrane remodeling. A distinct molecular grammar, namely the preference for glutamine versus asparagine residues, underlies the cohesive interactions that give rise to endocytic condensates. We incorporate material properties inferred using active rheology into a mechanical model to explain how cohesive interactions within condensates and interfacial tensions among condensates, membranes, and the cytosol can drive membrane invagination to initiate endocyosis.
Mortality trends and lengths of stay among hospitalized COVID-19 patients in Ontario and Québec (Canada): a population-based cohort study of the first three epidemic waves
Yiqing Xia
Huiting Ma
David L Buckeridge
Marc Brisson
Beate Sander
Adrienne Chan
Iris Ganser
Nadine Kronfli
Sharmistha Mishra
Mathieu Maheu-Giroux
Epidemic waves of COVID-19 strained hospital resources. We describe temporal trends in mortality risk and length of stay in intensive cares … (voir plus)units (ICUs) among COVID-19 patients hospitalized through the first three epidemic waves in Canada. We used population-based provincial hospitalization data from Ontario and Québec to examine mortality risk and lengths of ICU stay. For each province, adjusted estimates were obtained using marginal standardization of logistic regression models, adjusting for patient-level characteristics and hospital-level determinants. Using all hospitalizations from Ontario (N=26,541) and Québec (N=23,857), we found that unadjusted in-hospital mortality risks peaked at 31% in the first wave and was lowest at the end of the third wave at 6-7%. This general trend remained after controlling for confounders. The odds of in-hospital mortality in the highest hospital occupancy quintile was 1.2 (95%CI: 1.0-1.4; Ontario) and 1.6 (95%CI: 1.3-1.9; Québec) times that of the lowest quintile. Variants of concerns were associated with an increased in-hospital mortality. Length of ICU stay decreased over time from a mean of 16 days (SD=18) to 15 days (SD=15) in the third wave but were consistently higher in Ontario than Québec by 3-6 days. In-hospital mortality risks and lengths of ICU stay declined over time in both provinces, despite changing patient demographics, suggesting that new therapeutics and treatment, as well as improved clinical protocols, could have contributed to this reduction. Continuous population-based monitoring of patient outcomes in an evolving epidemic is necessary for health system preparedness and response.
Curating the Twitter Election Integrity Datasets for Better Online Troll Characterization
Albert M. Orozco Camacho
In modern days, social media platforms provide accessible channels for the inter-1 action and immediate reflection of the most important ev… (voir plus)ents happening around 2 the world. In this paper, we, firstly, present a curated set of datasets whose origin 3 stem from the Twitter’s Information Operations 1 efforts. More notably, these 4 accounts, which have been already suspended, provide a notion of how state-backed 5 human trolls operate. 6 Secondly, we present detailed analyses of how these behaviours vary over time, 7 and motivate its use and abstraction in the context of deep representation learning: 8 for instance, to learn and, potentially track, troll behaviour. We present baselines 9 for such tasks and highlight the differences there may exist within the literature. 10 Finally, we utilize the representations learned for behaviour prediction to classify 11 trolls from "real" users, using a sample of non-suspended active accounts. 12
Flexible Option Learning
Temporal abstraction in reinforcement learning (RL), offers the promise of improving generalization and knowledge transfer in complex enviro… (voir plus)nments, by propagating information more efficiently over time. Although option learning was initially formulated in a way that allows updating many options simultaneously, using off-policy, intra-option learning (Sutton, Precup & Singh, 1999), many of the recent hierarchical reinforcement learning approaches only update a single option at a time: the option currently executing. We revisit and extend intra-option learning in the context of deep reinforcement learning, in order to enable updating all options consistent with current primitive action choices, without introducing any additional estimates. Our method can therefore be naturally adopted in most hierarchical RL frameworks. When we combine our approach with the option-critic algorithm for option discovery, we obtain significant improvements in performance and data-efficiency across a wide variety of domains.
Patient health records and whole viral genomes from an early SARS-CoV-2 outbreak in a Quebec hospital reveal features associated with favorable outcomes
Bastien Paré
Marieke Rozendaal
Raphaël Poujol
Shawn M. Simpson
Jean-Christophe Grenier
Henry Xing
Miguelle Sanchez
Ariane Yechouron
Ronald Racette
Julie G. Hussin
Ivan Pavlov
Martin A. Smith
The first confirmed case of COVID-19 in Quebec, Canada, occurred at Verdun Hospital on February 25, 2020. A month later, a localized outbrea… (voir plus)k was observed at this hospital. We performed tiled amplicon whole genome nanopore sequencing on nasopharyngeal swabs from all SARS-CoV-2 positive samples from 31 March to 17 April 2020 in 2 local hospitals to assess the viral diversity of the outbreak. We report 264 viral genomes from 242 individuals (both staff and patients) with associated clinical features and outcomes, as well as longitudinal samples, technical replicates and the first publicly disseminated SARS-CoV-2 genomes in Quebec. Viral lineage assessment identified multiple subclades in both hospitals, with a predominant subclade in the Verdun outbreak, indicative of hospital-acquired transmission. Dimensionality reduction identified two subclades that evaded supervised lineage assignment methods, including Pangolin, and identified certain symptoms (headache, myalgia and sore throat) that are significantly associated with favorable patient outcomes. We also address certain limitations of standard SARS-CoV-2 bioinformatics procedures, notably when presented with multiple viral haplotypes.
Adapting to the COVID‐19 pandemic in cohort studies: Validation of online assessments of cognition and neuropsychiatric symptoms in an aging population
Firoza Z Lussier
Stijn Servaes
Min Su Kang
Gleb Bezgin
Mira Chamoun
Jenna Stevenson
Nesrine Rahmouni
Alyssa Stevenson
Tharick A. Pascoal
Suzanne King
Serge Gauthier
Pedro Rosa‐Neto
The occurrence of the COVID‐19 pandemic has had a significant impact on cohort studies, particularly those whose subjects are at higher ri… (voir plus)sk of developing complications from the virus. As such, assessment methods must be adapted to minimize COVID‐19 exposure risk. The TRIAD (Translational Biomarkers of Aging and Dementia) cohort assessed N=292 individuals during initial COVID‐19 lockdown measures by telephone interview to rate cognition, neuropsychiatric symptoms, and impact of the pandemic. To increase speed and efficiency of data collection, we aim to follow these individuals by means of online survey. Here, we present a validation of our online assessment tools by comparing data obtained through both methods (phone interview and online survey) in the same subjects.
Cognitive health mediates the effect of hippocampal volume on COVID‐19‒related knowledge or anxiety change during the COVID‐19 pandemic
Min Su Kang
Julie Ottoy
Stijn Servaes
Firoza Z Lussier
Gleb Bezgin
Mira Chamoun
Jenna Stevenson
Suzanne King
Serge Gauthier
Pedro Rosa‐Neto
Our finding highlights the poorer knowledge of COVID19 and related risks in individuals with cognitive/memory impairments; the CDRSOB, indic… (voir plus)ative of cognitive health, significantly mediated the effect of hippocampal volume on the rate of change in anxiety or knowledge on COVID19 in our cohort. This study urges for a more effective strategy and policy about informing and educating the individual with cognitive/memory impairment on COVID19 and related risks.
Learning Assisted Identification of Scenarios Where Network Optimization Algorithms Under-Perform
Dmitriy Rivkin
X. T. Chen
Xue Liu
We present a generative adversarial method that uses deep learning to identify network load traffic conditions in which network optimization… (voir plus) algorithms under-perform other known algorithms: the Deep Convolutional Failure Generator (DCFG). The spatial distribution of network load presents challenges for network operators for tasks such as load balancing, in which a network optimizer attempts to maintain high quality communication while at the same time abiding capacity constraints. Testing a network optimizer for all possible load distributions is challenging if not impossible. We propose a novel method that searches for load situations where a target network optimization method underperforms baseline, which are key test cases that can be used for future refinement and performance optimization. By modeling a realistic network simulator's quality assessments with a deep network and, in parallel, optimizing a load generation network, our method efficiently searches the high dimensional space of load patterns and reliably finds cases in which a target network optimization method under-performs a baseline by a significant margin.
Online Partisan Polarization of COVID-19
Sacha Lévy
Gabrielle Desrosiers-Brisebois
Andre Blais
In today’s age of (mis)information, many people utilize various social media platforms in an attempt to shape public opinion on sever… (voir plus)al important issues, including elections and the COVID-19 pandemic. These two topics have recently become intertwined given the importance of complying with public health measures related to COVID-19 and politicians’ management of the pandemic. Motivated by this, we study the partisan polarization of COVID-19 discussions on social media. We propose and utilize a novel measure of partisan polarization to analyze more than 380 million posts from Twitter and Parler around the 2020 US presidential election. We find strong correlation between peaks in polarization and polarizing events, such as the January 6th Capitol Hill riot. We further classify each post into key COVID-19 issues of lockdown, masks, vaccines, as well as miscellaneous, to investigate both the volume and polarization on these topics and how they vary through time. Parler includes more negative discussions around lockdown and masks, as expected, but not much around vaccines. We also observe more balanced discussions on Twitter and a general disconnect between the discussions on Parler and Twitter.