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Guillaume Huguet

Doctorat - UdeM
Superviseur⋅e principal⋅e
Guy Wolf
Sujets de recherche
Apprentissage spectral
Biologie computationnelle
Modèles génératifs
Google Scholar
GitHub

Publications

THE EFFECT SIZE OF GENES ON COGNITIVE ABILITIES IS LINKED TO THEIR EXPRESSION ALONG THE MAJOR HIERARCHICAL GRADIENT IN THE HUMAN BRAIN
Sébastien Jacquemont
Guillaume Huguet
Elise Douard
Zohra Saci
Guillaume Dumas
Laura Almasy
David C. Glahn
2021-10-01
European Neuropsychopharmacology (publié)
doi.org
Embedding Signals on Knowledge Graphs with Unbalanced Diffusion Earth Mover's Distance
Alexander Tong
Guillaume Huguet
Dennis Shung
Amine Natik
Manik Kuchroo
Guillaume Lajoie
Guy Wolf
Smita Krishnaswamy
In modern relational machine learning it is common to encounter large graphs that arise via interactions or similarities between observation… (voir plus)s in many domains. Further
2021-01-01
arXiv.org (prépublication)
dblp.uni-trier.de
Embedding Signals on Knowledge Graphs with Unbalanced Diffusion Earth Mover's Distance
Alexander Tong
Guillaume Huguet
Dennis L. Shung
Amine Natik
Manik Kuchroo
Guillaume Lajoie
Guy Wolf
Smita Krishnaswamy
In modern relational machine learning it is common to encounter large graphs that arise via interactions or similarities between observation… (voir plus)s in many domains. Further
2021-01-01
arXiv.org (preprint)
dblp.uni-trier.de
Mutations associated with neuropsychiatric conditions delineate functional brain connectivity dimensions contributing to autism and schizophrenia
Clara A. Moreau
Sebastian G. W. Urchs
Kumar Kuldeep
Pierre Orban
Catherine Schramm
Guillaume Dumas
Aurélie Labbe
Guillaume Huguet
Elise Douard
Pierre-Olivier Quirion
Amy Lin
Leila Kushan
Stephanie Grot
David Luck
Adrianna Mendrek
Stephane Potvin
Emmanuel Stip
Thomas Bourgeron
Alan C. Evans
Carrie E. Bearden … (voir 2 de plus)
Lune Bellec
Sébastien Jacquemont
2020-10-19
Nature Communications (publié)
doi.org
General Principles of Gene Dosage Effects on Brain Structure
Claudia Modenato
Kuldeep Kumar
Clara A. Moreau
Catherine Schramm
Guillaume Huguet
Sandra Martin-Brevet
Aurélie Pain
Anne M. Maillard
Sonia Richetin
Borja Rodriguez-Herreros
Lester Melie-Garcia
Ana Dos Santos Silva
Marianne B.M. van den Bree
David E.J. Linden
Carrie E. Bearden
Danilo Bzdok
Sarah Lippé
Mallar Chakravarty
Bogdan Draganski
Sébastien Jacquemont
2020-05-01
Biological Psychiatry (publié)
doi.org
Neuropsychiatric copy number variants exert shared effects on human brain structure
Claudia Modenato
Kuldeep Kumar
Clara A. Moreau
Sandra Martin-Brevet
Guillaume Huguet
Catherine Schramm
Jean-Louis Martineau
Charles-Olivier Martin
C.O. Martin
Nadine Younis
Petra Tamer
Elise Douard
Fanny Thébault-Dagher
Valérie Côté
Audrey-Rose Charlebois
Florence Deguire
Anne M. Maillard
Borja Rodriguez-Herreros
Aurélie Pain
Sonia Richetin … (voir 15 de plus)
16p11.2 European Consortium
Simons Variation in Individuals Project Consortium
Ana I. Silva
Leila Kushan
Lester Melie-Garcia
Marianne B.M. van den Bree
David E.J. Linden
M. J. Owen
Jeremy Hall
Sarah Lippé
Mallar Chakravarty
Danilo Bzdok
Carrie E. Bearden
Bogdan Draganski
Sébastien Jacquemont
2020-04-17
medRxiv (prépublication)
doi.org
Neuropsychiatric mutations delineate functional brain connectivity dimensions contributing to autism and schizophrenia
Clara A. Moreau
Sebastian Urchs
Pierre Orban
Catherine Schramm
Guillaume Dumas
Aurélie Labbe
Guillaume Huguet
Elise Douard
Pierre-Olivier Quirion
Amy Lin
Leila Kushan
Stephanie Grot
David Luck
Adrianna Mendrek
Stephane Potvin
Emmanuel Stip
Thomas Bourgeron
Alan C. Evans
Carrie E. Bearden
Lune Bellec … (voir 1 de plus)
Sébastien Jacquemont
16p11.2 and 22q11.2 Copy Number Variants (CNVs) confer high risk for Autism Spectrum Disorder (ASD), schizophrenia (SZ), and Attention-Defic… (voir plus)it-Hyperactivity-Disorder (ADHD), but their impact on functional connectivity (FC) remains unclear. We analyzed resting-state functional magnetic resonance imaging data from 101 CNV carriers, 755 individuals with idiopathic ASD, SZ, or ADHD and 1,072 controls. We used CNV FC-signatures to identify dimensions contributing to complex idiopathic conditions. CNVs had large mirror effects on FC at the global and regional level. Thalamus, somatomotor, and posterior insula regions played a critical role in dysconnectivity shared across deletions, duplications, idiopathic ASD, SZ but not ADHD. Individuals with higher similarity to deletion FC-signatures exhibited worse cognitive and behavioral symptoms. Deletion similarities identified at the connectivity level could be related to the redundant associations observed genome-wide between gene expression spatial patterns and FC-signatures. Results may explain why many CNVs affect a similar range of neuropsychiatric symptoms.
2019-12-06
bioRxiv (prépublication)
doi.org