Publications

Association Between Circulating Vitamin K Levels, Gut Microbiome, and Type 1 Diabetes: A Mendelian Randomization Study
Samuel De La Barrera
Benjamin De La Barrera
Isabel Gamache
Despoina Manousaki
Background/Objectives: Nutritional deficiencies have been proposed as possible etiological causes for autoimmune diseases, among which type … (voir plus)1 diabetes (T1D). Vitamin K (VK) has potentially positive effects on type 2 diabetes, but its role on T1D in humans remains largely unknown. We aimed to examine the presence of a causal association between VK and T1D using a Mendelian randomization (MR) approach. Methods: Genetic variants from a genome-wide association study (GWAS) for VK (N = 2138 Europeans) were used as instruments in our two-sample MR study to investigate whether circulating VK levels are causally associated with the risk of T1D in a large European T1D GWAS cohort (18,942 cases/520,580 controls). Through a multivariable MR (MVMR), the effects of both VK and specific gut microbiota on T1D were investigated given that the gut microbiome synthesizes VK. Results: We found that changes in levels of circulating VK did not affect T1D risk in our univariate two-sample MR, but this study had limited power to detect small effects of VK (OR for T1D of less than 0.8). However, our MVMR indicated a suggestive association of VK with the risk of T1D adjusting for two different gut microbiome populations. Conclusions: In conclusion, VK levels are unlikely to significantly affect the risk of T1D, but small effects cannot be excluded, and the role of gut microbiome in this association should be further investigated.
Community-based reconstruction and simulation of a full-scale model of the rat hippocampus CA1 region
Armando Romani
Alberto Antonietti
Davide Bella
Julian Budd
Elisabetta Giacalone
Kerem Kurban
Sára Sáray
Marwan Abdellah
Alexis Arnaudon
Elvis Boci
Cristina Colangelo
Jean-Denis Courcol
Thomas Delemontex
András Ecker
Joanne Falck
Cyrille Favreau
Michael Gevaert
Juan B. Hernando
Joni Herttuainen
Genrich Ivaska … (voir 28 de plus)
Lida Kanari
Anna-Kristin Kaufmann
James Gonzalo King
Pramod Kumbhar
Sigrun Lange
Huanxiang Lu
Carmen Alina Lupascu
Rosanna Migliore
Fabien Petitjean
Judit Planas
Pranav Rai
Srikanth Ramaswamy
Michael W. Reimann
Juan Luis Riquelme
Nadir Román Guerrero
Ying Shi
Vishal Sood
Mohameth François Sy
Werner Van Geit
Liesbeth Vanherpe
Tamás F. Freund
Audrey Mercer
Felix Schürmann
Alex M. Thomson
Michele Migliore
Szabolcs Káli
Henry Markram
The CA1 region of the hippocampus is one of the most studied regions of the rodent brain, thought to play an important role in cognitive fun… (voir plus)ctions such as memory and spatial navigation. Despite a wealth of experimental data on its structure and function, it has been challenging to integrate information obtained from diverse experimental approaches. To address this challenge, we present a community-based, full-scale in silico model of the rat CA1 that integrates a broad range of experimental data, from synapse to network, including the reconstruction of its principal afferents, the Schaffer collaterals, and a model of the effects that acetylcholine has on the system. We tested and validated each model component and the final network model, and made input data, assumptions, and strategies explicit and transparent. The unique flexibility of the model allows scientists to potentially address a range of scientific questions. In this article, we describe the methods used to set up simulations to reproduce in vitro and in vivo experiments. Among several applications in the article, we focus on theta rhythm, a prominent hippocampal oscillation associated with various behavioral correlates and use our computer model to reproduce experimental findings. Finally, we make data, code, and model available through the hippocampushub.eu portal, which also provides an extensive set of analyses of the model and a user-friendly interface to facilitate adoption and usage. This community-based model represents a valuable tool for integrating diverse experimental data and provides a foundation for further research into the complex workings of the hippocampal CA1 region.
Evaluating Generative AI Systems is a Social Science Measurement Challenge
Hanna Wallach
Meera Desai
Nicholas Pangakis
A. Feder Cooper
Angelina Wang
Solon Barocas
Alexandra Chouldechova
Chad Atalla
Emily Corvi
P. A. Dow
Jean Garcia-Gathright
A.R. Olteanu
Stefanie Reed
Emily Sheng
Dan Vann
Jennifer Wortman Vaughan
Matthew Vogel
Hannah Washington
Abigail Z. Jacobs … (voir 1 de plus)
Microsoft Research
Across academia, industry, and government, there is an increasing awareness that the measurement tasks involved in evaluating generative AI … (voir plus)(GenAI) systems are especially difficult. We argue that these measurement tasks are highly reminiscent of measurement tasks found throughout the social sciences. With this in mind, we present a framework, grounded in measurement theory from the social sciences, for measuring concepts related to the capabilities, impacts, opportunities, and risks of GenAI systems. The framework distinguishes between four levels: the background concept, the systematized concept, the measurement instrument(s), and the instance-level measurements themselves. This four-level approach differs from the way measurement is typically done in ML, where researchers and practitioners appear to jump straight from background concepts to measurement instruments, with little to no explicit systematization in between. As well as surfacing assumptions, thereby making it easier to understand exactly what the resulting measurements do and do not mean, this framework has two important implications for evaluating evaluations: First, it can enable stakeholders from different worlds to participate in conceptual debates, broadening the expertise involved in evaluating GenAI systems. Second, it brings rigor to operational debates by offering a set of lenses for interrogating the validity of measurement instruments and their resulting measurements.
Evaluating the effectiveness of the Smart About Meds (SAM) mobile application among patients discharged from hospital: protocol of a randomised controlled trial
Robyn Tamblyn
Bettina Habib
David L Buckeridge
Daniala L Weir
Elizaveta Frolova
Rolan Alattar
Jessica Rogozinsky
Caroline Beauchamp
Rosalba Pupo
Susan J Bartlett
Emily McDonald
NCT05371548.
GitChameleon: Unmasking the Version-Switching Capabilities of Code Generation Models
Eilif Benjamin Muller
Terry Yue Zhuo
Massimo Caccia
Imagining and building wise machines: The centrality of AI metacognition
Samuel G. B. Johnson
Amir-Hossein Karimi
Nick Chater
Tobias Gerstenberg
Kate Larson
Sydney Levine
Melanie Mitchell
Iyad Rahwan
Bernhard Schölkopf
Igor Grossmann
Impact of LLM-based Review Comment Generation in Practice: A Mixed Open-/Closed-source User Study
Doriane Olewicki
Leuson Da Silva
Suhaib Mujahid
Arezou Amini
Benjamin Mah
Marco Castelluccio
Sarra Habchi
Bram Adams
Inhibition of the inferior parietal lobe triggers state-dependent network adaptations
Kathleen A. Williams
Ole Numssen
Juan David Guerra
Gesa Hartwigsen
The human brain comprises large-scale networks that flexibly interact to support diverse cognitive functions and adapt to variability in dai… (voir plus)ly life. The inferior parietal lobe (IPL) is a hub of multiple brain networks that sustain various cognitive domains. It remains unclear how networks respond to acute regional perturbations to maintain normal function. To provoke network-level adaptive responses to local inhibition, we combined offline transcranial magnetic stimulation (TMS) over left or right IPL with neuroimaging during attention, semantic and social cognition tasks, and rest. Across tasks, TMS specifically affected task-active network activity with inhibition and facilitation. Network interaction responses differed between rest and tasks. After TMS over both IPL regions, large-scale network interactions were exclusively facilitated at rest, but mainly inhibited during tasks. Overall, responses to TMS primarily occurred in and between domain-general default mode and frontoparietal subnetworks. These findings elucidate short-term adaptive plasticity in response to network node inhibition.
PP259 Topic: AS25–Sedation/Analgesia/Delirium/Withdrawal Syndrome/Other: PSYCHOMOTOR AGITATION DETECTION USING DEEP LEARNING
S. Dastani
A. Harakeh
A. Wiedemann
Philippe Jouvet
S. Ebrahimi Kahou
Predictive Modeling of Body Image Dissatisfaction in People With Type 1 Diabetes
COURTNEY SOUTH
SHAHRYAR EBRAHIMI
ANNE-SOPHIE BRAZEAU
Soft Condorcet Optimization for Ranking of General Agents
Marc Lanctot
Kate Larson
Michael Kaisers
Quentin Berthet
Ian Gemp
Manfred Diaz
Roberto-Rafael Maura-Rivero
Yoram Bachrach
Anna Koop
A common way to drive progress of AI models and agents is to compare their performance on standardized benchmarks. Comparing the performance… (voir plus) of general agents requires aggregating their individual performances across a potentially wide variety of different tasks. In this paper, we describe a novel ranking scheme inspired by social choice frameworks, called Soft Condorcet Optimization (SCO), to compute the optimal ranking of agents: the one that makes the fewest mistakes in predicting the agent comparisons in the evaluation data. This optimal ranking is the maximum likelihood estimate when evaluation data (which we view as votes) are interpreted as noisy samples from a ground truth ranking, a solution to Condorcet's original voting system criteria. SCO ratings are maximal for Condorcet winners when they exist, which we show is not necessarily true for the classical rating system Elo. We propose three optimization algorithms to compute SCO ratings and evaluate their empirical performance. When serving as an approximation to the Kemeny-Young voting method, SCO rankings are on average 0 to 0.043 away from the optimal ranking in normalized Kendall-tau distance across 865 preference profiles from the PrefLib open ranking archive. In a simulated noisy tournament setting, SCO achieves accurate approximations to the ground truth ranking and the best among several baselines when 59\% or more of the preference data is missing. Finally, SCO ranking provides the best approximation to the optimal ranking, measured on held-out test sets, in a problem containing 52,958 human players across 31,049 games of the classic seven-player game of Diplomacy.
SpeechBrain-MOABB: An open-source Python library for benchmarking deep neural networks applied to EEG signals