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How can neural networks learn the rich internal representations required for difficult tasks such as recognizing objects or understanding la… (see more)nguage?
Brain-imaging research enjoys increasing adoption of supervised machine learning for singlesubject disease classification. Yet, the success … (see more)of these algorithms likely depends on population diversity, including demographic differences and other factors that may be outside of primary scientific interest. Here, we capitalize on propensity scores as a composite confound index to quantify diversity due to major sources of population stratification. We delineate the impact of population heterogeneity on the predictive accuracy and pattern stability in two separate clinical cohorts: the Autism Brain Imaging Data Exchange (ABIDE, n=297) and the Healthy Brain Network (HBN, n=551). Across various analysis scenarios, our results uncover the extent to which cross-validated prediction performances are interlocked with diversity. The instability of extracted brain patterns attributable to diversity is located preferentially to the default mode network. Our collective findings highlight the limitations of prevailing deconfounding practices in mitigating the full consequences of population diversity.
Recent work has shown that Continuous Normalizing Flows (CNFs) can serve as generative models of images with exact likelihood calculation an… (see more)d invertible generation/density estimation. In this work we introduce a Multi-Resolution variant of such models (MRCNF). We introduce a transformation between resolutions that allows for no change in the log likelihood. We show that this approach yields comparable likelihood values for various image datasets, with improved performance at higher resolutions, with fewer parameters, using only 1 GPU.
Learning the causal structure that underlies data is a crucial step towards robust real-world decision making. The majority of existing work… (see more) in causal inference focuses on determining a single directed acyclic graph (DAG) or a Markov equivalence class thereof. However, a crucial aspect to acting intelligently upon the knowledge about causal structure which has been inferred from finite data demands reasoning about its uncertainty. For instance, planning interventions to find out more about the causal mechanisms that govern our data requires quantifying epistemic uncertainty over DAGs. While Bayesian causal inference allows to do so, the posterior over DAGs becomes intractable even for a small number of variables. Aiming to overcome this issue, we propose a form of variational inference over the graphs of Structural Causal Models (SCMs). To this end, we introduce a parametric variational family modelled by an autoregressive distribution over the space of discrete DAGs. Its number of parameters does not grow exponentially with the number of variables and can be tractably learned by maximising an Evidence Lower Bound (ELBO). In our experiments, we demonstrate that the proposed variational posterior is able to provide a good approximation of the true posterior.
SpeechBrain is an open-source and all-in-one speech toolkit. It is designed to facilitate the research and development of neural speech proc… (see more)essing technologies by being simple, flexible, user-friendly, and well-documented. This paper describes the core architecture designed to support several tasks of common interest, allowing users to naturally conceive, compare and share novel speech processing pipelines. SpeechBrain achieves competitive or state-of-the-art performance in a wide range of speech benchmarks. It also provides training recipes, pretrained models, and inference scripts for popular speech datasets, as well as tutorials which allow anyone with basic Python proficiency to familiarize themselves with speech technologies.
Many natural systems, especially biological ones, exhibit complex multivariate nonlinear dynamical behaviors that can be hard to capture by … (see more)linear autoregressive models. On the other hand, generic nonlinear models such as deep recurrent neural networks often require large amounts of training data, not always available in domains such as brain imaging; also, they often lack interpretability. Domain knowledge about the types of dynamics typically observed in such systems, such as a certain type of dynamical systems models, could complement purely data-driven techniques by providing a good prior. In this work, we consider a class of ordinary differential equation (ODE) models known as van der Pol (VDP) oscil lators and evaluate their ability to capture a low-dimensional representation of neural activity measured by different brain imaging modalities, such as calcium imaging (CaI) and fMRI, in different living organisms: larval zebrafish, rat, and human. We develop a novel and efficient approach to the nontrivial problem of parameters estimation for a network of coupled dynamical systems from multivariate data and demonstrate that the resulting VDP models are both accurate and interpretable, as VDP's coupling matrix reveals anatomically meaningful excitatory and inhibitory interactions across different brain subsystems. VDP outperforms linear autoregressive models (VAR) in terms of both the data fit accuracy and the quality of insight provided by the coupling matrices and often tends to generalize better to unseen data when predicting future brain activity, being comparable to and sometimes better than the recurrent neural networks (LSTMs). Finally, we demonstrate that our (generative) VDP model can also serve as a data-augmentation tool leading to marked improvements in predictive accuracy of recurrent neural networks. Thus, our work contributes to both basic and applied dimensions of neuroimaging: gaining scientific insights and improving brain-based predictive models, an area of potentially high practical importance in clinical diagnosis and neurotechnology.
In hospitals, data are siloed to specific information systems that make the same information available under different modalities such as th… (see more)e different medical imaging exams the patient undergoes (CT scans, MRI, PET, Ultrasound, etc.) and their associated radiology reports. This offers unique opportunities to obtain and use at train-time those multiple views of the same information that might not always be available at test-time.In this paper, we propose an innovative framework that makes the most of available data by learning good representations of a multi-modal input that are resilient to modality dropping at test-time, using recent advances in mutual information maximization. By maximizing cross-modal information at train time, we are able to outperform several state-of-the-art baselines in two different settings, medical image classification, and segmentation. In particular, our method is shown to have a strong impact on the inference-time performance of weaker modalities.
2021-06-05
IEEE International Conference on Acoustics, Speech, and Signal Processing (published)
In this paper, we analyze and extend an online learning frame-work known as Context-Attentive Bandit, motivated by various practical applica… (see more)tions, from medical diagnosis to dialog systems, where due to observation costs only a small subset of a potentially large number of context variables can be observed at each iteration; however, the agent has a freedom to choose which variables to observe. We derive a novel algorithm, called Context-Attentive Thompson Sampling (CATS), which builds upon the Linear Thompson Sampling approach, adapting it to Context-Attentive Bandit setting. We provide a theoretical regret analysis and an extensive empirical evaluation demonstrating advantages of the proposed approach over several baseline methods on a variety of real-life datasets.
2021-06-05
ICASSP 2021 - 2021 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP) (published)