Publications

Temporal Graph Learning Workshop
Shenyang Huang
Daniele Zambon
Andrea Cini
Farimah Poursafaei
Jacob Chmura
Julia Gastinger
Reihaneh Rabbany
Micheal Bronstein
2025-08-03
Proceedings of the 31st ACM SIGKDD Conference on Knowledge Discovery and Data Mining V.2 (published)
doi.org
From Technical Excellence to Practical Adoption: Lessons Learned Building an ML-Enhanced Trace Analysis Tool
Kaveh Shahedi
Matthew Khouzam
Heng Li
Maxime Lamothe
Foutse Khomh
System tracing has become essential for understanding complex software behavior in modern systems, yet sophisticated trace analysis tools fa… (see more)ce significant adoption gaps in industrial settings. Through a year-long collaboration with Ericsson Montr\'eal, developing TMLL (Trace-Server Machine Learning Library, now in the Eclipse Foundation), we investigated barriers to trace analysis adoption. Contrary to assumptions about complexity or automation needs, practitioners struggled with translating expert knowledge into actionable insights, integrating analysis into their workflows, and trusting automated results they could not validate. We identified what we called the Excellence Paradox: technical excellence can actively impede adoption when conflicting with usability, transparency, and practitioner trust. TMLL addresses this through adoption-focused design that embeds expert knowledge in interfaces, provides transparent explanations, and enables incremental adoption. Validation through Ericsson's experts'feedback, Eclipse Foundation's integration, and a survey of 40 industry and academic professionals revealed consistent patterns: survey results showed that 77.5% prioritize quality and trust in results over technical sophistication, while 67.5% prefer semi-automated analysis with user control, findings supported by qualitative feedback from industrial collaboration and external peer review. Results validate three core principles: cognitive compatibility, embedded expertise, and transparency-based trust. This challenges conventional capability-focused tool development, demonstrating that sustainable adoption requires reorientation toward adoption-focused design with actionable implications for automated software engineering tools.
2025-08-02
ArXiv (preprint)
arxiv.org
arxiv.org
From Technical Excellence to Practical Adoption: Lessons Learned Building an ML-Enhanced Trace Analysis Tool
Kaveh Shahedi
Matthew Khouzam
Heng Li
Maxime Lamothe
Foutse Khomh
2025-08-02
ArXiv (preprint)
arxiv.org
arxiv.org
Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models
Darcy Elizabeth Wagner
Hani N. Alsafadi
Nilay Mitash
Aurelien Justet
Qianjiang Hu
Ricardo Pineda
Claudia Staab-Weijnitz
Martina Korfei
Nika Gvazava
Kristin Wannemo
Ugochi Onwuka
Molly Mozurak
Adriana Estrada-Bernal
Juan Cala Garcia
Katrin Mutze
Rita Costa
Deniz Bölükbas
John Stegmayr
Wioletta Skronska-Wasek
Stephan Klee … (see 14 more)
Chiharu Ota
Hoeke A. Baarsma
Jingtao Wang
John Sembrat
Anne Hilgendorff
Jun Ding
Andreas Günther
Rachel Chambers
Ivan O Rosas
Stijn de Langhe
Naftali Kaminski
Mareike Lehmann
Oliver Eickelberg
Melanie Königshoff
Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disease characterized by excessive extracellular matrix deposition. Current … (see more)IPF therapies slow disease progression but do not stop or reverse it. The (myo)fibroblasts are thought to be the main cellular contributors to excessive extracellular matrix production in IPF. Here we show that fibrotic alveolar type II cells regulate production and crosslinking of extracellular matrix via the co-transcriptional activator YAP. YAP leads to increased expression of Lysl oxidase (LOX) and subsequent LOX-mediated crosslinking by fibrotic alveolar type II cells. Pharmacological YAP inhibition via verteporfin reverses fibrotic alveolar type II cell reprogramming and LOX expression in experimental lung fibrosis in vivo and in human fibrotic tissue ex vivo. We thus identify YAP-TEAD/LOX inhibition in alveolar type II cells as a promising potential therapy for IPF patients.
2025-08-02
Nature Communications (published)
doi.org
Adaptation, Comparison and Practical Implementation of Fairness Schemes in Kidney Exchange Programs
William St-Arnaud
Margarida Carvalho
Golnoosh Farnadi
In Kidney Exchange Programs (KEPs), each participating patient is registered together with an incompatible donor. Donors without an incompat… (see more)ible patient can also register. Then, KEPs typically maximize overall patient benefit through donor exchanges. This aggregation of benefits calls into question potential individual patient disparities in terms of access to transplantation in KEPs. Considering solely this utilitarian objective may become an issue in the case where multiple exchange plans are optimal or near-optimal. In fact, current KEP policies are all-or-nothing, meaning that only one exchange plan is determined. Each patient is either selected or not as part of that unique solution. In this work, we seek instead to find a policy that contemplates the probability of patients of being in a solution. To guide the determination of our policy, we adapt popular fairness schemes to KEPs to balance the usual approach of maximizing the utilitarian objective. Different combinations of fairness and utilitarian objectives are modelled as conic programs with an exponential number of variables. We propose a column generation approach to solve them effectively in practice. Finally, we make an extensive comparison of the different schemes in terms of the balance of utility and fairness score, and validate the scalability of our methodology for benchmark instances from the literature.
2025-08-01
European Journal of Operational Research (published)
doi.org
arxiv.org
Efficient Deep Reinforcement Learning-Based Supplementary Damping Control with a Coordinated RMS Training and EMT Testing Scheme
Tao Xue
Mingxuan Zhao
Ilhan Kocar
Mohsen Ghafouri
Antoine Lesage-Landry
Siqi Bu
Ziqing Zhu
2025-08-01
IEEE Transactions on Power Delivery (published)
doi.org
Efficient Deep Reinforcement Learning-Based Supplementary Damping Control With a Coordinated RMS Training and EMT Testing Scheme
Tao Xue
Mingxuan Zhao
Ilhan Kocar
Mohsen Ghafouri
Antoine Lesage-Landry
Siqi Bu
Ziqing Zhu
Inverter-based resources (IBRs) can cause instability in weak AC grids. While supplementary damping controllers (SDCs) effectively mitigate … (see more)this instability, they are typically designed for specific resonance frequencies but struggle with large shifts caused by changing grid conditions. This paper proposes a deep reinforcement learning-based agent (DRL Agent) as an adaptive SDC to handle shifted resonance frequencies. To address the time-consuming nature of training DRL Agents in electromagnetic transient (EMT) simulations, we coordinate fast root mean square (RMS) and EMT simulations. Resonance frequencies of the weak grid instability are accurately reproduced by RMS simulations to support the training process. The DRL Agent’s efficacy is tested in unseen scenarios outside the training dataset. We then iteratively improve the DRL Agent’s performance by modifying the reward function and hyper-parameters.
2025-08-01
IEEE Transactions on Power Delivery (published)
doi.org
Efficient Deep Reinforcement Learning-Based Supplementary Damping Control With a Coordinated RMS Training and EMT Testing Scheme
Tao Xue
Mingxuan Zhao
Ilhan Kocar
Mohsen Ghafouri
Antoine Lesage-Landry
Siqi Bu
Ziqing Zhu
Inverter-based resources (IBRs) can cause instability in weak AC grids. While supplementary damping controllers (SDCs) effectively mitigate … (see more)this instability, they are typically designed for specific resonance frequencies but struggle with large shifts caused by changing grid conditions. This paper proposes a deep reinforcement learning-based agent (DRL Agent) as an adaptive SDC to handle shifted resonance frequencies. To address the time-consuming nature of training DRL Agents in electromagnetic transient (EMT) simulations, we coordinate fast root mean square (RMS) and EMT simulations. Resonance frequencies of the weak grid instability are accurately reproduced by RMS simulations to support the training process. The DRL Agent’s efficacy is tested in unseen scenarios outside the training dataset. We then iteratively improve the DRL Agent’s performance by modifying the reward function and hyper-parameters.
2025-08-01
IEEE Transactions on Power Delivery (published)
doi.org
Posttraumatic Growth in Intensive Care Unit Health Care Professionals After COVID-19
Elie Azoulay
Laurent Argaud
Vincent Labbé
Guillaume Dumas
Fabrice Bruneel
Mercé Jourdain
Christophe Guitton
Amélie Seguin
Samir Jaber
David Schnell
Isabelle Vinatier
Fanny Ardisson
Michel Ramakers
Antoine Herault
Olivier Lesieur
Alain Cariou
Antoine Vieillard-Baron
Olivier Guisset
Frédéric Pochard
Michael Darmon … (see 1 more)
Nancy Kentish-Barnes
2025-08-01
JAMA Network Open (published)
doi.org
The Promise of RL for Autoregressive Image Editing
Saba Ahmadi
Rabiul Awal
Ankur Sikarwar
Amirhossein Kazemnejad
Ge Ya Luo
Juan A. Rodriguez
Sai Rajeswar
Siva Reddy
Chris Pal
Benno Krojer
Aishwarya Agrawal
We explore three strategies to enhance performance on a wide range of image editing tasks: supervised fine-tuning (SFT), reinforcement learn… (see more)ing (RL), and Chain-of-Thought (CoT) reasoning. In order to study all these components in one consistent framework, we adopt an autoregressive multimodal model that processes textual and visual tokens in a unified manner. We find RL combined with a large multi-modal LLM verifier to be the most effective of these strategies. As a result, we release EARL: Editing with Autoregression and RL, a strong RL-based image editing model that performs competitively on a diverse range of edits compared to strong baselines, despite using much less training data. Thus, EARL pushes the frontier of autoregressive multimodal models on image editing. We release our code, training data, and trained models at https://github.com/mair-lab/EARL.
2025-08-01
ArXiv (preprint)
arxiv.org
arxiv.org
Towards an Interpretable Machine Learning Model for Predicting Antimicrobial Resistance
Mohamed Mediouni
Vladimir Makarenkov
Abdoulaye Banire Diallo
2025-08-01
Journal of Global Antimicrobial Resistance (published)
doi.org
Zero-Shot Anomaly Detection with Dual-Branch Prompt Learning
Zihan Wang
Samira Ebrahimi Kahou
Narges Armanfard
Zero-shot anomaly detection (ZSAD) enables identifying and localizing defects in unseen categories by relying solely on generalizable featur… (see more)es rather than requiring any labeled examples of anomalies. However, existing ZSAD methods, whether using fixed or learned prompts, struggle under domain shifts because their training data are derived from limited training domains and fail to generalize to new distributions. In this paper, we introduce PILOT, a framework designed to overcome these challenges through two key innovations: (1) a novel dual-branch prompt learning mechanism that dynamically integrates a pool of learnable prompts with structured semantic attributes, enabling the model to adaptively weight the most relevant anomaly cues for each input image; and (2) a label-free test-time adaptation strategy that updates the learnable prompt parameters using high-confidence pseudo-labels from unlabeled test data. Extensive experiments on 13 industrial and medical benchmarks demonstrate that PILOT achieves state-of-the-art performance in both anomaly detection and localization under domain shift.
2025-08-01
ArXiv (preprint)
arxiv.org
arxiv.org