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Publications
Diminished social memory and hippocampal correlates of social interactions in chronic social defeat stress susceptibility
This study introduces a self-supervised learning (SSL) approach to hyperscanning electroencephalography (EEG) data, targeting the identifica… (see more)tion of autism spectrum condition (ASC) during social interactions. Hyperscanning enables simultaneous recording of neural activity across interacting individuals, offering a novel path for studying brain-to-brain synchrony in ASC. Leveraging a large-scale, single-brain EEG dataset for SSL pretraining, we developed a multi-brain classification model fine-tuned with hyperscanning data from dyadic interactions involving ASC and neurotypical participants. The SSL model demonstrated superior performance (78.13% accuracy) compared to supervised baselines and logistic regression using spectral EEG biomarkers. These results underscore the efficacy of SSL in addressing the challenges of limited labeled data, enhancing EEG-based diagnostic tools for ASC, and advancing research in social neuroscience.
Nous étudions l’impact de la crise du COVID-19 sur la gestion des impressions pratiquée par les entreprises françaises cotées. Cette c… (see more)rise ayant eu un impact fort sur l’activité des entreprises, nous observons si les dirigeants modifient la manière de présenter l’information liée aux résultats non-GAAP, à travers l’utilisation de stratégies d’obscurcissement. Les données sur la gestion des impressions ont été collectées manuellement dans les communiqués de résultats annuels des entreprises du SBF 120 sur la période 2018-2020. Nous constatons une diminution générale du niveau de gestion des impressions en période de crise, notamment pour les entreprises des secteurs ayant été les plus impactés par la crise COVID. Cette diminution est toutefois moins prononcée pour les entreprises ayant sous-performé par rapport à leur secteur d’activité et pour les entreprises dont la performance a le plus diminué (indépendamment du secteur auquel elles appartiennent). Nos résultats suggèrent que les entreprises dont la baisse de performance pourrait être attribuée à des causes internes (résultats très défavorables, résultats en deçà du secteur d’activité) demeurent soucieuses de l’image qu’elles renvoient et maintiennent leur niveau de gestion des impressions malgré la crise.
Traditional recommender systems rely on high-dimensional (latent)
embeddings for modeling user-item interactions, often resulting in
opaque … (see more)representations that lack interpretability. Moreover, these
systems offer limited control to users over their recommendations.
Inspired by recent work, we introduce TExtuAl Representations for
Scrutable recommendations (TEARS) to address these challenges.
Instead of representing a user’s interests through latent embed-
dings, TEARS encodes them in natural text, providing transparency
and allowing users to edit them. To encode such preferences, we
use modern LLMs to generate high-quality user summaries which
we find uniquely capture user preferences. Using these summaries
we take a hybrid approach where we use an optimal transport
procedure to align the summaries’ representations with the repre-
sentation of a standard VAE for collaborative filtering. We find this
approach can surpass the performance of the three popular VAE
models while providing user-controllable recommendations. We
further analyze the controllability of TEARS through three simu-
lated user tasks to evaluate the effectiveness of user edits on their
summaries. Our code and all user-summaries can be seen in an
anonymized repository.
Integrating multimodal single-cell data, such as scRNA-seq and scATAC-seq, is key for decoding gene regulatory networks but remains challeng… (see more)ing due to issues like feature harmonization and limited quantity of paired data. To address these challenges, we introduce ECLARE, a novel framework combining multi-teacher ensemble knowledge distillation with contrastive learning for diagonal integration of single-cell multi-omic data. ECLARE trains teacher models on paired datasets to guide a student model for unpaired data, leveraging a refined contrastive objective and transport-based loss for precise cross-modality alignment. Experiments demonstrate ECLARE’s competitive performance in cell pairing accuracy, multimodal integration and biological structure preservation, indicating that multi-teacher knowledge distillation provides an effective mean to improve a diagonal integration model beyond its zero-shot capabilities. Additionally, we validate ECLARE’s applicability through a case study on major depressive disorder (MDD) data, illustrating its capability to reveal gene regulatory insights from unpaired nuclei. While current results highlight the potential of ensemble distillation in multi-omic analyses, future work will focus on optimizing model complexity, dataset scalability, and exploring applications in diverse multi-omic contexts. ECLARE establishes a robust foundation for biologically informed single-cell data integration, facilitating advanced downstream analyses and scaling multi-omic data for training advanced machine learning models.
Spatial transcriptomics has revolutionized our ability to characterize tissues and diseases by contextualizing gene expression with spatial … (see more)organization. Available methods require researchers to either train a model using histology-based annotations or use annotation-free clustering approaches to uncover spatial domains. However, few methods provide researchers with a way to jointly analyze spatial data from both annotation-free and annotation-guided perspectives using consistent inductive biases and levels of interpretability. A single framework with consistent inductive biases ensures coherence and transferability across tasks, reducing the risks of conflicting assumptions. To this end, we propose the Spatial Topic Model (SpaTM), a topic-modeling framework capable of annotation-guided and annotation-free analysis of spatial transcriptomics data. SpaTM can be used to learn gene programs that represent histology-based annotations while providing researchers with the ability to infer spatial domains with an annotation-free approach if manual annotations are limited or noisy. We demonstrate SpaTM’s interpretability with its use of topic mixtures to represent cell states and transcriptional programs and how its intuitive framework facilitates the integration of annotation-guided and annotation-free analyses of spatial data with downstream analyses such as cell type deconvolution. Finally, we demonstrate how both approaches can be used to extend the analysis of large-scale snRNA-seq atlases with the inference of cell proximity and spatial annotations in human brains with Major Depressive Disorder.
A multivariable prediction model for invasive pulmonary aspergillosis in immunocompromised patients with acute respiratory failure (IPA-GRRR-OH score).
Deep learning models have achieved remarkable success in segmenting brain white matter lesions in multiple sclerosis (MS), becoming integral… (see more) to both research and clinical workflows. While brain lesions have gained significant attention in MS research, the involvement of spinal cord lesions in MS is relatively understudied. This is largely owed to the variability in spinal cord magnetic resonance imaging (MRI) acquisition protocols, high individual anatomical differences, the complex morphology and size of spinal cord lesions - and lastly, the scarcity of labeled datasets required to develop robust segmentation tools. As a result, automatic segmentation of spinal cord MS lesions remains a significant challenge. Although some segmentation tools exist for spinal cord lesions, most have been developed using sagittal T2-weighted (T2w) sequences primarily focusing on cervical spines. With the growing importance of spinal cord imaging in MS, axial T2w scans are becoming increasingly relevant due to their superior sensitivity in detecting lesions compared to sagittal acquisition protocols. However, most existing segmentation methods struggle to effectively generalize to axial sequences due to differences in image characteristics caused by the highly anisotropic spinal cord scans. To address these challenges, we developed a robust, open-source lesion segmentation tool tailored specifically for axial T2w scans covering the whole spinal cord. We investigated key factors influencing lesion segmentation, including the impact of stitching together individually acquired spinal regions, straightening the spinal cord, and comparing the effectiveness of 2D and 3D convolutional neural networks (CNNs). Drawing on these insights, we trained a multi-center model using an extensive dataset of 582 MS patients, resulting in a dataset comprising an entirety of 2,167 scans. We empirically evaluated the model's segmentation performance across various spinal segments for lesions with varying sizes. Our model significantly outperforms the current state-of-the-art methods, providing consistent segmentation across cervical, thoracic and lumbar regions. To support the broader research community, we integrate our model into the widely-used Spinal Cord Toolbox (v7.0 and above), making it accessible via the command sct_deepseg -task seg_sc_ms_lesion_axial_t2w -i .
Deep learning models have achieved remarkable success in segmenting brain white matter lesions in multiple sclerosis (MS), becoming integral… (see more) to both research and clinical workflows. While brain lesions have gained significant attention in MS research, the involvement of spinal cord lesions in MS is relatively understudied. This is largely owed to the variability in spinal cord magnetic resonance imaging (MRI) acquisition protocols, high individual anatomical differences, the complex morphology and size of spinal cord lesions - and lastly, the scarcity of labeled datasets required to develop robust segmentation tools. As a result, automatic segmentation of spinal cord MS lesions remains a significant challenge. Although some segmentation tools exist for spinal cord lesions, most have been developed using sagittal T2-weighted (T2w) sequences primarily focusing on cervical spines. With the growing importance of spinal cord imaging in MS, axial T2w scans are becoming increasingly relevant due to their superior sensitivity in detecting lesions compared to sagittal acquisition protocols. However, most existing segmentation methods struggle to effectively generalize to axial sequences due to differences in image characteristics caused by the highly anisotropic spinal cord scans. To address these challenges, we developed a robust, open-source lesion segmentation tool tailored specifically for axial T2w scans covering the whole spinal cord. We investigated key factors influencing lesion segmentation, including the impact of stitching together individually acquired spinal regions, straightening the spinal cord, and comparing the effectiveness of 2D and 3D convolutional neural networks (CNNs). Drawing on these insights, we trained a multi-center model using an extensive dataset of 582 MS patients, resulting in a dataset comprising an entirety of 2,167 scans. We empirically evaluated the model's segmentation performance across various spinal segments for lesions with varying sizes. Our model significantly outperforms the current state-of-the-art methods, providing consistent segmentation across cervical, thoracic and lumbar regions. To support the broader research community, we integrate our model into the widely-used Spinal Cord Toolbox (v7.0 and above), making it accessible via the command sct_deepseg -task seg_sc_ms_lesion_axial_t2w -i .
