Publications

The race to understand immunopathology in COVID-19: Perspectives on the impact of quantitative approaches to understand within-host interactions
Sonia Gazeau
Xiaoyan Deng
Hsu Kiang Ooi
Fatima Mostefai
Julie Hussin
Jane Heffernan
Adrianne L. Jenner
Morgan Craig
2023-01-01
ImmunoInformatics (published)
doi.org
The StatCan Dialogue Dataset: Retrieving Data Tables through Conversations with Genuine Intents
Xing Han Lu
Siva Reddy
Harm de Vries
2023-01-01
EACL (published)
doi.org
arxiv.org
The Statistical Benefits of Quantile Temporal-Difference Learning for Value Estimation
Mark Rowland
Yunhao Tang
Clare Lyle
Remi Munos
Marc Gendron-Bellemare
Will Dabney
2023-01-01
ICML (published)
doi.org
openreview.net
The Statistical Benefits of Quantile Temporal-Difference Learning for Value Estimation
Mark Rowland
Yunhao Tang
Clare Lyle
Remi Munos
Marc Gendron-Bellemare
Will Dabney
We study the problem of temporal-difference-based policy evaluation in reinforcement learning. In particular, we analyse the use of a distri… (see more)butional reinforcement learning algorithm, quantile temporal-difference learning (QTD), for this task. We reach the surprising conclusion that even if a practitioner has no interest in the return distribution beyond the mean, QTD (which learns predictions about the full distribution of returns) may offer performance superior to approaches such as classical TD learning, which predict only the mean return, even in the tabular setting.
2023-01-01
ICML (published)
doi.org
openreview.net
A theory of continuous generative flow networks
Salem Lahlou
Tristan Deleu
Pablo Lemos
Dinghuai Zhang
Alexandra Volokhova
Alex Hernandez-Garcia
Lena Nehale Ezzine
Yoshua Bengio
Nikolay Malkin
2023-01-01
ICML (published)
doi.org
openreview.net
A theory of continuous generative flow networks
Salem Lahlou
Tristan Deleu
Pablo Lemos
Dinghuai Zhang
Alexandra Volokhova
Alex Hernandez-Garcia
Lena Nehale Ezzine
Yoshua Bengio
Nikolay Malkin
Generative flow networks (GFlowNets) are amortized variational inference algorithms that are trained to sample from unnormalized target dist… (see more)ributions over compositional objects. A key limitation of GFlowNets until this time has been that they are restricted to discrete spaces. We present a theory for generalized GFlowNets, which encompasses both existing discrete GFlowNets and ones with continuous or hybrid state spaces, and perform experiments with two goals in mind. First, we illustrate critical points of the theory and the importance of various assumptions. Second, we empirically demonstrate how observations about discrete GFlowNets transfer to the continuous case and show strong results compared to non-GFlowNet baselines on several previously studied tasks. This work greatly widens the perspectives for the application of GFlowNets in probabilistic inference and various modeling settings.
2023-01-01
ICML (published)
doi.org
openreview.net
Towards Detecting Contextual Real-Time Toxicity for In-Game Chat
Zachary Yang
Nicolas Grenon-Godbout
Reihaneh Rabbany
Real-time toxicity detection in online environments poses a significant challenge, due to the increasing prevalence of social media and gami… (see more)ng platforms. We introduce ToxBuster, a simple and scalable model that reliably detects toxic content in real-time for a line of chat by including chat history and metadata. ToxBuster consistently outperforms conventional toxicity models across popular multiplayer games, including Rainbow Six Siege, For Honor, and DOTA 2. We conduct an ablation study to assess the importance of each model component and explore ToxBuster's transferability across the datasets. Furthermore, we showcase ToxBuster's efficacy in post-game moderation, successfully flagging 82.1% of chat-reported players at a precision level of 90.0%. Additionally, we show how an additional 6% of unreported toxic players can be proactively moderated.
2023-01-01
EMNLP (Findings) (published)
doi.org
openreview.net
Towards Learning to Imitate from a Single Video Demonstration
Glen Berseth
Florian Golemo
Chris Pal
Agents that can learn to imitate given video observation -- \emph{without direct access to state or action information} are more applicable … (see more)to learning in the natural world. However, formulating a reinforcement learning (RL) agent that facilitates this goal remains a significant challenge. We approach this challenge using contrastive training to learn a reward function comparing an agent's behaviour with a single demonstration. We use a Siamese recurrent neural network architecture to learn rewards in space and time between motion clips while training an RL policy to minimize this distance. Through experimentation, we also find that the inclusion of multi-task data and additional image encoding losses improve the temporal consistency of the learned rewards and, as a result, significantly improves policy learning. We demonstrate our approach on simulated humanoid, dog, and raptor agents in 2D and a quadruped and a humanoid in 3D. We show that our method outperforms current state-of-the-art techniques in these environments and can learn to imitate from a single video demonstration.
arxiv.org
Towards Reliable Neural Specifications
Chuqin Geng
Nham Le
Xiaojie Xu
Zhaoyue Wang
Arie Gurfinkel
Xujie Si
2023-01-01
ICML (published)
openreview.net
openreview.net
Towards Reliable Neural Specifications
Chuqin Geng
Nham Le
Xiaojie Xu
Zhaoyue Wang
Arie Gurfinkel
Xujie Si
2023-01-01
ICML (published)
proceedings.mlr.press
openreview.net
TrafficVis: Visualizing Organized Activity and Spatio-Temporal Patterns for Detecting and Labeling Human Trafficking
Catalina Vajiac
Duen Horng Chau
Andreas Olligschlaeger
Rebecca Mackenzie
Pratheeksha Nair
Meng-Chieh Lee
Yifei Li
Namyong Park
Reihaneh Rabbany
Christos Faloutsos
Law enforcement and domain experts can detect human trafficking (HT) in online escort websites by analyzing suspicious clusters of connected… (see more) ads. How can we explain clustering results intuitively and interactively, visualizing potential evidence for experts to analyze? We present TrafficVis, the first interface for cluster-level HT detection and labeling. Developed through months of participatory design with domain experts, TrafficVis provides coordinated views in conjunction with carefully chosen backend algorithms to effectively show spatio-temporal and text patterns to a wide variety of anti-HT stakeholders. We build upon state-of-the-art text clustering algorithms by incorporating shared metadata as a signal of connected and possibly suspicious activity, then visualize the results. Domain experts can use TrafficVis to label clusters as HT, or other, suspicious, but non-HT activity such as spam and scam, quickly creating labeled datasets to enable further HT research. Through domain expert feedback and a usage scenario, we demonstrate TRAFFICVIS's efficacy. The feedback was overwhelmingly positive, with repeated high praises for the usability and explainability of our tool, the latter being vital for indicting possible criminals.
2023-01-01
IEEE Transactions on Visualization and Computer Graphics (published)
doi.org
Transposable elements regulate thymus development and function 1
Jean-David Larouche
Céline M. Laumont
Assya Trofimov
Krystel Vincent
Leslie Hesnard
Sylvie Brochu
Caroline Côté
Juliette Humeau
Eric Bonneil
Joël Lanoix
Chantal Durette
Patrick Gendron
Jean-Philippe Laverdure
Ellen Rothman Richie
Sébastien Lemieux
Pierre Thibault
Claude Perreault
21 Transposable elements (TE) are repetitive sequences representing ~45% of the human and mouse genomes 22 and are highly expressed by medul… (see more)lary thymic epithelial cells (mTEC). In this study, we investigated the 23 role of transposable elements (TE), which are highly expressed by medullary thymic epithelial cells 24 (mTEC), on T-cell development in the thymus. We performed multi-omic analyses of TEs in human and 25 mouse thymic cells to elucidate their role in T cell development. We report that TE expression in the 26 human thymus is high and shows extensive ageand cell lineage-related variations. TEs interact with 27 multiple transcription factors in all cell types of the human thymus. Two cell types express particularly 28 broad TE repertoires: mTECs and plasmacytoid dendritic cells (pDC). In mTECs, TEs interact with 29 transcription factors essential for mTEC development and function (e.g., PAX1 and RELB) and generate 30 MHC-I-associated peptides implicated in thymocyte education. Notably, AIRE, FEZF2, and CHD4 31 regulate non-redundant sets of TEs in murine mTECs. Human thymic pDCs homogenously express large 32 numbers of TEs that lead to the formation of dsRNA, triggering RIG-I and MDA5 signaling and 33 explaining why thymic pDCs constitutively secrete IFN ɑ/β. This study illustrates the diversity of 34 interactions between TEs and the adaptive immune system. TEs are genetic parasites, and the two thymic 35 cell types most affected by TEs (mTEcs and pDCs) are essential to establishing central T-cell tolerance. 36 Therefore, we propose that the orchestration of TE expression in thymic cells is critical to prevent 37 autoimmunity in vertebrates. 38