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Marco Bonizzato

Alumni

Publications

Combining cortical and spinal stimulation maximizes the improvement of gait after spinal cord injury
Roxanne Drainville
Rose Guay-Hottin
Alexandre Sheasby
Marina Martinez
Most spinal cord injuries (SCI) spare descending motor pathways and sublesional networks, which can be activated through motor cortex and sp… (voir plus)inal cord stimulation to mitigate locomotor deficits. However, the potential synergy between cortical and spinal stimulation as a neuroprosthetic intervention remains unknown. Here, we first investigated phase-locked electrical stimulation of the motor cortex and lumbar spinal cord at 40 Hz in a rat model of unilateral SCI. Combining cortical and lumbar stimulation around the anticipated lift synergistically enhanced leg movements. When integrated into rehabilitation training, cortical stimulation proved essential for recovery of skilled locomotion. As a further refinement, we next investigated the effects of high-frequency (330 Hz) lumbar and sacral stimulation combined with cortical stimulation. Timely integration during the swing phase showed that cortical and rostral lumbar stimulations enhance the initial and mid-swing phases, while sacral stimulation improves extension velocity in the late swing. These findings indicate that supraspinal and sublesional neuromodulation offer complementary neuroprosthetic effects in targeted SCI gait rehabilitation. Highlights Cortical and spinal stimulations summate motor outputs via distinct pathways. Each improves gait post-SCI, but combined stimulation maximizes gait improvement. Integrating cortico-spinal stimulation into rehabilitation promotes lasting recovery. EES capabilities extended using high-frequency lumbosacral protocols.
Hallucination Detox: Sensitivity Dropout (SenD) for Large Language Model Training
Modulation of leg trajectory by transcranial magnetic stimulation during walking
H. Bourgeois
Rose Guay-Hottin
El-Mehdi Meftah
Marina Martinez
D. Barthélemy
Combining cortical and spinal stimulation maximizes improvement of gait after spinal cord injury
Roxanne Drainville
Rose Guay-Hottin
Alexandre Sheasby
Marina Martinez
Bidirectional Information Flow (BIF) - A Sample Efficient Hierarchical Gaussian Process for Bayesian Optimization
Hierarchical Gaussian Process (H-GP) models divide problems into different subtasks, allowing for different models to address each part, mak… (voir plus)ing them well-suited for problems with inherent hierarchical structure. However, typical H-GP models do not fully take advantage of this structure, only sending information up or down the hierarchy. This one-way coupling limits sample efficiency and slows convergence. We propose Bidirectional Information Flow (BIF), an efficient H-GP framework that establishes bidirectional information exchange between parent and child models in H-GPs for online training. BIF retains the modular structure of hierarchical models - the parent combines subtask knowledge from children GPs - while introducing top-down feedback to continually refine children models during online learning. This mutual exchange improves sample efficiency, enables robust training, and allows modular reuse of learned subtask models. BIF outperforms conventional H-GP Bayesian Optimization methods, achieving up to 85% and 5x higher
Hallucination Detox: Sensitivity Dropout (SenD) for Large Language Model Training
Robust prior-biased acquisition function for human-in-the-loop Bayesian optimization
Modulation of leg trajectory by transcranial magnetic stimulation during walking
H. Bourgeois
Rose Guay-Hottin
E.-M. Meftah
M. Martinez
D. Barthélemy
The primary motor cortex is involved in initiation and adaptive control of locomotion. However, the role of the motor cortex in controlling … (voir plus)gait trajectories remains unclear. In animals, cortical neuromodulation allows for precise control of step height. We hypothesized that a similar control framework applies to humans, whereby cortical stimulation would primarily increase foot elevation. Transcranial magnetic stimulation (TMS) was applied over the motor cortex to assess the involvement of the corticospinal tract over the limb trajectory during human walking. Eight healthy adults (aged 20-32 years) participated in treadmill walking at 1.5 km/h. TMS was applied over the left motor cortex at an intensity of 120% of the threshold to elicit a dorsiflexion of the right ankle during the swing phase of gait. Electromyographic (EMG) measurements and three-dimensional (3D) lower limb kinematics were collected. When delivered during the early swing phase, TMS led to a significant increase in the maximum height of the right toe by a mean of 40.7% ± 14.9% (25.6mm ± 9.4 mm, p = 0.0352) and knee height by 57.8%± 16.8%; (32mm ± 9.3 mm; p = 0.008) across participants. These findings indicate that TMS can influence limb trajectory during walking, highlighting its potential as a tool for studying cortical control of locomotion.
Hallucination Detox: Sensitive Neuron Dropout (SeND) for Large Language Model Training
As large language models (LLMs) are increasingly deployed across various industries, concerns regarding their reliability, particularly due … (voir plus)to hallucinations - outputs that are factually inaccurate or irrelevant to user input - have grown. Our research investigates the relationship between the training process and the emergence of hallucinations to address a key gap in existing research that focuses primarily on post hoc detection and mitigation strategies. Using models from the Pythia suite (70M - 12B parameters) and several hallucination detection metrics, we analyze hallucination trends throughout training and explore LLM internal dynamics. We introduce Sensitivity Dropout (SenD), a novel training protocol designed to mitigate hallucinations by reducing variance during training. SenD achieves this by deterministically dropping embedding indices with significant variability, referred to as Sensitive Embedding Indices. In addition, we develop an unsupervised hallucination detection metric, Efficient EigenScore (EES), which approximates the traditional EigenScore at 2x speed. This efficient metric is integrated into our protocol, allowing SenD to be both computationally scalable and effective at reducing hallucinations. Our empirical evaluation demonstrates that our approach improves LLM reliability at test time by up to 40% compared to normal training while also providing an efficient method to improve factual accuracy when adapting LLMs to Wikipedia, Medical, and LegalBench domains.
Hallucination Detox: Sensitivity Dropout (SenD) for Large Language Model Training
As large language models (LLMs) are increasingly deployed across various industries, concerns regarding their reliability, particularly due … (voir plus)to hallucinations - outputs that are factually inaccurate or irrelevant to user input - have grown. Our research investigates the relationship between the training process and the emergence of hallucinations to address a key gap in existing research that focuses primarily on post hoc detection and mitigation strategies. Using models from the Pythia suite (70M - 12B parameters) and several hallucination detection metrics, we analyze hallucination trends throughout training and explore LLM internal dynamics. We introduce Sensitivity Dropout (SenD), a novel training protocol designed to mitigate hallucinations by reducing variance during training. SenD achieves this by deterministically dropping embedding indices with significant variability, referred to as Sensitive Embedding Indices. In addition, we develop an unsupervised hallucination detection metric, Efficient EigenScore (EES), which approximates the traditional EigenScore at 2x speed. This efficient metric is integrated into our protocol, allowing SenD to be both computationally scalable and effective at reducing hallucinations. Our empirical evaluation demonstrates that our approach improves LLM reliability at test time by up to 40% compared to normal training while also providing an efficient method to improve factual accuracy when adapting LLMs to Wikipedia, Medical, and LegalBench domains.
Hallucination Detox: Sensitivity Dropout (SenD) for Large Language Model Training
Hallucination Detox: Sensitive Neuron Dropout (SeND) for Large Language Model Training
As large language models (LLMs) become increasingly deployed across various industries, concerns regarding their reliability, particularly d… (voir plus)ue to hallucinations-outputs that are factually inaccurate or irrelevant to user input-have grown. Our research investigates the relationship between the training process and the emergence of hallucinations to address a key gap in existing research that focuses primarily on post hoc detection and mitigation strategies. Using models from the Pythia suite (70M-12B parameters) and several hallucination detection metrics, we analyze hallucination trends throughout training and explore LLM internal dynamics. We introduce SEnsitive Neuron Dropout (SeND), a novel training protocol designed to mitigate hallucinations by reducing variance during training. SeND achieves this by deterministically dropping neurons with significant variability on a dataset, referred to as Sensitive Neurons. In addition, we develop an unsupervised hallucination detection metric, Efficient EigenScore (EES), which approximates the traditional EigenScore in 2x speed. This efficient metric is integrated into our protocol, allowing SeND to be both computationally scalable and effective at reducing hallucinations. Our empirical evaluation demonstrates that our approach improves LLM reliability at test time by up to 40% compared to normal training while also providing an efficient method to improve factual accuracy when adapting LLMs to domains such as Wikipedia and Medical datasets.