Proactive Contact Tracing
Prateek Gupta
Martin Weiss
Nasim Rahaman
Hannah Alsdurf
Nanor Minoyan
Soren Harnois-Leblanc
Joanna Merckx
andrew williams
Victor Schmidt
Pierre-Luc St-Charles
Akshay Patel
Yang Zhang
David L Buckeridge
Bernhard Schölkopf
The COVID-19 pandemic has spurred an unprecedented demand for interventions that can reduce disease spread without excessively restricting d… (see more)aily activity, given negative impacts on mental health and economic outcomes. Digital contact tracing (DCT) apps have emerged as a component of the epidemic management toolkit. Existing DCT apps typically recommend quarantine to all digitally-recorded contacts of test-confirmed cases. Over-reliance on testing may, however, impede the effectiveness of such apps, since by the time cases are confirmed through testing, onward transmissions are likely to have occurred. Furthermore, most cases are infectious over a short period; only a subset of their contacts are likely to become infected. These apps do not fully utilize data sources to base their predictions of transmission risk during an encounter, leading to recommendations of quarantine to many uninfected people and associated slowdowns in economic activity. This phenomenon, commonly termed as “pingdemic,” may additionally contribute to reduced compliance to public health measures. In this work, we propose a novel DCT framework, Proactive Contact Tracing (PCT), which uses multiple sources of information (e.g. self-reported symptoms, received messages from contacts) to estimate app users’ infectiousness histories and provide behavioral recommendations. PCT methods are by design proactive, predicting spread before it occurs. We present an interpretable instance of this framework, the Rule-based PCT algorithm, designed via a multi-disciplinary collaboration among epidemiologists, computer scientists, and behavior experts. Finally, we develop an agent-based model that allows us to compare different DCT methods and evaluate their performance in negotiating the trade-off between epidemic control and restricting population mobility. Performing extensive sensitivity analysis across user behavior, public health policy, and virological parameters, we compare Rule-based PCT to i) binary contact tracing (BCT), which exclusively relies on test results and recommends a fixed-duration quarantine, and ii) household quarantine (HQ). Our results suggest that both BCT and Rule-based PCT improve upon HQ, however, Rule-based PCT is more efficient at controlling spread of disease than BCT across a range of scenarios. In terms of cost-effectiveness, we show that Rule-based PCT pareto-dominates BCT, as demonstrated by a decrease in Disability Adjusted Life Years, as well as Temporary Productivity Loss. Overall, we find that Rule-based PCT outperforms existing approaches across a varying range of parameters. By leveraging anonymized infectiousness estimates received from digitally-recorded contacts, PCT is able to notify potentially infected users earlier than BCT methods and prevent onward transmissions. Our results suggest that PCT-based applications could be a useful tool in managing future epidemics.
Proactive Contact Tracing
Prateek Gupta
Martin Weiss
Nasim Rahaman
Hannah Alsdurf
Nanor Minoyan
Soren Harnois-Leblanc
Joanna Merckx
andrew williams
Victor Schmidt
Pierre-Luc St-Charles
Akshay Patel
Yang Zhang
David L Buckeridge
Bernhard Schölkopf
The COVID-19 pandemic has spurred an unprecedented demand for interventions that can reduce disease spread without excessively restricting d… (see more)aily activity, given negative impacts on mental health and economic outcomes. Digital contact tracing (DCT) apps have emerged as a component of the epidemic management toolkit. Existing DCT apps typically recommend quarantine to all digitally-recorded contacts of test-confirmed cases. Over-reliance on testing may, however, impede the effectiveness of such apps, since by the time cases are confirmed through testing, onward transmissions are likely to have occurred. Furthermore, most cases are infectious over a short period; only a subset of their contacts are likely to become infected. These apps do not fully utilize data sources to base their predictions of transmission risk during an encounter, leading to recommendations of quarantine to many uninfected people and associated slowdowns in economic activity. This phenomenon, commonly termed as “pingdemic,” may additionally contribute to reduced compliance to public health measures. In this work, we propose a novel DCT framework, Proactive Contact Tracing (PCT), which uses multiple sources of information (e.g. self-reported symptoms, received messages from contacts) to estimate app users’ infectiousness histories and provide behavioral recommendations. PCT methods are by design proactive, predicting spread before it occurs. We present an interpretable instance of this framework, the Rule-based PCT algorithm, designed via a multi-disciplinary collaboration among epidemiologists, computer scientists, and behavior experts. Finally, we develop an agent-based model that allows us to compare different DCT methods and evaluate their performance in negotiating the trade-off between epidemic control and restricting population mobility. Performing extensive sensitivity analysis across user behavior, public health policy, and virological parameters, we compare Rule-based PCT to i) binary contact tracing (BCT), which exclusively relies on test results and recommends a fixed-duration quarantine, and ii) household quarantine (HQ). Our results suggest that both BCT and Rule-based PCT improve upon HQ, however, Rule-based PCT is more efficient at controlling spread of disease than BCT across a range of scenarios. In terms of cost-effectiveness, we show that Rule-based PCT pareto-dominates BCT, as demonstrated by a decrease in Disability Adjusted Life Years, as well as Temporary Productivity Loss. Overall, we find that Rule-based PCT outperforms existing approaches across a varying range of parameters. By leveraging anonymized infectiousness estimates received from digitally-recorded contacts, PCT is able to notify potentially infected users earlier than BCT methods and prevent onward transmissions. Our results suggest that PCT-based applications could be a useful tool in managing future epidemics.
A Probabilistic Framework for Mutation Testing in Deep Neural Networks
Florian Tambon
Giuliano Antoniol
Processing of social and monetary rewards in autism spectrum disorders
Sarah Baumeister
Carolin Moessnang
Nico Bast
Sarah Hohmann
Pascal Aggensteiner
Anna Kaiser
Julian Tillmann
David Goyard
Tony Charman
Sara Ambrosino
Simon Baron-Cohen
Christian Beckmann
Sven Bölte
Thomas Bourgeron
Annika Rausch
Daisy Crawley
Flavio Dell’Acqua
Sarah Durston
Christine Ecker … (see 21 more)
Dorothea L. Floris
Vincent Frouin
Hannah Hayward
Rosemary Holt
Mark Johnson
Emily J. H. Jones
Meng-Chuan Lai
Michael V. Lombardo
Luke Mason
Beth Oakley
Marianne Oldehinkel
Antonio Persico
Antonia San José Cáceres
Thomas Wolfers
Eva Loth
Declan Murphy
Jan K. Buitelaar
Heike Tost
Andreas Meyer-Lindenberg
Tobias Banaschewski
Daniel Brandeis
Background Reward processing has been proposed to underpin the atypical social feature of autism spectrum disorder (ASD). However, previous … (see more)neuroimaging studies have yielded inconsistent results regarding the specificity of atypicalities for social reward processing in ASD. Aims Utilising a large sample, we aimed to assess reward processing in response to reward type (social, monetary) and reward phase (anticipation, delivery) in ASD. Method Functional magnetic resonance imaging during social and monetary reward anticipation and delivery was performed in 212 individuals with ASD (7.6–30.6 years of age) and 181 typically developing participants (7.6–30.8 years of age). Results Across social and monetary reward anticipation, whole-brain analyses showed hypoactivation of the right ventral striatum in participants with ASD compared with typically developing participants. Further, region of interest analysis across both reward types yielded ASD-related hypoactivation in both the left and right ventral striatum. Across delivery of social and monetary reward, hyperactivation of the ventral striatum in individuals with ASD did not survive correction for multiple comparisons. Dimensional analyses of autism and attention-deficit hyperactivity disorder (ADHD) scores were not significant. In categorical analyses, post hoc comparisons showed that ASD effects were most pronounced in participants with ASD without co-occurring ADHD. Conclusions Our results do not support current theories linking atypical social interaction in ASD to specific alterations in social reward processing. Instead, they point towards a generalised hypoactivity of ventral striatum in ASD during anticipation of both social and monetary rewards. We suggest this indicates attenuated reward seeking in ASD independent of social content and that elevated ADHD symptoms may attenuate altered reward seeking in ASD.
Real-time simulation of viscoelastic tissue behavior with physics-guided deep learning
Mohammad Karami
David Rivest‐henault
Scalable Regret for Learning to Control Network-Coupled Subsystems With Unknown Dynamics
Sagar Sudhakara
Ashutosh Nayyar
Yi Ouyang
In this article, we consider the problem of controlling an unknown linear quadratic Gaussian (LQG) system consisting of multiple subsystems … (see more)connected over a network. Our goal is to minimize and quantify the regret (i.e., loss in performance) of our learning and control strategy with respect to an oracle who knows the system model. Upfront viewing the interconnected subsystems globally and directly using existing LQG learning algorithms for the global system results in a regret that increases super-linearly with the number of subsystems. Instead, we propose a new Thompson sampling-based learning algorithm which exploits the structure of the underlying network. We show that the expected regret of the proposed algorithm is bounded by
Use of Invasive Brain-Computer Interfaces in Pediatric Neurosurgery: Technical and Ethical Considerations
David Bergeron
Christian Iorio-Morin
Nathalie Orr Gaucher
Éric Racine
Alexander G. Weil
Differentially Private Release of Heterogeneous Network for Managing Healthcare Data
Rashid Hussain Khokhar
Farkhund Iqbal
Khalil Al-Hussaeni
Mohammed Hussain
With the increasing adoption of digital health platforms through mobile apps and online services, people have greater flexibility connecting… (see more) with medical practitioners, pharmacists, and laboratories and accessing resources to manage their own health-related concerns. Many healthcare institutions are connecting with each other to facilitate the exchange of healthcare data, with the goal of effective healthcare data management. The contents generated over these platforms are often shared with third parties for a variety of purposes. However, sharing healthcare data comes with the potential risk of exposing patients’ sensitive information to privacy threats. In this article, we address the challenge of sharing healthcare data while protecting patients’ privacy. We first model a complex healthcare dataset using a heterogeneous information network that consists of multi-type entities and their relationships. We then propose DiffHetNet, an edge-based differentially private algorithm, to protect the sensitive links of patients from inbound and outbound attacks in the heterogeneous health network. We evaluate the performance of our proposed method in terms of information utility and efficiency on different types of real-life datasets that can be modeled as networks. Experimental results suggest that DiffHetNet generally yields less information loss and is significantly more efficient in terms of runtime in comparison with existing network anonymization methods. Furthermore, DiffHetNet is scalable to large network datasets.
A case–control study on predicting population risk of suicide using health administrative data: a research protocol
JianLi Wang
Fatemeh Gholi Zadeh Kharrat
Jean-François Pelletier
Louis Rochette
Eric Pelletier
Pascale Lévesque
Victoria Massamba
Camille Brousseau-Paradis
Mada Mohammed
Geneviève Gariépy
Alain Lesage
DisKeyword: Tweet Corpora Exploration for Keyword Selection
Sacha Lévy
Homotopic local-global parcellation of the human cerebral cortex from resting-state functional connectivity
Xiaoxuan Yan
Ru Kong
Aihuiping Xue
Qing Yang
Csaba Orban
Lijun An
Avram J. Holmes
Xing Qian
Jianzhong Chen
Xi-Nian Zuo
Juan Helen Zhou
Marielle V Fortier
Ai Peng Tan
Peter Gluckman
Yap Seng Chong
Michael J Meaney
Simon B. Eickhoff
B.T. Thomas Yeo
Commonality in Recommender Systems: Evaluating Recommender Systems to Enhance Cultural Citizenship
Andres Ferraro
Gustavo Ferreira
Georgina Born