Publications

INFERNO: Inferring Object-Centric 3D Scene Representations without Supervision
Lluis Castrejon
Nicolas Ballas
Aaron Courville
We propose INFERNO, a method to infer object-centric representations of visual scenes without annotations. Our method decomposes a scene int… (voir plus)o multiple objects, with each object having a structured representation that disentangles its shape, appearance and pose. Each object representation defines a localized neural radiance field used to generate 2D views of the scene through differentiable rendering. Our model is subsequently trained by minimizing a reconstruction loss between inputs and corresponding rendered scenes. We empirically show that INFERNO discovers objects in a scene without supervision. We also validate the interpretability of the learned representations by manipulating inferred scenes and showing the corresponding effect in the rendered output. Finally, we demonstrate the usefulness of our 3D object representations in a visual reasoning task using the CATER dataset.
2022-03-24
ICLR.cc/2022/Workshop/OSC (poster)
openreview.net
openreview.net
Neurobiological Correlates of Change in Adaptive Behavior in Autism.
Charlotte M. Pretzsch
Tim Schäfer
Michael V. Lombardo
Varun Warrier
Caroline Mann
Anke Bletsch
Chris H. Chatham
Dorothea L. Floris
Julian Tillmann
Afsheen Yousaf
Emily J. H. Jones
Tony Charman
Sara Ambrosino
Thomas Bourgeron
Guillaume Dumas
Eva Loth
Beth Oakley
Jan K. Buitelaar
Freddy Cliquet
Claire Leblond … (voir 7 de plus)
Simon Baron-Cohen
Christian Beckmann
Tobias Banaschewski
Sarah Durston
Christine M. Freitag
Declan Murphy
Christine Ecker
2022-03-24
American Journal of Psychiatry (publié)
doi.org
Object-centric Compositional Imagination for Visual Abstract Reasoning
Rim Assouel
Pau Rodríguez
Perouz Taslakian
David Vázquez
Yoshua Bengio
Like humans devoid of imagination, current machine learning systems lack the ability to adapt to new, unexpected situations by foreseeing th… (voir plus)em, which makes them unable to solve new tasks by analogical reasoning. In this work, we introduce a new compositional imagination framework that improves a model's ability to generalize. One of the key components of our framework is object-centric inductive biases that enables models to perceive the environment as a series of objects, properties, and transformations. By composing these key ingredients, it is possible to generate new unseen tasks that, when used to train the model, improve generalization. Experiments on a simplified version of the Abstraction and Reasoning Corpus (ARC) demonstrate the effectiveness of our framework.
2022-03-24
ICLR.cc/2022/Workshop/OSC (poster)
openreview.net
openreview.net
Monoallelic Heb/Tcf12 Deletion Reduces the Requirement for NOTCH1 Hyperactivation in T-Cell Acute Lymphoblastic Leukemia
Diogo F. T. Veiga
Mathieu Tremblay
Bastien Gerby
Sabine Herblot
André Haman
Patrick Gendron
Sébastien Lemieux
Juan Carlos Zúñiga-Pflücker
Josée Hébert
Joseph Paul Cohen
Trang Hoang
Early T-cell development is precisely controlled by E proteins, that indistinguishably include HEB/TCF12 and E2A/TCF3 transcription factors,… (voir plus) together with NOTCH1 and pre-T cell receptor (TCR) signalling. Importantly, perturbations of early T-cell regulatory networks are implicated in leukemogenesis. NOTCH1 gain of function mutations invariably lead to T-cell acute lymphoblastic leukemia (T-ALL), whereas inhibition of E proteins accelerates leukemogenesis. Thus, NOTCH1, pre-TCR, E2A and HEB functions are intertwined, but how these pathways contribute individually or synergistically to leukemogenesis remain to be documented. To directly address these questions, we leveraged Cd3e-deficient mice in which pre-TCR signaling and progression through β-selection is abrogated to dissect and decouple the roles of pre-TCR, NOTCH1, E2A and HEB in SCL/TAL1-induced T-ALL, via the use of Notch1 gain of function transgenic (Notch1ICtg) and Tcf12+/- or Tcf3+/- heterozygote mice. As a result, we now provide evidence that both HEB and E2A restrain cell proliferation at the β-selection checkpoint while the clonal expansion of SCL-LMO1-induced pre-leukemic stem cells in T-ALL is uniquely dependent on Tcf12 gene dosage. At the molecular level, HEB protein levels are decreased via proteasomal degradation at the leukemic stage, pointing to a reversible loss of function mechanism. Moreover, in SCL-LMO1-induced T-ALL, loss of one Tcf12 allele is sufficient to bypass pre-TCR signaling which is required for Notch1 gain of function mutations and for progression to T-ALL. In contrast, Tcf12 monoallelic deletion does not accelerate Notch1IC-induced T-ALL, indicating that Tcf12 and Notch1 operate in the same pathway. Finally, we identify a tumor suppressor gene set downstream of HEB, exhibiting significantly lower expression levels in pediatric T-ALL compared to B-ALL and brain cancer samples, the three most frequent pediatric cancers. In summary, our results indicate a tumor suppressor function of HEB/TCF12 in T-ALL to mitigate cell proliferation controlled by NOTCH1 in pre-leukemic stem cells and prevent NOTCH1-driven progression to T-ALL.
2022-03-23
Frontiers in Immunology (publié)
doi.org
Mapping parallelism in a functional IR through constraint satisfaction: a case study on convolution for mobile GPUs
Naums Mogers
Li Li
Valentin Radu
Christophe Dubach
Graphics Processing Units (GPUs) are notoriously hard to optimize for manually. What is needed are good automatic code generators and optimi… (voir plus)zers. Accelerate, Futhark and Lift demonstrated that a functional approach is well suited for this challenge. Lift, for instance, uses a system of rewrite rules with a multi-stage approach. Algorithmic optimizations are first explored, followed by hardware-specific optimizations such as using shared memory and mapping parallelism. While the algorithmic exploration leads to correct transformed programs by construction, it is not necessarily true for the latter phase. Exploiting shared memory and mapping parallelism while ensuring correct synchronization is a delicate balancing act, and is hard to encode in a rewrite system. Currently, Lift relies on heuristics with ad-hoc mechanisms to check for correctness. Although this practical approach eventually produces high-performance code, it is not an ideal state of affairs. This paper proposes to extract parallelization constraints automatically from a functional IR and use a solver to identify valid rewriting. Using a convolutional neural network on a mobile GPU as a use case, this approach matches the performance of the ARM Compute Library GEMM convolution and the TVM-generated kernel consuming between 2.7x and 3.6x less memory on average. Furthermore, a speedup of 12x is achieved over the ARM Compute Library direct convolution implementation.
2022-03-17
Proceedings of the 31st ACM SIGPLAN International Conference on Compiler Construction (publié)
doi.org
WOODS: Benchmarks for Out-of-Distribution Generalization in Time Series Tasks
Jean-christophe Gagnon-audet
Kartik Ahuja
Mohammad Javad Darvishi Bayazi
Guillaume Dumas
Irina Rish
2022-03-17
ArXiv (prépublication)
doi.org
arxiv.org
<i>APOE</i> ɛ2 vs <i>APOE</i> ɛ4 dosage shows sex-specific links to hippocampus-default network subregion co-variation
Chloé Savignac
Sylvia Villeneuve
AmanPreet Badhwar
Karin Saltoun
Kimia Shafighi
Chris Zajner
Vaibhav Sharma
Sarah A Gagliano Taliun
Sali Farhan
Judes Poirier
Danilo Bzdok
Alzheimer’s disease and related dementias (ADRD) are marked by intracellular tau aggregates in the medial-temporal lobe (MTL) and extracel… (voir plus)lular amyloid aggregates in the default network (DN). Here, we sought to clarify ADRD-related co-dependencies between the MTL’s most vulnerable structure, the hippocampus (HC), and the highly associative DN at a subregion resolution. We confronted the effects of APOE ɛ2 and ɛ4, rarely investigated together, with their impact on HC-DN co-variation regimes at the population level. In a two-pronged decomposition of structural brain scans from ∼40,000 UK Biobank participants, we located co-deviating structural patterns in HC and DN subregions as a function of ADRD family risk. Across the disclosed HC-DN signatures, recurrent deviations in the CA1, CA2/3, molecular layer, fornix’s fimbria, and their cortical partners related to ADRD risk. Phenome-wide profiling of HC-DN co- variation expressions from these population signatures revealed male-specific associations with air-pollution, and female-specific associations with cardiovascular traits. We highlighted three main factors associated with brain-APOE associations across the different gene variants: happiness, and satisfaction with friendships, and with family. We further showed that APOE ɛ2/2 interacts preferentially with HC-DN co-variation patterns in estimating social lifestyle in males and physical activity in females. Our findings reinvigorate the often-neglected interplay between APOE ɛ2 dosage and sex, which we have linked to fine-grained structural divergences indicative of ADRD susceptibility.
2022-03-14
bioRxiv (prépublication)
doi.org
A connectomics-based taxonomy of mammals
Laura E Suarez
Yossi Yovel
Martijn P van den Heuvel
Olaf Sporns
Yaniv Assaf
Guillaume Lajoie
Bratislav Misic
Mammalian taxonomies are conventionally defined by morphological traits and genetics. How species differ in terms of neural circuits and whe… (voir plus)ther inter-species differences in neural circuit organization conform to these taxonomies is unknown. The main obstacle to the comparison of neural architectures has been differences in network reconstruction techniques, yielding species-specific connectomes that are not directly comparable to one another. Here, we comprehensively chart connectome organization across the mammalian phylogenetic spectrum using a common reconstruction protocol. We analyse the mammalian MRI (MaMI) data set, a database that encompasses high-resolution ex vivo structural and diffusion MRI scans of 124 species across 12 taxonomic orders and 5 superorders, collected using a unified MRI protocol. We assess similarity between species connectomes using two methods: similarity of Laplacian eigenspectra and similarity of multiscale topological features. We find greater inter-species similarities among species within the same taxonomic order, suggesting that connectome organization reflects established taxonomic relationships defined by morphology and genetics. While all connectomes retain hallmark global features and relative proportions of connection classes, inter-species variation is driven by local regional connectivity profiles. By encoding connectomes into a common frame of reference, these findings establish a foundation for investigating how neural circuits change over phylogeny, forging a link from genes to circuits to behaviour.
2022-03-11
bioRxiv (prépublication)
doi.org
Medical Image Segmentation on MRI Images with Missing Modalities: A Review
Reza Azad
Nika Khosravi
Mohammad Dehghanmanshadi
Julien Cohen-Adad
Dorit Merhof
2022-03-10
ArXiv (prépublication)
doi.org
arxiv.org
Misinterpreting the horseshoe effect in neuroscience
Timothée Proix
Matthew G Perich
Tomislav Milekovic
2022-03-06
bioRxiv (prépublication)
doi.org
A New Era: Intelligent Tutoring Systems Will Transform Online Learning for Millions
Francois St-Hilaire
Dung D. Vu
Antoine Frau
Nathan J. Burns
Farid Faraji
Joseph Potochny
Stephane Robert
Arnaud Roussel
Selene Zheng
Taylor Glazier
Junfel Vincent Romano
Robert Belfer
Muhammad Shayan
Ariella Smofsky
Tommy Delarosbil
Seulmin Ahn
Simon Eden-Walker
Kritika Sony
Ansona Onyi Ching
Sabina Elkins … (voir 11 de plus)
A. Stepanyan
Adela Matajova
Victor Chen
Hossein Sahraei
Robert Larson
N. Markova
Andrew Barkett
Laurent Charlin
Yoshua Bengio
Iulian V. Serban
Ekaterina Kochmar
2022-03-02
ArXiv (prépublication)
doi.org
arxiv.org
Application of AI in community based primary health care: Systematic review and critical appraisal
S. A. Rahimi
Patrick Archambault
Herve Tchala Vignon Zomahoun
Sam Chandavong
Marie-Pierre Gagnon
Sabrina M. Wong
Gauri Sharma
Lyse Langlois
Nathalie Rheault
Yves Couturier
Jean Légaré
2022-02-28
Systematic review, meta-analysis, or scoping review (publié)
doi.org