Publications

Technologically-assisted communication attenuates inter-brain synchrony
Linoy Schwartz
Jonathan Levy
Yaara Endevelt-Shapira
Amir Djalovski
Olga Hayut
Guillaume Dumas
Ruth Pinkenson Feldman
2022-06-05
NeuroImage (published)
doi.org
How Can Digital Mental Health Enhance Psychiatry?
Emilie Stern
Jean-Arthur MICOULAUD FRANCHI
Guillaume Dumas
Jeverson Moreira
Stephane Mouchabac
Julia Maruani
Pierre Philip
Michel Lejoyeux
Pierre A. GEOFFROY
The use of digital technologies is constantly growing around the world. The wider-spread adoption of digital technologies and solutions in t… (see more)he daily clinical practice in psychiatry seems to be a question of when, not if. We propose a synthesis of the scientific literature on digital technologies in psychiatry and discuss the main aspects of its possible uses and interests in psychiatry according to three domains of influence that appeared to us: 1) assist and improve current care: digital psychiatry allows for more people to have access to care by simply being more accessible but also by being less stigmatized and more convenient; 2) develop new treatments: digital psychiatry allows for new treatments to be distributed via apps, and practical guidelines can reduce ethical challenges and increase the efficacy of digital tools; and 3) produce scientific and medical knowledge: digital technologies offer larger and more objective data collection, allowing for more detection and prevention of symptoms. Finally, ethical and efficacy issues remain, and some guidelines have been put forth on how to safely use these solutions and prepare for the future.
2022-06-03
The Neuroscientist (published)
doi.org
Modeling electronic health record data using a knowledge-graph-embedded topic model
Yuesong Zou
Ahmad Pesaranghader
Aman Verma
David L Buckeridge
Yuemei Li
The rapid growth of electronic health record (EHR) datasets opens up promising opportunities to understand human diseases in a systematic wa… (see more)y. However, effective extraction of clinical knowledge from the EHR data has been hindered by its sparsity and noisy information. We present KG-ETM, an end-to-end knowledge graph-based multimodal embedded topic model. KG-ETM distills latent disease topics from EHR data by learning the embedding from the medical knowledge graphs. We applied KG-ETM to a large-scale EHR dataset consisting of over 1 million patients. We evaluated its performance based on EHR reconstruction and drug imputation. KG-ETM demonstrated superior performance over the alternative methods on both tasks. Moreover, our model learned clinically meaningful graph-informed embedding of the EHR codes. In additional, our model is also able to discover interpretable and accurate patient representations for patient stratification and drug recommendations.
2022-06-02
ArXiv (preprint)
doi.org
arxiv.org
Vendor-neutral sequences and fully transparent workflows improve inter-vendor reproducibility of quantitative MRI
Agah Karakuzu
Labonny Biswas
Julien Cohen-Adad
Nikola Stikov
We conclude that vendor-neutral workflows are feasible and compatible with clinical MRI scanners. The significant reduction of inter-vendor … (see more)variability using vendor-neutral sequences has important implications for qMRI research and for the reliability of multicenter clinical trials.
2022-06-02
Magnetic Resonance in Medicine (unknown)
doi.org
Genetic correlates of phenotypic heterogeneity in autism
Varun Warrier
Xinhe Zhang
Patrick Reed
Alexandra Havdahl
Tyler M. Moore
Freddy Cliquet
Claire Leblond
Thomas Rolland
Anders Rosengren
Antonia San Jose Hannah Daisy Jessica Jessica Claire Bethany Eva Tony Declan Rosemary Jack Jessica Nicola Meng-Chuan Gwilym Amber Emily Hisham Julia Sara Ambrosino Sarai Yvonne Tabitha Miriam Alyssia Iris Maarten Anna Ver Loren Nico Sarah Larry Carsten Annika Daniel Ineke Yvette Maartje Elzbieta Elodie Kristiina Rouslan Guillaume Yang-Min Thomas Caceres
Antonia San Jose Hannah Daisy Jessica Jessica Claire Betha Caceres Hayward Crawley Faulkner Sabet Ellis Oakle
Antonia San José Cáceres
Hannah Hayward
Daisy Crawley
Jessica Faulkner
Jessica Sabet
Claire Ellis
Beth Oakley
Eva Loth
Tony Charman … (see 67 more)
Declan Murphy
Rosemary Holt
Jack Waldman
Jessica Upadhyay
Nicola Gunby
Meng-Chuan Lai
Gwilym Renouf
Amber N. V. Ruigrok
Emily Taylor
Hisham Ziauddeen
Julia Deakin
Sara Ambrosino di Bruttopilo
Sarai van Dijk
Yvonne Rijks
Tabitha Koops
Miriam Douma
Alyssia Spaan
Iris Selten
Maarten Steffers
Anna Ver Loren van Themaat
Nico Bast
Sarah Baumeister
Larry O’Dwyer
Carsten Bours
Annika Rausch
Daniel von Rhein
Ineke Cornelissen
Yvette de Bruin
Maartje Graauwmans
Elzbieta Kostrzewa
Elodie Cauvet
Kristiina Tammimies
Rouslan Sitnikow
Guillaume Dumas
Yang-Min Kim
Thomas Bourgeron
David M. Jonas Thomas Preben Bo Ole Merete Hougaard
David M. Hougaard
Jonas Bybjerg-Grauholm
Thomas Werge
Preben Bo Mortensen
Ole Mors
Merete Nordentoft
Dwaipayan Armandina Carrie Isabelle Tracey Paula Alex Graham J. Alexander E. P. Lidia V. Tal Madeline A. Deepak P. Jonathan Adhya
Dwaipayan Armandina Carrie Isabelle Tracey Paula Alex Graham Adhya Alamanza Allison Garvey Parsons Smith Tsompa
Dwaipayan Adhya
Armandina Alamanza
Carrie Allison
Isabelle Garvey
Tracey Parsons
Paula Smith
Alex Tsompanidis
Graham J. Burton
Alexander E. P. Heazell
Lidia V. Gabis
Tal Biron-Shental
Madeline A. Lancaster
Deepak P. Srivastava
Jonathan Mill
David H. Rowitch
Matthew E. Hurles
Daniel H. Geschwind
Anders D. Børglum
Elise B. Robinson
Jakob Grove
Hilary C. Martin
Simon Baron-Cohen
2022-06-01
Nature Genetics (published)
doi.org
Monocular Robot Navigation with Self-Supervised Pretrained Vision Transformers
Miguel Saavedra-Ruiz
Sacha Morin
Liam Paull
In this work, we consider the problem of learning a perception model for monocular robot navigation using few annotated images. Using a Visi… (see more)on Transformer (ViT) pretrained with a label-free self-supervised method, we successfully train a coarse image segmentation model for the Duckietown environment using 70 training images. Our model performs coarse image segmentation at the 8x8 patch level, and the inference resolution can be adjusted to balance prediction granularity and real-time perception constraints. We study how best to adapt a ViT to our task and environment, and find that some lightweight architectures can yield good single-image segmentation at a usable frame rate, even on CPU. The resulting perception model is used as the backbone for a simple yet robust visual servoing agent, which we deploy on a differential drive mobile robot to perform two tasks: lane following and obstacle avoidance.
2022-06-01
2022 19th Conference on Robots and Vision (CRV) (published)
doi.org
arxiv.org
Aligning artificial intelligence with climate change mitigation
Lynn H. Kaack
Priya L. Donti
Emma Strubell
George Kamiya
Felix Creutzig
David Rolnick
2022-05-31
Nature Climate Change (unknown)
doi.org
Biomedical Research and Informatics Living Laboratory for Innovative Advances of New Technologies in Community Mobility Rehabilitation: Protocol for Evaluation and Rehabilitation of Mobility Across Continuums of Care
Sara Ahmed
Philippe Archambault
Claudine Auger
Audrey Durand
Joyce Fung
Eva Kehayia
Anouk Lamontagne
Annette Majnemer
Sylvie Nadeau
Joelle Pineau
Alain Ptito
Bonnie Swaine
Rapid advances in technologies over the past 10 years have enabled large-scale biomedical and psychosocial rehabilitation research to improv… (see more)e the function and social integration of persons with physical impairments across the lifespan. The Biomedical Research and Informatics Living Laboratory for Innovative Advances of New Technologies (BRILLIANT) in community mobility rehabilitation aims to generate evidence-based research to improve rehabilitation for individuals with acquired brain injury (ABI). This study aims to (1) identify the factors limiting or enhancing mobility in real-world community environments (public spaces, including the mall, home, and outdoors) and understand their complex interplay in individuals of all ages with ABI and (2) customize community environment mobility training by identifying, on a continuous basis, the specific rehabilitation strategies and interventions that patient subgroups benefit from most. Here, we present the research and technology plan for the BRILLIANT initiative. A cohort of individuals, adults and children, with ABI (N=1500) will be recruited. Patients will be recruited from the acute care and rehabilitation partner centers within 4 health regions (living labs) and followed throughout the continuum of rehabilitation. Participants will also be recruited from the community. Biomedical, clinician-reported, patient-reported, and brain imaging data will be collected. Theme 1 will implement and evaluate the feasibility of collecting data across BRILLIANT living labs and conduct predictive analyses and artificial intelligence (AI) to identify mobility subgroups. Theme 2 will implement, evaluate, and identify community mobility interventions that optimize outcomes for mobility subgroups of patients with ABI. The biomedical infrastructure and equipment have been established across the living labs, and development of the clinician- and patient-reported outcome digital solutions is underway. Recruitment is expected to begin in May 2022. The program will develop and deploy a comprehensive clinical and community-based mobility-monitoring system to evaluate the factors that result in poor mobility, and develop personalized mobility interventions that are optimized for specific patient subgroups. Technology solutions will be designed to support clinicians and patients to deliver cost-effective care and the right intervention to the right person at the right time to optimize long-term functional potential and meaningful participation in the community. PRR1-10.2196/12506
2022-05-31
JMIR Research Protocols (published)
doi.org
A calcium-based plasticity model for predicting long-term potentiation and depression in the neocortex
Giuseppe Chindemi
Marwan Abdellah
Oren Amsalem
Ruth Benavides-Piccione
Vincent Delattre
Michael Doron
András Ecker
Aurélien T. Jaquier
James King
Pramod Kumbhar
Caitlin Monney
Rodrigo Perin
Christian Rössert
Anil M. Tuncel
Werner Van Geit
Javier DeFelipe
Michael Graupner
Idan Segev
Henry Markram
Eilif B. Muller
Pyramidal cells (PCs) form the backbone of the layered structure of the neocortex, and plasticity of their synapses is thought to underlie l… (see more)earning in the brain. However, such long-term synaptic changes have been experimentally characterized between only a few types of PCs, posing a significant barrier for studying neocortical learning mechanisms. Here we introduce a model of synaptic plasticity based on data-constrained postsynaptic calcium dynamics, and show in a neocortical microcircuit model that a single parameter set is sufficient to unify the available experimental findings on long-term potentiation (LTP) and long-term depression (LTD) of PC connections. In particular, we find that the diverse plasticity outcomes across the different PC types can be explained by cell-type-specific synaptic physiology, cell morphology and innervation patterns, without requiring type-specific plasticity. Generalizing the model to in vivo extracellular calcium concentrations, we predict qualitatively different plasticity dynamics from those observed in vitro. This work provides a first comprehensive null model for LTP/LTD between neocortical PC types in vivo, and an open framework for further developing models of cortical synaptic plasticity.
2022-05-31
Nature Communications (published)
doi.org
Conjugate Adder Net (CAddNet) - a Space-Efficient Approximate CNN
Lulan Shen
Maryam Ziaeefard
Brett Meyer
Warren Gross
James J. Clark
The AdderNet was recently developed as a way to implement deep neural networks without needing multiplication operations to combine weights … (see more)and inputs. Instead, absolute values of the difference between weights and inputs are used, greatly reducing the gate-level implementation complexity. Training of AdderNets is challenging, however, and the loss curves during training tend to fluctuate significantly. In this paper we propose the Conjugate Adder Network, or CAddNet, which uses the difference between the absolute values of conjugate pairs of inputs and the weights. We show that this can be implemented simply via a single minimum operation, resulting in a roughly 50% reduction in logic gate complexity as compared with AdderNets. The CAddNet method also stabilizes training as compared with AdderNets, yielding training curves similar to standard CNNs.
2022-05-31
2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW) (published)
doi.org
A data-driven approach to include availability of ICU beds in the planning of the operating room
Augustin A
Jouvet P
Lahrichi N
Lodi A
Rousseau LM
2022-05-31
Omega, The International Journal of Management Science (published)
doi.org
EpiTopics: A dynamic machine learning model to predict and inform non-pharmacological public health interventions from global news reports
Zhi Wen
Jingfu Zhang
Guido Powell
Imane Chafi
David L. Buckeridge
Yue Li
2022-05-31
STAR Protocols (published)
doi.org