The Mila AI Policy Fellowship translates deep AI expertise into rigorous, public-interest policy. Read the newest publication Bridging the Expertise Gap: Knowledge Transfer Mechanisms for AI Regulation by Moritz von Knebel
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Publications
Lugha-Llama: Adapting Large Language Models for African Languages
Examining the detailed structure of galaxy populations provides valuable insights into their formation and evolution mechanisms. Significant… (see more) barriers to such analysis are the nontrivial noise properties of real astronomical images and the point-spread function, which blurs structure. Here we present a framework which combines recent advances in score-based likelihood characterization and diffusion model priors to perform a Bayesian analysis of image deconvolution. The method, when applied to minimally processed Hubble Space Telescope data, recovers structures which have otherwise only become visible in next-generation James Webb Space Telescope imaging.
Diffusion wavelets extract information from graph signals at different scales of resolution by utilizing graph diffusion operators raised to… (see more) various powers, known as diffusion scales. Traditionally, the diffusion scales are chosen to be dyadic integers,
Integrating multimodal single-cell data such as scRNA-seq with scATAC-seq is essential for decoding gene regulatory networks, but remains di… (see more)fficult due to feature harmonization and limited paired multiome data. We introduce ECLARE, a framework that uses multi-teacher ensemble knowledge distillation with contrastive learning and optimal-transport alignment to integrate unpaired single-cell multi-omic datasets. Across benchmarks, ECLARE achieves competitive performance for multimodal integration and biological structure preservation. We further demonstrate utility in a major depressive disorder case study using unpaired snRNA-seq and snATAC-seq, identifying transcription factor–target gene programs that are differentially regulated with sex- and cell-type specificity. Finally, ECLARE learns continuous representations that capture longitudinal structure, highlighting altered neurodevelopmental programs associated with depression in female subjects. Altogether, ECLARE expands the practical reach of multimodal single-cell analysis by enabling diagonal integration of unpaired data with strong biological preservation, facilitating integrative regulatory studies across diverse cohorts and conditions.