Peu importe la taille : démocratiser la découverte de protéines avec l'IA
Des chercheurs de Mila ont créé un puissant modèle de langage protéique à source ouverte plus compact et efficace afin de démocratiser la découverte de protéines.
La prochaine cohorte de notre programme, conçu pour fournir aux participant·e·s une compréhension fondamentale des technologies de l'IA, se déroulera à Ottawa les 28 et 29 novembre.
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Publications
A cry for help: Early detection of brain injury in newborns
Over the past years, foundation models have caused a paradigm shift in machine learning due to their unprecedented capabilities for zero-sho… (voir plus)t and few-shot generalization. However, despite the success of foundation models in modalities such as natural language processing and computer vision, the development of foundation models for time series forecasting has lagged behind. We present Lag-Llama, a general-purpose foundation model for univariate probabilistic time series forecasting based on a decoder-only transformer architecture that uses lags as covariates. Lag-Llama is pretrained on a large corpus of diverse time series data from several domains, and demonstrates strong zero-shot generalization capabilities compared to a wide range of forecasting models on downstream datasets across domains. Moreover, when fine-tuned on relatively small fractions of such previously unseen datasets, Lag-Llama achieves state-of-the-art performance, outperforming prior deep learning approaches, emerging as the best general-purpose model on average. Lag-Llama serves as a strong contender to the current state-of-art in time series forecasting and paves the way for future advancements in foundation models tailored to time series data.
Deep Learning Benchmark for First Break Detection from Hardrock Seismic Reflection Data
Pierre-Luc St-Charles
Bruno Rousseau
Joumana Ghosn
Gilles Bellefleur
E. Schetselaar
Deep learning techniques are used to tackle a variety of tasks related to seismic data processing and interpretation. While many works have … (voir plus)shown the benefits of deep learning, assessing the generalization capabilities of proposed methods to data acquired in different conditions and geological environments remains challenging. This is especially true for applications in hardrock environments where seismic surveys are still relatively rare. The primary factors that impede the adoption of machine learning in geosciences include the lack of publicly available and labeled datasets, and the use of inadequate evaluation methodologies. Since machine learning models are prone to overfit and underperform when the data used to train them is site-specific, the applicability of these models on new survey data that could be considered “out-of-distribution” is rarely addressed. This is unfortunate, as evaluating predictive models in out-of-distribution settings can provide a good insight into their usefulness in real-world use cases. To tackle these issues, we propose a simple benchmarking methodology for first break picking to evaluate the transferability of deep learning models that are trained across different environments and acquisition conditions. For this, we consider a reflection seismic survey dataset acquired at five distinct hardrock mining sites combined with annotations for first break picking. We train and evaluate a baseline deep learning solution based on a U-Net for future comparisons, and discuss potential improvements to this approach.
Deep learning models can perform well in complex medical imaging classification tasks, even when basing their conclusions on spurious correl… (voir plus)ations (i.e. confounders), should they be prevalent in the training dataset, rather than on the causal image markers of interest. This would thereby limit their ability to generalize across the population. Explainability based on counterfactual image generation can be used to expose the confounders but does not provide a strategy to mitigate the bias. In this work, we introduce the first end-to-end training framework that integrates both (i) popular debiasing classifiers (e.g. distributionally robust optimization (DRO)) to avoid latching onto the spurious correlations and (ii) counterfactual image generation to unveil generalizable imaging markers of relevance to the task. Additionally, we propose a novel metric, Spurious Correlation Latching Score (SCLS), to quantify the extent of the classifier reliance on the spurious correlation as exposed by the counterfactual images. Through comprehensive experiments on two public datasets (with the simulated and real visual artifacts), we demonstrate that the debiasing method: (i) learns generalizable markers across the population, and (ii) successfully ignores spurious correlations and focuses on the underlying disease pathology.
2023-10-09
Clinical Image-Based Procedures, Fairness of AI in Medical Imaging, and Ethical and Philosophical Issues in Medical Imaging (publié)
Image-based precision medicine aims to personalize treatment decisions based on an individual's unique imaging features so as to improve the… (voir plus)ir clinical outcome. Machine learning frameworks that integrate uncertainty estimation as part of their treatment recommendations would be safer and more reliable. However, little work has been done in adapting uncertainty estimation techniques and validation metrics for precision medicine. In this paper, we use Bayesian deep learning for estimating the posterior distribution over factual and counterfactual outcomes on several treatments. This allows for estimating the uncertainty for each treatment option and for the individual treatment effects (ITE) between any two treatments. We train and evaluate this model to predict future new and enlarging T2 lesion counts on a large, multi-center dataset of MR brain images of patients with multiple sclerosis, exposed to several treatments during randomized controlled trials. We evaluate the correlation of the uncertainty estimate with the factual error, and, given the lack of ground truth counterfactual outcomes, demonstrate how uncertainty for the ITE prediction relates to bounds on the ITE error. Lastly, we demonstrate how knowledge of uncertainty could modify clinical decision-making to improve individual patient and clinical trial outcomes.
In this study, we highlight the importance of enhancing the quality of pretraining data in multilingual language models.
Existing web crawl… (voir plus)s have demonstrated quality issues, particularly in the context of low-resource languages.
Consequently, we introduce a new multilingual pretraining corpus for