Guy Wolf

Biography

Guy Wolf is a Full Professor in the Department of Mathematics and Statistics (DMS) at the Université de Montréal (UdeM), a Canada CIFAR AI Chair & Core Academic Member at Mila (the Quebec AI institute), an Associate Researcher with CRCHUM (the Montreal university hospital research center), and a participating PI in the Helmholtz International Lab for Causal Cell Dynamics.

In 2024 he has been awarded a Humboldt Experienced Research Fellowship, as part of which he was a visiting professor at Heidelberg University (2024) and Helmholtz Munich (2024-2026) in Germany. Prior to joining UdeM and Mila, he was a Gibbs Assistant Professor (2015-2018) in the Applied Math Program and an Associate Research Scientist in the Department of Genetics (2018) at Yale University (CT, USA). Previously, he was a Postdoctoral Researcher (2013-2015) in the Department of Computer Science at École Normale Supérieure in Paris (France). He holds a Ph.D. in Computer Science from Tel Aviv University (Israel), and has five years of prior experience in IT software design & development for data analysis in military settings.

His current research focuses on guided representation learning for data exploration, including methods that leverage manifold learning and geometric deep learning for dimensionality reduction, visualization, denoising, data augmentation, and coarse graining. While relevant for a wide range of applications, he is particularly interested in the intersection of AI & health, including tools supporting exploratory analysis of biomedical data, e.g., in single-cell multiomics, drug discovery, and neuroscience.

Current Students

Adrien Aumon

PhD - Université de Montréal

adrien.aumon@mila.quebec

Semih Cantürk

PhD - Université de Montréal

semihcanturk00@gmail.com

Joao Felipe Carneiro Barbosa Rocha

Collaborating researcher - Yale University

Co-supervisor :

joaofelipe.rocha@mila.quebec

sebastian.damrich@mila.quebec

Sebastian Damrich

Collaborating researcher - University of Tübingen

Maxine Dussault

Master's Research - Université de Montréal

Co-supervisor :

Margarida Carvalho

maxine.dussault@mila.quebec

Stefan Horoi

PhD - Université de Montréal

stefan.horoi@mila.quebec

Xiao Huang

Master's Research - Concordia University

Principal supervisor :

xiaolong.huang@mila.quebec

Collaborating Alumni - Université de Montréal

guillaume.huguet@mila.quebec

Paul Janson

PhD - Concordia University

Principal supervisor :

myriam.lizotte@mila.quebec

paul.janson@mila.quebec

PhD - Université de Montréal

Gabriele Malagoli

Independent visiting researcher - Helmholtz Munich

gabriele.malagoli@mila.quebec

Philippe Martin

PhD - Université de Montréal

Co-supervisor :

Paul François

philippe.martin@mila.quebec

Paria Mehrbod

Master's Research - Concordia University

Principal supervisor :

paria.mehrbod@mila.quebec

Lydia Mezrag

PhD - Université de Montréal

lydia.mezrag@mila.quebec

Kevin Moon

Collaborating researcher

Sacha Morin

PhD - Université de Montréal

Co-supervisor :

Liam Paull

sacha.morin@mila.quebec

Postdoctorate - Concordia University

Principal supervisor :

geraldin.nanfack@mila.quebec

Shuang Ni

PhD - Université de Montréal

shuang.ni@mila.quebec

Albert Orozco Camacho

PhD - Concordia University

Principal supervisor :

Jake Rhodes

Collaborating researcher - BYU

rhodes@stat.byu.edu

thomas.sabourin@mila.quebec

Thomas Sabourin

Master's Research - Université de Montréal

matthew.scicluna@mila.quebec

Matthew Scicluna

PhD - Université de Montréal

Principal supervisor :

Julie Hussin

francisco.jose.tellez@mila.quebec

Simeon Tchoffo

PhD - Université de Montréal

simeontchoffo@gmail.com

Francisco Tellez

Master's Research - Université de Montréal

Jesuino Vieira Filho

Master's Research - Université de Montréal

Collaborating Alumni - Université de Montréal

Co-supervisor :

yanlei.zhang@mila.quebec

stephanie.zandee@mcgill.ca

Stephanie Zandee

Collaborating researcher - McGill University (assistant professor)

Exploring the COVID-19 Interferon Paradox with Dimensionality Reduction and Clustering

Blog Posts

Graph and representation of working methodology, and graph of data on deaths 60 days after onset of symptoms.

February 19, 2025

Sacha Morin

Elsa Brunet-Ratnasingham

Guy Wolf

Read the article

Publications

Uncovering the Topology of Time-Varying fMRI Data using Cubical Persistence

Bastian Rieck

Tristan Yates

Christian Bock

Karsten Borgwardt

Nicholas Turk-Browne

Functional magnetic resonance imaging (fMRI) is a crucial technology for gaining insights into cognitive processes in humans. Data amassed f… (see more)rom fMRI measurements result in volumetric data sets that vary over time. However, analysing such data presents a challenge due to the large degree of noise and person-to-person variation in how information is represented in the brain. To address this challenge, we present a novel topological approach that encodes each time point in an fMRI data set as a persistence diagram of topological features, i.e. high-dimensional voids present in the data. This representation naturally does not rely on voxel-by-voxel correspondence and is robust to noise. We show that these time-varying persistence diagrams can be clustered to find meaningful groupings between participants, and that they are also useful in studying within-subject brain state trajectories of subjects performing a particular task. Here, we apply both clustering and trajectory analysis techniques to a group of participants watching the movie 'Partly Cloudy'. We observe significant differences in both brain state trajectories and overall topological activity between adults and children watching the same movie.

2020-12-06

Conference on Neural Information Processing Systems (Accept (poster))

arxiv.org

Multiscale PHATE Exploration of SARS-CoV-2 Data Reveals Multimodal Signatures of Disease

Manik Kuchroo

Jessie Huang

Patrick Wong

Jean-Christophe Grenier

Dennis Shung

Alexander Tong

Carolina Lucas

Jon Klein

Daniel B. Burkhardt

Scott Gigante

Abhinav Godavarthi

Benjamin Israelow

Tianyang Mao

Ji Eun Oh

Julio Silva

Takehiro Takahashi

Camila D. Odio

Arnau Casanovas-Massana

John Fournier

Shelli Farhadian … (see 7 more)

Charles S. Dela Cruz

Albert I. Ko

F. Perry Wilson

Julie Hussin

Akiko Iwasaki

Abstract

The biomedical community is producing increasingly high dimensional datasets, integrated from hundreds of… (see more) patient samples, which current computational techniques struggle to explore. To uncover biological meaning from these complex datasets, we present an approach called Multiscale PHATE, which learns abstracted biological features from data that can be directly predictive of disease. Built on a coarse graining process called diffusion condensation, Multiscale PHATE learns a data topology that can be analyzed at coarse levels for high level summarizations of data, as well as at fine levels for detailed representations on subsets. We apply Multiscale PHATE to study the immune response to COVID-19 in 54 million cells from 168 hospitalized patients. Through our analysis of patient samples, we identify CD16-hi,CD66b-lo neutrophil and IFNγ+,GranzymeB+ Th17 cell responses enriched in patients who die. Furthermore, we show that population groupings Multiscale PHATE discovers can be directly fed into a classifier to predict disease outcome. We also use Multiscale PHATE-derived features to construct two different manifolds of patients, one from abstracted flow cytometry features and another directly on patient clinical features, both associating immune subsets and clinical markers with outcome.

2020-11-16

bioRxiv (preprint)

Learning General Transformations of Data for Out-of-Sample Extensions

Matthew Amodio

David van Dijk

While generative models such as GANs have been successful at mapping from noise to specific distributions of data, or more generally from on… (see more)e distribution of data to another, they cannot isolate the transformation that is occurring and apply it to a new distribution not seen in training. Thus, they memorize the domain of the transformation, and cannot generalize the transformation out of sample. To address this, we propose a new neural network called a Neuron Transformation Network (NTNet) that isolates the signal representing the transformation itself from the other signals representing internal distribution variation. This signal can then be removed from a new dataset distributed differently from the original one trained on. We demonstrate the effectiveness of our NTNet on more than a dozen synthetic and biomedical single-cell RNA sequencing datasets, where the NTNet is able to learn the data transformation performed by genetic and drug perturbations on one sample of cells and successfully apply it to another sample of cells to predict treatment outcome.

2020-08-31

Europe PubMed Central (accepted)

TrajectoryNet: A Dynamic Optimal Transport Network for Modeling Cellular Dynamics

David van Dijk

It is increasingly common to encounter data from dynamic processes captured by static cross-sectional measurements over time, particularly i… (see more)n biomedical settings. Recent attempts to model individual trajectories from this data use optimal transport to create pairwise matchings between time points. However, these methods cannot model continuous dynamics and non-linear paths that entities can take in these systems. To address this issue, we establish a link between continuous normalizing flows and dynamic optimal transport, that allows us to model the expected paths of points over time. Continuous normalizing flows are generally under constrained, as they are allowed to take an arbitrary path from the source to the target distribution. We present TrajectoryNet, which controls the continuous paths taken between distributions to produce dynamic optimal transport. We show how this is particularly applicable for studying cellular dynamics in data from single-cell RNA sequencing (scRNA-seq) technologies, and that TrajectoryNet improves upon recently proposed static optimal transport-based models that can be used for interpolating cellular distributions.

2020-07-13

International Conference on Machine Learning (Accept)

proceedings.mlr.press

Geometric Wavelet Scattering Networks on Compact Riemannian Manifolds

Michael Perlmutter

Feng Gao

Matthew Hirn

The Euclidean scattering transform was introduced nearly a decade ago to improve the mathematical understanding of convolutional neural netw… (see more)orks. Inspired by recent interest in geometric deep learning, which aims to generalize convolutional neural networks to manifold and graph-structured domains, we define a geometric scattering transform on manifolds. Similar to the Euclidean scattering transform, the geometric scattering transform is based on a cascade of wavelet filters and pointwise nonlinearities. It is invariant to local isometries and stable to certain types of diffeomorphisms. Empirical results demonstrate its utility on several geometric learning tasks. Our results generalize the deformation stability and local translation invariance of Euclidean scattering, and demonstrate the importance of linking the used filter structures to the underlying geometry of the data.

2020-06-30

PubMed (unknown)

proceedings.mlr.press

Advantages of biologically-inspired adaptive neural activation in RNNs during learning

Dynamic adaptation in single-neuron response plays a fundamental role in neural coding in biological neural networks. Yet, most neural activ… (see more)ation functions used in artificial networks are fixed and mostly considered as an inconsequential architecture choice. In this paper, we investigate nonlinear activation function adaptation over the large time scale of learning, and outline its impact on sequential processing in recurrent neural networks. We introduce a novel parametric family of nonlinear activation functions, inspired by input-frequency response curves of biological neurons, which allows interpolation between well-known activation functions such as ReLU and sigmoid. Using simple numerical experiments and tools from dynamical systems and information theory, we study the role of neural activation features in learning dynamics. We find that activation adaptation provides distinct task-specific solutions and in some cases, improves both learning speed and performance. Importantly, we find that optimal activation features emerging from our parametric family are considerably different from typical functions used in the literature, suggesting that exploiting the gap between these usual configurations can help learning. Finally, we outline situations where neural activation adaptation alone may help mitigate changes in input statistics in a given task, suggesting mechanisms for transfer learning optimization.

2020-06-21

ArXiv (preprint)

arxiv.org

Visualizing structure and transitions in high-dimensional biological data

Kevin R. Moon

David van Dijk

Zheng Wang

Scott Gigante

Daniel B. Burkhardt

William S. Chen

Kristina Yim

Antonia van den Elzen

Matthew Hirn

Ronald R. Coifman

Natalia Ivanova

2019-11-30

Nature Biotechnology (published)

Author Correction: Visualizing structure and transitions in high-dimensional biological data

Kevin R. Moon

David van Dijk

Zheng Wang

Scott Gigante

Daniel B. Burkhardt

William S. Chen

Kristina Yim

Antonia van den Elzen

Matthew Hirn

Ronald R. Coifman

Natalia Ivanova

Tess C. Branon

Justin A. Bosch

Ariana D. Sanchez

Namrata D. Udeshi

Tanya Svinkina

Steven A. Carr

Jessica L. Feldman … (see 2 more)

Norbert Perrimon

Alice Y. Ting

2019-11-19

Nature Biotechnology (published)