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Publications
Temporal trends in disparities in COVID-19 seropositivity among Canadian blood donors
Abstract Background In Canada’s largest COVID-19 serological study, SARS-CoV-2 antibodies in blood donors have been monitored since 2020. … (voir plus)No study has analysed changes in the association between anti-N seropositivity (a marker of recent infection) and geographic and sociodemographic characteristics over the pandemic. Methods Using Bayesian multi-level models with spatial effects at the census division level, we analysed changes in correlates of SARS-CoV-2 anti-N seropositivity across three periods in which different variants predominated (pre-Delta, Delta and Omicron). We analysed disparities by geographic area, individual traits (age, sex, race) and neighbourhood factors (urbanicity, material deprivation and social deprivation). Data were from 420 319 blood donations across four regions (Ontario, British Columbia [BC], the Prairies and the Atlantic region) from December 2020 to November 2022. Results Seropositivity was higher for racialized minorities, males and individuals in more materially deprived neighbourhoods in the pre-Delta and Delta waves. These subgroup differences dissipated in the Omicron wave as large swaths of the population became infected. Across all waves, seropositivity was higher in younger individuals and those with lower neighbourhood social deprivation. Rural residents had high seropositivity in the Prairies, but not other regions. Compared to generalized linear models, multi-level models with spatial effects had better fit and lower error when predicting SARS-CoV-2 anti-N seropositivity by geographic region. Conclusions Correlates of recent COVID-19 infection have evolved over the pandemic. Many disparities lessened during the Omicron wave, but public health intervention may be warranted to address persistently higher burden among young people and those with less social deprivation.
Association between arterial oxygen and mortality across critically ill patients with hematologic malignancies: results from an international collaborative network
Building on the remarkable achievements in generative sampling of natural images, we propose an innovative challenge, potentially overly amb… (voir plus)itious, which involves generating samples of entire multivariate time series that resemble images. However, the statistical challenge lies in the small sample size, sometimes consisting of a few hundred subjects. This issue is especially problematic for deep generative models that follow the conventional approach of generating samples from a canonical distribution and then decoding or denoising them to match the true data distribution. In contrast, our method is grounded in information theory and aims to implicitly characterize the distribution of images, particularly the (global and local) dependency structure between pixels. We achieve this by empirically estimating its KL-divergence in the dual form with respect to the respective marginal distribution. This enables us to perform generative sampling directly in the optimized 1-D dual divergence space. Specifically, in the dual space, training samples representing the data distribution are embedded in the form of various clusters between two end points. In theory, any sample embedded between those two end points is in-distribution w.r.t. the data distribution. Our key idea for generating novel samples of images is to interpolate between the clusters via a walk as per gradients of the dual function w.r.t. the data dimensions. In addition to the data efficiency gained from direct sampling, we propose an algorithm that offers a significant reduction in sample complexity for estimating the divergence of the data distribution with respect to the marginal distribution. We provide strong theoretical guarantees along with an extensive empirical evaluation using many real-world datasets from diverse domains, establishing the superiority of our approach w.r.t. state-of-the-art deep learning methods.
Dr Narges Armanfard, Professor, talks us through the AI healthcare research at McGill University which is spearheading a groundbreaking init… (voir plus)iative – the iSMART Lab. Access to high-quality healthcare is not just a fundamental human right; it is the bedrock of our societal wellbeing, with the crucial roles played by doctors, nurses, and hospitals. Yet, healthcare systems globally face mounting challenges, particularly from aging populations. Dr Narges Armanfard, affiliated with McGill University and Mila Quebec AI Institute in Montreal, Canada, has spearheaded a groundbreaking initiative – the iSMART Lab. This laboratory represents a revolutionary leap into the future of healthcare, with its pioneering research in AI for health applications garnering significant attention. Renowned for its innovative integration of AI across diverse domains, iSMART Lab stands at the forefront of harnessing Artificial Intelligence to elevate and streamline health services.
Large decoder-only language models (LLMs) are the state-of-the-art models on most of today's NLP tasks and benchmarks. Yet, the community is… (voir plus) only slowly adopting these models for text embedding tasks, which require rich contextualized representations. In this work, we introduce LLM2Vec, a simple unsupervised approach that can transform any decoder-only LLM into a strong text encoder. LLM2Vec consists of three simple steps: 1) enabling bidirectional attention, 2) masked next token prediction, and 3) unsupervised contrastive learning. We demonstrate the effectiveness of LLM2Vec by applying it to 4 popular LLMs ranging from 1.3B to 8B parameters and evaluate the transformed models on English word- and sequence-level tasks. We outperform encoder-only models by a large margin on word-level tasks and reach a new unsupervised state-of-the-art performance on the Massive Text Embeddings Benchmark (MTEB). Moreover, when combining LLM2Vec with supervised contrastive learning, we achieve state-of-the-art performance on MTEB among models that train only on publicly available data (as of May 24, 2024). Our strong empirical results and extensive analysis demonstrate that LLMs can be effectively transformed into universal text encoders in a parameter-efficient manner without the need for expensive adaptation or synthetic GPT-4 generated data.
Large decoder-only language models (LLMs) are the state-of-the-art models on most of today's NLP tasks and benchmarks. Yet, the community is… (voir plus) only slowly adopting these models for text embedding tasks, which require rich contextualized representations. In this work, we introduce LLM2Vec, a simple unsupervised approach that can transform any decoder-only LLM into a strong text encoder. LLM2Vec consists of three simple steps: 1) enabling bidirectional attention, 2) masked next token prediction, and 3) unsupervised contrastive learning. We demonstrate the effectiveness of LLM2Vec by applying it to 4 popular LLMs ranging from 1.3B to 8B parameters and evaluate the transformed models on English word- and sequence-level tasks. We outperform encoder-only models by a large margin on word-level tasks and reach a new unsupervised state-of-the-art performance on the Massive Text Embeddings Benchmark (MTEB). Moreover, when combining LLM2Vec with supervised contrastive learning, we achieve state-of-the-art performance on MTEB among models that train only on publicly available data (as of May 24, 2024). Our strong empirical results and extensive analysis demonstrate that LLMs can be effectively transformed into universal text encoders in a parameter-efficient manner without the need for expensive adaptation or synthetic GPT-4 generated data.
Large decoder-only language models (LLMs) are the state-of-the-art models on most of today's NLP tasks and benchmarks. Yet, the community is… (voir plus) only slowly adopting these models for text embedding tasks, which require rich contextualized representations. In this work, we introduce LLM2Vec, a simple unsupervised approach that can transform any decoder-only LLM into a strong text encoder. LLM2Vec consists of three simple steps: 1) enabling bidirectional attention, 2) masked next token prediction, and 3) unsupervised contrastive learning. We demonstrate the effectiveness of LLM2Vec by applying it to 4 popular LLMs ranging from 1.3B to 8B parameters and evaluate the transformed models on English word- and sequence-level tasks. We outperform encoder-only models by a large margin on word-level tasks and reach a new unsupervised state-of-the-art performance on the Massive Text Embeddings Benchmark (MTEB). Moreover, when combining LLM2Vec with supervised contrastive learning, we achieve state-of-the-art performance on MTEB among models that train only on publicly available data (as of May 24, 2024). Our strong empirical results and extensive analysis demonstrate that LLMs can be effectively transformed into universal text encoders in a parameter-efficient manner without the need for expensive adaptation or synthetic GPT-4 generated data.
Large decoder-only language models (LLMs) are the state-of-the-art models on most of today's NLP tasks and benchmarks. Yet, the community is… (voir plus) only slowly adopting these models for text embedding tasks, which require rich contextualized representations. In this work, we introduce LLM2Vec, a simple unsupervised approach that can transform any decoder-only LLM into a strong text encoder. LLM2Vec consists of three simple steps: 1) enabling bidirectional attention, 2) masked next token prediction, and 3) unsupervised contrastive learning. We demonstrate the effectiveness of LLM2Vec by applying it to 4 popular LLMs ranging from 1.3B to 8B parameters and evaluate the transformed models on English word- and sequence-level tasks. We outperform encoder-only models by a large margin on word-level tasks and reach a new unsupervised state-of-the-art performance on the Massive Text Embeddings Benchmark (MTEB). Moreover, when combining LLM2Vec with supervised contrastive learning, we achieve state-of-the-art performance on MTEB among models that train only on publicly available data (as of May 24, 2024). Our strong empirical results and extensive analysis demonstrate that LLMs can be effectively transformed into universal text encoders in a parameter-efficient manner without the need for expensive adaptation or synthetic GPT-4 generated data.
Large decoder-only language models (LLMs) are the state-of-the-art models on most of today's NLP tasks and benchmarks. Yet, the community is… (voir plus) only slowly adopting these models for text embedding tasks, which require rich contextualized representations. In this work, we introduce LLM2Vec, a simple unsupervised approach that can transform any decoder-only LLM into a strong text encoder. LLM2Vec consists of three simple steps: 1) enabling bidirectional attention, 2) masked next token prediction, and 3) unsupervised contrastive learning. We demonstrate the effectiveness of LLM2Vec by applying it to 3 popular LLMs ranging from 1.3B to 7B parameters and evaluate the transformed models on English word- and sequence-level tasks. We outperform encoder-only models by a large margin on word-level tasks and reach a new unsupervised state-of-the-art performance on the Massive Text Embeddings Benchmark (MTEB). Moreover, when combining LLM2Vec with supervised contrastive learning, we achieve state-of-the-art performance on MTEB among models that train only on publicly available data. Our strong empirical results and extensive analysis demonstrate that LLMs can be effectively transformed into universal text encoders in a parameter-efficient manner without the need for expensive adaptation or synthetic GPT-4 generated data.
Large decoder-only language models (LLMs) are the state-of-the-art models on most of today's NLP tasks and benchmarks. Yet, the community is… (voir plus) only slowly adopting these models for text embedding tasks, which require rich contextualized representations. In this work, we introduce LLM2Vec, a simple unsupervised approach that can transform any decoder-only LLM into a strong text encoder. LLM2Vec consists of three simple steps: 1) enabling bidirectional attention, 2) masked next token prediction, and 3) unsupervised contrastive learning. We demonstrate the effectiveness of LLM2Vec by applying it to 4 popular LLMs ranging from 1.3B to 8B parameters and evaluate the transformed models on English word- and sequence-level tasks. We outperform encoder-only models by a large margin on word-level tasks and reach a new unsupervised state-of-the-art performance on the Massive Text Embeddings Benchmark (MTEB). Moreover, when combining LLM2Vec with supervised contrastive learning, we achieve state-of-the-art performance on MTEB among models that train only on publicly available data (as of May 24, 2024). Our strong empirical results and extensive analysis demonstrate that LLMs can be effectively transformed into universal text encoders in a parameter-efficient manner without the need for expensive adaptation or synthetic GPT-4 generated data.
