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Armand Collin

Doctorat - Polytechnique
Superviseur⋅e principal⋅e
Julien Cohen-Adad
Sujets de recherche
Apprentissage automatique médical
Apprentissage profond
Biologie computationnelle
Photographie computationnelle
Vision par ordinateur
GitHub

Publications

Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, plasticity, and density of resident glial cells
Hooman Bagheri
Hana Friedman
Amanda Hadwen
Celia Jarweh
Ellis Cooper
Lawrence Oprea
Claire Guerrier
Anmar Khadra
Armand Collin
Julien Cohen-Adad
Amanda Young
Gerardo Mendez Victoriano
Matthew Swire
Andrew Jarjour
Marie E. Bechler
Rachel S. Pryce
Pierre Chaurand
Lise Cougnaud
Dajana Vuckovic
Elliott Wilion … (voir 11 de plus)
Owen Greene
Akiko Nishiyama
Anouk Benmamar‐Badel
Trevor Owens
Vladimir Grouza
Marius Tuznik
Hanwen Liu
David A. Rudko
Jinyi Zhang
Katherine A. Siminovitch
Alan C. Peterson
Abstract Myelin Basic Protein (MBP) is essential for both elaboration and maintenance of CNS myelin, and its reduced accumulation results in… (voir plus) hypomyelination. How different Mbp mRNA levels affect myelin dimensions across the lifespan and how resident glial cells may respond to such changes are unknown. Here, to investigate these questions, we used enhancer‐edited mouse lines that accumulate Mbp mRNA levels ranging from 8% to 160% of wild type. In young mice, reduced Mbp mRNA levels resulted in corresponding decreases in Mbp protein accumulation and myelin sheath thickness, confirming the previously demonstrated rate‐limiting role of Mbp transcription in the control of initial myelin synthesis. However, despite maintaining lower line specific Mbp mRNA levels into old age, both MBP protein levels and myelin thickness improved or fully normalized at rates defined by the relative Mbp mRNA level. Sheath length, in contrast, was affected only when mRNA levels were very low, demonstrating that sheath thickness and length are not equally coupled to Mbp mRNA level. Striking abnormalities in sheath structure also emerged with reduced mRNA levels. Unexpectedly, an increase in the density of all glial cell types arose in response to reduced Mbp mRNA levels. This investigation extends understanding of the role MBP plays in myelin sheath elaboration, architecture, and plasticity across the mouse lifespan and illuminates a novel axis of glial cell crosstalk.
2024-07-18
Glia (publié)
doi.org
Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, plasticity, and density of resident glial cells
Hooman Bagheri
Hana Friedman
Amanda Hadwen
Celia Jarweh
Ellis Cooper
Lawrence Oprea
Claire Guerrier
Anmar Khadra
Armand Collin
Julien Cohen-Adad
Amanda Young
Gerardo Mendez Victoriano
Matthew Swire
Andrew Jarjour
Marie E. Bechler
Rachel S. Pryce
Pierre Chaurand
Lise Cougnaud
Dajana Vuckovic
Elliott Wilion … (voir 11 de plus)
Owen Greene
Akiko Nishiyama
Anouk Benmamar‐Badel
Trevor Owens
Vladimir Grouza
Marius Tuznik
Hanwen Liu
David A. Rudko
Jinyi Zhang
Katherine A. Siminovitch
Alan C. Peterson
2024-07-18
Glia (publié)
doi.org
Myelin basic protein mRNA levels affect myelin sheath dimensions, architecture, plasticity, and density of resident glial cells
Hooman Bagheri
Hana Friedman
Amanda Hadwen
Celia Jarweh
Ellis Cooper
Lawrence Oprea
Claire Guerrier
Anmar Khadra
Armand Collin
Julien Cohen-Adad
Amanda Young
Gerardo Mendez Victoriano
Matthew Swire
Andrew Jarjour
Marie E. Bechler
Rachel S. Pryce
Pierre Chaurand
Lise Cougnaud
Dajana Vuckovic
Elliott Wilion … (voir 11 de plus)
Owen Greene
Akiko Nishiyama
Anouk Benmamar‐Badel
Trevor Owens
Vladimir Grouza
Marius Tuznik
Hanwen Liu
David A. Rudko
Jinyi Zhang
Katherine A. Siminovitch
Alan C. Peterson
Abstract Myelin Basic Protein (MBP) is essential for both elaboration and maintenance of CNS myelin, and its reduced accumulation results in… (voir plus) hypomyelination. How different Mbp mRNA levels affect myelin dimensions across the lifespan and how resident glial cells may respond to such changes are unknown. Here, to investigate these questions, we used enhancer‐edited mouse lines that accumulate Mbp mRNA levels ranging from 8% to 160% of wild type. In young mice, reduced Mbp mRNA levels resulted in corresponding decreases in Mbp protein accumulation and myelin sheath thickness, confirming the previously demonstrated rate‐limiting role of Mbp transcription in the control of initial myelin synthesis. However, despite maintaining lower line specific Mbp mRNA levels into old age, both MBP protein levels and myelin thickness improved or fully normalized at rates defined by the relative Mbp mRNA level. Sheath length, in contrast, was affected only when mRNA levels were very low, demonstrating that sheath thickness and length are not equally coupled to Mbp mRNA level. Striking abnormalities in sheath structure also emerged with reduced mRNA levels. Unexpectedly, an increase in the density of all glial cell types arose in response to reduced Mbp mRNA levels. This investigation extends understanding of the role MBP plays in myelin sheath elaboration, architecture, and plasticity across the mouse lifespan and illuminates a novel axis of glial cell crosstalk.
2024-07-18
Glia (publié)
doi.org