Portrait de Kevin Moon

Kevin Moon

Collaborateur·rice de recherche
Superviseur⋅e principal⋅e
Guy Wolf
Sujets de recherche
Analyse exploratoire des données
Apprentissage profond
Apprentissage sur variétés
IA explicable
Méthodes de réduction de la dimensionnalité
Modèles de diffusion
Théorie de l'information
Site web
Google Scholar
GitHub

Publications

Sustained IFN signaling is associated with delayed development of SARS-CoV-2-specific immunity
Elsa Brunet-Ratnasingham
Sacha Morin
Haley E. Randolph
Marjorie Labrecque
Justin Bélair
Raphaël Lima-Barbosa
Amélie Pagliuzza
Lorie Marchitto
Michael Hultström
Julia Niessl
Rose Cloutier
Alina M. Sreng Flores
Nathalie Brassard
Mehdi Benlarbi
Jérémie Prévost
Shilei Ding
Sai Priya Anand
Gérémy Sannier
Anders Larsson
Dick Wågsäter … (voir 27 de plus)
Eric Bareke
Hugo Zeberg
Miklos Lipcsey
Robert Frithiof
Anders Larsson
Sirui Zhou
Tomoko Nakanishi
David Morrison
Dani Vezina
Catherine Bourassa
Gabrielle Gendron-Lepage
Halima Medjahed
Floriane Point
Jonathan Richard
Catherine Larochelle
Alexandre Prat
Elsa Brunet-Ratnasingham
Nathalie Arbour
Madeleine Durand
J Brent Richards
Kevin Moon
Nicolas Chomont
Andrés Finzi
Martine Tétreault
Luis Barreiro
Guy Wolf
Daniel E. Kaufmann
Plasma RNAemia, delayed antibody responses and inflammation predict COVID-19 outcomes, but the mechanisms underlying these immunovirological… (voir plus) patterns are poorly understood. We profile 782 longitudinal plasma samples from 318 hospitalized patients with COVID-19. Integrated analysis using k-means reveals four patient clusters in a discovery cohort: mechanically ventilated critically-ill cases are subdivided into good prognosis and high-fatality clusters (reproduced in a validation cohort), while non-critical survivors segregate into high and low early antibody responders. Only the high-fatality cluster is enriched for transcriptomic signatures associated with COVID-19 severity, and each cluster has distinct RBD-specific antibody elicitation kinetics. Both critical and non-critical clusters with delayed antibody responses exhibit sustained IFN signatures, which negatively correlate with contemporaneous RBD-specific IgG levels and absolute SARS-CoV-2-specific B and CD4+ T cell frequencies. These data suggest that the “Interferon paradox” previously described in murine LCMV models is operative in COVID-19, with excessive IFN signaling delaying development of adaptive virus-specific immunity.
2024-05-15
Nature Communications (publié)
doi.org
Extendable and invertible manifold learning with geometry regularized autoencoders
Andrés F. Duque
Sacha Morin
Guy Wolf
Kevin Moon
A fundamental task in data exploration is to extract simplified low dimensional representations that capture intrinsic geometry in data, esp… (voir plus)ecially for faithfully visualizing data in two or three dimensions. Common approaches to this task use kernel methods for manifold learning. However, these methods typically only provide an embedding of fixed input data and cannot extend to new data points. Autoencoders have also recently become popular for representation learning. But while they naturally compute feature extractors that are both extendable to new data and invertible (i.e., reconstructing original features from latent representation), they have limited capabilities to follow global intrinsic geometry compared to kernel-based manifold learning. We present a new method for integrating both approaches by incorporating a geometric regularization term in the bottleneck of the autoencoder. Our regularization, based on the diffusion potential distances from the recently-proposed PHATE visualization method, encourages the learned latent representation to follow intrinsic data geometry, similar to manifold learning algorithms, while still enabling faithful extension to new data and reconstruction of data in the original feature space from latent coordinates. We compare our approach with leading kernel methods and autoencoder models for manifold learning to provide qualitative and quantitative evidence of our advantages in preserving intrinsic structure, out of sample extension, and reconstruction. Our method is easily implemented for big-data applications, whereas other methods are limited in this regard.
2020-12-09
2020 IEEE International Conference on Big Data (Big Data) (publié)
doi.org
arxiv.org