Publications

A Unified Solution to Diverse Heterogeneities in One-Shot Federated Learning
Jun Bai
Yiliao Song
Di Wu
Atul Sajjanhar
Yong Xiang
Wei Zhou
Xiaohui Tao
Yan Li
Yue Li
One-Shot Federated Learning (OSFL) restricts communication between the server and clients to a single round, significantly reducing communic… (see more)ation costs and minimizing privacy leakage risks compared to traditional Federated Learning (FL), which requires multiple rounds of communication. However, existing OSFL frameworks remain vulnerable to distributional heterogeneity, as they primarily focus on model heterogeneity while neglecting data heterogeneity. To bridge this gap, we propose FedHydra, a unified, data-free, OSFL framework designed to effectively address both model and data heterogeneity. Unlike existing OSFL approaches, FedHydra introduces a novel two-stage learning mechanism. Specifically, it incorporates model stratification and heterogeneity-aware stratified aggregation to mitigate the challenges posed by both model and data heterogeneity. By this design, the data and model heterogeneity issues are simultaneously monitored from different aspects during learning. Consequently, FedHydra can effectively mitigate both issues by minimizing their inherent conflicts. We compared FedHydra with five SOTA baselines on four benchmark datasets. Experimental results show that our method outperforms the previous OSFL methods in both homogeneous and heterogeneous settings. The code is available at https://github.com/Jun-B0518/FedHydra.
2025-08-02
Proceedings of the 31st ACM SIGKDD Conference on Knowledge Discovery and Data Mining V.2 (published)
doi.org
arxiv.org
Inhibition of epithelial cell YAP-TEAD/LOX signaling attenuates pulmonary fibrosis in preclinical models
Darcy Elizabeth Wagner
Hani N. Alsafadi
Nilay Mitash
Aurelien Justet
Qianjiang Hu
Ricardo Pineda
Claudia Staab-Weijnitz
Martina Korfei
Nika Gvazava
Kristin Wannemo
Ugochi Onwuka
Molly Mozurak
Adriana Estrada-Bernal
Juan Cala Garcia
Katrin Mutze
Rita Costa
Deniz Bölükbas
John Stegmayr
Wioletta Skronska-Wasek
Stephan Klee … (see 14 more)
Chiharu Ota
Hoeke A. Baarsma
Jingtao Wang
John Sembrat
Anne Hilgendorff
Jun Ding
Andreas Günther
Rachel Chambers
Ivan O Rosas
Stijn de Langhe
Naftali Kaminski
Mareike Lehmann
Oliver Eickelberg
Melanie Königshoff
Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal disease characterized by excessive extracellular matrix deposition. Current … (see more)IPF therapies slow disease progression but do not stop or reverse it. The (myo)fibroblasts are thought to be the main cellular contributors to excessive extracellular matrix production in IPF. Here we show that fibrotic alveolar type II cells regulate production and crosslinking of extracellular matrix via the co-transcriptional activator YAP. YAP leads to increased expression of Lysl oxidase (LOX) and subsequent LOX-mediated crosslinking by fibrotic alveolar type II cells. Pharmacological YAP inhibition via verteporfin reverses fibrotic alveolar type II cell reprogramming and LOX expression in experimental lung fibrosis in vivo and in human fibrotic tissue ex vivo. We thus identify YAP-TEAD/LOX inhibition in alveolar type II cells as a promising potential therapy for IPF patients.
2025-08-01
Nature Communications (published)
doi.org
Efficient Deep Reinforcement Learning-Based Supplementary Damping Control with a Coordinated RMS Training and EMT Testing Scheme
Tao Xue
Mingxuan Zhao
Ilhan Kocar
Mohsen Ghafouri
Antoine Lesage-Landry
Siqi Bu
Ziqing Zhu
2025-07-31
IEEE Transactions on Power Delivery (published)
doi.org
An Empirical Study on Method-Level Performance Evolution in Open-Source Java Projects
Kaveh Shahedi
Nana Gyambrah
Heng Li
Maxime Lamothe
Foutse Khomh
Performance is a critical quality attribute in software development, yet the impact of method-level code changes on performance evolution re… (see more)mains poorly understood. While developers often make intuitive assumptions about which types of modifications are likely to cause performance regressions or improvements, these beliefs lack empirical validation at a fine-grained level. We conducted a large-scale empirical study analyzing performance evolution in 15 mature open-source Java projects hosted on GitHub. Our analysis encompassed 739 commits containing 1,499 method-level code changes, using Java Microbenchmark Harness (JMH) for precise performance measurement and rigorous statistical analysis to quantify both the significance and magnitude of performance variations. We employed bytecode instrumentation to capture method-specific execution metrics and systematically analyzed four key aspects: temporal performance patterns, code change type correlations, developer and complexity factors, and domain-size interactions. Our findings reveal that 32.7% of method-level changes result in measurable performance impacts, with regressions occurring 1.3 times more frequently than improvements. Contrary to conventional wisdom, we found no significant differences in performance impact distributions across code change categories, challenging risk-stratified development strategies. Algorithmic changes demonstrate the highest improvement potential but carry substantial regression risk. Senior developers produce more stable changes with fewer extreme variations, while code complexity correlates with increased regression likelihood. Domain-size interactions reveal significant patterns, with web server + small projects exhibiting the highest performance instability. Our study provides empirical evidence for integrating automated performance testing into continuous integration pipelines.
2025-07-31
arXiv (published)
doi.org
arxiv.org
Low-Rank Expert Merging for Multi-Source Domain Adaptation in Person Re-Identification
Taha Mustapha Nehdi
Nairouz Mrabah
Atif Belal
Marco Pedersoli
Eric Granger
2025-07-31
arXiv (published)
doi.org
arxiv.org
MuSACo: Multimodal Subject-Specific Selection and Adaptation for Expression Recognition with Co-Training
Muhammad Osama Zeeshan
Natacha Gillet
Alessandro Lameiras Koerich
Marco Pedersoli
Francois Bremond
Eric Granger
2025-07-31
arXiv (published)
doi.org
arxiv.org
Personalized Feature Translation for Expression Recognition: An Efficient Source-Free Domain Adaptation Method
Masoumeh Sharafi
Soufiane Belharbi
Houssem Ben Salem
Ali Etemad
Alessandro Lameiras Koerich
Marco Pedersoli
Simon Bacon
Eric Granger
Facial expression recognition (FER) models are employed in many video-based affective computing applications, such as human-computer interac… (see more)tion and healthcare monitoring. However, deep FER models often struggle with subtle expressions and high inter-subject variability, limiting their performance in real-world applications. To improve their performance, source-free domain adaptation (SFDA) methods have been proposed to personalize a pretrained source model using only unlabeled target domain data, thereby avoiding data privacy, storage, and transmission constraints. This paper addresses a challenging scenario where source data is unavailable for adaptation, and only unlabeled target data consisting solely of neutral expressions is available. SFDA methods are not typically designed to adapt using target data from only a single class. Further, using models to generate facial images with non-neutral expressions can be unstable and computationally intensive. In this paper, personalized feature translation (PFT) is proposed for SFDA. Unlike current image translation methods for SFDA, our lightweight method operates in the latent space. We first pre-train the translator on the source domain data to transform the subject-specific style features from one source subject into another. Expression information is preserved by optimizing a combination of expression consistency and style-aware objectives. Then, the translator is adapted on neutral target data, without using source data or image synthesis. By translating in the latent space, PFT avoids the complexity and noise of face expression generation, producing discriminative embeddings optimized for classification. Using PFT eliminates the need for image synthesis, reduces computational overhead (using a lightweight translator), and only adapts part of the model, making the method efficient compared to image-based translation.
2025-07-31
arXiv (published)
doi.org
arxiv.org
Posttraumatic Growth in Intensive Care Unit Health Care Professionals After COVID-19
Elie Azoulay
Laurent Argaud
Vincent Labbé
Guillaume Dumas
Fabrice Bruneel
Mercé Jourdain
Christophe Guitton
Amelie Seguin
Samir Jaber
David Schnell
Isabelle Vinatier
Fanny Ardisson
Michel Ramakers
Antoine Herault
Olivier Lesieur
Alain Cariou
Antoine Vieillard-Baron
Olivier Guisset
Frédéric Pochard
Michael Darmon … (see 1 more)
Nancy Kentish-Barnes
2025-07-31
JAMA Network Open (published)
doi.org
Single-nucleus chromatin accessibility profiling identifies cell types and functional variants contributing to major depression
Anjali Chawla
Doruk Cakmakci
Laura M. Fiori
Wenmin Zang
Malosree Maitra
Jennie Yang
Dariusz Żurawek
Gabriella Frosi
Reza Rahimian
Haruka Mitsuhashi
Maria Antonietta Davoli
MA Davoli
Ryan Denniston
Gary Gang Chen
Volodymyr Yerko
Deborah Mash
Kiran Girdhar
Schahram Akbarian
Naguib Mechawar
Matthew Suderman … (see 3 more)
Yuemei Li
Corina Nagy
Gustavo Turecki
2025-07-31
Nature Genetics (published)
doi.org
Spatio-Temporal Conditional Diffusion Models for Forecasting Future Multiple Sclerosis Lesion Masks Conditioned on Treatments
Gian Mario Favero
Ge Ya Luo
Nima Fathi
Justin Szeto
Douglas Arnold
Brennan Nichyporuk
Christopher Pal
Tal Arbel
2025-07-31
arXiv (published)
doi.org
arxiv.org
Towards an Interpretable Machine Learning Model for Predicting Antimicrobial Resistance
Mohamed Mediouni
Vladimir Makarenkov
Abdoulaye Banire Diallo
2025-07-31
Journal of Global Antimicrobial Resistance (published)
doi.org
Zero-Shot Anomaly Detection with Dual-Branch Prompt Learning
Zihan Wang
S Ebrahimi Kahou
Narges Armanfard
Zero-shot anomaly detection (ZSAD) enables identifying and localizing defects in unseen categories by relying solely on generalizable featur… (see more)es rather than requiring any labeled examples of anomalies. However, existing ZSAD methods, whether using fixed or learned prompts, struggle under domain shifts because their training data are derived from limited training domains and fail to generalize to new distributions. In this paper, we introduce PILOT, a framework designed to overcome these challenges through two key innovations: (1) a novel dual-branch prompt learning mechanism that dynamically integrates a pool of learnable prompts with structured semantic attributes, enabling the model to adaptively weight the most relevant anomaly cues for each input image; and (2) a label-free test-time adaptation strategy that updates the learnable prompt parameters using high-confidence pseudo-labels from unlabeled test data. Extensive experiments on 13 industrial and medical benchmarks demonstrate that PILOT achieves state-of-the-art performance in both anomaly detection and localization under domain shift.
2025-07-31
arXiv (published)
doi.org
arxiv.org