Publications

Title : Differential functional neural circuitry behind autism subtypes with marked imbalance between social-communicative and restricted repetitive behavior symptom domains
Natasha Bertelsen
Isotta Landi
Richard A.I. Bethlehem
Jakob Seidlitz
Elena
Maria Busuoli
Veronica Mandelli
Eleonora Satta
Stavros Trakoshis
Bonnie Auyeung
Prantik Kundu
Eva Loth
Sarah Baumeister
Christian Beckmann
Sven Bölte
Thomas Bourgeron
Tony Charman
Sarah Durston
Christine Ecker … (see 22 more)
Rosemary Holt
Mark Johnson
Emily J. H. Jones
Luke Mason
-. AndreasMeyer
Lindenberg
Carolin
Moessnang
Marianne
Oldehinkel
Antonio
Persico
Julián
Tillmann
Steven C. R. Williams
Will Spooren
Declan Murphy
Katherine Jan
Buitelaar
Simon Baron-Cohen
Meng-Chuan Lai
Michael V. Lombardo
Social-communication (SC) and restricted repetitive behaviors (RRB) are autism diagnostic symptom domains. SC and RRB severity can markedly … (see more)differ within and between individuals and is underpinned by different neural circuitry and genetic mechanisms. Modeling SC-RRB balance could help identify how neural circuitry and genetic mechanisms map onto such phenotypic heterogeneity. Here we developed a phenotypic stratification model that makes highly accurate (96-98%) out-of-sample SC=RRB, SC>RRB, and RRB>SC subtype predictions. Applying this model to resting state fMRI data from the EU-AIMS LEAP dataset (n=509), we find replicable somatomotor-perisylvian hypoconnectivity in the SC>RRB subtype versus a typically-developing (TD) comparison group. In contrast, replicable motor-anterior salience hyperconnectivity is apparent in the SC=RRB subtype versus TD. Autism-associated genes affecting astrocytes, excitatory, and inhibitory neurons are highly expressed specifically within SC>RRB hypoconnected networks, but not SC=RRB hyperconnected networks. SC-RRB balance subtypes may indicate different paths individuals take from genome, neural circuitry, to the clinical phenotype. (CIMH). Procedures were undertaken to optimize the MRI sequences for the best scanner-specific options, and phantoms and travelling heads were employed to assure standardization and quality assurance of the multisite image-acquisition 20 . Structural images were obtained using a 5.5 minute MPRAGE sequence (TR=2300ms, TE=2.93ms, T1=900ms, voxels size=1.1x1.1x1.2mm, flip angle=9°, matrix size=256x256, FOV=270mm, 176 slices). An eight-to-ten minute resting-state fMRI (rsfMRI) scan was acquired using a multi-echo planar imaging (ME-EPI) sequence 65,66 ; TR=2300ms, TE~12ms, 31ms, and 48ms (slight variations are present across centers), flip angle=80°, matrix size=64x64, (UMCU), 215 (KCL, CIMH), 265 (RUMC, UCAM). were to relax, with eyes open and fixate on a cross presented on the screen for the duration of the rsfMRI scan.
Toward Training Recurrent Neural Networks for Lifelong Learning.
Catastrophic forgetting and capacity saturation are the central challenges of any parametric lifelong learning system. In this work, we stud… (see more)y these challenges in the context of sequential supervised learning with an emphasis on recurrent neural networks. To evaluate the models in the lifelong learning setting, we propose a curriculum-based, simple, and intuitive benchmark where the models are trained on tasks with increasing levels of difficulty. To measure the impact of catastrophic forgetting, the model is tested on all the previous tasks as it completes any task. As a step toward developing true lifelong learning systems, we unify gradient episodic memory (a catastrophic forgetting alleviation approach) and Net2Net (a capacity expansion approach). Both models are proposed in the context of feedforward networks, and we evaluate the feasibility of using them for recurrent networks. Evaluation on the proposed benchmark shows that the unified model is more suitable than the constituent models for lifelong learning setting.
Toward Trustworthy AI Development: Mechanisms for Supporting Verifiable Claims
Miles Brundage
Shahar Avin
Haydn Belfield
Gretchen Krueger
Gillian Hadfield
Heidy Khlaaf
Jingying Yang
Helen Toner
Ruth Fong
Pang Wei Koh
Sara Hooker
Jade Leung
Andrew Trask
Emma Bluemke
Cullen O’Keefe
Mark Koren
Théo Ryffel … (see 39 more)
JB Rubinovitz
Tamay Besiroglu
Federica Carugati
Jack Clark
Peter Eckersley
Sarah de Haas
Maritza Johnson
Ben Laurie
Alex Ingerman
Igor Krawczuk
Amanda Askell
Rosario Cammarota
Andrew Lohn
David Krueger
Charlotte Stix
Logan Graham
Carina Prunkl
Bianca Martin
Elizabeth Seger
Noa Zilberman
Seán Ó hÉigeartaigh
Frens Kroeger
Girish Sastry
Rebecca Kagan
Adrian Weller
Brian Tse
Elizabeth Barnes
Allan Dafoe
Paul Scharre
Ariel Herbert-Voss
Martijn Rasser
Carrick Flynn
Thomas Krendl Gilbert
Lisa Dyer
Saif Khan
Markus Anderljung
With the recent wave of progress in artificial intelligence (AI) has come a growing awareness of the large-scale impacts of AI systems, and … (see more)recognition that existing regulations and norms in industry and academia are insufficient to ensure responsible AI development. In order for AI developers to earn trust from system users, customers, civil society, governments, and other stakeholders that they are building AI responsibly, they will need to make verifiable claims to which they can be held accountable. Those outside of a given organization also need effective means of scrutinizing such claims. This report suggests various steps that different stakeholders can take to improve the verifiability of claims made about AI systems and their associated development processes, with a focus on providing evidence about the safety, security, fairness, and privacy protection of AI systems. We analyze ten mechanisms for this purpose--spanning institutions, software, and hardware--and make recommendations aimed at implementing, exploring, or improving those mechanisms.
Towards robust and replicable sex differences in the intrinsic brain 1 function of autism 2 3
Dorothea L. Floris
José O. A. Filho
Meng-Chuan Lai
Steve
Giavasis
Marianne Oldehinkel
Maarten Mennes
Tony Charman
Julián
Tillmann
Christine Ecker
Flavio Dell’Acqua
Tobias Banaschewski
Carolin Moessnang
Simon Baron-Cohen
Sarah
Durston
Eva Loth
Declan Murphy … (see 4 more)
Jan K. Buitelaar
Christian Beckmann
Michael P. Milham
A. Martino
84 Background: Marked sex differences in autism prevalence accentuate the need to understand 85 the role of biological sex-related factors i… (see more)n autism. Efforts to unravel sex differences in the 86 brain organization of autism have, however, been challenged by the limited availability of 87 female data. Methods: We addressed this gap by using a large sample of males and females 88 with autism and neurotypical (NT) control individuals (ABIDE; Autism: 362 males, 82 89 females; NT: 409 males, 166 females; 7-18 years). Discovery analyses examined main effects 90 of diagnosis, sex and their interaction across five resting-state fMRI (R-fMRI) metrics 91 (voxel-level Z > 3.1, cluster-level P 0.01, gaussian random field corrected). Secondary 92 analyses assessed the robustness of the results to different pre-processing approaches and 93 their replicability in two independent samples: the EU-AIMS Longitudinal European Autism 94 Project (LEAP) and the Gender Explorations of Neurogenetics and Development to Advance 95 Autism Research (GENDAAR). Results: Discovery analyses in ABIDE revealed significant 96 main effects across the intrinsic functional connectivity (iFC) of the posterior cingulate 97 cortex, regional homogeneity and voxel-mirrored homotopic connectivity (VMHC) in several 98 cortical regions, largely converging in the default network midline. Sex-by-diagnosis 99 interactions were confined to the dorsolateral occipital cortex, with reduced VMHC in 100 females with autism. All findings were robust to different pre-processing steps. Replicability 101 in independent samples varied by R-fMRI measures and effects with the targeted sex-by102 diagnosis interaction being replicated in the larger of the two replication samples – EU-AIMS 103 LEAP. Limitations: Given the lack of a priori harmonization among the discovery and 104 replication datasets available to date, sample-related variation remained and may have 105 affected replicability. Conclusions: Atypical cross-hemispheric interactions are 106 neurobiologically relevant to autism. They likely result from the combination of sex107
Training PPO-Clip with Parallelized Data Generation: A Case of Fixed-Point Convergence
In recent years, with the increase in the compute power of GPUs, parallelized data collection has become the dominant approach for training … (see more)reinforcement learning (RL) agents. Proximal Policy Optimization (PPO) is one of the widely-used on-policy methods for training RL agents. In this paper, we focus on the training behavior of PPO-Clip with the increase in the number of parallel environments. In particular, we show that as we increase the amount of data used to train PPO-Clip, the optimized policy would converge to a fixed distribution. We use the results to study the behavior of PPO-Clip in two case studies: the effect of change in the minibatch size and the effect of increase in the number of parallel environments versus the increase in the rollout lengths. The experiments show that settings with high-return PPO runs result in slower convergence to the fixed-distribution and higher consecutive KL divergence changes. Our results aim to offer a better understanding for the prediction of the performance of PPO with the scaling of the parallel environments.
Université de Montréal Balancing Signals for Semi-Supervised Sequence Learning
Ya Xu
Christopher Pal
Training recurrent neural networks (RNNs) on long sequences using backpropagation through time (BPTT) remains a fundamental challenge. It ha… (see more)s been shown that adding a local unsupervised loss term into the optimization objective makes the training of RNNs on long sequences more effective. While the importance of an unsupervised task can in principle be controlled by a coefficient in the objective function, the gradients with respect to the unsupervised loss term still influence all the hidden state dimensions, which might cause important information about the supervised task to be degraded or erased. Compared to existing semi-supervised sequence learning methods, this thesis focuses upon a traditionally overlooked mechanism – an architecture with explicitly designed private and shared hidden units designed to mitigate the detrimental influence of the auxiliary unsupervised loss over the main supervised task. We achieve this by dividing the RNN hidden space into a private space for the supervised task or a shared space for both the supervised and unsupervised tasks. We present extensive experiments with the proposed framework on several long sequence modeling benchmark datasets. Results indicate that the proposed framework can yield performance gains in RNN models where long term dependencies are notoriously challenging to deal with.
S UPPLEMENTARY M ATERIAL - L EARNING T O N AVIGATE T HE S YNTHETICALLY A CCESSIBLE C HEMICAL S PACE U SING R EINFORCEMENT L EARNING
Sai Krishna
Gottipati
B. Sattarov
Sufeng Niu
Yashaswi Pathak
Haoran Wei
Karam M. J. Thomas
Simon R. Blackburn
Connor Wilson. Coley
A. Chandar
While updating the critic network, we multiply the normal random noise vector with policy noise of 0.2 and then clip it in the range -0.2 to… (see more) 0.2. This clipped policy noise is added to the action at the next time step a′ computed by the target actor networks f and π. The actor networks (f and π networks), target critic and target actor networks are updated once every two updates to the critic network.
Value-driven Hindsight Modelling
Arthur Guez
Theophane Weber
Lars Buesing
Steven Kapturowski
David Silver
Nicolas Heess
Value estimation is a critical component of the reinforcement learning (RL) paradigm. The question of how to effectively learn predictors fo… (see more)r value from data is one of the major problems studied by the RL community, and different approaches exploit structure in the problem domain in different ways. Model learning can make use of the rich transition structure present in sequences of observations, but this approach is usually not sensitive to the reward function. In contrast, model-free methods directly leverage the quantity of interest from the future but have to compose with a potentially weak scalar signal (an estimate of the return). In this paper we develop an approach for representation learning in RL that sits in between these two extremes: we propose to learn what to model in a way that can directly help value prediction. To this end we determine which features of the future trajectory provide useful information to predict the associated return. This provides us with tractable prediction targets that are directly relevant for a task, and can thus accelerate learning of the value function. The idea can be understood as reasoning, in hindsight, about which aspects of the future observations could help past value prediction. We show how this can help dramatically even in simple policy evaluation settings. We then test our approach at scale in challenging domains, including on 57 Atari 2600 games.
Learning from Learning Machines: Optimisation, Rules, and Social Norms
There is an analogy between machine learning systems and economic entities in that they are both adaptive, and their behaviour is specified … (see more)in a more-or-less explicit way. It appears that the area of AI that is most analogous to the behaviour of economic entities is that of morally good decision-making, but it is an open question as to how precisely moral behaviour can be achieved in an AI system. This paper explores the analogy between these two complex systems, and we suggest that a clearer understanding of this apparent analogy may help us forward in both the socio-economic domain and the AI domain: known results in economics may help inform feasible solutions in AI safety, but also known results in AI may inform economic policy. If this claim is correct, then the recent successes of deep learning for AI suggest that more implicit specifications work better than explicit ones for solving such problems.
Assessment of Extubation Readiness Using Spontaneous Breathing Trials in Extremely Preterm Neonates
Wissam Shalish
Lara Kanbar
Lajos Kovacs
Sanjay Chawla
Martin Keszler
Smita Rao
Samantha Latremouille
Karen Brown
Robert E. Kearney
Guilherme M. Sant’Anna
Importance Spontaneous breathing trials (SBTs) are used to determine extubation readiness in extremely preterm neonates (gestational age ≤… (see more)28 weeks), but these trials rely on empirical combinations of clinical events during endotracheal continuous positive airway pressure (ET-CPAP). Objectives To describe clinical events during ET-CPAP and to assess accuracy of comprehensive clinical event combinations in predicting successful extubation compared with clinical judgment alone. Design, Setting, and Participants This multicenter diagnostic study used data from 259 neonates seen at 5 neonatal intensive care units from the prospective Automated Prediction of Extubation Readiness (APEX) study from September 1, 2013, through August 31, 2018. Neonates with birth weight less than 1250 g who required mechanical ventilation were eligible. Neonates deemed to be ready for extubation and who underwent ET-CPAP before extubation were included. Interventions In the APEX study, cardiorespiratory signals were recorded during 5-minute ET-CPAP, and signs of clinical instability were monitored. Main Outcomes and Measures Four clinical events were documented during ET-CPAP: apnea requiring stimulation, presence and cumulative durations of bradycardia and desaturation, and increased supplemental oxygen. Clinical event occurrence was assessed and compared between extubation pass and fail (defined as reintubation within 7 days). An automated algorithm was developed to generate SBT definitions using all clinical event combinations and to compute diagnostic accuracies of an SBT in predicting extubation success. Results Of 259 neonates (139 [54%] male) with a median gestational age of 26.1 weeks (interquartile range [IQR], 24.9-27.4 weeks) and median birth weight of 830 g (IQR, 690-1019 g), 147 (57%) had at least 1 clinical event during ET-CPAP. Apneas occurred in 10% (26 of 259) of neonates, bradycardias in 19% (48), desaturations in 53% (138), and increased oxygen needs in 41% (107). Neonates with successful extubation (71% [184 of 259]) had significantly fewer clinical events (51% [93 of 184] vs 72% [54 of 75], P = .002), shorter cumulative bradycardia duration (median, 0 seconds [IQR, 0 seconds] vs 0 seconds [IQR, 0-9 seconds], P  .001), shorter cumulative desaturation duration (median, 0 seconds [IQR, 0-59 seconds] vs 25 seconds [IQR, 0-90 seconds], P = .003),
CLOSURE: Assessing Systematic Generalization of CLEVR Models
Timothy J. O'Donnell
Shikhar Murty
Philippe Beaudoin
The CLEVR dataset of natural-looking questions about 3D-rendered scenes has recently received much attention from the research community. A … (see more)number of models have been proposed for this task, many of which achieved very high accuracies of around 97-99%. In this work, we study how systematic the generalization of such models is, that is to which extent they are capable of handling novel combinations of known linguistic constructs. To this end, we test models' understanding of referring expressions based on matching object properties (such as e.g. "the object that is the same size as the red ball") in novel contexts. Our experiments on the thereby constructed CLOSURE benchmark show that state-of-the-art models often do not exhibit systematicity after being trained on CLEVR. Surprisingly, we find that an explicitly compositional Neural Module Network model also generalizes badly on CLOSURE, even when it has access to the ground-truth programs at test time. We improve the NMN's systematic generalization by developing a novel Vector-NMN module architecture with vector-valued inputs and outputs. Lastly, we investigate the extent to which few-shot transfer learning can help models that are pretrained on CLEVR to adapt to CLOSURE. Our few-shot learning experiments contrast the adaptation behavior of the models with intermediate discrete programs with that of the end-to-end continuous models.
Shaping representations through communication: community size effect in artificial learning systems
Olivier Tieleman
Angeliki Lazaridou
Shibl Mourad
Charles Blundell
Motivated by theories of language and communication that explain why communities with large numbers of speakers have, on average, simpler la… (see more)nguages with more regularity, we cast the representation learning problem in terms of learning to communicate. Our starting point sees the traditional autoencoder setup as a single encoder with a fixed decoder partner that must learn to communicate. Generalizing from there, we introduce community-based autoencoders in which multiple encoders and decoders collectively learn representations by being randomly paired up on successive training iterations. We find that increasing community sizes reduce idiosyncrasies in the learned codes, resulting in representations that better encode concept categories and correlate with human feature norms.