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Milo Sobral

milo.sobral@mila.quebec
Développeur logiciel, Neuro-AI, Solutions IA et Technologie

Publications

Personalizing brain stimulation: continual learning for sleep spindle detection
Milo Sobral
Hugo R Jourde
S Ehsan M Bajestani
Emily B J Coffey
Giovanni Beltrame
Objective. Personalized stimulation, in which algorithms used to detect neural events adapt to a user’s unique neural characteristics, may… (voir plus) be crucial to enable optimized and consistent stimulation quality for both fundamental research and clinical applications. Precise stimulation of sleep spindles-transient patterns of brain activity that occur during non rapid eye movement sleep that are involved in memory consolidation-presents an exciting frontier for studying memory functions; however, this endeavour is challenged by the spindles’ fleeting nature, inter-individual variability, and the necessity of real-time detection. Approach. We tackle these challenges using a novel continual learning framework. Using a pre-trained model capable of both online classification of sleep stages and spindle detection, we implement an algorithm that refines spindle detection, tailoring it to the individual throughout one or more nights without manual intervention. Main results. Our methodology achieves accurate, subject-specific targeting of sleep spindles and enables advanced closed-loop stimulation studies. While fine-tuning alone offers minimal benefits for single nights, our approach combining weight averaging demonstrates significant improvement over multiple nights, effectively mitigating catastrophic forgetting. Significance. This work represents an important step towards signal-level personalization of brain stimulation that can be applied to different brain stimulation paradigms including closed-loop brain stimulation, and to different neural events. Applications in fundamental neuroscience may enhance the investigative potential of brain stimulation to understand cognitive processes such as the role of sleep spindles in memory consolidation, and may lead to novel therapeutic applications.
2025-07-02
Journal of Neural Engineering (publié)
doi.org
Neurophysiological effects of targeting sleep spindles with closed-loop auditory stimulation
Hugo R Jourde
Milo Sobral
Giovanni Beltrame
Emily B J Coffey
Sleep spindles are neural events unique to nonrapid eye movement sleep that play key roles in memory reactivation and consolidation. However… (voir plus), much of the evidence for their function remains correlational rather than causal. Closed-loop brain stimulation uses real-time monitoring of neural events (often via electroencephalography; EEG) to deliver precise auditory, magnetic, or electrical stimulation for research or therapeutic purposes. Automated online algorithms to detect and stimulate sleep spindles have recently been validated, but the time- and frequency-resolved physiological responses generated by them have not yet been documented. Building on the recent findings that sleep spindles do not block the transmission of sound to cortex, the present work investigates the neurophysiological responses to closed-loop auditory stimulation of sleep spindles. EEG data were collected from 10 healthy human adults (6 nights each), whilst sleep spindles were detected and in half the nights, targeted with auditory stimulation. Spindles were successfully stimulated before their offset in 97.6% of detections and did not disturb sleep. Comparing stimulation with sham, we observed that stimulation resulted in increased sigma activity (11–16 Hz) at about 1 second poststimulation but that stimulation occurring at the beginning of the spindle also resulted in early termination of the spindle. Finally, we observed that stimulating an evoked spindle did not elicit additional sigma activity. Our results validate the use of closed-loop auditory stimulation targeting sleep spindles, and document its neural effects, as a basis for future causal investigations concerning spindles’ roles in memory consolidation.
2025-03-31
Sleep Advances (publié)
doi.org