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Berardino Barile

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Publications

The role of AI for MRI-analysis in multiple sclerosis—A brief overview
Jean-Pierre R. Falet
Steven Nobile
Aliya Szpindel
Berardino Barile
Amar Kumar
Joshua D. Durso-Finley
Tal Arbel
Douglas Arnold
2025-01-01
Frontiers Artif. Intell. (published)
doi.org
Probabilistic Temporal Prediction of Continuous Disease Trajectories and Treatment Effects Using Neural SDEs
Joshua D. Durso-Finley
Berardino Barile
Jean-Pierre R. Falet
Douglas Arnold
Nick Pawlowski
Tal Arbel
Personalized medicine based on medical images, including predicting future individualized clinical disease progression and treatment respons… (see more)e, would have an enormous impact on healthcare and drug development, particularly for diseases (e.g. multiple sclerosis (MS)) with long term, complex, heterogeneous evolutions and no cure. In this work, we present the first stochastic causal temporal framework to model the continuous temporal evolution of disease progression via Neural Stochastic Differential Equations (NSDE). The proposed causal inference model takes as input the patient's high dimensional images (MRI) and tabular data, and predicts both factual and counterfactual progression trajectories on different treatments in latent space. The NSDE permits the estimation of high-confidence personalized trajectories and treatment effects. Extensive experiments were performed on a large, multi-centre, proprietary dataset of patient 3D MRI and clinical data acquired during several randomized clinical trials for MS treatments. Our results present the first successful uncertainty-based causal Deep Learning (DL) model to: (a) accurately predict future patient MS disability evolution (e.g. EDSS) and treatment effects leveraging baseline MRI, and (b) permit the discovery of subgroups of patients for which the model has high confidence in their response to treatment even in clinical trials which did not reach their clinical endpoints.
2024-10-03
Lecture Notes in Computer Science (published)
doi.org
arxiv.org