Portrait de David Buckeridge

David Buckeridge

Membre académique associé
Professeur titulaire, McGill University, Département d'épidémiologie, biostatistique et santé au travail
Sujets de recherche
Apprentissage automatique médical
Google Scholar
LinkedIn

Biographie

David Buckeridge est professeur titulaire à l'École de santé des populations et de santé mondiale de l'Université McGill, responsable de la santé numérique au Centre universitaire de santé McGill et directeur scientifique exécutif pour l'Agence de la santé publique du Canada. Titulaire d'une chaire de recherche du Canada (niveau 1) en informatique de la santé et en science des données, il a établi les projections concernant la demande dans le système de santé du Québec, dirigé la gestion des données et l'analyse pour le groupe de travail sur l'immunité canadienne et aidé l'Organisation mondiale de la santé à surveiller l'immunité mondiale contre le SRAS-CoV-2. Il est titulaire d'un doctorat en médecine (Université Queen's), d'une maîtrise en épidémiologie (Université de Toronto) et d'un doctorat en informatique biomédicale (Université Stanford), et est membre du Collège royal des médecins du Canada.

Étudiants actuels

Kalash Dave
Maîtrise recherche - McGill
Github
Eva Gao
Doctorat - McGill
yachen li Li
Maîtrise recherche - McGill
yachen.li@mail.mcgill.ca
Aidan Licoppe
Maîtrise recherche - McGill
Github
Yannan Shen
Maîtrise recherche - McGill

Publications

Opioid prescribing among new users for non-cancer pain in the USA, Canada, UK, and Taiwan: A population-based cohort study
Meghna Jani
Nadyne Girard
David W. Bates
David Buckeridge
Therese Sheppard
Jack Li
Usman Iqbal
Shelly Vik
Colin Weaver
Judy Seidel
William G. Dixon
Robyn Tamblyn
Background The opioid epidemic in North America has been driven by an increase in the use and potency of prescription opioids, with ensuing … (voir plus)excessive opioid-related deaths. Internationally, there are lower rates of opioid-related mortality, possibly because of differences in prescribing and health system policies. Our aim was to compare opioid prescribing rates in patients without cancer, across 5 centers in 4 countries. In addition, we evaluated differences in the type, strength, and starting dose of medication and whether these characteristics changed over time. Methods and findings We conducted a retrospective multicenter cohort study of adults who are new users of opioids without prior cancer. Electronic health records and administrative health records from Boston (United States), Quebec and Alberta (Canada), United Kingdom, and Taiwan were used to identify patients between 2006 and 2015. Standard dosages in morphine milligram equivalents (MMEs) were calculated according to The Centers for Disease Control and Prevention. Age- and sex-standardized opioid prescribing rates were calculated for each jurisdiction. Of the 2,542,890 patients included, 44,690 were from Boston (US), 1,420,136 Alberta, 26,871 Quebec (Canada), 1,012,939 UK, and 38,254 Taiwan. The highest standardized opioid prescribing rates in 2014 were observed in Alberta at 66/1,000 persons compared to 52, 51, and 18/1,000 in the UK, US, and Quebec, respectively. The median MME/day (IQR) at initiation was highest in Boston at 38 (20 to 45); followed by Quebec, 27 (18 to 43); Alberta, 23 (9 to 38); UK, 12 (7 to 20); and Taiwan, 8 (4 to 11). Oxycodone was the first prescribed opioid in 65% of patients in the US cohort compared to 14% in Quebec, 4% in Alberta, 0.1% in the UK, and none in Taiwan. One of the limitations was that data were not available from all centers for the entirety of the 10-year period. Conclusions In this study, we observed substantial differences in opioid prescribing practices for non-cancer pain between jurisdictions. The preference to start patients on higher MME/day and more potent opioids in North America may be a contributing cause to the opioid epidemic.
2021-11-01
PLoS Medicine (publié)
doi.org
Evaluating Montréal’s harm reduction interventions for people who inject drugs: protocol for observational study and cost-effectiveness analysis
Dimitra Panagiotoglou
Michal Abrahamowicz
David Buckeridge
J Jaime Caro
Eric Latimer
Mathieu Maheu-Giroux
Erin C Strumpf
2021-10-26
BMJ Open (publié)
doi.org
Stringency of containment and closures on the growth of SARS-CoV-2 in Canada prior to accelerated vaccine roll-out
D. Vickers
S. Baral
Sharmistha Mishra
J. Kwong
M. Sundaram
Alan W. Katz
Andrew J. Calzavara
Mathieu Maheu-Giroux
David Buckeridge
Tyler Williamson
2021-10-21
International Journal of Infectious Diseases (published)
doi.org
Evaluation of real-life use of Point-Of-Care Rapid Antigen TEsting for SARS-CoV-2 in schools for outbreak control (EPOCRATES)
A. Blanchard
Marc Desforges
A. Labbé
C. Nguyen
Y. Petit
Derek Besner
Kate A. Zinszer
Olivier Séguin
Zineb Laghdir
K. Adams
Marie-ève Benoit
Ghislain Leduc
Jean Longtin
Ioannis. Ragoussis
David Buckeridge
Caroline Quach
We evaluated the use of rapid antigen detection tests (RADT) for the diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-… (voir plus)2) infection in school settings to determine RADT performance characteristics compared to PCR. Methods: We did a real-world, prospective observational cohort study where recruited high-school students and staff from two high-schools in Montreal (Canada) were followed from January 25th to June 10th, 2021. Twenty-five percent of asymptomatic participants were tested weekly by RADT (nasal) and PCR (gargle). Class contacts of a case were tested. Symptomatic participants were tested by RADT (nasal) and PCR (nasal and gargle). The number of cases/outbreak and number of outbreaks were compared to other high schools in the same area. Results: Overall, 2,099 students and 286 school staff members consented to participate. The overall RADT specificity varied from 99.8 to 100%, with a lower sensitivity, varying from 28.6% in asymptomatic to 83.3% in symptomatic participants. The number of outbreaks was not different in the 2 participating schools compared to other high schools in the same area, but included a greater proportion of asymptomatic cases. Returning students to school after a 7-day quarantine, with a negative PCR on D6-7 after exposure, did not lead to subsequent outbreaks, as shown by serial testing. Of cases for whom the source was known, 37 of 57 (72.5%) were secondary to household transmission, 13 (25%) to intra-school transmission and one to community contacts between students in the same school. Conclusion: RADT did not perform well as a screening tool in asymptomatic individuals. Reinforcing policies for symptom screening when entering schools and testing symptomatic individuals with RADT on the spot may avoid subsequent significant exposures in class.
2021-10-14
medRxiv (prépublication)
doi.org
Transfer functions: learning about a lagged exposure-outcome association in time-series data
Hiroshi Mamiya
Alexandra M. Schmidt
Erica E. M. Moodie
David Buckeridge
Many population exposures in time-series analysis, including food marketing, exhibit a time-lagged association with population health outcom… (voir plus)es such as food purchasing. A common approach to measuring patterns of associations over different time lags relies on a finite-lag model, which requires correct specification of the maximum duration over which the lagged association extends. However, the maximum lag is frequently unknown due to the lack of substantive knowledge or the geographic variation of lag length. We describe a time-series analytical approach based on an infinite lag specification under a transfer function model that avoids the specification of an arbitrary maximum lag length. We demonstrate its application to estimate the lagged exposure-outcome association in food environmental research: display promotion of sugary beverages with lagged sales.
2021-10-01
medRxiv (prépublication)
doi.org
Estimating the lagged effect of price discounting: a time-series study using transaction data of sugar sweetened beverages.
Hiroshi Mamiya
Alexandra M. Schmidt
Erica E. M. Moodie
David Buckeridge
2021-09-28
medRxiv (prépublication)
doi.org
Monitoring non-pharmaceutical public health interventions during the COVID-19 pandemic
Yannan Shen
Guido Powell
Iris Ganser
Qulu Zheng
Chris Grundy
Anya Okhmatovskaia
David Buckeridge
2021-08-24
Scientific Data (publié)
doi.org
Generating community measures of food purchasing activities using store-level electronic grocery transaction records: an ecological study in Montreal, Canada
Hiroshi Mamiya
Alexandra M. Schmidt
Erica E.M. Moodie
Yu Ma
David Buckeridge
2021-08-23
Public Health Nutrition (publié)
doi.org
Supervised multi-specialist topic model with applications on large-scale electronic health record data
Ziyang Song
Xavier Sumba Toral
Yixin Xu
Aihua Liu
Liming Guo
Guido Powell
Aman Verma
David Buckeridge
Ariane Marelli
Yue Li
Motivation: Electronic health record (EHR) data provides a new venue to elucidate disease comorbidities and latent phenotypes for precision … (voir plus)medicine. To fully exploit its potential, a realistic data generative process of the EHR data needs to be modelled. Materials and Methods: We present MixEHR-S to jointly infer specialist-disease topics from the EHR data. As the key contribution, we model the specialist assignments and ICD-coded diagnoses as the latent topics based on patient's underlying disease topic mixture in a novel unified supervised hierarchical Bayesian topic model. For efficient inference, we developed a closed-form collapsed variational inference algorithm to learn the model distributions of MixEHR-S. Results: We applied MixEHR-S to two independent large-scale EHR databases in Quebec with three targeted applications: (1) Congenital Heart Disease (CHD) diagnostic prediction among 154,775 patients; (2) Chronic obstructive pulmonary disease (COPD) diagnostic prediction among 73,791 patients; (3) future insulin treatment prediction among 78,712 patients diagnosed with diabetes as a mean to assess the disease exacerbation. In all three applications, MixEHR-S conferred clinically meaningful latent topics among the most predictive latent topics and achieved superior target prediction accuracy compared to the existing methods, providing opportunities for prioritizing high-risk patients for healthcare services. Availability and implementation: MixEHR-S source code and scripts of the experiments are freely available at https://github.com/li-lab-mcgill/mixehrS
2021-08-01
Proceedings of the 12th ACM Conference on Bioinformatics, Computational Biology, and Health Informatics (publié)
doi.org
arxiv.org
Geographical concentration of COVID-19 cases by social determinants of health in 16 large metropolitan areas in Canada - a cross-sectional study
Yiqing Xia
Huiting Ma
Gary Moloney
Héctor A. Velásquez García
Monica Sirski
Naveed Janjua
David Vickers
Tyler Williamson
Alan Katz
Kristy Yu
Rafal Kustra
David Buckeridge
Marc Brisson
Stefan Baral
Sharmistha Mishra
Mathieu Maheu-Giroux
Background: There is a growing recognition that strategies to reduce SARS-CoV-2 transmission should be responsive to local transmission dyna… (voir plus)mics. Studies have revealed inequalities along social determinants of health, but little investigation was conducted surrounding geographic concentration within cities. We quantified social determinants of geographic concentration of COVID-19 cases across sixteen census metropolitan areas (CMA) in four Canadian provinces. Methods: We used surveillance data on confirmed COVID-19 cases at the level of dissemination area. Gini (co-Gini) coefficients were calculated by CMA based on the proportion of the population in ranks of diagnosed cases and each social determinant using census data (income, education, visible minority, recent immigration, suitable housing, and essential workers) and the corresponding share of cases. Heterogeneity was visualized using Lorenz (concentration) curves. Results: Geographic concentration was observed in all CMAs (half of the cumulative cases were concentrated among 21-35% of each city's population): with the greatest geographic heterogeneity in Ontario CMAs (Gini coefficients, 0.32-0.47), followed by British Columbia (0.23-0.36), Manitoba (0.32), and Quebec (0.28-0.37). Cases were disproportionately concentrated in areas with lower income, education attainment, and suitable housing; and higher proportion of visible minorities, recent immigrants, and essential workers. Although a consistent feature across CMAs was concentration by proportion visible minorities, the magnitude of concentration by social determinants varied across CMAs. Interpretation: The feature of geographical concentration of COVID-19 cases was consistent across CMAs, but the pattern by social determinants varied. Geographically-prioritized allocation of resources and services should be tailored to the local drivers of inequalities in transmission in response to SARS-CoV-2's resurgence.
2021-07-26
medRxiv (prépublication)
doi.org
Smart About Meds (SAM): a pilot randomized controlled trial of a mobile application to improve medication adherence following hospital discharge
Bettina Habib
David Buckeridge
Melissa Bustillo
Santiago Nicolas Marquez
Manish Thakur
Thai Tran
Daniala L Weir
Robyn Tamblyn
2021-07-01
JAMIA Open (publié)
doi.org
Smart about medications (SAM): a digital solution to enhance medication management following hospital discharge
Santiago Márquez Fosser
Nadar Mahmoud
Bettina Habib
Daniala L Weir
Fiona Chan
Rola El Halabieh
Jeanne Vachon
Manish Thakur
Thai Tran
Melissa Bustillo
Caroline Beauchamp
André Bonnici
David Buckeridge
Robyn Tamblyn
2021-06-18
JAMIA Open (publié)
doi.org