Learn how to leverage generative AI to support and improve your productivity at work. The next cohort will take place online on April 28 and 30, 2026, in French.
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Discrete audio tokens have recently gained considerable attention for their potential to connect audio and language processing, enabling the… (see more) creation of modern multimodal large language models. Ideal audio tokens must effectively preserve phonetic and semantic content along with paralinguistic information, speaker identity, and other details. While several types of audio tokens have been recently proposed, identifying the optimal tokenizer for various tasks is challenging due to the inconsistent evaluation settings in existing studies. To address this gap, we release the Discrete Audio and Speech Benchmark (DASB), a comprehensive leaderboard for benchmarking discrete audio tokens across a wide range of discriminative tasks, including speech recognition, speaker identification and verification, emotion recognition, keyword spotting, and intent classification, as well as generative tasks such as speech enhancement, separation, and text-to-speech. Our results show that, on average, semantic tokens outperform compression tokens across most discriminative and generative tasks. However, the performance gap between semantic tokens and standard continuous representations remains substantial, highlighting the need for further research in this field.
Advances in medical imaging technologies have enabled the collection of longitudinal images, which involve repeated scanning of the same pat… (see more)ients over time, to monitor disease progression. However, predictive modeling of such data remains challenging due to high dimensionality, irregular sampling, and data sparsity. To address these issues, we propose ImageFlowNet, a novel model designed to forecast disease trajectories from initial images while preserving spatial details. ImageFlowNet first learns multiscale joint representation spaces across patients and time points, then optimizes deterministic or stochastic flow fields within these spaces using a position-parameterized neural ODE/SDE framework. The model leverages a UNet architecture to create robust multiscale representations and mitigates data scarcity by combining knowledge from all patients. We provide theoretical insights that support our formulation of ODEs, and motivate our regularizations involving high-level visual features, latent space organization, and trajectory smoothness. We validate ImageFlowNet on three longitudinal medical image datasets depicting progression in geographic atrophy, multiple sclerosis, and glioblastoma, demonstrating its ability to effectively forecast disease progression and outperform existing methods. Our contributions include the development of ImageFlowNet, its theoretical underpinnings, and empirical validation on real-world datasets. The official implementation is available at https://github.com/KrishnaswamyLab/ImageFlowNet.
Large Language Models (LLMs) have demonstrated superior performance in language understanding benchmarks. A recent use case for LLMs involve… (see more)s training decision-making agents over textual information. The existing approach leverages LLM's linguistic priors for action candidate recommendations in text games, i.e., to operate without environment-provided actions. However, adapting LLMs to specific games/tasks requires a massive amount of annotated human gameplay. Moreover, in the existing approach, the language model was kept frozen during an agent's training process, which limits learning from in-game knowledge about the world. Hence, we explore strategies to adapt the language model for candidate recommendation with in-game transition in an online learning fashion to mitigate reliance on human-annotated gameplays, which are costly to acquire. In this paper, we propose in-game transition selection methods to adapt the LLM in the loop, reducing the dependency on using human-annotated gameplays while improving performance and convergence. Our method demonstrates a 53% relative improvement in average game score over the previous state-of-the-art model, achieving more than twice the convergence rate in a full-annotated dataset setting. Furthermore, even with only 10% of human annotation, we surpassed the 100\% state-of-the-art performance benchmark.
Large Language Models (LLMs) have become increasingly capable of handling diverse tasks with the aid of well-crafted prompts and integration… (see more) of external tools, but as task complexity rises, the workflow involving LLMs can be complicated and thus challenging to implement and maintain. To address this challenge, we propose APPL, A Prompt Programming Language that acts as a bridge between computer programs and LLMs, allowing seamless embedding of prompts into Python functions, and vice versa. APPL provides an intuitive and Python-native syntax, an efficient parallelized runtime with asynchronous semantics, and a tracing module supporting effective failure diagnosis and replaying without extra costs. We demonstrate that APPL programs are intuitive, concise, and efficient through three representative scenarios: Chain-of-Thought with self-consistency (CoT-SC), ReAct tool use agent, and multi-agent chat. Experiments on three parallelizable workflows further show that APPL can effectively parallelize independent LLM calls, with a significant speedup ratio that almost matches the estimation.
GAPS phase II: development and pilot results of the global assessment in pediatric surgery, an evidence-based pediatric surgical capacity assessment tool for low-resource settings.
Biological neural networks operate in parallel, a feature that sets them apart from artificial neural networks and can significantly enhance… (see more) inference speed. However, this parallelism introduces challenges: when each neuron operates asynchronously with a fixed execution time, an
Realtime environments change even as agents perform action inference and learning, thus requiring high interaction frequencies to effectivel… (see more)y minimize long-term regret. However, recent advances in machine learning involve larger neural networks with longer inference times, raising questions about their applicability in realtime systems where reaction time is crucial. We present an analysis of lower bounds on regret in realtime environments to show that minimizing long-term regret is generally impossible within the typical sequential interaction and learning paradigm, but often becomes possible when sufficient asynchronous compute is available. We propose novel algorithms for staggering asynchronous inference processes to ensure that actions are taken at consistent time intervals, and demonstrate that
use of models with high action inference times is only constrained by the environment's effective stochasticity over the inference horizon, and not by action frequency. Our analysis shows that the number of inference processes needed scales linearly with increasing inference times while enabling use of models that are multiple orders of magnitude larger than existing approaches when learning from a realtime simulation of Game Boy games such as Pokemon and Tetris.
Large Language Models (LLMs) are not only resource-intensive to train but even more costly to deploy in production. Therefore, recent work h… (see more)as attempted to prune blocks of LLMs based on cheap proxies for estimating block importance, effectively removing 10% of blocks in well-trained LLaMa-2 and Mistral 7b models without any significant degradation of downstream metrics. In this paper, we explore different block importance metrics by considering adaptive metrics such as Shapley value in addition to static ones explored in prior work. We show that *adaptive metrics exhibit a trade-off in performance between tasks i.e., improvement on one task may degrade performance on the other due to differences in the computed block influences*. Furthermore, we extend this analysis from a complete block to individual self-attention and feed-forward layers, highlighting the propensity of the self-attention layers to be more amendable to pruning, even allowing ***removal of upto 33% of the self-attention layers without incurring any performance degradation on MMLU for Mistral 7b*** (significant reduction in costly maintenance of KV-cache). Finally, we look at simple performance recovery techniques to emulate the pruned layers by training lightweight additive bias or low-rank linear adapters. *Performance recovery using emulated updates avoids performance degradation for the initial blocks (up to 5% absolute improvement on MMLU)*, which is either competitive or superior to the learning-based technique.
Understanding complex interactions in biomedical networks is crucial for advancements in biomedicine, but traditional link prediction (LP) m… (see more)ethods are limited in capturing this complexity. Representation-based learning techniques improve prediction accuracy by mapping nodes to low-dimensional embeddings, yet they often struggle with interpretability and scalability. We present BioPathNet, a novel graph neural network framework based on the Neural Bellman-Ford Network (NBFNet), addressing these limitations through path-based reasoning for LP in biomedical knowledge graphs. Unlike node-embedding frameworks, BioPathNet learns representations between node pairs by considering all relations along paths, enhancing prediction accuracy and interpretability. This allows visualization of influential paths and facilitates biological validation. BioPathNet leverages a background regulatory graph (BRG) for enhanced message passing and uses stringent negative sampling to improve precision. In evaluations across various LP tasks, such as gene function annotation, drug-disease indication, synthetic lethality, and lncRNA-mRNA interaction prediction, BioPathNet consistently outperformed shallow node embedding methods, relational graph neural networks and task-specific state-of-the-art methods, demonstrating robust performance and versatility. Our study predicts novel drug indications for diseases like acute lymphoblastic leukemia (ALL) and Alzheimer’s, validated by medical experts and clinical trials. We also identified new synthetic lethality gene pairs and regulatory interactions involving lncRNAs and target genes, confirmed through literature reviews. BioPathNet’s interpretability will enable researchers to trace prediction paths and gain molecular insights, making it a valuable tool for drug discovery, personalized medicine and biology in general.
A major challenge as we move towards building agents for real-world problems, which could involve a massive number of human and/or machine a… (see more)gents, is that we must learn to reason about the behavior of these many other agents. In this paper, we consider the problem of scaling a predictive Theory of Mind (ToM) model to a very large number of interacting agents with a fixed computational budget. Motivated by the limited diversity of agent types, existing approaches to scalable TOM learn versatile single-agent representations for quickly adapting to new agents encountered sequentially. We consider the more general setting that many agents are observed in parallel and formulate the corresponding Theory of Many Minds (ToMM) problem of estimating the joint policy. We frame the scaling behavior of solutions in terms of parameter sharing schemes and in particular propose two parameter-free architectural features that endow models with the ability to exploit action correlations: encoding a multi-agent context, and decoding through an abstracted joint action space. The increased predictive capabilities that have come with foundation models have made it easier to imagine the possibility of using these models to make simulations that imitate the behavior of many agents within complex real-world systems. Being able to perform these simulations in a general-purpose way would not only help make more capable agents, it also would be a very useful capability for applications in social science, political science, and economics.