Publications

OC-0290 Investigation of the feasibility of selenium-75 as a viable brachytherapy source
J. Reid
Jonathan Kalinowski
J. Munro
A. Armstrong
Shirin A. Enger
2023-05-01
Radiotherapy and Oncology (published)
doi.org
PD-0334 Techniques to optimize auto-segmentation of small OARs in pediatric patients undergoing CSI
J. Tsui
M. Popovic
O. Ates
C. Hua
J. Schneider
S. Skamene
C. Freeman
Shirin A. Enger
2023-05-01
Radiotherapy and Oncology (published)
doi.org
PD-0505 Monte Carlo simulated correction factors of a novel phantom for brachytherapy dosimetry audits
K. Chelminski
R. Abdulrahim
A. Dimitriadis
E. Granizo-Roman
Jonathan Kalinowski
Shirin A. Enger
G. Azangwe
J. Swamidas
2023-05-01
Radiotherapy and Oncology (published)
doi.org
PD-0586 Design and assembly of a non-invasive radiation detector to measure the AIF in dynamic PET.
Liam Carroll
Y. Daoud
Shirin A. Enger
2023-05-01
Radiotherapy and Oncology (published)
doi.org
PO-1632 deep learning-based automatic segmentation of rectal tumors in endoscopy images
A. Thibodeau-Antonacci
L. Weishaupt
Aurélie Garant
C. Miller
T. Vuong
P. Nicolaï
Shirin A. Enger
2023-05-01
Radiotherapy and Oncology (published)
doi.org
PO-2166 Commissioning of new rectal applicator using electronic brachytherapy source
Nada Tomic
L. Liang
A. Esmaelbeigi
Jonathan Kalinowski
Shirin A. Enger
T. Vuong
S. Devic
2023-05-01
Radiotherapy and Oncology (published)
doi.org
PO-2225 Characterization of the RBE of various photon radiation qualities on human cancer cell lines
N. Chabaytah
J. Babik
J. Li
B. Behmand
T. Connell
M. Evans
R. Ruo
H. Bekerat
Shirin A. Enger
T. Vuong
2023-05-01
Radiotherapy and Oncology (published)
doi.org
Protective effectiveness of previous SARS-CoV-2 infection and hybrid immunity against the omicron variant and severe disease: a systematic review and meta-regression
Niklas Bobrovitz
Harriet Ware
Xiaomeng Ma
Zihan Li
Reza Hosseini
Christian Cao
Anabel Selemon
Mairead Whelan
Zahra Premji
Hanane Issa
Brianna Cheng
Laith J Abu Raddad
David Buckeridge
Maria D Van Kerkhove
Vanessa Piechotta
Melissa M Higdon
Annelies Wilder-Smith
Isabel Bergeri
Daniel R Feikin
Rahul K. Arora … (see 2 more)
Minal K Patel
Lorenzo Subissi
2023-05-01
The Lancet Infectious Diseases (published)
doi.org
Reassessing Evaluation Practices in Visual Question Answering: A Case Study on Out-of-Distribution Generalization
Aishwarya Agrawal
Ivana Kaji'c
Emanuele Bugliarello
Elnaz Davoodi
Anita Gergely
Phil Blunsom
Aida Nematzadeh
2023-05-01
Findings of the Association for Computational Linguistics: EACL 2023 (published)
doi.org
arxiv.org
RIGAA at the SBFT 2023 Tool Competition - Cyber-Physical Systems Track
Dmytro Humeniuk
Foutse Khomh
Giuliano Antoniol
Testing and verification of autonomous systems is critically important. In the context of SBFT 2023 CPS testing tool competition, we present… (see more) our tool RIGAA for generating virtual roads to test an autonomous vehicle lane keeping assist system. RIGAA combines reinforcement learning as well as evolutionary search to generate test scenarios. It has achieved the second highest final score among 5 other submitted tools.
2023-05-01
2023 IEEE/ACM International Workshop on Search-Based and Fuzz Testing (SBFT) (published)
doi.org
TCR/Chimeric Antigen Receptor (CAR) Cross-Antagonism to Fine-Tune CAR-T cell Immunotherapy
Grégoire Altan-Bonnet
Taisuke Kondo
François X. P. Bourassa
Sooraj R. Achar
Justyn DuSold
Pablo Cespedes
Madison Wahlsten
Guillaume Gaud
Paul E Love
Mike Dustin
Paul François
Naomi Taylor
Chimeric antigen receptor (CAR) T cells, are created by extracting T cells from a cancer patient, engineering them to express a CAR targetin… (see more)g a tumor specific molecule, then reintroducing them back into the patient. A patient’s T cells contain their own endogenous T cell receptors (TCRs) however, which could potentially interact with the exogenous CAR inserted into the cell. In this study, we examine how TCR and CAR signals interact upon CAR-T activation. We show that weak TCR stimulation can reduce (antagonize) or increase overall CAR-T response, both in vitro and in vivo, across multiple tumor models, in both mouse and human T cells. We further show that the behavior of these TCR/CAR interactions can be manipulated by changing various characteristics of the TCR, CAR, and associated ligands. While this behavior is complex, we show that it can be described by a single mathematical model based on the adaptive kinetic proofreading scheme of ligand discrimination. We conclude by presenting potential applications for cancer immunotherapy. Intramural Research Program of the National Cancer Institute
2023-05-01
Journal of Immunology (published)
doi.org
The study of plasticity has always been about gradients
Blake Richards
Konrad Paul Kording
2023-05-01
The Journal of Physiology (published)
doi.org