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Publications
CNN to detect differences in cerebral cortical anatomy of left- and right- handers
Handedness is one of the most obvious functional asymmetries, but its relation to anatomical asymmetry in the brain has not yet been clearly… (see more) demonstrated. However, there is no significant evidence to prove or disprove this structure-function correlation, thus left-handed patients are often excluded from magnetic resonance imaging (MRI) studies. MRI classification of left and right hemispheres is a difficult task on its own due to the complexity of the images and the structural similarities between the two halves. We demonstrate a deep artificial neural network approach in connection with a detailed preprocessing pipeline for the classification of lateralization in T1-weighted MR images of the human brain. Preprocessing includes bias field correction and registration on the MNI template. Our classifier is a convolutional neural network (CNN) that was trained on 287 images. Each image was duplicated and mirrored on the mid-sagittal plane. The best model reached an accuracy of 97.594% with a mean of 95.42% and standard deviation of 1.37%. Additionally, our model’s performance was evaluated on an independent set of 118 images and reached a classification accuracy of 97%. In a larger study we tested the model on grey-matter images of 927 left and 927 right-handed patients from the UK Biobank. Here all right-handed images and all left-handed images were classified as belonging to one class. The results suggest that there is no structural difference in grey-matter between the two hemispheres that can be distinguished by the deep learning classifier.
2020-04-27
Real-Time Image Processing and Deep Learning 2020 (published)
A decentralized linear quadratic system with a major agent and a collection of minor agents is considered. The major agent affects the minor… (see more) agents, but not vice versa. The state of the major agent is observed by all agents. In addition, the minor agents have a noisy observation of their local state. The noise process is not assumed to be Gaussian. The structures of the optimal strategy and the best linear strategy are characterized. It is shown that the major agent's optimal control action is a linear function of the major agent's minimum mean-squared error (MMSE) estimate of the system state while the minor agent's optimal control action is a linear function of the major agent's MMSE estimate of the system state and a “correction term” that depends on the difference of the minor agent's MMSE estimate of its local state and the major agent's MMSE estimate of the minor agent's local state. Since the noise is non-Gaussian, the minor agent's MMSE estimate is a nonlinear function of its observation. It is shown that replacing the minor agent's MMSE estimate with its linear least mean square estimate gives the best linear control strategy. The results are proved using a direct method based on conditional independence, common-information-based splitting of state and control actions, and simplifying the per-step cost based on conditional independence, orthogonality principle, and completion of squares.
In open-source software (OSS), the design of usability is often influenced by the discussions among community members on platforms such as i… (see more)ssue tracking systems (ITSs). However, digesting the rich information embedded in issue discussions can be a major challenge due to the vast number and diversity of the comments. We propose and evaluate ArguLens, a conceptual framework and automated technique leveraging an argumentation model to support effective understanding and consolidation of community opinions in ITSs. Through content analysis, we anatomized highly discussed usability issues from a large, active OSS project, into their argumentation components and standpoints. We then experimented with supervised machine learning techniques for automated argument extraction. Finally, through a study with experienced ITS users, we show that the information provided by ArguLens supported the digestion of usability-related opinions and facilitated the review of lengthy issues. ArguLens provides the direction of designing valuable tools for high-level reasoning and effective discussion about usability.
2020-04-23
Proceedings of the 2020 CHI Conference on Human Factors in Computing Systems (published)
Travel time is essential for making travel decisions in real-world transportation networks. Understanding its distribution can resolve many … (see more)fundamental problems in transportation. Empirically, single-edge travel-time is well studied, but how to aggregate such information over many edges to arrive at the distribution of travel time over a route is still daunting. A range of statistical tools have been developed for network analysis; tools to study statistical behaviors of processes on dynamical networks are still lacking. This paper develops a novel statistical perspective to specific type of mixing ergodic processes (travel time), that mimic the behavior of travel time on real-world networks. Under general conditions on the single-edge speed (resistance) distribution, we show that travel time, normalized by distance, follows a Gaussian distribution with universal mean and variance parameters. We propose efficient inference methods for such parameters, and consequently asymptotic universal confidence and prediction intervals of travel time. We further develop path(route)-specific parameters that enable tighter Gaussian-based prediction intervals. We illustrate our methods with a real-world case study using mobile GPS data, where we show that the route-specific and universal intervals both achieve the 95\% theoretical coverage levels. Moreover, the route-specific prediction intervals result in tighter bounds that outperform competing models.
Prediction intervals for travel time on transportation networks
Estimating travel-time is essential for making travel decisions in transportation networks. Empirically, single road-segment travel-time is … (see more)well studied, but how to aggregate such information over many edges to arrive at the distribution of travel time over a route is still theoretically challenging. Understanding travel-time distribution can help resolve many fundamental problems in transportation, quantifying travel uncertainty as an example. We develop a novel statistical perspective to specific types of dynamical processes that mimic the behavior of travel time on real-world networks. We show that, under general conditions, travel-time normalized by distance, follows a Gaussian distribution with route-invariant (universal) location and scale parameters. We develop efficient inference methods for such parameters, with which we propose asymptotic universal confidence and prediction intervals of travel time. We further develop our theory to include road-segment level information to construct route-specific location and scale parameter sequences that produce tighter route-specific Gaussian-based prediction intervals. We illustrate our methods with a real-world case study using precollected mobile GPS data, where we show that the route-specific and route-invariant intervals both achieve the 95\% theoretical coverage levels, where the former result in tighter bounds that also outperform competing models.
Distinct roles of parvalbumin and somatostatin interneurons in gating the synchronization of spike times in the neocortex
Sensory information–driven spikes are synchronized across cortical layers by distinct subtypes of interneurons. Synchronization of precise… (see more) spike times across multiple neurons carries information about sensory stimuli. Inhibitory interneurons are suggested to promote this synchronization, but it is unclear whether distinct interneuron subtypes provide different contributions. To test this, we examined single-unit recordings from barrel cortex in vivo and used optogenetics to determine the contribution of parvalbumin (PV)– and somatostatin (SST)–positive interneurons to the synchronization of spike times across cortical layers. We found that PV interneurons preferentially promote the synchronization of spike times when instantaneous firing rates are low (12 Hz), whereas SST interneurons preferentially promote the synchronization of spike times when instantaneous firing rates are high (>12 Hz). Furthermore, using a computational model, we demonstrate that these effects can be explained by PV and SST interneurons having preferential contributions to feedforward and feedback inhibition, respectively. Our findings demonstrate that distinct subtypes of inhibitory interneurons have frequency-selective roles in the spatiotemporal synchronization of precise spike times.
Although anger may weaken response inhibition (RI) by allowing outbursts to bypass deliberate processing, it is equally likely that RI defic… (see more)its precipitate a state of anger (SA). In adolescents, for instance, anger occurs more frequently and often leads to escalating aggressive behaviors. Even though RI is considered a key component in explaining individual differences in SA expression, the neural overlap between SA and RI remains elusive. Here, we aimed to meta‐analytically revisit and update the neural correlates of motor RI, to determine a consistent neural architecture of SA, and to identify their joint neural network. Considering that inhibitory abilities follow a protracted maturation until early adulthood, we additionally computed RI meta‐analyses in youths and adults. Using activation likelihood estimation, we calculated twelve meta‐analyses across 157 RI and 39 SA experiments on healthy individuals. Consistent with previous findings, RI was associated with a broad frontoparietal network including the anterior insula/inferior frontal gyrus (aI/IFG), premotor and midcingulate cortices, extending into right temporoparietal areas. Youths showed convergent activity in right midcingulate and medial prefrontal areas, left aI/IFG, and the temporal poles. SA, on the other hand, reliably recruited the right aI/IFG and anterior cingulate cortex. Conjunction analyses between RI and SA yielded a single convergence cluster in the right aI/IFG. While frontoparietal networks and bilateral aI are ubiquitously recruited during RI, the right aI/IFG cluster likely represents a node in a dynamically‐adjusting monitoring network that integrates salient information thereby facilitating the execution of goal‐directed behaviors under highly unpredictable scenarios.
Writing and its means have become detached. Unlike written and drawn practices developed prior to the 20th century, notation for programming… (see more) computers developed in concert and conflict with discretizing infrastructure such as the shift-key typewriter and data processing pipelines. In this paper, I recall the emergence of high-level notation for representing computation. I show how the earliest inventors of programming notations borrowed from various written cultural practices, some of which came into conflict with the constraints of digitizing machines, most prominently the typewriter. As such, I trace how practices of "writing code" were fabricated along social, cultural, and material lines at the time of their emergence. By juxtaposing early visions with the modern status quo, I question long-standing terminology, dichotomies, and epistemological tendencies in the field of computer programming. Finally, I argue that translation work is a fundamental property of the practice of writing code by advancing an intercultural lens on programming practice rooted in history.
2020-04-21
International Conference on Human Factors in Computing Systems (published)
The ability to ask questions is important in both human and machine intelligence. Learning to ask questions helps knowledge acquisition, imp… (see more)roves question-answering and machine reading comprehension tasks, and helps a chatbot to keep the conversation flowing with a human. Existing question generation models are ineffective at generating a large amount of high-quality question-answer pairs from unstructured text, since given an answer and an input passage, question generation is inherently a one-to-many mapping. In this paper, we propose Answer-Clue-Style-aware Question Generation (ACS-QG), which aims at automatically generating high-quality and diverse question-answer pairs from unlabeled text corpus at scale by imitating the way a human asks questions. Our system consists of: i) an information extractor, which samples from the text multiple types of assistive information to guide question generation; ii) neural question generators, which generate diverse and controllable questions, leveraging the extracted assistive information; and iii) a neural quality controller, which removes low-quality generated data based on text entailment. We compare our question generation models with existing approaches and resort to voluntary human evaluation to assess the quality of the generated question-answer pairs. The evaluation results suggest that our system dramatically outperforms state-of-the-art neural question generation models in terms of the generation quality, while being scalable in the meantime. With models trained on a relatively smaller amount of data, we can generate 2.8 million quality-assured question-answer pairs from a million sentences found in Wikipedia.
2020-04-20
Proceedings of The Web Conference 2020 (published)
The problem of selecting a subset of nodes with greatest influence in a graph, commonly known as influence maximization, has been well studi… (see more)ed over the past decade. This problem has real world applications which can potentially affect lives of individuals. Algorithmic decision making in such domains raises concerns about their societal implications. One of these concerns, which surprisingly has only received limited attention so far, is algorithmic bias and fairness. We propose a flexible framework that extends and unifies the existing works in fairness-aware influence maximization. This framework is based on an integer programming formulation of the influence maximization problem. The fairness requirements are enforced by adding linear constraints or modifying the objective function. Contrary to the previous work which designs specific algorithms for each variant, we develop a formalism which is general enough for specifying different notions of fairness. A problem defined in this formalism can be then solved using efficient mixed integer programming solvers. The experimental evaluation indicates that our framework not only is general but also is competitive with existing algorithms.
2020-04-20
Companion Proceedings of the Web Conference 2020 (published)
