Publications

Expressiveness and Learnability: A Unifying View for Evaluating Self-Supervised Learning
General anaesthesia reduces the uniqueness of brain connectivity across individuals and across species
Andrea I. Luppi
Daniel Golkowski
Andreas Ranft
Rudiger Ilg
Denis Jordan
Adrian M. Owen
Lorina Naci
Emmanuel A. Stamatakis
Enrico Amico
Bratislav Misic
The human brain is characterised by idiosyncratic patterns of spontaneous thought, rendering each brain uniquely identifiable from its neura… (see more)l activity. However, deep general anaesthesia suppresses subjective experience. Does it also suppress what makes each brain unique? Here we used functional MRI under the effects of the general anaesthetics sevoflurane and propofol to determine whether anaesthetic-induced unconsciousness diminishes the uniqueness of the human brain: both with respect to the brains of other individuals, and the brains of another species. We report that under anaesthesia individual brains become less self-similar and less distinguishable from each other. Loss of distinctiveness is highly organised: it co-localises with the archetypal sensory-association axis, correlating with genetic and morphometric markers of phylogenetic differences between humans and other primates. This effect is more evident at greater anaesthetic depths, reproducible across sevoflurane and propofol, and reversed upon recovery. Providing convergent evidence, we show that under anaesthesia the functional connectivity of the human brain becomes more similar to the macaque brain. Finally, anaesthesia diminishes the match between spontaneous brain activity and meta-analytic brain patterns aggregated from the NeuroSynth engine. Collectively, the present results reveal that anaesthetised human brains are not only less distinguishable from each other, but also less distinguishable from the brains of other primates, with specifically human-expanded regions being the most affected by anaesthesia.
Language Model-In-The-Loop: Data Optimal Approach to Learn-To-Recommend Actions in Text Games
Towards Climate Variable Prediction with Conditioned Spatio-Temporal Normalizing Flows
Bridging the Gap Between Offline and Online Reinforcement Learning Evaluation Methodologies
Shiva Kanth Sujit
Pedro Braga
S Ebrahimi Kahou
Reinforcement learning (RL) has shown great promise with algorithms learning in environments with large state and action spaces purely from … (see more)scalar reward signals. A crucial challenge for current deep RL algorithms is that they require a tremendous amount of environment interactions for learning. This can be infeasible in situations where such interactions are expensive, such as in robotics. Offline RL algorithms try to address this issue by bootstrapping the learning process from existing logged data without needing to interact with the environment from the very beginning. While online RL algorithms are typically evaluated as a function of the number of environment interactions, there isn't a single established protocol for evaluating offline RL methods. In this paper, we propose a sequential approach to evaluate offline RL algorithms as a function of the training set size and thus by their data efficiency. Sequential evaluation provides valuable insights into the data efficiency of the learning process and the robustness of algorithms to distribution changes in the dataset while also harmonizing the visualization of the offline and online learning phases. Our approach is generally applicable and easy to implement. We compare several existing offline RL algorithms using this approach and present insights from a variety of tasks and offline datasets.
DASVDD: Deep Autoencoding Support Vector Data Descriptor for Anomaly Detection
Semi-supervised anomaly detection aims to detect anomalies from normal samples using a model that is trained on normal data. With recent adv… (see more)ancements in deep learning, researchers have designed efficient deep anomaly detection methods. Existing works commonly use neural networks to map the data into a more informative representation and then apply an anomaly detection algorithm. In this paper, we propose a method, DASVDD, that jointly learns the parameters of an autoencoder while minimizing the volume of an enclosing hyper-sphere on its latent representation. We propose an anomaly score which is a combination of autoencoder's reconstruction error and the distance from the center of the enclosing hypersphere in the latent representation. Minimizing this anomaly score aids us in learning the underlying distribution of the normal class during training. Including the reconstruction error in the anomaly score ensures that DASVDD does not suffer from the common hypersphere collapse issue since the DASVDD model does not converge to the trivial solution of mapping all inputs to a constant point in the latent representation. Experimental evaluations on several benchmark datasets show that the proposed method outperforms the commonly used state-of-the-art anomaly detection algorithms while maintaining robust performance across different anomaly classes.
CD3ζ ITAMs enable ligand discrimination and antagonism by inhibiting TCR signaling in response to low-affinity peptides
Guillaume Gaud
Sooraj Achar
François X. P. Bourassa
John Davies
Teri Hatzihristidis
Seeyoung Choi
Taisuke Kondo
Selamawit Gossa
Jan Lee
Paul Juneau
Naomi Taylor
Christian S. Hinrichs
Dorian B. McGavern
Grégoire Altan‐Bonnet
Paul E. Love
Stochastic Mirror Descent: Convergence Analysis and Adaptive Variants via the Mirror Stochastic Polyak Stepsize
We investigate the convergence of stochastic mirror descent (SMD) under interpolation in relatively smooth and smooth convex optimization. I… (see more)n relatively smooth convex optimization we provide new convergence guarantees for SMD with a constant stepsize. For smooth convex optimization we propose a new adaptive stepsize scheme --- the mirror stochastic Polyak stepsize (mSPS). Notably, our convergence results in both settings do not make bounded gradient assumptions or bounded variance assumptions, and we show convergence to a neighborhood that vanishes under interpolation. Consequently, these results correspond to the first convergence guarantees under interpolation for the exponentiated gradient algorithm for fixed or adaptive stepsizes. mSPS generalizes the recently proposed stochastic Polyak stepsize (SPS) (Loizou et al. 2021) to mirror descent and remains both practical and efficient for modern machine learning applications while inheriting the benefits of mirror descent. We complement our results with experiments across various supervised learning tasks and different instances of SMD, demonstrating the effectiveness of mSPS.
Capture the Flag: Uncovering Data Insights with Large Language Models.
Issam H. Laradji
Sai Rajeswar
Valentina Zantedeschi
Alexandre Lacoste
Christopher Pal
The extraction of a small number of relevant insights from vast amounts of data is a crucial component of data-driven decision-making. Howev… (see more)er, accomplishing this task requires considerable technical skills, domain expertise, and human labor. This study explores the potential of using Large Language Models (LLMs) to automate the discovery of insights in data, leveraging recent advances in reasoning and code generation techniques. We propose a new evaluation methodology based on a "capture the flag" principle, measuring the ability of such models to recognize meaningful and pertinent information (flags) in a dataset. We further propose two proof-of-concept agents, with different inner workings, and compare their ability to capture such flags in a real-world sales dataset. While the work reported here is preliminary, our results are sufficiently interesting to mandate future exploration by the community.
The Unsolved Challenges of LLMs as Generalist Web Agents: A Case Study
Massimo Caccia
Issam Hadj Laradji
Sai Rajeswar
Hector Palacios
Maxime Gasse
Alexandre Lacoste
30×30 biodiversity gains rely on national coordination
Isaac Eckert
Andrea Brown
Dominique Caron
Federico Riva
Laplacian Change Point Detection for Single and Multi-view Dynamic Graphs
Dynamic graphs are rich data structures that are used to model complex relationships between entities over time. In particular, anomaly dete… (see more)ction in temporal graphs is crucial for many real world applications such as intrusion identification in network systems, detection of ecosystem disturbances and detection of epidemic outbreaks. In this paper, we focus on change point detection in dynamic graphs and address three main challenges associated with this problem: i). how to compare graph snapshots across time, ii). how to capture temporal dependencies, and iii). how to combine different views of a temporal graph. To solve the above challenges, we first propose Laplacian Anomaly Detection (LAD) which uses the spectrum of graph Laplacian as the low dimensional embedding of the graph structure at each snapshot. LAD explicitly models short term and long term dependencies by applying two sliding windows. Next, we propose MultiLAD, a simple and effective generalization of LAD to multi-view graphs. MultiLAD provides the first change point detection method for multi-view dynamic graphs. It aggregates the singular values of the normalized graph Laplacian from different views through the scalar power mean operation. Through extensive synthetic experiments, we show that i). LAD and MultiLAD are accurate and outperforms state-of-the-art baselines and their multi-view extensions by a large margin, ii). MultiLAD's advantage over contenders significantly increases when additional views are available, and iii). MultiLAD is highly robust to noise from individual views. In five real world dynamic graphs, we demonstrate that LAD and MultiLAD identify significant events as top anomalies such as the implementation of government COVID-19 interventions which impacted the population mobility in multi-view traffic networks.