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Publications
Myeloarchitecture gradients in the human insula: Histological underpinnings and association to intrinsic functional connectivity
The problem of selecting a subset of nodes with greatest influence in a graph, commonly known as influence maximization, has been well studi… (voir plus)ed over the past decade. This problem has real world applications which can potentially affect lives of individuals. Algorithmic decision making in such domains raises concerns about their societal implications. One of these concerns, which surprisingly has only received limited attention so far, is algorithmic bias and fairness. We propose a flexible framework that extends and unifies the existing works in fairness-aware influence maximization. This framework is based on an integer programming formulation of the influence maximization problem. The fairness requirements are enforced by adding linear constraints or modifying the objective function. Contrary to the previous work which designs specific algorithms for each variant, we develop a formalism which is general enough for specifying different notions of fairness. A problem defined in this formalism can be then solved using efficient mixed integer programming solvers. The experimental evaluation indicates that our framework not only is general but also is competitive with existing algorithms.
2020-04-20
Companion Proceedings of the Web Conference 2020 (publié)
In this paper, we develop a metric designed to assess and rank uncertainty measures for the task of brain tumour sub-tissue segmentation in … (voir plus)the BraTS 2019 sub-challenge on uncertainty quantification. The metric is designed to: (1) reward uncertainty measures where high confidence is assigned to correct assertions, and where incorrect assertions are assigned low confidence and (2) penalize measures that have higher percentages of under-confident correct assertions. Here, the workings of the components of the metric are explored based on a number of popular uncertainty measures evaluated on the BraTS 2019 dataset.
We develop clustering procedures for longitudinal trajectories based on a continuous-time hidden Markov model (CTHMM) and a generalized line… (voir plus)ar observation model. Specifically in this paper, we carry out infinite mixture model-based clustering for CTHMM and achieve inference using Markov chain Monte Carlo (MCMC). Specifically, for Bayesian nonparametric inference using a Dirichlet process mixture model, we utilize restricted Gibbs sampling split-merge proposals to expedite the MCMC algorithm. We employ the proposed algorithm to the simulated data as well as a large real data example, and the results demonstrate the desired performance of the new sampler.
Establishing an evaluation metric to quantify climate change image realism
Accurate detection and segmentation of new lesional activity in longitudinal Magnetic Resonance Images (MRIs) of patients with Multiple Scle… (voir plus)rosis (MS) is important for monitoring disease activity, as well as for assessing treatment effects. In this work, we present the first deep learning framework to automatically detect and segment new and enlarging (NE) T2w lesions from longitudinal brain MRIs acquired from relapsing-remitting MS (RRMS) patients. The proposed framework is an adapted 3D U-Net [1] which includes as inputs the reference multi-modal MRI and T2-weighted lesion maps, as well an attention mechanism based on the subtraction MRI (between the two timepoints) which serves to assist the network in learning to differentiate between real anatomical change and artifactual change, while constraining the search space for small lesions. Experiments on a large, proprietary, multi -center, multi-modal, clinical trial dataset consisting of 1677 multi-modal scans illustrate that network achieves high overall detection accuracy (detection AUC=.95), outperforming (1) a U-Net without an attention mechanism (de-tection AUC=.93), (2) a framework based on subtracting independent T2-weighted segmentations (detection AUC=.57), and (3) DeepMedic (detection AUC=.84) [2], particularly for small lesions. In addition, the method was able to accurately classify patients as active/inactive with (sensitivities of. 69 and specificities of. 97).
2020-04-03
2020 IEEE 17th International Symposium on Biomedical Imaging (ISBI) (publié)
